-
1
-
-
0026597063
-
Alzheimer's disease: The amyloid cascade hypothesis
-
1566067
-
Hardy J. A. and Higgins G. A. (1992) Alzheimer's disease: the amyloid cascade hypothesis. Science, 256:184-185. PMID: 1566067
-
(1992)
Science
, vol.256
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
2
-
-
0026646604
-
Amyloid beta-peptide is produced by cultured cells during normal metabolism
-
1383826
-
Haass C., Schlossmacher M. G., Hung A. Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B. L., et al. (1992) Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature, 359:322-325. PMID: 1383826
-
(1992)
Nature
, vol.359
, pp. 322-325
-
-
Haass, C.1
Schlossmacher, M.G.2
Hung, A.Y.3
Vigo-Pelfrey, C.4
Mellon, A.5
Ostaszewski, B.L.6
-
3
-
-
77950222812
-
Presenilins and the gamma-secretase: Still a complex problem
-
20181106
-
Small D. H., Klaver D. W., and Foa L. (2010) Presenilins and the gamma-secretase: still a complex problem. Mol Brain, 3:7. doi: 10.1186/1756-6606-3-7 PMID: 20181106
-
(2010)
Mol Brain
, vol.3
, pp. 7
-
-
Small, D.H.1
Klaver, D.W.2
Foa, L.3
-
4
-
-
0025773835
-
Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein
-
1652752
-
Cras P., Kawai M., Lowery D., Gonzalez-De Whitt P., Greenberg B., and Perry G. (1991) Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc. Natl. Acad. Sci. USA., 88:7552-7556. PMID: 1652752
-
(1991)
Proc. Natl. Acad. Sci. USA.
, vol.88
, pp. 7552-7556
-
-
Cras, P.1
Kawai, M.2
Lowery, D.3
Gonzalez-De Whitt, P.4
Greenberg, B.5
Perry, G.6
-
5
-
-
20444496481
-
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
-
15722360
-
Demuro A., Mina E., Kayed R., Milton S. C., Parker I., and Glabe C. G. (2005) Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J Biol Chem., 280:17294-17300. PMID: 15722360
-
(2005)
J Biol Chem.
, vol.280
, pp. 17294-17300
-
-
Demuro, A.1
Mina, E.2
Kayed, R.3
Milton, S.C.4
Parker, I.5
Glabe, C.G.6
-
6
-
-
0033603459
-
Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes
-
10373497
-
Mason R. P., Jacob R. F., Walter M. F., Mason P. E., Avdulov N. A., Chochina S. V., et al. (1999) Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes. J. Biol. Chem., 274:18801-18807. PMID: 10373497
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18801-18807
-
-
Mason, R.P.1
Jacob, R.F.2
Walter, M.F.3
Mason, P.E.4
Avdulov, N.A.5
Chochina, S.V.6
-
7
-
-
33751516396
-
Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure
-
17101816
-
Sokolov Y., Kozak J. A., Kayed R., Chanturiya A., Glabe C., Hall J. E. (2006) Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure. J. Gen. Physiol., 128:637-647. PMID: 17101816
-
(2006)
J. Gen. Physiol.
, vol.128
, pp. 637-647
-
-
Sokolov, Y.1
Kozak, J.A.2
Kayed, R.3
Chanturiya, A.4
Glabe, C.5
Hall, J.E.6
-
8
-
-
0035997234
-
The channel hypothesis of Alzheimer's disease: Current status
-
12128087
-
Kagan B. L., Hirakura Y., Azimov R., Azimova R., and Lin M. C. (2002) The channel hypothesis of Alzheimer's disease: current status. Peptides, 23(7), 1311-1315. PMID: 12128087
-
(2002)
Peptides
, vol.23
, Issue.7
, pp. 1311-1315
-
-
Kagan, B.L.1
Hirakura, Y.2
Azimov, R.3
Azimova, R.4
Lin, M.C.5
-
9
-
-
84903756361
-
Activity and architecture of pyroglutamate-modified Amyloid-β (AβpE3-42) pores
-
24922585
-
Gillman A. L., Jang H., Lee J., Ramachandran S., Kagan B. L., Nussinov R., and Teran Arce F. (2014) Activity and architecture of pyroglutamate-modified Amyloid-β (AβpE3-42) pores. The Journal of Physical Chemistry B, 118(26), 7335-7344. doi: 10.1021/jp5040954 PMID: 24922585
-
(2014)
The Journal of Physical Chemistry B
, vol.118
, Issue.26
, pp. 7335-7344
-
-
Gillman, A.L.1
Jang, H.2
Lee, J.3
Ramachandran, S.4
Kagan, B.L.5
Nussinov, R.6
Arce, F.T.7
-
10
-
-
84856262919
-
Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions
-
22242635
-
Capone R., Jang H., Kotler S. A., Kagan B. L., Nussinov R., and Lal R. (2012) Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions. Biochemistry, 51(3), 776-785. doi: 10.1021/bi2017427 PMID: 22242635
-
(2012)
Biochemistry
, vol.51
, Issue.3
, pp. 776-785
-
-
Capone, R.1
Jang, H.2
Kotler, S.A.3
Kagan, B.L.4
Nussinov, R.5
Lal, R.6
-
12
-
-
77949899089
-
Calcium hypothesis of Alzheimer's disease
-
19795132
-
Berridge M. J. (2010) Calcium hypothesis of Alzheimer's disease. Pflugers Arch., 459:441-449. doi: 10.1007/s00424-009-0736-1 PMID: 19795132
-
(2010)
Pflugers Arch.
, vol.459
, pp. 441-449
-
-
Berridge, M.J.1
-
13
-
-
77953658771
-
Deleterious effects of amyloid β oligomers acting as an extracellular scaffold for mGluR5
-
20547131
-
Renner M., Lacor P. N., Velasco P. T., Xu J., Contractor A., Klein W. L., et al. (2010). Deleterious effects of amyloid β oligomers acting as an extracellular scaffold for mGluR5. Neuron, 66:739-754. doi: 10. 1016/j.neuron. 2010.04.029 PMID: 20547131
-
(2010)
Neuron
, vol.66
, pp. 739-754
-
-
Renner, M.1
Lacor, P.N.2
Velasco, P.T.3
Xu, J.4
Contractor, A.5
Klein, W.L.6
-
14
-
-
34249672242
-
Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine
-
17308309
-
De Felice F. G., Velasco P. T., Lambert M. P., Viola K., Fernandez S. J., Ferreira S. T., et al. (2007) Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. J. Biol. Chem., 282:11590-11601. PMID: 17308309
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 11590-11601
-
-
De Felice, F.G.1
Velasco, P.T.2
Lambert, M.P.3
Viola, K.4
Fernandez, S.J.5
Ferreira, S.T.6
-
15
-
-
0034006944
-
Beta-Amyloid (1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology
-
10681545
-
Wang H. Y., Lee D. H., D'Andrea M. R., Peterson P. A., Shank R. P., Reitz A. B. (2000) beta-Amyloid (1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J. Biol. Chem., 275:5626-5632. PMID: 10681545
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5626-5632
-
-
Wang, H.Y.1
Lee, D.H.2
D'Andrea, M.R.3
Peterson, P.A.4
Shank, R.P.5
Reitz, A.B.6
-
16
-
-
0027490362
-
Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes
-
7504270
-
Arispe N., Pollard H. B., and Rojas E. (1993) Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes. Proc. Natl. Acad. Sci. USA. 90:10573-10577. PMID: 7504270
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 10573-10577
-
-
Arispe, N.1
Pollard, H.B.2
Rojas, E.3
-
17
-
-
34547203205
-
Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm
-
17553456
-
Lal R., Lin H., and Quist A. P. (2007) Amyloid beta ion channel: 3D structure and relevance to amyloid channel paradigm. Biochim. Biophys. Acta. 1768:1966-1975. PMID: 17553456
-
(2007)
Biochim. Biophys. Acta.
, vol.1768
, pp. 1966-1975
-
-
Lal, R.1
Lin, H.2
Quist, A.P.3
-
18
-
-
0035159553
-
Amyloid β protein forms ion channels: Implications for Alzheimer's disease pathophysiology
-
11689468
-
Lin H., Bhatia R., and Lal R. (2001) Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology. FASEB J. 15:2433-2444. PMID: 11689468
-
(2001)
FASEB J.
, vol.15
, pp. 2433-2444
-
-
Lin, H.1
Bhatia, R.2
Lal, R.3
-
19
-
-
84855750207
-
2+ imaging implicates Abeta1-42 amyloid pores in Alzheimer's disease pathology
-
22024165
-
2+ imaging implicates Abeta1-42 amyloid pores in Alzheimer's disease pathology. J. Cell. Biol., 195:515-524. doi: 10.1083/jcb.201104133 PMID: 22024165
-
(2011)
J. Cell. Biol.
, vol.195
, pp. 515-524
-
-
Demuro, A.1
Smith, M.2
Parker, I.3
-
20
-
-
84874590326
-
2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate
-
2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate. J. Neurosci., 9:3824-3833
-
(2013)
J. Neurosci.
, vol.9
, pp. 3824-3833
-
-
Demuro, A.1
Parker, I.2
-
21
-
-
61849142791
-
Calcium signaling and neurodegenerative diseases
-
19230774
-
Bezprozvanny I. (2009) Calcium signaling and neurodegenerative diseases. Trends. Mol. Med., 15:89-100. doi: 10.1016/j.molmed.2009.01.001 PMID: 19230774
-
(2009)
Trends. Mol. Med.
, vol.15
, pp. 89-100
-
-
Bezprozvanny, I.1
-
22
-
-
50249135503
-
Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease
-
18675468
-
Bezprozvanny I. and Mattson M. P. (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease. Trends Neurosci., 31:454-463. doi: 10.1016/j.tins.2008.06.005 PMID: 18675468
-
(2008)
Trends Neurosci.
, vol.31
, pp. 454-463
-
-
Bezprozvanny, I.1
Mattson, M.P.2
-
23
-
-
79959907270
-
2+ signaling and Alzheimer's disease
-
2+ signaling and Alzheimer's disease. Neuroschem. Res., 36:1149-1156.
-
(2011)
Neuroschem. Res.
, vol.36
, pp. 1149-1156
-
-
Berridge, M.J.1
-
24
-
-
34447564164
-
Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice
-
16876915
-
Knobloch M., Konietzko U., Krebs D. C., and Nitsch R. M. (2007) Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice. Neurobiol. Aging, 28:1297-1306. PMID: 16876915
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1297-1306
-
-
Knobloch, M.1
Konietzko, U.2
Krebs, D.C.3
Nitsch, R.M.4
-
26
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
-
12895417
-
Oddo S., Caccamo A., Shepherd J. D., Murphy M. P., Golde T. E., Kayed R., et al. (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron, 39:409-421. PMID: 12895417
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
Caccamo, A.2
Shepherd, J.D.3
Murphy, M.P.4
Golde, T.E.5
Kayed, R.6
-
27
-
-
77951251848
-
Calcium signaling and amyloid toxicity in Alzheimer disease
-
20212036
-
Demuro A., Parker I., Stutzmann G. E. (2010) Calcium signaling and amyloid toxicity in Alzheimer disease. J. Biol. Chem., 285:12463-12468. doi: 10.1074/jbc. R109.080895 PMID: 20212036
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 12463-12468
-
-
Demuro, A.1
Parker, I.2
Stutzmann, G.E.3
-
28
-
-
47749095383
-
Linking calcium to Abeta and Alzheimer's disease
-
18667147
-
Green K. N. and La Ferla F. M. (2008) Linking calcium to Abeta and Alzheimer's disease. Neuron, 59:190-194. doi: 10.1016/j.neuron. 2008.07.013 PMID: 18667147
-
(2008)
Neuron
, vol.59
, pp. 190-194
-
-
Green, K.N.1
La Ferla, F.M.2
-
29
-
-
62649172167
-
Small molecule blockers of the Alzheimer Ap calcium channel potently protect neurons from Ap cytotoxicity
-
Diaz J. C., Simakova O., Jacobson K. A., Arispe N., and Pollard H. B. (2009) Small molecule blockers of the Alzheimer Ap calcium channel potently protect neurons from Ap cytotoxicity. Proceedings of the National Academy of Sciences, 106(9), 3348-3353.
-
(2009)
Proceedings of the National Academy of Sciences
, vol.106
, Issue.9
, pp. 3348-3353
-
-
Diaz, J.C.1
Simakova, O.2
Jacobson, K.A.3
Arispe, N.4
Pollard, H.B.5
-
30
-
-
34547214510
-
Ap ion channels. Prospects for treating Alzheimer's disease with Ap channel blockers
-
Arispe N., Diaz J. C., and Simakova O. (2007) Ap ion channels. Prospects for treating Alzheimer's disease with Ap channel blockers. Biochimicaet Biophysica Acta (BBA)-Biomembranes, 1768(8), 1952-1965.
-
(2007)
Biochimicaet Biophysica Acta (BBA)-Biomembranes
, vol.1768
, Issue.8
, pp. 1952-1965
-
-
Arispe, N.1
Diaz, J.C.2
Simakova, O.3
-
31
-
-
84879824377
-
Automated maximum likelihood separation of signal from baseline in noisy quantal data
-
23823225
-
Bruno W. J., Ullah G., Mak D. O. D., and Pearson J. E. (2013) Automated maximum likelihood separation of signal from baseline in noisy quantal data. Biophys. J., 105:68-79. doi: 10.1016/j.bpj.2013.02. 060 PMID: 23823225
-
(2013)
Biophys. J.
, vol.105
, pp. 68-79
-
-
Bruno, W.J.1
Ullah, G.2
Mak, D.O.D.3
Pearson, J.E.4
-
32
-
-
80755151119
-
Effects of 8-residue p sheet breaker peptides on aged Ap40-induced memory impairment and Ap40 expression in rat brain and serum following intraamygdaloid injection
-
20977411
-
Hatip F. F., Hatip-Al-Khatib I., Matsunaga Y., Suenaga M., and Sen N. (2010) Effects of 8-residue p sheet breaker peptides on aged Ap40-induced memory impairment and Ap40 expression in rat brain and serum following intraamygdaloid injection. Current Alzheimer research, 7(7), 602-614. PMID: 20977411
-
(2010)
Current Alzheimer Research
, vol.7
, Issue.7
, pp. 602-614
-
-
Hatip, F.F.1
Hatip-Al-Khatib, I.2
Matsunaga, Y.3
Suenaga, M.4
Sen, N.5
-
33
-
-
84867492819
-
Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity
-
23077580
-
Prangkio P., Yusko E. C., Sept D., Yang J., and Mayer M. (2012) Multivariate analyses of amyloid-beta oligomer populations indicate a connection between pore formation and cytotoxicity. Plos One, 7(10):e47261 doi: 10.1371/journal.pone.0047261 PMID: 23077580
-
(2012)
Plos One
, vol.7
, Issue.10
, pp. e47261
-
-
Prangkio, P.1
Yusko, E.C.2
Sept, D.3
Yang, J.4
Mayer, M.5
-
34
-
-
24344510184
-
2+ flux through individual muscle acetylcholine receptor channels
-
2+ flux through individual muscle acetylcholine receptor channels. J. Gen. Physiol., 126:179-192.
-
(2005)
J. Gen. Physiol.
, vol.126
, pp. 179-192
-
-
Demuro, A.1
Parker, I.2
-
35
-
-
21844468879
-
Imaging single-channel calcium microdomains by total internal reflection microscopy
-
15709697
-
Demuro A. and Parker I.. (2004) Imaging single-channel calcium microdomains by total internal reflection microscopy. Biol. Res., 37:675-679. PMID: 15709697
-
(2004)
Biol. Res.
, vol.37
, pp. 675-679
-
-
Demuro, A.1
Parker, I.2
-
38
-
-
0030956174
-
Maximum likelihood estimation of aggregated Markov processes
-
Qin F., Auerbach A., and Sachs F. (1997) Maximum likelihood estimation of aggregated Markov processes. Proc. Biol. Sci. 264:375-383.
-
(1997)
Proc. Biol. Sci.
, vol.264
, pp. 375-383
-
-
Qin, F.1
Auerbach, A.2
Sachs, F.3
-
39
-
-
18144410993
-
Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics
-
15843461
-
Bruno W. J., Yang J., and Pearson J. E. (2005). Using independent open-to-closed transitions to simplify aggregated Markov models of ion channel gating kinetics. Proc. Natl. Acad. Sci. USA. 102:6326-6331. PMID: 15843461
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 6326-6331
-
-
Bruno, W.J.1
Yang, J.2
Pearson, J.E.3
-
40
-
-
33646175493
-
Modeling the statistics of elementary calcium release events
-
16513779
-
Ullah G. and Jung P. (2006). Modeling the statistics of elementary calcium release events. Biophys. J., 90:3485-3495. PMID: 16513779
-
(2006)
Biophys. J.
, vol.90
, pp. 3485-3495
-
-
Ullah, G.1
Jung, P.2
-
41
-
-
84863634386
-
Multi-scale data-driven modeling and observation of calcium puffs
-
22682010
-
Ullah G., Parker I., Mak D. O. D., and Pearson J. E. (2012). Multi-scale data-driven modeling and observation of calcium puffs. Cell Calcium, 52:152-160. doi: 10.1016/j.ceca.2012.04.018 PMID: 22682010
-
(2012)
Cell Calcium
, vol.52
, pp. 152-160
-
-
Ullah, G.1
Parker, I.2
Mak, D.O.D.3
Pearson, J.E.4
-
42
-
-
84865607039
-
A data-driven model of a modal gated ion channel: The inositol 1, 4, 5-trisphosphate receptor in insect Sf9 cells
-
Ullah G., Mak D. O. D., and Pearson J. E. (2012a). A data-driven model of a modal gated ion channel: The inositol 1, 4, 5-trisphosphate receptor in insect Sf9 cells. J. Gen. Physiol. 140:159-173.
-
(2012)
J. Gen. Physiol.
, vol.140
, pp. 159-173
-
-
Ullah, G.1
Mak, D.O.D.2
Pearson, J.E.3
-
43
-
-
0141736796
-
The Ca-activated Cl channel and its control in rat olfactory receptor neurons
-
Reisert J., Bauer P. J., Yau K. W., and Frings S. (2003). The Ca-activated Cl channel and its control in rat olfactory receptor neurons. The Journal of general physiology, 122(3), 349-364.
-
(2003)
The Journal of General Physiology
, vol.122
, Issue.3
, pp. 349-364
-
-
Reisert, J.1
Bauer, P.J.2
Yau, K.W.3
Frings, S.4
-
44
-
-
0036428586
-
Characterization of large conductance Ca2+-activated K+ channels in cerebellar Purkinje neurons
-
Womack M. D., and Khodakhah K. (2002). Characterization of large conductance Ca2+-activated K+ channels in cerebellar Purkinje neurons. European Journal of Neuroscience, 16(7), 1214-1222.
-
(2002)
European Journal of Neuroscience
, vol.16
, Issue.7
, pp. 1214-1222
-
-
Womack, M.D.1
Khodakhah, K.2
-
45
-
-
0024566934
-
Equivalence of aggregated Markov models of ion-channel gating
-
Kienker P. (1989) Equivalence of aggregated Markov models of ion-channel gating. Proc. R. Soc. London B. Biol. Sci., 236:269-309.
-
(1989)
Proc. R. Soc. London B. Biol. Sci.
, vol.236
, pp. 269-309
-
-
Kienker, P.1
-
46
-
-
0023462332
-
Theory of the kinetic analysis of patch-clamp data
-
2447973
-
Bauer R. J. and Bowman B. F., and Kenyon J. L. (1987) Theory of the kinetic analysis of patch-clamp data. Biophys. J., 52:961-978. PMID: 2447973
-
(1987)
Biophys. J.
, vol.52
, pp. 961-978
-
-
Bauer, R.J.1
Bowman, B.F.2
Kenyon, J.L.3
-
47
-
-
0033566369
-
Alzheimer amyloid Aβ1-42 channels: Effects of solvent, pH, and congo red
-
10440895
-
Hirakura Y., Meng-Chin L., and Kagan B. L. (1999) Alzheimer amyloid Aβ1-42 channels: Effects of solvent, pH, and congo red. J. Neurosci. Res. 57:458-466. PMID: 10440895
-
(1999)
J. Neurosci. Res.
, vol.57
, pp. 458-466
-
-
Hirakura, Y.1
Meng-Chin, L.2
Kagan, B.L.3
-
48
-
-
0344739827
-
2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes
-
14572808
-
2+ flux through individual N-type voltage-gated channels expressed in Xenopus oocytes. Cell Calcium 34:499-509. PMID: 14572808
-
(2003)
Cell Calcium
, vol.34
, pp. 499-509
-
-
Demuro, A.1
Parker, I.2
-
49
-
-
2142763928
-
2+ channels by total internal reflection fluorescence microscopy
-
15111438
-
2+ channels by total internal reflection fluorescence microscopy. Biophys. J. 86:3250-3259. PMID: 15111438
-
(2004)
Biophys. J.
, vol.86
, pp. 3250-3259
-
-
Demuro, A.1
Parker, I.2
|