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Volumn 138, Issue 1, 2016, Pages 110-120

Expression of proteins involved in DNA damage response in familial and sporadic breast cancer patients

Author keywords

BRCA1; BRIT1; immunohistochemistry; PARP1; sporadic and familial breast cancers

Indexed keywords

BRCA1 PROTEIN; BRCT REPEAT INHIBITOR OF HTERT EXPRESSION; EPIDERMAL GROWTH FACTOR RECEPTOR 2; KI 67 ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; REGULATOR PROTEIN; SWITCH 5 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; TUMOR MARKER;

EID: 84944275238     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.29699     Document Type: Article
Times cited : (12)

References (50)
  • 1
    • 84872853140 scopus 로고    scopus 로고
    • Global estimates of cancer prevalence for 27 sites in the adult population in 2008
    • Bray F, Ren JS, Masuyer E, et al., Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer 2013; 132: 1133-45.
    • (2013) Int J Cancer , vol.132 , pp. 1133-1145
    • Bray, F.1    Ren, J.S.2    Masuyer, E.3
  • 2
    • 0033857349 scopus 로고    scopus 로고
    • Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens
    • Rice JC, Ozcelik H, Maxeiner P, et al., Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis 2000; 21: 1761-5.
    • (2000) Carcinogenesis , vol.21 , pp. 1761-1765
    • Rice, J.C.1    Ozcelik, H.2    Maxeiner, P.3
  • 3
    • 33847271255 scopus 로고    scopus 로고
    • Links between DNA double strand break repair and breast cancer: Accumulating evidence from both familial and nonfamilial cases
    • Ralhan R, Kaur J, Kreienberg R, et al., Links between DNA double strand break repair and breast cancer: Accumulating evidence from both familial and nonfamilial cases. Cancer Lett 2007; 248: 1-17.
    • (2007) Cancer Lett , vol.248 , pp. 1-17
    • Ralhan, R.1    Kaur, J.2    Kreienberg, R.3
  • 4
    • 84896272979 scopus 로고    scopus 로고
    • DNA damage response genes and the development of cancer metastasis
    • Broustas CG, Lieberman HB., DNA damage response genes and the development of cancer metastasis. Radiat Res 2014; 181: 111-30.
    • (2014) Radiat Res , vol.181 , pp. 111-130
    • Broustas, C.G.1    Lieberman, H.B.2
  • 5
    • 77953872952 scopus 로고    scopus 로고
    • Genetic susceptibility to breast cancer
    • Mavaddat N, Antoniou AC, Easton DF, et al., Genetic susceptibility to breast cancer. Mol Oncol 2010; 4: 174-91.
    • (2010) Mol Oncol , vol.4 , pp. 174-191
    • Mavaddat, N.1    Antoniou, A.C.2    Easton, D.F.3
  • 6
    • 33645003172 scopus 로고    scopus 로고
    • BRCA1: Cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution
    • Deng CX., BRCA1: Cell cycle checkpoint, genetic instability, DNA damage response and cancer evolution. Nucleic Acids Res 2006; 34: 1416-26.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1416-1426
    • Deng, C.X.1
  • 7
    • 84870337437 scopus 로고    scopus 로고
    • Evidence that BRCA1- or BRCA2-associated cancers are not inevitable
    • Levin B, Lech D, Friedenson B., Evidence that BRCA1- or BRCA2-associated cancers are not inevitable. Mol Med 2012; 18: 1327-37.
    • (2012) Mol Med , vol.18 , pp. 1327-1337
    • Levin, B.1    Lech, D.2    Friedenson, B.3
  • 9
    • 79952852791 scopus 로고    scopus 로고
    • Upregulation of poly (ADP-ribose) polymerase-1 (PARP1) in triple-negative breast cancer and other primary human tumor types
    • Ossovskaya V, Koo IC, Kaldjian EP, et al., Upregulation of poly (ADP-ribose) polymerase-1 (PARP1) in triple-negative breast cancer and other primary human tumor types. Genes Cancer 2010; 1: 812-21.
    • (2010) Genes Cancer , vol.1 , pp. 812-821
    • Ossovskaya, V.1    Koo, I.C.2    Kaldjian, E.P.3
  • 10
    • 84885604912 scopus 로고    scopus 로고
    • Variations in the mRNA expression of poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase and ADP-ribosylhydrolase 3 in breast tumors and impact on clinical outcome
    • Bieche I, Pennaneach V, Driouch K, et al., Variations in the mRNA expression of poly(ADP-ribose) polymerases, poly(ADP-ribose) glycohydrolase and ADP-ribosylhydrolase 3 in breast tumors and impact on clinical outcome. Int J Cancer 2013; 133: 2791-800.
    • (2013) Int J Cancer , vol.133 , pp. 2791-2800
    • Bieche, I.1    Pennaneach, V.2    Driouch, K.3
  • 11
    • 79955738892 scopus 로고    scopus 로고
    • PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: Possible implications for PARP-1 inhibitor therapy
    • Domagala P, Huzarski T, Lubinski J, et al., PARP-1 expression in breast cancer including BRCA1-associated, triple negative and basal-like tumors: Possible implications for PARP-1 inhibitor therapy. Breast Cancer Res Treat 2011; 127: 861-9.
    • (2011) Breast Cancer Res Treat , vol.127 , pp. 861-869
    • Domagala, P.1    Huzarski, T.2    Lubinski, J.3
  • 12
    • 79954745823 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase-1 mRNA expression in human breast cancer: A meta-analysis
    • Gonçalves A, Finetti P, Sabatier R, et al., Poly (ADP-ribose) polymerase-1 mRNA expression in human breast cancer: A meta-analysis. Breast Cancer Res Treat 2011; 127: 273-81.
    • (2011) Breast Cancer Res Treat , vol.127 , pp. 273-281
    • Gonçalves, A.1    Finetti, P.2    Sabatier, R.3
  • 13
    • 84858957528 scopus 로고    scopus 로고
    • Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer
    • Rojo F, García-Parra J, Zazo S, et al., Nuclear PARP-1 protein overexpression is associated with poor overall survival in early breast cancer. Ann Oncol 2012; 23: 1156-64.
    • (2012) Ann Oncol , vol.23 , pp. 1156-1164
    • Rojo, F.1    García-Parra, J.2    Zazo, S.3
  • 14
    • 84864843538 scopus 로고    scopus 로고
    • Colorectal cancers differ in respect of PARP-1 protein expression
    • Sulzyc-Bielicka V, Domagala P, Hybiak J, et al., Colorectal cancers differ in respect of PARP-1 protein expression. Pol J Pathol 2012; 63: 87-92.
    • (2012) Pol J Pathol , vol.63 , pp. 87-92
    • Sulzyc-Bielicka, V.1    Domagala, P.2    Hybiak, J.3
  • 15
    • 84865393927 scopus 로고    scopus 로고
    • High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer
    • Klauschen F, von Winterfeld M, Stenzinger A, et al., High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer. Histopathology 2012; 61: 409-16.
    • (2012) Histopathology , vol.61 , pp. 409-416
    • Klauschen, F.1    Von Winterfeld, M.2    Stenzinger, A.3
  • 16
    • 84892641981 scopus 로고    scopus 로고
    • Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue
    • Salemi M, Galia A, Fraggetta F, et al., Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue. Eur J Histochem 2013; 57: E13.
    • (2013) Eur J Histochem , vol.57 , pp. e13
    • Salemi, M.1    Galia, A.2    Fraggetta, F.3
  • 17
    • 84897012760 scopus 로고    scopus 로고
    • PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies
    • Lee JM, Ledermann JA, Kohn EC., PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies. Ann Oncol 2014; 25: 32-40.
    • (2014) Ann Oncol , vol.25 , pp. 32-40
    • Lee, J.M.1    Ledermann, J.A.2    Kohn, E.C.3
  • 18
    • 84925270121 scopus 로고    scopus 로고
    • An update on PARP inhibitors - moving to the adjuvant setting
    • Sonnenblick A, de Azambuja E, Azim HA, Jr, et al., An update on PARP inhibitors-moving to the adjuvant setting. Nat Rev Clin Oncol 2015; 12: 27-41.
    • (2015) Nat Rev Clin Oncol , vol.12 , pp. 27-41
    • Sonnenblick, A.1    De Azambuja, E.2    Azim, H.A.3
  • 19
    • 0037821661 scopus 로고    scopus 로고
    • Multiple tumor suppressor pathways negatively regulate telomerase
    • Lin SY, Elledge SJ., Multiple tumor suppressor pathways negatively regulate telomerase. Cell 2003; 113: 881-9.
    • (2003) Cell , vol.113 , pp. 881-889
    • Lin, S.Y.1    Elledge, S.J.2
  • 20
    • 4544269236 scopus 로고    scopus 로고
    • Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1
    • Xu X, Lee J, Stern DF., Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. J Biol Chem 2004; 279: 34091-4.
    • (2004) J Biol Chem , vol.279 , pp. 34091-34094
    • Xu, X.1    Lee, J.2    Stern, D.F.3
  • 21
    • 33746857684 scopus 로고    scopus 로고
    • BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
    • Rai R, Dai H, Multani AS, et al., BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell 2006; 10: 145-57.
    • (2006) Cancer Cell , vol.10 , pp. 145-157
    • Rai, R.1    Dai, H.2    Multani, A.S.3
  • 22
    • 51049100399 scopus 로고    scopus 로고
    • MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis
    • Yang SZ, Lin FT, Lin WC., MCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosis. EMBO Rep 2008; 9: 907-15.
    • (2008) EMBO Rep , vol.9 , pp. 907-915
    • Yang, S.Z.1    Lin, F.T.2    Lin, W.C.3
  • 23
    • 0036176172 scopus 로고    scopus 로고
    • Transcription activator interactions with multiple SWI/SNF subunits
    • Neely KE, Hassan AH, Brown CE, et al., Transcription activator interactions with multiple SWI/SNF subunits. Mol Cell Biol 2002; 22: 1615-25.
    • (2002) Mol Cell Biol , vol.22 , pp. 1615-1625
    • Neely, K.E.1    Hassan, A.H.2    Brown, C.E.3
  • 24
    • 33947155404 scopus 로고    scopus 로고
    • Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes
    • Akamatsu Y, Tsutsui Y, Morishita T, et al., Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes. EMBO J 2007; 26: 1352-62.
    • (2007) EMBO J , vol.26 , pp. 1352-1362
    • Akamatsu, Y.1    Tsutsui, Y.2    Morishita, T.3
  • 25
    • 78449233040 scopus 로고    scopus 로고
    • Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination
    • Akamatsu Y, Jasin M., Role for the mammalian Swi5-Sfr1 complex in DNA strand break repair through homologous recombination. PLoS Genet 2010; 6: E1001160.
    • (2010) PLoS Genet , vol.6 , pp. e1001160
    • Akamatsu, Y.1    Jasin, M.2
  • 26
    • 79953232004 scopus 로고    scopus 로고
    • The role of the human SWI5-MEI5 complex in homologous recombination repair
    • Yuan J, Chen J., The role of the human SWI5-MEI5 complex in homologous recombination repair. J Biol Chem 2011; 286: 9888-93.
    • (2011) J Biol Chem , vol.286 , pp. 9888-9893
    • Yuan, J.1    Chen, J.2
  • 27
    • 84895787308 scopus 로고    scopus 로고
    • Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament
    • Fornander LH, Renodon-Cornière A, Kuwabara N, et al., Swi5-Sfr1 protein stimulates Rad51-mediated DNA strand exchange reaction through organization of DNA bases in the presynaptic filament. Nucleic Acids Res 2014; 42: 2358-65.
    • (2014) Nucleic Acids Res , vol.42 , pp. 2358-2365
    • Fornander, L.H.1    Renodon-Cornière, A.2    Kuwabara, N.3
  • 28
    • 0034697973 scopus 로고    scopus 로고
    • BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer
    • Bochar DA, Wang L, Beniya H, et al., BRCA1 is associated with a human SWI/SNF-related complex: Linking chromatin remodeling to breast cancer. Cell 2000; 102: 257-65.
    • (2000) Cell , vol.102 , pp. 257-265
    • Bochar, D.A.1    Wang, L.2    Beniya, H.3
  • 29
    • 67650034511 scopus 로고    scopus 로고
    • BRIT1/MCPH1 links chromatin remodelling to DNA damage response
    • Peng G, Yim EK, Dai H, et al., BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol 2009; 11: 865-72.
    • (2009) Nat Cell Biol , vol.11 , pp. 865-872
    • Peng, G.1    Yim, E.K.2    Dai, H.3
  • 30
    • 80054714991 scopus 로고    scopus 로고
    • + exchanger regulatory factor 1, and breast cancer susceptibility gene-1 as new biomarkers for familial breast cancers
    • + exchanger regulatory factor 1, and breast cancer susceptibility gene-1 as new biomarkers for familial breast cancers. Hum Pathol 2011; 42: 1589-95.
    • (2011) Hum Pathol , vol.42 , pp. 1589-1595
    • Mangia, A.1    Malfettone, A.2    Saponaro, C.3
  • 31
    • 33846568336 scopus 로고    scopus 로고
    • American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer
    • Wolff AC, Hammond ME, Schwartz JN, et al., American Society of Clinical Oncology/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer. Arch Pathol Lab Med 2007; 131: 18-43.
    • (2007) Arch Pathol Lab Med , vol.131 , pp. 18-43
    • Wolff, A.C.1    Hammond, M.E.2    Schwartz, J.N.3
  • 32
    • 84925541094 scopus 로고    scopus 로고
    • Biological and clinical significance of PARP1 protein expression in breast cancer
    • Green AR, Caracappa D, Benhasouna AA, et al., Biological and clinical significance of PARP1 protein expression in breast cancer. Breast Cancer Res Treat 2015; 149: 353-62.
    • (2015) Breast Cancer Res Treat , vol.149 , pp. 353-362
    • Green, A.R.1    Caracappa, D.2    Benhasouna, A.A.3
  • 33
    • 84896775467 scopus 로고    scopus 로고
    • Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer
    • De Summa S, Pinto R, Pilato B, et al., Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer. Cell Death Dis 2014; 5: E1076.
    • (2014) Cell Death Dis , vol.5 , pp. e1076
    • De Summa, S.1    Pinto, R.2    Pilato, B.3
  • 34
    • 10744232066 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors
    • Ghabreau L, Roux JP, Frappart PO, et al., Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors. Int J Cancer 2004; 109: 317-21.
    • (2004) Int J Cancer , vol.109 , pp. 317-321
    • Ghabreau, L.1    Roux, J.P.2    Frappart, P.O.3
  • 35
    • 77954698850 scopus 로고    scopus 로고
    • BRCA1 16 years later: Nuclear import and export processes
    • Thompson ME., BRCA1 16 years later: Nuclear import and export processes. FEBS J 2010; 277: 3072-8.
    • (2010) FEBS J , vol.277 , pp. 3072-3078
    • Thompson, M.E.1
  • 36
    • 84876092158 scopus 로고    scopus 로고
    • Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours
    • Milner R, Wombwell H, Eckersley S, et al., Validation of the BRCA1 antibody MS110 and the utility of BRCA1 as a patient selection biomarker in immunohistochemical analysis of breast and ovarian tumours. Virchows Arch 2013; 462: 269-79.
    • (2013) Virchows Arch , vol.462 , pp. 269-279
    • Milner, R.1    Wombwell, H.2    Eckersley, S.3
  • 37
    • 44649095619 scopus 로고    scopus 로고
    • Expression of BRCA1 protein in breast cancer and its prognostic significance
    • Rakha EA, El-Sheikh SE, Kandil MA, et al., Expression of BRCA1 protein in breast cancer and its prognostic significance. Hum Pathol 2008; 39: 857-65.
    • (2008) Hum Pathol , vol.39 , pp. 857-865
    • Rakha, E.A.1    El-Sheikh, S.E.2    Kandil, M.A.3
  • 38
    • 84905723219 scopus 로고    scopus 로고
    • Effect of BRCA1 immunohistochemical localizations on prognosis of patients with sporadic breast carcinomas
    • Mylona E, Melissaris S, Nomikos A, et al., Effect of BRCA1 immunohistochemical localizations on prognosis of patients with sporadic breast carcinomas. Pathol Res Pract 2014; 210: 533-40.
    • (2014) Pathol Res Pract , vol.210 , pp. 533-540
    • Mylona, E.1    Melissaris, S.2    Nomikos, A.3
  • 39
    • 60549088737 scopus 로고    scopus 로고
    • BRCA1 expression and molecular alterations in familial breast cancer
    • Mangia A, Chiriatti A, Tommasi S, et al., BRCA1 expression and molecular alterations in familial breast cancer. Histol Histopathol 2009; 24: 69-76.
    • (2009) Histol Histopathol , vol.24 , pp. 69-76
    • Mangia, A.1    Chiriatti, A.2    Tommasi, S.3
  • 40
    • 0037809375 scopus 로고    scopus 로고
    • A role for BRCA1 in sporadic breast cancer
    • Fraser JA, Reeves JR, Stanton PD, et al., A role for BRCA1 in sporadic breast cancer. Br J Cancer 2003; 88: 1263-70.
    • (2003) Br J Cancer , vol.88 , pp. 1263-1270
    • Fraser, J.A.1    Reeves, J.R.2    Stanton, P.D.3
  • 41
    • 33847022042 scopus 로고    scopus 로고
    • BRCA1 dysfunction in sporadic basal-like breast cancer
    • Turner NC, Reis-Filho JS, Russell AM, et al., BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene 2007; 26: 2126-32.
    • (2007) Oncogene , vol.26 , pp. 2126-2132
    • Turner, N.C.1    Reis-Filho, J.S.2    Russell, A.M.3
  • 42
    • 0032912590 scopus 로고    scopus 로고
    • Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: A correlation with other biological parameters
    • Lee WY, Jin YT, Chang TW, et al., Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: A correlation with other biological parameters. Histopathology 1999; 34: 106-12.
    • (1999) Histopathology , vol.34 , pp. 106-112
    • Lee, W.Y.1    Jin, Y.T.2    Chang, T.W.3
  • 43
    • 0038207152 scopus 로고    scopus 로고
    • Prognostic significance of BRCA1 expression in sporadic breast carcinomas
    • Lambie H, Miremadi A, Pinder SE, et al., Prognostic significance of BRCA1 expression in sporadic breast carcinomas. J Pathol 2003; 200: 207-13.
    • (2003) J Pathol , vol.200 , pp. 207-213
    • Lambie, H.1    Miremadi, A.2    Pinder, S.E.3
  • 44
    • 0032032322 scopus 로고    scopus 로고
    • Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype
    • Jarvis EM, Kirk JA, Clarke CL., Loss of nuclear BRCA1 expression in breast cancers is associated with a highly proliferative tumor phenotype. Cancer Genet Cytogenet 1998; 101: 109-15.
    • (1998) Cancer Genet Cytogenet , vol.101 , pp. 109-115
    • Jarvis, E.M.1    Kirk, J.A.2    Clarke, C.L.3
  • 45
    • 0033055801 scopus 로고    scopus 로고
    • Reduction of BRCA1 protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases
    • Yoshikawa K, Honda K, Inamoto T, et al., Reduction of BRCA1 protein expression in Japanese sporadic breast carcinomas and its frequent loss in BRCA1-associated cases. Clin Cancer Res 1999; 5: 1249-61.
    • (1999) Clin Cancer Res , vol.5 , pp. 1249-1261
    • Yoshikawa, K.1    Honda, K.2    Inamoto, T.3
  • 46
    • 79958279660 scopus 로고    scopus 로고
    • Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation
    • Richardson J, Shaaban AM, Kamal M, et al., Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation. Breast Cancer Res Treat 2011; 127: 639-48.
    • (2011) Breast Cancer Res Treat , vol.127 , pp. 639-648
    • Richardson, J.1    Shaaban, A.M.2    Kamal, M.3
  • 47
    • 84873751220 scopus 로고    scopus 로고
    • MCPH1 protein expression and polymorphisms are associated with risk of breast cancer
    • Jo YH, Kim HO, Lee J, et al., MCPH1 protein expression and polymorphisms are associated with risk of breast cancer. Gene 2013; 517: 184-90.
    • (2013) Gene , vol.517 , pp. 184-190
    • Jo, Y.H.1    Kim, H.O.2    Lee, J.3
  • 48
    • 84855698070 scopus 로고    scopus 로고
    • BRCAness profile of sporadic ovarian cancer predicts disease recurrence
    • Wysham WZ, Mhawech-Fauceglia P, Li H, et al., BRCAness profile of sporadic ovarian cancer predicts disease recurrence. PLoS One 2012; 7: E30042.
    • (2012) PLoS One , vol.7 , pp. e30042
    • Wysham, W.Z.1    Mhawech-Fauceglia, P.2    Li, H.3
  • 49
    • 17244373777 scopus 로고    scopus 로고
    • Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
    • Farmer H, McCabe N, Lord CJ, et al., Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005; 434: 917-21.
    • (2005) Nature , vol.434 , pp. 917-921
    • Farmer, H.1    McCabe, N.2    Lord, C.J.3
  • 50
    • 84863166648 scopus 로고    scopus 로고
    • Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment
    • Pan MR, Hsieh HJ, Dai H, et al., Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment. J Biol Chem 2012; 287: 6764-72.
    • (2012) J Biol Chem , vol.287 , pp. 6764-6772
    • Pan, M.R.1    Hsieh, H.J.2    Dai, H.3


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