BRCA1 expression and molecular alterations in familial breast cancer

Histology and Histopathology

Volumn 24, Issue 1, 2009, Pages 69-76

  Mangia, Anita ^a   Chiriatti, Annalisa ^a   Tommasi, Stefania ^a   Menolascina, Filippo ^a   Petroni, Stella ^a   Zito, Francesco A ^a   Simone, Giovanni ^a   Schittulli, Francesco ^a   Paradiso, Angelo ^a  

^a NATIONAL CANCER INSTITUTE GIOVANNI PAOLO II   (Italy)

Author keywords

BRCA1; Breast cancer; Family history; Tissue microarrays

Indexed keywords

BRCA1 PROTEIN; ESTROGEN RECEPTOR ALPHA; MONOCLONAL ANTIBODY; DIAGNOSTIC AGENT; PROGESTERONE RECEPTOR;

ADULT; ARTICLE; BREAST CANCER; CANCER STAGING; CONTROLLED STUDY; DNA POLYMORPHISM; EXON; FAMILIAL CANCER; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE LOSS; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MUTATIONAL ANALYSIS; PROTEIN EXPRESSION; WILD TYPE; BIOSYNTHESIS; BREAST TUMOR; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; METABOLISM; METHODOLOGY; MIDDLE AGED; MUTATION; PATHOLOGY; TISSUE MICROARRAY;

ADULT; ANTIBODIES, MONOCLONAL; BRCA1 PROTEIN; BREAST NEOPLASMS; ESTROGEN RECEPTOR ALPHA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MUTATION; POLYMORPHISM, GENETIC; RECEPTORS, PROGESTERONE; TISSUE ARRAY ANALYSIS;

EID: 60549088737     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Al-Mulla F., Abdulrahman M., Varadharaj G., Akhter N. and Anim J.T. (2005). BRCA1 Gene Expression in Breast Cancer: A Correlative Study between Real-time RT-PCR and Immunohistochemistry. J. Histochem. Cytochem. 53, 621-629.
2. Bernard-Gallon D.J., De Latour M.P., Rio P.G., Penault-Llorca F.M., Favy D.A., Hizel C., Chassagne J. and Bignon Y.J. (1999). Subcellular localization of BRCA1 protein in sporadic breast carcinoma with or without allelic loss of BRCA1 gene. Int. J. Oncol. 14, 653-661.
3. Breast Cancer Linkage Consortium (No authors listed) (1997). Pathology of familial breast cancer: differences between breast cancers in carriers of BRCA1 or BRCA2 mutations and sporadic cases. Lancet 349, 1505-1510.
4. Bruno M., Tommasi S., Stea B., Quaranta M., Schittulli F., Mastropasqua A., Distante A., Di Paola L. and Paradiso A. (2004). Awareness of breast cancer genetics and interest in predictive genetic testing: a survey in Southern Italian population. Ann. Oncol. Suppl. 1, i48-i54.
5. Coene E., Van Oostveldt P., Willems K., van Emmelo J. and De Potter C.R. (1997). BRCA1 is localized in cytoplasmic tube-like invaginations in the nucleus. Nat. Genet. 16, 122-124.
6. Frank T.S., Deffenbaugh A.M., Reid J.E., Hulick M., Ward B.E., Lingenfelter B., Gumpper K.L., Scholl T., Tavtigian S.V., Pruss D.R. and Critchfield G.C. (2002). Clinical characteristics of individuals with germline mutations in BRCA1 and BRCA2: analysis of 10,000 individuals. J. Clin. Oncol. 20, 1480-1490.
7. Hermanek P. and Sobin L.H. UICC TNM. (1988). Classification of malignant tumours. 4th edition. John Wiley & Sons Inc.
8. Holt J.T., Thompson M.E., Szabo C., Robinson-Benion C., Arteaga C.L., King M.C. and Jensen R.A. (1996). Growth-retardation and tumour-inhibition by BRCA1. Nat. Genet. 12, 298-302.
9. Jensen R.A., Thompson M.E., Jetton T.L., Szabo C.I., van der Meer R., Helou B., Tronick S.R., Page D.L., King M.C. and Holt J.T. (1996). BRCA1 is secreted and exhibits properties of a granin. Nat. Genet. 12, 303-308.
10. Jóhannsson O.T., Idvall I., Anderson C., Borg A., Barkardóttir R.B., Egilsson V. and Olsson H. (1997). Tumor biological features of BRCA1-induced breast and ovarian cancer. Eur. J. Cancer 33, 362-371.
11. Kononen J., Bubendorf L., Kallioniemi A., Bärlund M., Schraml P., Leighton S., Torhorst J., Mihatsch M.J., Sauter G. and Kallioniemi O.P. (1998). Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med. 4, 844-847.
12. Lambie H., Miremadi A., Pinder S.E., Bell J.A., Wencyk P., Paish E.C., Macmillan R.D. and Ellis I.O. (2003). Prognostic significance of BRCA1 expression in sporadic breast carcinomas. J. Pathol., 200, 207-213.
13. Lee W.Y., Jin Y.T., Chang T.W., Lin P.W. and Su I.J. (1999). Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: a correlation with other biological parameters. Histopathology 34, 106-112.
14. Mueller C.R., Kristoffersson U. and Stoppa-Lyonnet D. (2004). External quality assessment for mutation detection in the BRCA1 and BRCA2 genes: EMQN's experience of 3 years. Ann. Oncol. Suppl. 1, i14-i17.
15. Noruzinia M., Coupier I. and Pujol P. (2005). Is BRCA1/BRCA2-related breast carcinogenesis estrogen dependent? Cancer 104, 1567-74.
16. Paradiso A., Mangia A., Chiriatti A., Tommasi S., Zito A., Latorre A., Schittulli F. and Lorusso V. (2005). Biomarkers predictive for clinical efficacy of taxol-based chemotherapy in advanced breast cancer. Ann. Oncol. 16 (Supplement 4), iv14-iv19.
17. Pérez-Vallés A., Martorell-Cebollada M., Nogueira-Vázquez E., García-García J.A. and Fuster-Diana E. (2001). The usefulness of antibodies to the BRCA1 protein in detecting the mutated BRCA1 gene. An immunohistochemical study. J. Clin. Pathol. 54, 476-80
18. Rice J.C., MasseyBrown K.S. and Futscher B.W. (1998). Aberrant methylation of the BRCA1 cpg island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells. Oncogene 17, 1807-1812.
19. Rice J.C., Ozcelik H., Maxeiner P., Andrulis I. and Futscher B.W. (2000). Methylation of the BRCA1 promoter is associated with decreased BRCA1 mRNA levels in clinical breast cancer specimens. Carcinogenesis 21, 1761-1765.
20. Scully R., Chen J., Ochs R.L., Keegan K., Hoekstra M., Feunteun J. and Livingston D.M. (1997). Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90, 425-435.
21. Shao N., Chai Y.L., Shyam E., Reddy P. and Rao V.N. (1996). Induction of apoptosis by the tumor suppressor protein BRCA1. Oncogene 13, 1-7.
22. Taylor J., Lymboura M., Pace P.E., A'hern R.P., Desai A.J., Shousha S., Coombes R.C. and Ali S. (1998). An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers. Int. J. Cancer 79, 334-342.
23. Thakur S., Zhang H.B., Peng Y., Le H., Carroll B., Ward T., Yao J., Farid L.M., Couch F.J., Wilson R.B. and Weber B.L. (1997). Localization of BRCA1 and a splice variant identifies the nuclear localization signal. Mol. Cell Biol. 17, 444-452.
24. Thompson M.E., Jensen R.A., Obermiller P.S., Page D.L. and Holt J.T. (1995). Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat. Genet. 9, 444-450.
25. Tommasi S., Crapolicchio A., Lacalamita R., Bruno M., Monaco A., Petroni S., Schittulli F., Longo S., Digennaro M., Calistri D., Mangia A. and Paradiso A. (2005). BRCA1 mutations and polymorphisms in a hospital-based consecutive series of breast cancer patients from Apulia, Italy. Mutat. Res. 578, 395-405.
26. Wilson C.A., Ramos L., Villaseñor M.R., Anders K.H., Press M.F., Clarke K., Karlan B., Chen J.J., Scully R., Livingston D., Zuch R.H., Kanter M.H., Cohen S., Calzone F.J. and Slamon D.J. (1999). Localization of human BRCA1 and its loss in high-grade, noninherited breast carcinomas. Nat. Genet. 21, 236-240.
27. Yang Q., Sakurai T., Mori I., Yoshimura G., Nakamura M., Nakamura Y., Suzuma T., Tamaki T., Umemura T. and Kakudo K. (2001). Prognostic significance of BRCA1 expression in Japanese sporadic breast carcinomas. Cancer. 1, 92, 54-60.
28. Yang Q., Yoshimura G., Nakamura M., Nakamura Y., Suzuma T., Umemura T., Mori I., Sakurai T. and Kakudo K. (2002). BRCA1 in non-inherited breast carcinomas (Review). Oncol. Rep. 9, 1329-1333.
29. Yoshikawa K., Ogawa T., Baer R., Hemmi H., Honda K., Yamauchi A., Inamoto T., Ko K., Yazumi S., Motoda H., Kodama H., Noguchi S., Gazdar A.F., Yamaoka Y. and Takahashi R. (2000). Abnormal expression of BRCA1 and BRCA1-interactive DNA-repair proteins in breast carcinomas. Int. J. Cancer 88, 28-36.
30. Zhang H., Somasundaram K., Peng Y., Tian H., Zhang H., Bi D., Weber B.L. and El-Deiry W.S. (1998). BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene 16, 1731-1721.