Tonic Inhibitory control of dentate gyrus granule cells by α5-containing GABAA receptors reduces memory interference

Journal of Neuroscience

Volumn 35, Issue 40, 2015, Pages 13698-13712

  Engin, Elif ^a,c   Zarnowska, Ewa D ^d   Benke, Dietmar ^e   Tsvetkov, Evgeny ^b,c,f   Sigal, Maksim ^a,c   Keist, Ruth ^e   Bolshakov, Vadim Y ^b,c   Pearce, Robert A ^d   Rudolph, Uwe ^a,c  

^a Laboratory of Genetic Neuropharmacology   (United States)

^b MCLEAN HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e UNIVERSITY OF ZURICH   (Switzerland)

^f SECHENOV INSTITUTE OF EVOLUTIONARY PHYSIOLOGY AND BIOCHEMISTRY   (Russian Federation)

Author keywords

Alpha5 subunit; Dentate gyrus; GABAA receptors; Interference; Pattern separation; Reversal learning

Indexed keywords

4 AMINOBUTYRIC ACID; ALPHA 5 CONTAINING GABA RECEPTOR; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; GABRA5 PROTEIN, MOUSE; IMIDAZOLE DERIVATIVE; L 655,708; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; DISCRIMINATION LEARNING; ELECTROPHYSIOLOGY; ELEVATED PLUS MAZE TEST; FORCED SWIM TEST; GRANULE CELL; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MEMORY; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL INHIBITION; NONHUMAN; OPEN FIELD TEST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TONIC INHIBITION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; IN VITRO STUDY; INHIBITORY POSTSYNAPTIC POTENTIAL; MAZE TEST; METABOLISM; NERVE CELL; PERCEPTIVE DISCRIMINATION; PHYSIOLOGY; PSYCHOLOGY; RECOGNITION; SWIMMING;

ANIMALS; DENTATE GYRUS; DISCRIMINATION (PSYCHOLOGY); EXPLORATORY BEHAVIOR; GABA AGONISTS; GENE EXPRESSION REGULATION; IMIDAZOLES; IN VITRO TECHNIQUES; INHIBITORY POSTSYNAPTIC POTENTIALS; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURAL INHIBITION; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, GABA-A; RECOGNITION (PSYCHOLOGY); SWIMMING;

EID: 84944111794     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1370-15.2015     Document Type: Article

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