Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain

Nature Communications

Volumn 6, Issue , 2015, Pages

  Takeda, Shuko ^a   Wegmann, Susanne ^a   Cho, Hansang ^a,b   Devos, Sarah L ^a   Commins, Caitlin ^a   Roe, Allyson D ^a   Nicholls, Samantha B ^a   Carlson, George A ^c   Pitstick, Rose ^c   Nobuhara, Chloe K ^a   Costantino, Isabel ^a   Frosch, Matthew P ^a   Muller, Daniel J ^d   Irimia, Daniel ^a   Hyman, Bradley T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b University of North Carolina at Charlotte   (United States)

^c MCLAUGHLIN RESEARCH INSTITUTE   (United States)

^d ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOLECULAR WEIGHT TAU PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

BIOMARKER; BRAIN; MENTAL HEALTH; NEUROLOGY; PATHOLOGY; RODENT;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; BRAIN NERVE CELL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; INTERSTITIAL FLUID; MALE; MOUSE; NEUROTRANSMITTER UPTAKE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SYNAPSE; TRANSGENIC MOUSE; AGED; ANIMAL; BRAIN; C57BL MOUSE; CELL SURVIVAL; HEK293 CELL LINE; METABOLISM; MICROFLUIDIC ANALYSIS; NERVE CELL; PHOSPHORYLATION; VERY ELDERLY;

MUS MUSCULUS;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ANIMALS; BRAIN; CELL SURVIVAL; FEMALE; HEK293 CELLS; HUMANS; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROFLUIDIC ANALYTICAL TECHNIQUES; NEURONS; PHOSPHORYLATION; TAU PROTEINS;

EID: 84944088611     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9490     Document Type: Article

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