Memapsin 1

Handbook of Proteolytic Enzymes, Second Edition: Volume 1: Aspartic and Metallo Peptidases

Volumn 1, Issue , 2004, Pages 64-66

  Tang, Jordan ^a   Koelsch, Gerald ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84944069084     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-079611-3.50020-3     Document Type: Chapter

References (12)

1. B.D. Bennett, S. Babu-Khan, R. Loeloff, J.C. Louis, E. Curran, M. Citron and R. Vassar (2000) Expression analysis of BACE2 in brain and peripheral tissues. J. Biol. Chem. 275 20647-20651.
2. J. Ermolieff, J.A. Loy, G. Koelsch and J. Tang (2000) Proteolytic activation of recombinant pro-memapsin 2 (pro-β-Secretase) studies with new fluorogenic substrate. Biochemistry 39 12450-12456.
3. M. Farzan, C.E. Schnitzler, N. Vasilieva, D. Leung and H. Choe (2000) BACE2, a β-secretase homolog, cleaves at the β site and within the amyloid-β region of the amyloid-β precursor protein. Proc. Natl. Acad. Sci. USA 97 9712-9717.
4. A.K. Ghosh, G. Bilcer, C. Harwood, R. Kawahama, D. Shin, K.A. Hussain, L. Hong, J.A. Loy, C. Nguyen, G. Koelsch, J. Ermolieff and J. Tang (2001) Structure-based design: potent inhibitors of human brain memapsin 2 (β-secretase). J. Med. Chem. 44 2865-2868.
5. L. Hong, G. Koelsch, X. Lin, S. Wu, S. Terzyan, A.K. Ghosh, X.C. Zhang and J. Tang (2000) Structure of the protease domain of memapsin 2 (β-secretase) complexed with inhibitor. Science 290 150-153.
6. I. Hussain, D. Powell, D.R. Howlett, D.G. Tew, T.D. Meek, C. Chapman, I.S. Gloger, K.E. Murphy, C.D. Southan, D.M. Ryan, et al. (1999) Identification of a novel aspartic protease (Asp 2) as β-secretase. Mol. Cell Neurosci. 14 419-427.
7. I. Hussain, D.J. Powell, D.R. Howlett, G.A. Chapman, L. Gilmour, P.R. Murdock, D.G. Tew, T.D. Meek, C. Chapman, K. Schneider, et al. (2000) ASP1 (BACE2) cleaves the amyloid precursor protein at the β-secretase site. Mol. Cell Neurosci. 16 609-619.
8. I. Hussain, G. Christie, K. Schneider, S. Moore and C. Dingwall (2001) Prodomain processing of Aspl (BACE2) is autocatalytic. J. Biol. Chem. 276 23322-23328.
9. X. Lin, G. Koelsch, S. Wu, D. Downs, A. Dashti and J. Tang (2000) Human aspartic protease memapsin 2 cleaves the β-amyloid precursor protein. Proc. Natl. Acad. Sci. USA 97 1456-1460.
10. A.J. Saunders, T. Kim and R.E. Tanzi (1999) BACE2, a homolog of BACE, in the Down syndrome region of chromosome 21. Science 286 1255.
11. R. Vassar, B.D. Bennett, S. Babu-Khan, S. Kahn, E.A. Mendiaz, P. Denis, D.B. Teplow, S. Ross, P. Amarante, R. Loeloff, et al. (1999) β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 735-741.
12. R. Yan, M.J. Bienkowski, M.E. Shuck, H. Miao, M.C. Tory, A.M. Pauley, J.R. Brashier, N.C. Stratman, W.R. Mathews, A.E. Buhl, et al. (1999) Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity. Nature 402 533-537.