메뉴 건너뛰기




Volumn 51, Issue 1, 2010, Pages 103-111

Allele-specific regulation of MTTP expression influences the risk of ischemic heart disease

Author keywords

Lipid accumulation; Lipotoxcity; Myocardium; Promoter activity

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CYTOSINE; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; THYMINE;

EID: 73149107963     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M900195-JLR200     Document Type: Article
Times cited : (18)

References (31)
  • 1
    • 18144363262 scopus 로고    scopus 로고
    • Current biology of MTP: Implications for selective inhibition
    • Shoulders, C. C., and G. S. Shelness. 2005. Current biology of MTP: implications for selective inhibition. Curr. Top. Med. Chem. 5: 283-300.
    • (2005) Curr. Top. Med. Chem , vol.5 , pp. 283-300
    • Shoulders, C.C.1    Shelness, G.S.2
  • 2
    • 0344301949 scopus 로고    scopus 로고
    • Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: Evidence that the heart has the capacity to synthesize and secrete lipoproteins
    • Nielsen, L. B., M. Veniant, J. Boren, M. Raabe, J. S. Wong, C. Tam, L. Flynn, T. Vanni-Reyes, M. D. Gunn, I. J. Goldberg, et al. 1998. Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins. Circulation. 98: 13-16.
    • (1998) Circulation , vol.98 , pp. 13-16
    • Nielsen, L.B.1    Veniant, M.2    Boren, J.3    Raabe, M.4    Wong, J.S.5    Tam, C.6    Flynn, L.7    Vanni-Reyes, T.8    Gunn, M.D.9    Goldberg, I.J.10
  • 5
    • 0036738378 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein gene expression and triglyceride accumulation in hypoxic human hearts
    • Nielsen, L. B., M. Perko, H. Arendrup, and C. B. Andersen. 2002. Microsomal triglyceride transfer protein gene expression and triglyceride accumulation in hypoxic human hearts. Arterioscler. Thromb. Vasc. Biol. 22: 1489-1494.
    • (2002) Arterioscler. Thromb. Vasc. Biol , vol.22 , pp. 1489-1494
    • Nielsen, L.B.1    Perko, M.2    Arendrup, H.3    Andersen, C.B.4
  • 6
    • 2442675345 scopus 로고    scopus 로고
    • The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease
    • Ledmyr, H., A. D. McMahon, E. Ehrenborg, L. B. Nielsen, M. Neville, H. Lithell, P. W. MacFarlane, C. J. Packard, and F. Karpe. 2004. The microsomal triglyceride transfer protein gene-493T variant lowers cholesterol but increases the risk of coronary heart disease. Circulation. 109: 2279-2284.
    • (2004) Circulation , vol.109 , pp. 2279-2284
    • Ledmyr, H.1    McMahon, A.D.2    Ehrenborg, E.3    Nielsen, L.B.4    Neville, M.5    Lithell, H.6    MacFarlane, P.W.7    Packard, C.J.8    Karpe, F.9
  • 7
    • 0036161597 scopus 로고    scopus 로고
    • Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index
    • Ledmyr, H., F. Karpe, B. Lundahl, M. McKinnon, C. Skoglund-Andersson, and E. Ehrenborg. 2002. Variants of the microsomal triglyceride transfer protein gene are associated with plasma cholesterol levels and body mass index. J. Lipid Res. 43: 51-58.
    • (2002) J. Lipid Res , vol.43 , pp. 51-58
    • Ledmyr, H.1    Karpe, F.2    Lundahl, B.3    McKinnon, M.4    Skoglund-Andersson, C.5    Ehrenborg, E.6
  • 9
    • 0027945062 scopus 로고
    • Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators
    • Hagan, D., B. Kienzle, H. Jamil, and N. Hariharan. 1994. Transcriptional regulation of human and hamster microsomal triglyceride transfer protein genes. Cell type-specific expression and response to metabolic regulators. J. Biol. Chem. 269: 28737-28744.
    • (1994) J. Biol. Chem , vol.269 , pp. 28737-28744
    • Hagan, D.1    Kienzle, B.2    Jamil, H.3    Hariharan, N.4
  • 10
    • 35748972366 scopus 로고    scopus 로고
    • Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    • Westerbacka, J., M. Kolak, T. Kiviluoto, P. Arkkila, J. Siren, A. Hamsten, R. M. Fisher, and H. Yki-Jarvinen. 2007. Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes. 56: 2759-2765.
    • (2007) Diabetes , vol.56 , pp. 2759-2765
    • Westerbacka, J.1    Kolak, M.2    Kiviluoto, T.3    Arkkila, P.4    Siren, J.5    Hamsten, A.6    Fisher, R.M.7    Yki-Jarvinen, H.8
  • 11
    • 4644291564 scopus 로고    scopus 로고
    • Effect of macrophage differentiation and exposure to mildly oxidized LDL on the proteolytic repertoire of THP-1 monocytes
    • Whatling, C., H. Bjork, S. Gredmark, A. Hamsten, and P. Eriksson. 2004. Effect of macrophage differentiation and exposure to mildly oxidized LDL on the proteolytic repertoire of THP-1 monocytes. J. Lipid Res. 45: 1768-1776.
    • (2004) J. Lipid Res , vol.45 , pp. 1768-1776
    • Whatling, C.1    Bjork, H.2    Gredmark, S.3    Hamsten, A.4    Eriksson, P.5
  • 12
    • 38949210785 scopus 로고    scopus 로고
    • Detection of allelic imbalance in gene expression using pyrosequencing
    • Wang, H., and S. C. Elbein. 2007. Detection of allelic imbalance in gene expression using pyrosequencing. Methods Mol. Biol. 373: 157-176.
    • (2007) Methods Mol. Biol , vol.373 , pp. 157-176
    • Wang, H.1    Elbein, S.C.2
  • 13
    • 0031807231 scopus 로고    scopus 로고
    • A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels
    • Karpe, F., B. Lundahl, E. Ehrenborg, P. Eriksson, and A. Hamsten. 1998. A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene influences plasma LDL levels. Arterioscler. Thromb. Vasc. Biol. 18: 756-761.
    • (1998) Arterioscler. Thromb. Vasc. Biol , vol.18 , pp. 756-761
    • Karpe, F.1    Lundahl, B.2    Ehrenborg, E.3    Eriksson, P.4    Hamsten, A.5
  • 14
    • 0025776731 scopus 로고
    • High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells. Demonstration of ligand-induced down-regulation of expressed receptor mRNA and protein
    • Alksnis, M., T. Barkhem, P. Stromstedt, H. Ahola, E. Kutoh, J. Gustafsson, L. Poellinger, and S. Nilsson. 1991. High level expression of functional full length and truncated glucocorticoid receptor in Chinese hamster ovary cells. Demonstration of ligand-induced down-regulation of expressed receptor mRNA and protein. J. Biol. Chem. 266: 10078-10085.
    • (1991) J. Biol. Chem , vol.266 , pp. 10078-10085
    • Alksnis, M.1    Barkhem, T.2    Stromstedt, P.3    Ahola, H.4    Kutoh, E.5    Gustafsson, J.6    Poellinger, L.7    Nilsson, S.8
  • 15
    • 35549011440 scopus 로고    scopus 로고
    • Alternative splicing of human peroxisome proliferator-activated receptor delta (PPARdelta): Effects on translation efficiency and trans-activation ability
    • Lundell, K., P. Thulin, A. Hamsten, and E. Ehrenborg. 2007. Alternative splicing of human peroxisome proliferator-activated receptor delta (PPARdelta): effects on translation efficiency and trans-activation ability. BMC Mol. Biol. 8: 70.
    • (2007) BMC Mol. Biol , vol.8 , pp. 70
    • Lundell, K.1    Thulin, P.2    Hamsten, A.3    Ehrenborg, E.4
  • 17
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett, J. C., B. Fry, J. Maller, and M. J. Daly. 2005. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 21: 263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.C.1    Fry, B.2    Maller, J.3    Daly, M.J.4
  • 18
    • 0029047046 scopus 로고
    • Microsomal triglyceri de transfer protein (MTP) regulation in HepG2 cells: Insulin negatively regulates MTP gene expression
    • Lin, M. C., D. Gordon, and J. R. Wetterau. 1995. Microsomal triglyceri de transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. J. Lipid Res. 36: 1073-1081.
    • (1995) J. Lipid Res , vol.36 , pp. 1073-1081
    • Lin, M.C.1    Gordon, D.2    Wetterau, J.R.3
  • 19
    • 3042741134 scopus 로고    scopus 로고
    • Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells
    • Sekar, N., and J. D. Veldhuis. 2004. Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells. Am. J. Physiol. Endocrinol. Metab. 287: E128-E135.
    • (2004) Am. J. Physiol. Endocrinol. Metab , vol.287
    • Sekar, N.1    Veldhuis, J.D.2
  • 20
    • 2642660445 scopus 로고    scopus 로고
    • Apo B100-containing lipoproteins are secreted by the heart
    • Boren, J., M. M. Veniant, and S. G. Young. 1998. Apo B100-containing lipoproteins are secreted by the heart. J. Clin. Invest. 101: 1197-1202.
    • (1998) J. Clin. Invest , vol.101 , pp. 1197-1202
    • Boren, J.1    Veniant, M.M.2    Young, S.G.3
  • 21
    • 0014866305 scopus 로고
    • The cardiac lesions in Bassen-Kornzweig syndrome: Report of a case, with autopsy findings
    • Dische, M. R., and R. S. Porro. 1970. The cardiac lesions in Bassen-Kornzweig syndrome: report of a case, with autopsy findings. Am. J. Med. 49: 568-571.
    • (1970) Am. J. Med , vol.49 , pp. 568-571
    • Dische, M.R.1    Porro, R.S.2
  • 24
    • 0037178848 scopus 로고    scopus 로고
    • Overexpression of apolipoprotein B in the heart impedes cardiac triglyceride accumulation and development of cardiac dysfunction in diabetic mice
    • Nielsen, L. B., E. D. Bartels, and E. Bollano. 2002. Overexpression of apolipoprotein B in the heart impedes cardiac triglyceride accumulation and development of cardiac dysfunction in diabetic mice. J. Biol. Chem. 277: 27014-27020.
    • (2002) J. Biol. Chem , vol.277 , pp. 27014-27020
    • Nielsen, L.B.1    Bartels, E.D.2    Bollano, E.3
  • 25
    • 1042266664 scopus 로고    scopus 로고
    • Apolipoprotein B production reduces lipotoxic cardiomyopathy: Studies in heart-specific lipoprotein lipase transgenic mouse
    • Yokoyama, M., H. Yagyu, Y. Hu, T. Seo, K. Hirata, S. Homma, and I. J. Goldberg. 2004. Apolipoprotein B production reduces lipotoxic cardiomyopathy: studies in heart-specific lipoprotein lipase transgenic mouse. J. Biol. Chem. 279: 4204-4211.
    • (2004) J. Biol. Chem , vol.279 , pp. 4204-4211
    • Yokoyama, M.1    Yagyu, H.2    Hu, Y.3    Seo, T.4    Hirata, K.5    Homma, S.6    Goldberg, I.J.7
  • 26
    • 53149150247 scopus 로고    scopus 로고
    • ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice
    • Chen, Z., E. P. Newberry, J. Y. Norris, Y. Xie, J. Luo, S. M. Kennedy, and N. O. Davidson. 2008. ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice. J. Lipid Res. 49: 2013-2022.
    • (2008) J. Lipid Res , vol.49 , pp. 2013-2022
    • Chen, Z.1    Newberry, E.P.2    Norris, J.Y.3    Xie, Y.4    Luo, J.5    Kennedy, S.M.6    Davidson, N.O.7
  • 28
    • 34548390940 scopus 로고    scopus 로고
    • In vitro assays fail to predict in vivo effects of regulatory polymorphisms
    • Cirulli, E. T., and D. B. Goldstein. 2007. In vitro assays fail to predict in vivo effects of regulatory polymorphisms. Hum. Mol. Genet. 16: 1931-1939.
    • (2007) Hum. Mol. Genet , vol.16 , pp. 1931-1939
    • Cirulli, E.T.1    Goldstein, D.B.2
  • 29
    • 33746066022 scopus 로고    scopus 로고
    • The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein
    • Ledmyr, H., L. Ottosson, M. Sunnerhagen, and E. Ehrenborg. 2006. The Ile128Thr polymorphism influences stability and ligand binding properties of the microsomal triglyceride transfer protein. J. Lipid Res. 47: 1378-1385.
    • (2006) J. Lipid Res , vol.47 , pp. 1378-1385
    • Ledmyr, H.1    Ottosson, L.2    Sunnerhagen, M.3    Ehrenborg, E.4
  • 30
    • 0033984745 scopus 로고    scopus 로고
    • Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study
    • Couture, P., J. D. Otvos, L. A. Cupples, P. W. Wilson, E. J. Schaefer, and J. M. Ordovas. 2000. Absence of association between genetic variation in the promoter of the microsomal triglyceride transfer protein gene and plasma lipoproteins in the Framingham Offspring Study. Atherosclerosis. 148: 337-343.
    • (2000) Atherosclerosis , vol.148 , pp. 337-343
    • Couture, P.1    Otvos, J.D.2    Cupples, L.A.3    Wilson, P.W.4    Schaefer, E.J.5    Ordovas, J.M.6
  • 31
    • 0032428067 scopus 로고    scopus 로고
    • Identification of two polymorphisms in the promoter of the microsomal triglyceride transfer protein (MTP) gene: Lack of association with lipoprotein profiles
    • Herrmann, S. M., O. Poirier, V. Nicaud, A. Evans, J. B. Ruidavets, G. Luc, D. Arveiler, C. Bao-Sheng, and F. Cambien. 1998. Identification of two polymorphisms in the promoter of the microsomal triglyceride transfer protein (MTP) gene: lack of association with lipoprotein profiles. J. Lipid Res. 39: 2432-2435.
    • (1998) J. Lipid Res , vol.39 , pp. 2432-2435
    • Herrmann, S.M.1    Poirier, O.2    Nicaud, V.3    Evans, A.4    Ruidavets, J.B.5    Luc, G.6    Arveiler, D.7    Bao-Sheng, C.8    Cambien, F.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.