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Volumn 71, Issue 12, 2014, Pages 1001-1008

Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CYTOCHROME P450 3A4; LOMITAPIDE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SIMVASTATIN; WARFARIN; BENZIMIDAZOLE DERIVATIVE; CARRIER PROTEIN; HYPOCHOLESTEROLEMIC AGENT; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN;

EID: 84907224063     PISSN: 10792082     EISSN: 15352900     Source Type: Journal    
DOI: 10.2146/ajhp130592     Document Type: Review
Times cited : (17)

References (28)
  • 1
    • 84877581057 scopus 로고    scopus 로고
    • Emerging low-density lipoprotein therapies: Microsomal triglyceride transfer protein inhibitors
    • Goldberg AC. Emerging low-density lipoprotein therapies: microsomal triglyceride transfer protein inhibitors. J Clin Lipidol. 2013; 7(suppl 3):S16-20.
    • (2013) J Clin Lipidol , vol.7 , pp. S16-S20
    • Goldberg, A.C.1
  • 2
    • 84874956296 scopus 로고    scopus 로고
    • Management of familial hypercholesterolemia: A review of the recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia
    • Robinson JG. Management of familial hypercholesterolemia: a review of the recommendations from the National Lipid Association Expert Panel on Familial Hypercholesterolemia. J Manag Care Pharm. 2013; 19:139-49.
    • (2013) J Manag Care Pharm , vol.19 , pp. 139-149
    • Robinson, J.G.1
  • 3
    • 84864772507 scopus 로고    scopus 로고
    • Homozygous familial hypercholesterolemia: Current perspectives on diagnosis and treatment
    • Raal FJ, Santos RD. Homozygous familial hypercholesterolemia: current perspectives on diagnosis and treatment. Atherosclerosis. 2012; 223:262-8.
    • (2012) Atherosclerosis , vol.223 , pp. 262-268
    • Raal, F.J.1    Santos, R.D.2
  • 4
    • 84880608435 scopus 로고    scopus 로고
    • Recent advances in the treatment of homozygous familial hypercholesterolaemia
    • Marais AD, Blom DJ. Recent advances in the treatment of homozygous familial hypercholesterolaemia. Curr Opin Lipidol. 2013; 24:288-94.
    • (2013) Curr Opin Lipidol , vol.24 , pp. 288-294
    • Marais, A.D.1    Blom, D.J.2
  • 5
    • 79956267846 scopus 로고    scopus 로고
    • Familial hypercholesterolemia: Screening, diagnosis and management of pediatric and adult patients: Clinical guidance from the National Lipid Association expert panel on familial hypercholesterolemia
    • Goldberg AC, Hopkins PN, Toth PP et al. Familial hypercholesterolemia: screening, diagnosis and management of pediatric and adult patients: clinical guidance from the National Lipid Association expert panel on familial hypercholesterolemia. J Clin Lipidol. 2011; 5(suppl 3):S1-8.
    • (2011) J Clin Lipidol , vol.5 , pp. S1-S8
    • Goldberg, A.C.1    Hopkins, P.N.2    Toth, P.P.3
  • 6
    • 0034717836 scopus 로고    scopus 로고
    • Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly
    • Gordon DA, Jamil H. Progress towards understanding the role of microsomal triglyceride transfer protein in apolipoprotein-B lipoprotein assembly. Biochim Biophys Acta. 2000; 1486:72-83.
    • (2000) Biochim Biophys Acta , vol.1486 , pp. 72-83
    • Gordon, D.A.1    Jamil, H.2
  • 7
    • 48349085741 scopus 로고    scopus 로고
    • Microsomal triglyceride transfer protein inhibition - Friend or foe?
    • Joy TR, Hegele RA. Microsomal triglyceride transfer protein inhibition - friend or foe? Nat Clin Pract Cardiovasc Med. 2008; 5:506-8.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 506-508
    • Joy, T.R.1    Hegele, R.A.2
  • 8
    • 36049025844 scopus 로고    scopus 로고
    • New targets and emerging therapies for reducing LDL cholesterol
    • Lilly SM, Rader DJ. New targets and emerging therapies for reducing LDL cholesterol. Curr Opin Lipidol. 2007; 18:650-5.
    • (2007) Curr Opin Lipidol , vol.18 , pp. 650-655
    • Lilly, S.M.1    Rader, D.J.2
  • 9
    • 84856523563 scopus 로고    scopus 로고
    • Emerging therapies for dyslipidemia: Known knowns and known unknowns of MTP inhibitors
    • Raval SK, Raval PS, Jain MR. Emerging therapies for dyslipidemia: known knowns and known unknowns of MTP inhibitors. Recent Pat Endocr Metab Immune Drug Discov. 2012; 6:24-9.
    • (2012) Recent Pat Endocr Metab Immune Drug Discov , vol.6 , pp. 24-29
    • Raval, S.K.1    Raval, P.S.2    Jain, M.R.3
  • 10
    • 84882927131 scopus 로고    scopus 로고
    • New LDL-cholesterol lowering therapies: Pharmacology, clinical trials, and relevance to acute coronary syndromes
    • Sahebkar A, Watts GF. New LDL-cholesterol lowering therapies: pharmacology, clinical trials, and relevance to acute coronary syndromes. Clin Ther. 2013; 35:1082-98.
    • (2013) Clin Ther , vol.35 , pp. 1082-1098
    • Sahebkar, A.1    Watts, G.F.2
  • 11
    • 84907225310 scopus 로고    scopus 로고
    • Food and Drug Administration. Briefing document: NDA 203858. www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/EndocrinologicandMetabolicDrugsAdvisoryCommittee/UCM323841.pdf (accessed 2013 Aug 25).
    • Briefing Document: NDA 203858
  • 15
    • 84907219538 scopus 로고    scopus 로고
    • Cambridge, MA: Aegerion Pharmaceuticals, Inc.
    • Juxtapid (lomitapide) package insert. Cambridge, MA: Aegerion Pharmaceuticals, Inc.; 2012.
    • (2012) Juxtapid (Lomitapide) Package Insert
  • 16
    • 33846151732 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
    • Cuchel M, Bloedon LT, Szapary PO et al. Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia. N Engl J Med. 2007; 356:148-56.
    • (2007) N Engl J Med , vol.356 , pp. 148-156
    • Cuchel, M.1    Bloedon, L.T.2    Szapary, P.O.3
  • 17
    • 0031128192 scopus 로고    scopus 로고
    • Jami l H. Microsomal triglyceride transfer protein
    • Wetterau JR, Lin MC, Jami l H. Microsomal triglyceride transfer protein. Biochim Biophys Acta. 1997; 1345:136-50.
    • (1997) Biochim Biophys Acta , vol.1345 , pp. 136-150
    • Wetterau, J.R.1    Lin, M.C.2
  • 18
    • 48349088178 scopus 로고    scopus 로고
    • Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia
    • Samaha FF, McKenney J, Bloedon LT et al. Inhibition of microsomal triglyceride transfer protein alone or with ezetimibe in patients with moderate hypercholesterolemia. Nat Clin Pract Cardiovasc Med. 2008; 5:497-505.
    • (2008) Nat Clin Pract Cardiovasc Med , vol.5 , pp. 497-505
    • Samaha, F.F.1    McKenney, J.2    Bloedon, L.T.3
  • 19
    • 2442502479 scopus 로고    scopus 로고
    • The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: One-year follow-up of a randomized trial
    • Stern L, Iqbal N, Seshadri P et al. The effects of low-carbohydrate versus conventional weight loss diets in severely obese adults: one-year follow-up of a randomized trial. Ann Intern Med. 2004; 140:778-85.
    • (2004) Ann Intern Med , vol.140 , pp. 778-785
    • Stern, L.1    Iqbal, N.2    Seshadri, P.3
  • 20
    • 0028076352 scopus 로고
    • In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: Implications for the roles of apolipoproteins B and E in HDL metabolism
    • Ikewaki K, Rader DJ, Zech LA, Brewer HB Jr. In vivo metabolism of apolipoproteins A-I and E in patients with abetalipoproteinemia: implications for the roles of apolipoproteins B and E in HDL metabolism. J Lipid Res. 1994; 35:1809-19.
    • (1994) J Lipid Res , vol.35 , pp. 1809-1819
    • Ikewaki, K.1    Rader, D.J.2    Zech, L.A.3    Brewer, H.B.4
  • 21
    • 0032539162 scopus 로고    scopus 로고
    • Intensive lifestyle changes for reversal of coronary heart disease
    • [Erratum, JAMA. 1999; 281:1380]
    • Ornish D, Scherwitz LW, Billings JH et al. Intensive lifestyle changes for reversal of coronary heart disease. JAMA. 1998; 280:2001-7. [Erratum, JAMA. 1999; 281:1380.]
    • (1998) JAMA , vol.280 , pp. 2001-2007
    • Ornish, D.1    Scherwitz, L.W.2    Billings, J.H.3
  • 22
    • 84871945617 scopus 로고    scopus 로고
    • Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: A single-arm, open-label, phase 3 study
    • Cuchel M, Meagher EA, du Toit Theron H et al., for the Phase 3 HoFH Lomitapide Study investigators. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet. 2013; 381:40-6.
    • (2013) Lancet , vol.381 , pp. 40-46
    • Cuchel, M.1    Meagher, E.A.2    Du Toit Theron, H.3
  • 25
    • 84896786524 scopus 로고    scopus 로고
    • Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia
    • Epub ahead of print. 2013 Oct 15
    • Tuteja S, Duffy D, Dunbar R et al. Pharmacokinetic interactions of the microsomal triglyceride transfer protein inhibitor, lomitapide, with drugs commonly used in the management of hypercholesterolemia. Pharmacotherapy. 2013. Epub ahead of print. 2013 Oct 15.
    • (2013) Pharmacotherapy
    • Tuteja, S.1    Duffy, D.2    Dunbar, R.3
  • 26
    • 84868518061 scopus 로고    scopus 로고
    • Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: Results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease
    • Stein EA, Dufour R, Gagne C et al. Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease. Circulation. 2012; 126:2283-92.
    • (2012) Circulation , vol.126 , pp. 2283-2292
    • Stein, E.A.1    Dufour, R.2    Gagne, C.3
  • 27
    • 84862219022 scopus 로고    scopus 로고
    • Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
    • McKenney JM, Koren MJ, Kereiakes DJ et al. Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol. 2012; 59:2344-53.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 2344-2353
    • McKenney, J.M.1    Koren, M.J.2    Kereiakes, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.