Circulating giant macrophages as a potential biomarker of solid tumors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 9, 2014, Pages 3514-3519

  Adams, Daniel L ^a   Martin, Stuart S ^b   Alpaugh, R Katherine ^c   Charpentier, Monica ^b   Tsai, Susan ^d   Bergan, Raymond C ^e   Ogden, Irene M ^e   Catalona, William ^e   Chumsri, Saranya ^b   Tang, Cha Mei ^a   Cristofanilli, Massimo ^f  

^a CREATV MICROTECH INC   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

^c FOX CHASE CANCER CENTER   (United States)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e NORTHWESTERN UNIVERSITY   (United States)

^f THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

Blood cell biomarkers; Cancer biomarker; Cancer metastasis; Cancer screening; Liquid biopsy

Indexed keywords

BIOLOGICAL MARKER; CELL SURFACE MARKER;

ARTICLE; BLOOD; BREAST CANCER; CELL INTERACTION; CELL MIGRATION; CIRCULATING TUMOR CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISTANT METASTASIS; ENDOTHELIUM CELL; HUMAN; MACROPHAGE; MAJOR CLINICAL STUDY; MICROFILTRATION; MONOCYTE; PANCREAS CANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; SOLID TUMOR; TREATMENT RESPONSE; TUMOR ASSOCIATED LEUKOCYTE;

BLOOD CELL BIOMARKERS; CANCER BIOMARKER; CANCER METASTASIS; CANCER SCREENING; LIQUID BIOPSY;

BIOLOGICAL MARKERS; BIOPSY; CELL MOVEMENT; CELL SIZE; FILTRATION; FLUORESCEIN-5-ISOTHIOCYANATE; GIANT CELLS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KAPLAN-MEIER ESTIMATE; MACROPHAGES; MICROSCOPY; NEOPLASMS; NEOPLASTIC CELLS, CIRCULATING;

EID: 84895802375     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1320198111     Document Type: Article

References (26)

1. Heusinkveld M, van der Burg SH (2011) Identification and manipulation of tumor associated macrophages in human cancers. J Transl Med 9:216.
2. Shih JY, Yuan A, Chen JJW, Yang PC (2006) Tumor-associated macrophage: Its role in cancer invasion and metastasis. J Cancer Mol 2(3):101-106.
3. Solinas G, Germano G, Mantovani A, Allavena P (2009) Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J Leukoc Biol 86(5):1065-1073.
4. Condeelis J, Pollard JW (2006) Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis. Cell 124(2):263-266.
5. De Palma M, et al. (2005) Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8(3):211-226.
6. Wyckoff JB, et al. (2007) Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 67(6):2649-2656.
7. Roussos ET, et al. (2011) Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. J Cell Sci 124(Pt 13):2120-2131.
8. Ovchinnikov DA (2008) Macrophages in the embryo and beyond: Much more than just giant phagocytes. Genesis 46(9):447-462.
9. Dovas A, et al. (2011) Visualization of actin polymerization in invasive structures of macrophages and carcinoma cells using photoconvertible β-actin-Dendra2 fusion proteins. PLoS ONE 6(2):e16485.
10. Mego M, Mani SA, Cristofanilli M (2010) Molecular mechanisms of metastasis in breast cancer-clinical applications. Nat Rev Clin Oncol 7(12):693-701.
11. Pawelek JM, Chakraborty AK (2008) Fusion of tumour cells with bone marrow-derived cells: A unifying explanation for metastasis. Nat Rev Cancer 8(5):377-386.
12. Coffelt SB, et al. (2010) Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors. Am J Pathol 176(4):1564-1576.
13. Raker JW, Taft PD, Edmonds EE (1960) Significance of megakaryocytes in the search for tumor cells in the peripheral blood. N Engl J Med 263:993-996.
14. Hume R, West JT, Malmgren RA, Chu EA (1964) Quantitative Observations of Circulating Megakaryocytes in the Blood of Patients with Cancer. N Engl J Med 270: 111-117.
15. Bobek V, Hoffman RM, Kolostova K (2013) Site-specific cytomorphology of disseminated PC-3 prostate cancer cells visualized in vivo with fluorescent proteins. Diagn Cytopathol 41(5):413-417.
16. Adams DL, et al. (2014) The Systematic Study of Circulating Tumor Cell Isolation using Lithographic Microfilters. RSC Advances 4(9):4334-4342.
17. Quinn MT, Schepetkin IA (2009) Role of NADPH oxidase in formation and function of multinucleated giant cells. J Innate Immun 1(6):509-526.
18. Horrevoets AJ (2009) Angiogenic monocytes: Another colorful blow to endothelial progenitors. Am J Pathol 174(5):1594-1596.
19. Allard WJ, et al. (2004) Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin Cancer Res 10(20):6897-6904.
20. Chen JJ, et al. (2005) Tumor-associated macrophages: The double-edged sword in cancer progression. J Clin Oncol 23(5):953-964.
21. Fiumara A, et al. (1997) In situ evidence of neoplastic cell phagocytosis by macrophages in papillary thyroid cancer. J Clin Endocrinol Metab 82(5):1615-1620.
22. Medrek C, Pontén F, Jirström K, Leandersson K (2012) The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer 12:306.
23. Venneri MA, et al. (2007) Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer. Blood 109(12):5276-5285.
24. Rehman J, Li J, Orschell CM, March KL (2003) Peripheral blood "endothelial progenitor cells" are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation 107(8):1164-1169.
25. Schmeisser A, et al. (2001) Monocytes coexpress endothelial and macrophagocytic lineage markers and form cord-like structures in Matrigel under angiogenic conditions. Cardiovasc Res 49(3):671-680.
26. Kagan M, et al. (2002) A sample preparation and analysis system for identification of circulating tumor cells. J Clin Ligand Assay 25(1):104-110.