메뉴 건너뛰기




Volumn 20, Issue 22, 2014, Pages 5823-5834

Pik3ca mutational status in circulating tumor cells can change during disease recurrence or progression in patients with breast cancer

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; CYTOKERATIN 19; DOCETAXEL; DOUBLE STRANDED DNA; EPIRUBICIN; EPITHELIAL CELL ADHESION MOLECULE; MESSENGER RNA; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PIK3CA PROTEIN, HUMAN;

EID: 84916898794     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-0149     Document Type: Article
Times cited : (53)

References (52)
  • 1
    • 68549137924 scopus 로고    scopus 로고
    • Alix-Panabi -eres C, Riethdorf S. Cancer micrometastases
    • Pantel K, Alix-Panabi -eres C, Riethdorf S. Cancer micrometastases. Nat Rev Clin Oncol 2009;6:339-51.
    • (2009) Nat Rev Clin Oncol , vol.6 , pp. 339-351
    • Pantel, K.1
  • 2
    • 84879693078 scopus 로고    scopus 로고
    • Clinical challenges in the molecular characterization of circulating tumour cells in breast cancer
    • Lianidou ES, Mavroudis D, Georgoulias V. Clinical challenges in the molecular characterization of circulating tumour cells in breast cancer. Br J Cancer 2013;108:2426-32.
    • (2013) Br J Cancer , vol.108 , pp. 2426-2432
    • Lianidou, E.S.1    Mavroudis, D.2    Georgoulias, V.3
  • 3
    • 84883818940 scopus 로고    scopus 로고
    • Circulating Tumor Cells
    • Plaks V, Koopman C, Werb Z. Circulating Tumor Cells. Science 2013; 341:1186-8.
    • (2013) Science , vol.341 , pp. 1186-1188
    • Plaks, V.1    Koopman, C.2    Werb, Z.3
  • 4
    • 0037102125 scopus 로고    scopus 로고
    • Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: Evaluation of their prognostic significance
    • Stathopoulou A, Vlachonikolis I, Mavroudis D, Perraki M, Kouroussis C, Apostolaki S, et al. Molecular detection of cytokeratin-19-positive cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic significance. J Clin Oncol 2002;20: 3404-12.
    • (2002) J Clin Oncol , vol.20 , pp. 3404-3412
    • Stathopoulou, A.1    Vlachonikolis, I.2    Mavroudis, D.3    Perraki, M.4    Kouroussis, C.5    Apostolaki, S.6
  • 5
    • 33747341338 scopus 로고    scopus 로고
    • Predictive and prognostic value of peripheral blood cyto-keratin-19 mRNA-positive cells detected by real-time polymerase chain reaction in node-negative breast cancer patients
    • Xenidis N, Perraki M, Kafousi M, Apostolaki S, Bolonaki I, Stathopoulou A, et al.Predictive and prognostic value of peripheral blood cyto-keratin-19 mRNA-positive cells detected by real-time polymerase chain reaction in node-negative breast cancer patients. J Clin Oncol 2006;24:3756-62.
    • (2006) J Clin Oncol , vol.24 , pp. 3756-3762
    • Xenidis, N.1    Perraki, M.2    Kafousi, M.3    Apostolaki, S.4    Bolonaki, I.5    Stathopoulou, A.6
  • 6
    • 34848873089 scopus 로고    scopus 로고
    • Clinical relevance of circulating CK-19 mRNA-positive cells detected during the adjuvant tamoxifen treatment in patients with early breast cancer
    • Xenidis N, Markos V, Apostolaki S, Perraki M, Pallis A, Sfakiotaki G, et al. Clinical relevance of circulating CK-19 mRNA-positive cells detected during the adjuvant tamoxifen treatment in patients with early breast cancer. Ann Oncol 2007;18:1623-31.
    • (2007) Ann Oncol , vol.18 , pp. 1623-1631
    • Xenidis, N.1    Markos, V.2    Apostolaki, S.3    Perraki, M.4    Pallis, A.5    Sfakiotaki, G.6
  • 7
    • 65549086081 scopus 로고    scopus 로고
    • Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer
    • Xenidis N, Ignatiadis M, Apostolaki S, Perraki M, Kalbakis K, Agelaki S, et al. Cytokeratin-19 mRNA-positive circulating tumor cells after adjuvant chemotherapy in patients with early breast cancer. J Clin Oncol 2009;27:2177-84.
    • (2009) J Clin Oncol , vol.27 , pp. 2177-2184
    • Xenidis, N.1    Ignatiadis, M.2    Apostolaki, S.3    Perraki, M.4    Kalbakis, K.5    Agelaki, S.6
  • 8
    • 77951707834 scopus 로고    scopus 로고
    • Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer
    • Bidard FC, Mathiot C, Delaloge S, Brain E, Giachetti S, de Cremoux P, et al. Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer. Ann Oncol 2010;21:729-33.
    • (2010) Ann Oncol , vol.21 , pp. 729-733
    • Bidard, F.C.1    Mathiot, C.2    Delaloge, S.3    Brain, E.4    Giachetti, S.5    De Cremoux, P.6
  • 9
    • 79958181044 scopus 로고    scopus 로고
    • Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients with operable breast cancer: Prognostic relevance for late relapse
    • Saloustros E, Perraki M, Apostolaki S, Kallergi G, Xyrafas A, Kalbakis K, et al. Cytokeratin-19 mRNA-positive circulating tumor cells during follow-up of patients with operable breast cancer: prognostic relevance for late relapse. Breast Cancer Res 2011;13:R60.
    • (2011) Breast Cancer Res , vol.13 , pp. R60
    • Saloustros, E.1    Perraki, M.2    Apostolaki, S.3    Kallergi, G.4    Xyrafas, A.5    Kalbakis, K.6
  • 12
    • 84860390470 scopus 로고    scopus 로고
    • Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment
    • Giuliano M, Giordano A, Jackson S, Hess KR, De Giorgi U, Mego M, et al. Circulating tumor cells as prognostic and predictive markers in metastatic breast cancer patients receiving first-line systemic treatment. Breast Cancer Res 2011;13:R67.
    • (2011) Breast Cancer Res , vol.13 , pp. R67
    • Giuliano, M.1    Giordano, A.2    Jackson, S.3    Hess, K.R.4    De Giorgi, U.5    Mego, M.6
  • 13
    • 67349253810 scopus 로고    scopus 로고
    • Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: An option for monitoring response to breast cancer related therapies
    • Tewes M, Aktas B, Welt A, Mueller S, Hauch S, Kimmig R, et al. Molecular profiling and predictive value of circulating tumor cells in patients with metastatic breast cancer: an option for monitoring response to breast cancer related therapies. Breast Cancer Res Treat 2009;115:581-90.
    • (2009) Breast Cancer Res Treat , vol.115 , pp. 581-590
    • Tewes, M.1    Aktas, B.2    Welt, A.3    Mueller, S.4    Hauch, S.5    Kimmig, R.6
  • 14
    • 84857613654 scopus 로고    scopus 로고
    • High independent prognostic and predictive value of circulating tumor cells compared with serum tumor markers in a large prospective trial in first-line chemotherapy for metastatic breast cancer patients
    • Pierga JY, Hajage D, Bachelot T, Delaloge S, Brain E, Campone M, et al. High independent prognostic and predictive value of circulating tumor cells compared with serum tumor markers in a large prospective trial in first-line chemotherapy for metastatic breast cancer patients. Ann Oncol 2012;23:618-24.
    • (2012) Ann Oncol , vol.23 , pp. 618-624
    • Pierga, J.Y.1    Hajage, D.2    Bachelot, T.3    Delaloge, S.4    Brain, E.5    Campone, M.6
  • 15
    • 84862008956 scopus 로고    scopus 로고
    • Clinical relevance of circulating CK-19mRNA-positive tumour cells before front-line treatment in patients with metastatic breast cancer
    • Androulakis N, Agelaki S, Perraki M, Apostolaki S, Bozionelou V, Pallis A, et al. Clinical relevance of circulating CK-19mRNA-positive tumour cells before front-line treatment in patients with metastatic breast cancer. Br J Cancer 2012;106:1917-25.
    • (2012) Br J Cancer , vol.106 , pp. 1917-1925
    • Androulakis, N.1    Agelaki, S.2    Perraki, M.3    Apostolaki, S.4    Bozionelou, V.5    Pallis, A.6
  • 16
    • 84867556074 scopus 로고    scopus 로고
    • Metaanalysis of the prognostic value of circulating tumor cells in breast cancer
    • Zhang L, Riethdorf S, Wu G, Wang T, Yang K, Peng G, et al. Metaanalysis of the prognostic value of circulating tumor cells in breast cancer. Clin Cancer Res 2012;18:5701-10.
    • (2012) Clin Cancer Res , vol.18 , pp. 5701-5710
    • Zhang, L.1    Riethdorf, S.2    Wu, G.3    Wang, T.4    Yang, K.5    Peng, G.6
  • 17
    • 84878112286 scopus 로고    scopus 로고
    • Clinical application of circulating tumor cells in breast cancer: Overview of the current interventional trials
    • Bidard FC, Fehm T, Ignatiadis M, Smerage JB, Alix-Panabi -eres C, Janni W, et al. Clinical application of circulating tumor cells in breast cancer: overview of the current interventional trials. Cancer Metastasis Rev 2013;32:179-88.
    • (2013) Cancer Metastasis Rev , vol.32 , pp. 179-188
    • Bidard, F.C.1    Fehm, T.2    Ignatiadis, M.3    Smerage, J.B.4    Alix-Panabié Res, C.5    Janni, W.6
  • 18
    • 84867987016 scopus 로고    scopus 로고
    • Molecular characterization of circulating tumor cells in breast cancer: Challenges and promises for individualized cancer treatment
    • Lianidou ES, Markou A, Strati A. Molecular characterization of circulating tumor cells in breast cancer: challenges and promises for individualized cancer treatment. Cancer Metastasis Rev 2012;31: 663-71.
    • (2012) Cancer Metastasis Rev , vol.31 , pp. 663-671
    • Lianidou, E.S.1    Markou, A.2    Strati, A.3
  • 20
    • 79952239863 scopus 로고    scopus 로고
    • Molecular characterization of circulating tumor cells in breast cancer by a liquid bead array hybridization assay
    • Markou A, Strati A, Malamos N, Georgoulias V, Lianidou ES. Molecular characterization of circulating tumor cells in breast cancer by a liquid bead array hybridization assay. Clin Chem 2011;57: 421-30.
    • (2011) Clin Chem , vol.57 , pp. 421-430
    • Markou, A.1    Strati, A.2    Malamos, N.3    Georgoulias, V.4    Lianidou, E.S.5
  • 21
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R, Kasimir-Bauer S. Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res 2009;11:R46.
    • (2009) Breast Cancer Res , vol.11 , pp. R46
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 22
    • 70449598075 scopus 로고    scopus 로고
    • Molecular characterization of circulating tumor cells in large quantities of contaminating leukocytes by a multiplex real-time PCR
    • Sieuwerts AM, Kraan J, Bolt-de Vries J, van der Spoel P, Mostert B, Martens JW, et al. Molecular characterization of circulating tumor cells in large quantities of contaminating leukocytes by a multiplex real-time PCR. Breast Cancer Res Treat 2009;118:455-68.
    • (2009) Breast Cancer Res Treat , vol.118 , pp. 455-468
    • Sieuwerts, A.M.1    Kraan, J.2    Bolt-de Vries, J.3    Van Der Spoel, P.4    Mostert, B.5    Martens, J.W.6
  • 23
    • 79961093766 scopus 로고    scopus 로고
    • DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells
    • Chimonidou M, Strati A, Tzitzira A, Sotiropoulou G, Malamos N, Georgoulias V, et al. DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells. Clin Chem 2011;57:1169-77.
    • (2011) Clin Chem , vol.57 , pp. 1169-1177
    • Chimonidou, M.1    Strati, A.2    Tzitzira, A.3    Sotiropoulou, G.4    Malamos, N.5    Georgoulias, V.6
  • 24
    • 84872031717 scopus 로고    scopus 로고
    • SOX17 promoter methylation in circulating tumor cells and matched cell-free DNA isolated from plasma of patients with breast cancer
    • Chimonidou M, Strati A, Malamos N, Georgoulias V, Lianidou ES. SOX17 promoter methylation in circulating tumor cells and matched cell-free DNA isolated from plasma of patients with breast cancer. Clin Chem 2013;59:270-9.
    • (2013) Clin Chem , vol.59 , pp. 270-279
    • Chimonidou, M.1    Strati, A.2    Malamos, N.3    Georgoulias, V.4    Lianidou, E.S.5
  • 26
    • 84876674310 scopus 로고    scopus 로고
    • KRASand BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue
    • Mostert B, Jiang Y, Sieuwerts AM, Wang H, Bolt-de Vries J, Biermann K, et al.KRASand BRAF mutation status in circulating colorectal tumor cells and their correlation with primary and metastatic tumor tissue. Int J Cancer 2013;133:130-41.
    • (2013) Int J Cancer , vol.133 , pp. 130-141
    • Mostert, B.1    Jiang, Y.2    Sieuwerts, A.M.3    Wang, H.4    Bolt-de Vries, J.5    Biermann, K.6
  • 27
    • 84872048462 scopus 로고    scopus 로고
    • Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer
    • Gasch C, Bauernhofer T, Pichler M, Langer-Freitag S, Reeh M, Seifert AM, et al. Heterogeneity of epidermal growth factor receptor status and mutations of KRAS/PIK3CA in circulating tumor cells of patients with colorectal cancer. Clin Chem 2013;59:252-60.
    • (2013) Clin Chem , vol.59 , pp. 252-260
    • Gasch, C.1    Bauernhofer, T.2    Pichler, M.3    Langer-Freitag, S.4    Reeh, M.5    Seifert, A.M.6
  • 28
    • 84877865227 scopus 로고    scopus 로고
    • Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing
    • Heitzer E, Auer M, Gasch C, Pichler M, Ulz P, Hoffmann EM, et al. Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing. Cancer Res 2013;73: 2965-75.
    • (2013) Cancer Res , vol.73 , pp. 2965-2975
    • Heitzer, E.1    Auer, M.2    Gasch, C.3    Pichler, M.4    Ulz, P.5    Hoffmann, E.M.6
  • 29
    • 84884286445 scopus 로고    scopus 로고
    • Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients
    • Schneck H, Blassl C, Meier-Stiegen F, Neves RP, Janni W, Fehm T, et al. Analysing the mutational status of PIK3CA in circulating tumor cells from metastatic breast cancer patients. Mol Oncol 2013;7: 976-86.
    • (2013) Mol Oncol , vol.7 , pp. 976-986
    • Schneck, H.1    Blassl, C.2    Meier-Stiegen, F.3    Neves, R.P.4    Janni, W.5    Fehm, T.6
  • 30
    • 84861746437 scopus 로고    scopus 로고
    • Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasmaDNA
    • Forshew T, Murtaza M, Parkinson C, Gale D, Tsui DW, Kaper F, et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasmaDNA. Sci TranslMed 2012;4:136ra68.
    • (2012) Sci TranslMed , vol.4 , pp. 136ra68
    • Forshew, T.1    Murtaza, M.2    Parkinson, C.3    Gale, D.4    Tsui, D.W.5    Kaper, F.6
  • 31
  • 32
    • 84856767715 scopus 로고    scopus 로고
    • PIK3CA mutation impact on survival in breast cancer patients and in ERa, PR and ERBB2-based subgroups
    • Cizkova M, Susini A, Vacher S, Cizeron-Clairac G, Andrieu C, Driouch K, et al. PIK3CA mutation impact on survival in breast cancer patients and in ERa, PR and ERBB2-based subgroups. Breast Cancer Res 2012;14:R28.
    • (2012) Breast Cancer Res , vol.14 , pp. R28
    • Cizkova, M.1    Susini, A.2    Vacher, S.3    Cizeron-Clairac, G.4    Andrieu, C.5    Driouch, K.6
  • 33
    • 84878532044 scopus 로고    scopus 로고
    • Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab
    • Cizkova M, Dujaric ME, Lehmann-Che J, Scott V, Tembo O, Asselain B, et al. Outcome impact of PIK3CA mutations in HER2-positive breast cancer patients treated with trastuzumab. Br J Cancer 2013;108: 1807-9.
    • (2013) Br J Cancer , vol.108 , pp. 1807-1809
    • Cizkova, M.1    Dujaric, M.E.2    Lehmann-Che, J.3    Scott, V.4    Tembo, O.5    Asselain, B.6
  • 34
    • 84883396637 scopus 로고    scopus 로고
    • Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies
    • Hanker AB, Pfefferle AD, Balko JM, Kuba MG, Young CD, Sanchez V, et al. Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies. Proc Natl Acad Sci U S A 2013;110:14372-7.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 14372-14377
    • Hanker, A.B.1    Pfefferle, A.D.2    Balko, J.M.3    Kuba, M.G.4    Young, C.D.5    Sanchez, V.6
  • 36
    • 77955648969 scopus 로고    scopus 로고
    • Pathway-based identification of biomarkers for targeted therapeutics: Personalized oncology with PI3K pathway inhibitors
    • Andersen JN, Sathyanarayanan S, Di Bacco A, Chi T, Zhang AH, Chen AH, et al. Pathway-based identification of biomarkers for targeted therapeutics: personalized oncology with PI3K pathway inhibitors. Sci Transl Med 2010;2:43ra55.
    • (2010) Sci Transl Med , vol.2 , pp. 43ra55
    • Andersen, J.N.1    Sathyanarayanan, S.2    Di Bacco, A.3    Chi, T.4    Zhang, A.H.5    Chen, A.H.6
  • 37
    • 84860601923 scopus 로고    scopus 로고
    • Single cell profiling of circulating tumor cells: Transcriptional heterogeneity and diversity from breast cancer cell lines
    • Powell AA, Talasaz AH, Zhang H, Coram MA, Reddy A, Deng G, et al. Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines. PLoS ONE 2012;7: e33788
    • (2012) PLoS ONE , vol.7 , pp. e33788
    • Powell, A.A.1    Talasaz, A.H.2    Zhang, H.3    Coram, M.A.4    Reddy, A.5    Deng, G.6
  • 38
    • 83455182224 scopus 로고    scopus 로고
    • Rare allele enrichment and detection by allele-specific PCR, competitive probe blocking, and melting analysis
    • Zhou L, Wang Y, Wittwer CT. Rare allele enrichment and detection by allele-specific PCR, competitive probe blocking, and melting analysis. BioTechniques 2011;50:311-8.
    • (2011) Biotechniques , vol.50 , pp. 311-318
    • Zhou, L.1    Wang, Y.2    Wittwer, C.T.3
  • 39
    • 0026802077 scopus 로고
    • The kappa statistic
    • Berry CC. The kappa statistic. JAMA 1992;268:2513.
    • (1992) JAMA , vol.268 , pp. 2513
    • Berry, C.C.1
  • 40
    • 84863593329 scopus 로고    scopus 로고
    • Temperature-tolerant COLD-PCR reduces temperature stringency and enables robust mutation enrichment
    • Castellanos-Rizaldos E, Liu P, Milbury CA, Guha M, Brisci A, Cremonesi L, et al. Temperature-tolerant COLD-PCR reduces temperature stringency and enables robust mutation enrichment. Clin Chem 2012; 58:1130-8.
    • (2012) Clin Chem , vol.58 , pp. 1130-1138
    • Castellanos-Rizaldos, E.1    Liu, P.2    Milbury, C.A.3    Guha, M.4    Brisci, A.5    Cremonesi, L.6
  • 41
    • 77956839940 scopus 로고    scopus 로고
    • PIK3CA hotspot mutation scanning by a novel and highly sensitive high-resolution small amplicon melting analysis method
    • Vorkas PA, Poumpouridou N, Agelaki S, Kroupis C, Georgoulias V, Lianidou ES. PIK3CA hotspot mutation scanning by a novel and highly sensitive high-resolution small amplicon melting analysis method. J Mol Diagn 2010;12:697-704.
    • (2010) J Mol Diagn , vol.12 , pp. 697-704
    • Vorkas, P.A.1    Poumpouridou, N.2    Agelaki, S.3    Kroupis, C.4    Georgoulias, V.5    Lianidou, E.S.6
  • 43
    • 84872801531 scopus 로고    scopus 로고
    • Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: Correlation with clinicopathological criteria
    • Harl -e A, Lion M, Lozano N, Husson M, Harter V, Genin P, et al. Analysis of PIK3CA exon 9 and 20 mutations in breast cancers using PCR-HRM and PCR-ARMS: correlation with clinicopathological criteria. Oncol Rep 2013;29:1043-52.
    • (2013) Oncol Rep , vol.29 , pp. 1043-1052
    • Harlé, A.1    Lion, M.2    Lozano, N.3    Husson, M.4    Harter, V.5    Genin, P.6
  • 44
    • 84877314885 scopus 로고    scopus 로고
    • A novel fully automated molecular diagnostic system (AMDS) for colorectal cancer mutation detection
    • Kitano S, Myers J, Nakamura J, Yamane A, Yamashita M, Nakayama M, et al. A novel fully automated molecular diagnostic system (AMDS) for colorectal cancer mutation detection. PLoS ONE 2013;8:e62989.
    • (2013) PLoS ONE , vol.8 , pp. e62989
    • Kitano, S.1    Myers, J.2    Nakamura, J.3    Yamane, A.4    Yamashita, M.5    Nakayama, M.6
  • 45
    • 84871325703 scopus 로고    scopus 로고
    • Mutation scanning using MUT-MAP, a high-throughput, microfluidic chip-based, multi-analyte panel
    • Patel R, Tsan A, Tam R, Desai R, Schoenbrunner N, Myers TW, et al. Mutation scanning using MUT-MAP, a high-throughput, microfluidic chip-based, multi-analyte panel. PLoS ONE 2012;7:e51153.
    • (2012) PLoS ONE , vol.7 , pp. e51153
    • Patel, R.1    Tsan, A.2    Tam, R.3    Desai, R.4    Schoenbrunner, N.5    Myers, T.W.6
  • 46
    • 84860702958 scopus 로고    scopus 로고
    • PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients withKRAS wild-type metastatic colorectal cancer
    • Sood A, McClain D, Maitra R, Basu-Mallick A, Seetharam R, Kaubisch A, et al. PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients withKRAS wild-type metastatic colorectal cancer. Clin Colorectal Cancer 2012;11:143-50.
    • (2012) Clin Colorectal Cancer , vol.11 , pp. 143-150
    • Sood, A.1    McClain, D.2    Maitra, R.3    Basu-Mallick, A.4    Seetharam, R.5    Kaubisch, A.6
  • 47
    • 51049118140 scopus 로고    scopus 로고
    • An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
    • Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, et al. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 2008;68:6084-91.
    • (2008) Cancer Res , vol.68 , pp. 6084-6091
    • Stemke-Hale, K.1    Gonzalez-Angulo, A.M.2    Lluch, A.3    Neve, R.M.4    Kuo, W.L.5    Davies, M.6
  • 48
    • 84878453265 scopus 로고    scopus 로고
    • Detection and recovery of circulating colon cancer cells using a dielectrophor-esis-based device: KRAS mutation status in pure CTCs
    • Fabbri F, Carloni S, Zoli W, Ulivi P, Gallerani G, Fici P, et al. Detection and recovery of circulating colon cancer cells using a dielectrophor-esis-based device: KRAS mutation status in pure CTCs. Cancer Lett 2013;335:225-31.
    • (2013) Cancer Lett , vol.335 , pp. 225-231
    • Fabbri, F.1    Carloni, S.2    Zoli, W.3    Ulivi, P.4    Gallerani, G.5    Fici, P.6
  • 49
    • 84865442609 scopus 로고    scopus 로고
    • In fluence of chemotherapy on EGFR mutation status among patients with non-small-cell lung cancer
    • Bai H, Wang Z, Chen K, Zhao J, Lee JJ, Wang S, et al. In fluence of chemotherapy on EGFR mutation status among patients with non-small-cell lung cancer. J Clin Oncol 2012;30:3077-83.
    • (2012) J Clin Oncol , vol.30 , pp. 3077-3083
    • Bai, H.1    Wang, Z.2    Chen, K.3    Zhao, J.4    Lee, J.J.5    Wang, S.6
  • 50
    • 84869223443 scopus 로고    scopus 로고
    • Personalized medicine in a phase I clinical trials program: The MD Anderson Cancer Center initiative
    • Tsimberidou AM, Iskander NG, Hong DS, Wheler JJ, Falchook GS, Fu S, et al. Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative. Clin Cancer Res 2012;18: 6373-83.
    • (2012) Clin Cancer Res , vol.18 , pp. 6373-6383
    • Tsimberidou, A.M.1    Iskander, N.G.2    Hong, D.S.3    Wheler, J.J.4    Falchook, G.S.5    Fu, S.6
  • 51
    • 84864302254 scopus 로고    scopus 로고
    • Trastuzumab decreases the incidence of clinical relapses in patients with early breast cancer presenting chemother-apy-resistant CK-19mRNA-positive circulating tumor cells: Results of a randomized phase II study
    • Georgoulias V, Bozionelou V, Agelaki S, Perraki M, Apostolaki S, Kallergi G, et al. Trastuzumab decreases the incidence of clinical relapses in patients with early breast cancer presenting chemother-apy-resistant CK-19mRNA-positive circulating tumor cells: results of a randomized phase II study. Ann Oncol 2012;23:1744-50.
    • (2012) Ann Oncol , vol.23 , pp. 1744-1750
    • Georgoulias, V.1    Bozionelou, V.2    Agelaki, S.3    Perraki, M.4    Apostolaki, S.5    Kallergi, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.