Epidermal growth factor receptor mutation mediates crossresistance to panitumumab and cetuximab in gastrointestinal cancer

Oncotarget

Volumn 6, Issue 14, 2015, Pages 12035-12047

  Braig, Friederike ^a   März, Manuela ^a   Schieferdecker, Aneta ^a   Schulte, Alexander ^a   Voigt, Mareike ^a   Stein, Alexander ^a   Grob, Tobias ^a   Alawi, Malik ^a   Indenbirken, Daniela ^b   Kriegs, Malte ^a   Engel, Erik ^c   Vanhoefer, Udo ^d   Grundhoff, Adam ^b   Loges, Sonja ^a   Riecken, Kristoffer ^a   Fehse, Boris ^a   Bokemeyer, Carsten ^a   Binder, Mascha ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c Hämatologisch Onkologische Praxis Altona HOPA   (Germany)

^d Zentrum fur Innere Medizin   (Germany)

Author keywords

Cetuximab; Circulating tumor DNA; EGFR antibody resistance; Mutation; Panitumumab

Indexed keywords

CETUXIMAB; CHLOROPLAST DNA; EPIDERMAL GROWTH FACTOR RECEPTOR; K RAS PROTEIN; PANITUMUMAB; ANTINEOPLASTIC AGENT; EGFR PROTEIN, HUMAN; MONOCLONAL ANTIBODY;

ADULT; AGED; ANTIGEN BINDING; ARTICLE; CANCER CELL LINE; CELL CULTURE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CROSS RESISTANCE; DIGESTIVE SYSTEM CANCER; DRUG TARGETING; EGFR GENE; EXON; FEMALE; GASTROINTESTINAL BIOPSY; GENE; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; KRAS GENE; MALE; MIDDLE AGED; NEXT GENERATION SEQUENCING; NRAS GENE; PROTEIN BINDING; PROTEIN LOCALIZATION; GASTROINTESTINAL NEOPLASMS; GENETICS; METABOLISM; MUTATION;

ADULT; AGED; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CETUXIMAB; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; MALE; MIDDLE AGED; MUTATION; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 84931364786     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3574     Document Type: Article

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