Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

Nature

Volumn 526, Issue 7572, 2015, Pages 277-280

  Huang, Xin ^a   Chen, Hao ^a   Michelsen, Klaus ^a   Schneider, Stephen ^a   Shaffer, Paul L ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCINE RECEPTOR ALPHA 3; STRYCHNINE; UNCLASSIFIED DRUG; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA3 SUBUNIT;

ALKALOID; CELLS AND CELL COMPONENTS; CHEMICAL BINDING; CRYSTAL STRUCTURE; MOLECULAR ANALYSIS; NERVOUS SYSTEM DISORDER; PROTEIN;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; HUMAN; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; ANTAGONISTS AND INHIBITORS; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ENZYME SPECIFICITY; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

EUKARYOTA; PROKARYOTA; STRYCHNOS TOXIFERA;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; ION CHANNEL GATING; MODELS, MOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, GLYCINE; STRYCHNINE; SUBSTRATE SPECIFICITY;

EID: 84944052478     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14972     Document Type: Article

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