Polyphenol mixtures of Euphorbia supina the inhibit invasion and metastasis of highly metastatic breast cancer MDA-MB-231 cells

Oncology Reports

Volumn 34, Issue 6, 2015, Pages 3035-3042

  Ko, Young Shin ^a   Lee, Won Sup ^a   Joo, Young Nak ^a   Choi, Yung Hyun ^b   Kim, Gon Sup ^c   Jung, Jin Myung ^a   Ryu, Chung Ho ^c   Shin, Sung Chul ^c   Kim, Hye Jung ^a  

^a Gyeongsang National University School of Medicine   (South Korea)

^b Dong Eui University   (South Korea)

^c Gyeongsang National University   (South Korea)

Author keywords

Breast cancer cells; Endothelial cells; Epithelial mesenchymal transition; Euphorbia supina; Metastasis; VCAM 1

Indexed keywords

GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; NERVE CELL ADHESION MOLECULE; POLYPHENOL; POLYPHENOL MIXTURE; PROTEIN LYSINE 6 OXIDASE; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SNAIL1; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR ENDOTHELIAL CADHERIN; PLANT EXTRACT; TUMOR PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; CELL INVASION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG MIXTURE; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME RELEASE; EPITHELIAL MESENCHYMAL TRANSITION; EUPHORBIA MACULATA; HUMAN; HUMAN CELL; METASTASIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; BIOSYNTHESIS; BREAST NEOPLASMS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; EUPHORBIA; FEMALE; GENE EXPRESSION REGULATION; GENETICS; METASTASIS; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; TUMOR INVASION;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOTHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; EUPHORBIA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; PHOSPHORYLATION; PLANT EXTRACTS; POLYPHENOLS;

EID: 84943797838     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.4304     Document Type: Article

References (39)

1. Sliva D: Suppression of cancer invasiveness by dietary compounds. Mini Rev Med Chem 8: 677-688, 2008.
2. Tanaka R, Kurimoto M, Yoneda M and Matsunaga S: 17β,21β-Epoxyhopan-3β-ol and β-alnincanol from Euphorbia supina. Phytochemistry 29: 2253-2256, 1990.
3. An RB, Kwon JW, Kwon TO, Chung WT, Lee HS and Kim YC: Chemical constituents from the whole plants of Euphorbia supina Rafin. Korean J Pharmacognosy 38: 291-295, 2007.
4. Agata I, Hatano T, Nakaya Y, Sugaya T, Nishibe S, Yoshida T and Okuda T: Tannins and related polyphenols of euphorbiaceous plants. VIII. Eumaculin A and eusupinin A, and accompanying polyphenols from Euphorbia maculata L. and E. supina Rafin. Chem Pharm Bull (Tokyo) 39: 881-883, 1991.
5. Lee SH, Tanaka T, Nonaka G and Nishioka I: Tannins and related compounds. CV. Monomeric and dimeric hydrolyzable tannins having a dehydrohexahydroxydiphenoyl group, supinanin, euphorscopin, euphorhelin and jolkianin, from Euphorbia species. Chem Pharm Bull (Tokyo) 39: 630-638, 1991.
6. Fang Z, Zeng X, Zhang Y and Zhou G: Chemical constituents of spotted leaf euphorbia (Euphorbia supina) Zhongcaoyao 24: 230-233, 1993.
7. Erlund I: Review of the flavonoids quercetin, hesperetin, and naringenin. Dietary sources, bioactivities, bioavailability, and epidemiology. Nutr Res 24: 851-874, 2004.
8. Le Marchand L: Cancer preventive effects of flavonoids-a review. Biomed Pharmacother 56: 296-301, 2002.
9. Xu YC, Leung SW, Yeung DK, Hu LH, Chen GH, Che CM and Man RY : Structure-activity relationships of flavonoids for vascular relaxation in porcine coronary artery. Phytochemistry 68: 1179-1188, 2007.
10. Song Y, Jeong SW, Lee WS, Park S, Kim YH, Kim GS, Lee SJ, Jin JS, Kim CY, Lee JE, et al: Determination of polyphenol components of Korean prostrate spurge (Euphorbia supina) by using liquid chromatography-tandem mass spectrometry: Overall contribution to antioxidant activity. J Anal Methods Chem 2014: 418690, 2014.
11. Korean Breast Cancer Society: Korean breast cancer data of 1996. J Korean Surg Soc 55: 621-635, 1998.
12. Lu X and Kang Y : Hypoxia and hypoxia-inducible factors: Master regulators of metastasis. Clin Cancer Res 16: 5928-5935, 2010.
13. Kim HG, Kim GS, Park S, Lee JH, Seo ON, Lee SJ, Kim JH, Shim JH, Abd El-Aty AM, Jin JS, et al: Flavonoid profiling in three citrus varieties native to the Republic of Korea using liquid chromatography coupled with tandem mass spectrometry: Contribution to overall antioxidant activity. Biomed Chromatogr 26: 464-470, 2012.
14. Joo YN, Jin H, Eun SY, Park SW, Chang KC and Kim HJ: P2Y2R activation by nucleotides released from the highly metastatic breast cancer cell MDA-MB-231 contributes to pre-metastatic niche formation by mediating lysyl oxidase secretion, collagen crosslinking, and monocyte recruitment. Oncotarget 5: 9322-9334, 2014.
15. Rucci N, Sanità P and Angelucci A: Roles of metalloproteases in metastatic niche. Curr Mol Med 11: 609-622, 2011.
16. Deryugina EI and Quigley JP: Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25: 9-34, 2006.
17. Przybylowska K, Kluczna A, Zadrozny M, Krawczyk T, Kulig A, Rykala J, Kolacinska A, Morawiec Z, Drzewoski J and Blasiak J: Polymorphisms of the promoter regions of matrix metalloproteinases genes MMP-1 and MMP-9 in breast cancer. Breast Cancer Res Treat 95: 65-72, 2006.
18. Zoccoli A, Iuliani M, Pantano F, Imperatori M, Intagliata S, Vincenzi B, Marchetti P, Papapietro N, Denaro V, Tonini G, et al: Premetastatic niche: Ready for new therapeutic interventions? Expert Opin Ther Targets 16 (Suppl 2): S119-S129, 2012
19. Mousa SA: Cell adhesion molecules: Potential therapeutic and diagnostic implications. Mol Biotechnol 38: 33-40, 2008.
20. Price JT and Thompson EW: Mechanisms of tumour invasion and metastasis: Emerging targets for therapy. Expert Opin Ther Targets 6: 217-233, 2002.
21. Balkwill F and Mantovani A: Inflammation and cancer: Back to Virchow? Lancet 357: 539-545, 2001.
22. Christofori G: New signals from the invasive front. Nature 441: 444-450, 2006.
23. Mitra A, Mishra L and Li S: EMT, CTCs and CSCs in tumor relapse and drug-resistance. Oncotarget 6: 10697-10711, 2015.
24. Yang J and Weinberg RA: Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell 14: 818-829, 2008.
25. Fox SB, Turner GD, Gatter KC and Harris AL: The increased expression of adhesion molecules ICAM-3, E-and P-selectins on breast cancer endothelium. J Pathol 177: 369-376, 1995.
26. Nguyen M, Corless CL, Kräling BM, Tran C, Atha T, Bischoff J and Barsky SH: Vascular expression of E-selectin is increased in estrogen-receptor-negative breast cancer: A role for tumor-cell-secreted interleukin-1 alpha. Am J Pathol 150: 1307-1314, 1997.
27. Dejana E, Orsenigo F and Lampugnani MG: The role of adherens junctions and VE-cadherin in the control of vascular permeability. J Cell Sci 121: 2115-2122, 2008.
28. Middleton E Jr, K andaswami C and Theoharides TC: The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 52: 673-751, 2000.
29. Naderi GA, Asgary S, Sarraf-Zadegan N and Shirvany H: Anti-oxidant effect of flavonoids on the susceptibility of LDL oxidation. Mol Cell Biochem 246: 193-196, 2003.
30. Mamani-Matsuda M, Kauss T, Al-Kharrat A, Rambert J, Fawaz F, Thiolat D, Moynet D, Coves S, Malvy D and Mossalayi MD: Therapeutic and preventive properties of quercetin in experimental arthritis correlate with decreased macrophage inflammatory mediators. Biochem Pharmacol 72: 1304-1310, 2006.
31. Lotito SB and Frei B: Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism. J Biol Chem 281: 37102-37110, 2006.
32. Kang TB and Liang NC: Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemia cells. Biochem Pharmacol 54: 1013-1018, 1997.
33. Braganhol E, Zamin LL, Canedo AD, Horn F, Tamajusuku AS, Wink MR, Salbego C and Battastini AM: Antiproliferative effect of quercetin in the human U138MG glioma cell line. Anticancer Drugs 17: 663-671, 2006.
34. Indap MA, Radhika S, Motiwale L and Rao KVK: Quercetin: Antitumor activity and pharmacological manipulations for increased therapeutic gains. Indian J Pharm Sci 68: 465-469, 2006.
35. Choi EJ, Bae SM and Ahn WS: Antiproliferative effects of quercetin through cell cycle arrest and apoptosis in human breast cancer MDA-MB-453 cells. Arch Pharm Res 31: 1281-1285, 2008.
36. Lin CW, Hou WC, Shen SC, Juan SH, Ko CH, Wang LM and Chen YC: Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis 29: 1807-1815, 2008.
37. Phromnoi K, Yodkeeree S, Anuchapreeda S and Limtrakul P: Inhibition of MMP-3 activity and invasion of the MDA-MB-231 human invasive breast carcinoma cell line by bioflavonoids. Acta Pharmacol Sin 30: 1169-1176, 2009.
38. Calderón-Montaño JM, Burgos-Morón E, Pérez-Guerrero C and López-Lázaro M: A review on the dietary flavonoid kaempferol. Mini Rev Med Chem 11: 298-344, 2011.
39. Leung HW, Lin CJ, Hour MJ, Yang WH, Wang MY and Lee HZ: Kaempferol induces apoptosis in human lung non-small carcinoma cells accompanied by an induction of antioxidant enzymes. Food Chem Toxicol 45: 2005-2013, 2007.