Flavonoid profiling in three citrus varieties native to the Republic of Korea using liquid chromatography coupled with tandem mass spectrometry: Contribution to overall antioxidant activity

Biomedical Chromatography

Volumn 26, Issue 4, 2012, Pages 464-470

  Kim, Hae Gyeong ^a   Kim, Gon Sup ^a   Park, Semin ^a   Lee, Jung Han ^a   Seo, On Nuri ^a   Lee, Soo Jung ^a   Kim, Jae Hoon ^b   Shim, Jae Han ^c   Abd El Aty, A M ^d   Jin, Jong Sung ^e   Shin, Sung Chul ^a  

^a Gyeongsang National University   (South Korea)

^b Jeju National University   (South Korea)

^c Chonnam National University   (South Korea)

^d Cairo University   (Egypt)

^e Korea Basic Science Institute (KBSI)   (South Korea)

Author keywords

Antioxidant activity; Citrus; Coumarin; Flavonoids; HPLC MS MS

Indexed keywords

ANTIOXIDANTS; CITRUS FRUITS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; POSITIVE IONS; SILICA GEL;

ANTIOXIDANT ACTIVITIES; CITRUS; CITRUS AURANTIUM L.; COUMARIN; ETHYL-ACETATE; FLAVONOID; FRUIT PEEL; HPLC-MS-MS; LIQUID CHROMATOGRAPHY COUPLED WITH TANDEM MASS SPECTROMETRIES; REPUBLIC OF KOREA;

FLAVONOIDS;

3,5,6,7,3',4',5' HEPTAMETHOXYFLAVONE; AURANTIIN; COUMARIN DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOID; HESPERIDIN; HEXAMETHOXYFLAVONE; HYDROXYPENTAMETHOXYFLAVONE; ISOSINENSETIN; MERANZIN; NARINGIN DEHYDRATED HEXOSIDE; NOBILETIN; PENTAHYDROXYMETHOXYFLAVONE; PONCIRIN; SILICA GEL; SINENSETIN; TANGERETIN; TETRAMETHYL O ISOSCUTELLAREIN; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CITRUS; CITRUS ERYTHROSA; CITRUS LEIOCARPA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; SOUR ORANGE;

CITRUS; CITRUS AURANTIUM; CITRUS ERYTHROSA; CITRUS LEIOCARPA;

EID: 84858005467     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1688     Document Type: Article

References (21)

1. Blois MS. Antioxidant determination by the use of a stable free radical. Nature 1958; 181: 1199-1200.
2. Del Río JA, Gómez P, Baidez AG, Arcas MC, Botía JM and Ortuño A. Changes in the levels of polymethoxyflavones and flavanones as part of the defense mechanism of Citrus sinensis (Cv. Valencia Late) fruits against Phytophthora citrophthora. Journal of Agricultural and Food Chemistry 2004; 52: 1913-1917.
3. Dugo P, Mondello L, Dugo L, Stancanelli R and Dugo G. LC-MS for the identification of oxygen heterocyclic compounds in citrus essential oils. Journal of Pharmaceutical and Biomedical Analysis 2000; 24: 147-154.
4. Feger W, Brandauer H, Gabris P and Ziegler H. Nonvolatiles of commercial lime and grapefruit oils separated by high-speed countercurrent chromatography. Journal of Agricultural and Food Chemistry 2006; 54: 2242-2252.
5. Halliwell B, Aeschbach R, Loliger J and Aruoma OI. The characterization of antioxidants. Food and Chemical Toxicity 1995; 33: 601-617.
6. Kawaii S, Tomono Y, Katase E, Ogawa K and Yano M. Quantitation of flavonoid constituents in Citrus fruits. Journal of Agricultural and Food Chemistry 1999; 47: 3565-3571.
7. Ko H-C, Jang M-G, Kang C-H, Lee N-H, Kang S-I, Lee S-R, Park D-B and Kim S-J. Preparation of a polymethoxyflavone-rich fraction (PRF) of Citrus sunki Hort.ex Tanaka and its antiproliferative effects. Food Chemistry 2010; 123: 484-488.
8. Lee JH, Lee SJ, Park S, Kim HK, Jeong WY, Choi JY, Sung N-J, Lee WS, Lim C-S, Kim G-S and Shin SC. Characterisation of flavonoids in Orostachys japonicus A. Berger using HPLC-MS/MS: contribution to the overall antioxidant effect. Food Chemistry 2011a; 124: 1627-1633.
9. Lee S, Ra J, Song J-Y, Gwak C, Kwon H-J, Yim S-V, Hong S-P, Kim J, Lee K-H, Cho J-J, Park YS, Park C-S and Ahn H-J. Extracts from Citrus unshiu promote immune-mediated inhibition of tumor growth in a murine renal cell carcinoma model. Journal of Ethnopharmacology 2011b; 133: 973-979.
10. Londoño-Londoño J, Rodrigues de Lima V, Lara O, Gil A, Pasa TBC, A GJ and Pineda JRR. Clean recovery of antioxidant flavonoids from citrus peel: optimizing an aqueous ultrasound-assisted extraction method. Food Chemistry 2010; 119: 81-87.
11. Ma C, Gao W, Gao Y, Man S, Huang L and Liu C. Identification of chemical constituents in extracts and rat plasma from Fructus aurantii by UPLC-PDA-Q-TOF/MS. Phytochemical Analysis 2010; 22: 112-118.
12. Ma YL, Li QM, Van Den Heuvel H and Claeys M. Characterization of flavone and flavonol aglycones by collision-induced dissociation tandem mass spectrometry. Rapid Communications in Mass Spectrometry 1997; 11: 1357-1364.
13. Marchand LL. Cancer preventive effects of flavonoids - a review. Biomedicine and Pharmacotherapy 2002; 56: 296-301.
14. Nagata Y, Sakamoto K, Shiratsuchi H, Ishii T, Yano M and Ohta H. Flavonoid composition of fruit tissue of citrus species. Bioscience, Biotechnology, and Biochemistry 2006; 70: 178-192.
15. Oyaizu M. Studies on product of browning reaction prepared from glucose amine. Japanese Journal of Nutrition 1986; 44: 307-315.
16. Ponce MA, Scervino JM, Erra-Balsells R, Ocampo JA and Godeas AM. Flavonoids from shoots, roots and roots exudates of Brassica alba. Phytochemistry 2004; 65: 3131-3134.
17. Re R, Pellegrini N, Pannala A, Yang M and Rice-Evans C. Antioxidant activity applying an improved ABTs radical cation decolourization assay. Free Radical Biology & Medicine 1999; 26: 1231-1237.
18. Tripoli E, Guardia ML, Giammanco S, Majo DD and Giammanco M. Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review. Food Chemistry 2007; 104: 466-479.
19. Tsao R, Yang R, Young JC and Zhu H. Polyphenolic profiles in eight apple cultivars using high-performance liquid chromatography (HPLC). Journal of Agricultural and Food Chemistry 2003; 51: 6347-6353.
20. Yoo KM, Lee KW, Park JB, Lee HJ and Hwan IK. Variation in major antioxidants and total antioxidant activity of Yuzu (Citrus junos Sieb ex Tanaka) during maturation and between cultivars. Journal of Agricultural and Food Chemistry 2004; 52: 5907-5913.
21. Zhou D-Y, Xu Q, Xue X-Y, Zhang F-F, Jing Y and Liang X-M. Identification of O-diglycosylflavanones in Fructus aurantii by liquid chromatography with electrospray ionization and collision-induced dissociation mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2006; 42: 441-448.