SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA

Human Molecular Genetics

Volumn 24, Issue 19, 2015, Pages 5524-5541

  McGovern, Vicki L ^a   Iyer, Chitra C ^a   David Arnold, W ^a,b   Gombash, Sara E ^b   Zaworski, Phillip G ^c   Blatnik, Anton J ^a   Foust, Kevin D ^b   Burghes, Arthur H M ^a  

^a Department of Molecular and Cellular Biochemistry ^*  (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c PharmOptima   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAT CRE RECOMBINASE; CRE RECOMBINASE; NESTIN CRE RECOMBINASE; SURVIVAL MOTOR NEURON PROTEIN; UNCLASSIFIED DRUG; SMN1 PROTEIN, MOUSE; SURVIVAL MOTOR NEURON PROTEIN 1;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; CELL MATURATION; CELL SIZE; CELL VIABILITY; CONTROLLED STUDY; EXON; FEMALE; GENE EXPRESSION; GLIA; HINDLIMB MUSCLE; MALE; MOTONEURON; MOUSE; MUSCLE ACTION POTENTIAL; MUSCLE CELL; NERVE CELL; NERVOUS TISSUE; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; PROTEIN DETERMINATION; SPINAL CORD; SPINAL MUSCULAR ATROPHY; SURVIVAL; ACTION POTENTIAL; ANIMAL; DISEASE MODEL; ELECTROPHYSIOLOGY; GENE DELETION; GENETICS; HUMAN; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; SKELETAL MUSCLE; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANIMALS; DISEASE MODELS, ANIMAL; ELECTROPHYSIOLOGICAL PHENOMENA; HUMANS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUSCLE, SKELETAL; MUSCULAR ATROPHY, SPINAL; SEQUENCE DELETION; SURVIVAL OF MOTOR NEURON 1 PROTEIN;

EID: 84943781950     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv283     Document Type: Article

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