The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis

Autophagy

Volumn 11, Issue 6, 2015, Pages 881-890

  Zhao, Yan G ^a   Sun, Le ^a   Miao, Guangyan ^a   Ji, Cuicui ^a   Zhao, Hongyu ^a   Sun, Huayu ^a   Miao, Lin ^b   Yoshii, Saori R ^c   Mizushima, Noboru ^c   Zhang, Hong ^a  

^a INSTITUTE OF BIOPHYSICS   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Autophagy; Axon swelling; Learning and memory; Neurodegeneration; Wdr45 Wipi4

Indexed keywords

CELL PROTEIN; MESSENGER RNA; NEURON SPECIFIC NUCLEAR PROTEIN; UNCLASSIFIED DRUG; WDR45 PROTEIN; WIPI4 PROTEIN; CARRIER PROTEIN; WDR45 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BRAIN MITOCHONDRION; BRAIN REGION; COGNITIVE DEFECT; CONTROLLED STUDY; ESTRUS CYCLE; EXCITATORY POSTSYNAPTIC POTENTIAL; FEMALE; HOMEOSTASIS; IMMUNOBLOTTING; LEARNING; LEARNING DISORDER; LONG TERM MEMORY; LONG TERM POTENTIATION; LOXP SITE; MEMORY; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOTOR COORDINATION; MOUSE; NERVE CELL PLASTICITY; NERVE FIBER; NERVE FIBER DEGENERATION; NONHUMAN; PURKINJE CELL; REAL TIME POLYMERASE CHAIN REACTION; SHORT TERM MEMORY; SPATIAL MEMORY; SPHEROID CELL; X CHROMOSOME; Y-MAZE TEST; ANIMAL; AXON; DEGENERATIVE DISEASE; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; AUTOPHAGY; AXONS; CARRIER PROTEINS; HOMEOSTASIS; LEARNING; MEMORY; MICE, TRANSGENIC; MUTATION; NEURODEGENERATIVE DISEASES;

EID: 84943779840     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2015.1047127     Document Type: Article

References (24)

1. Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y. Dynamics and diversity in autophagy mechanisms: lessons from yeast. Nat Rev Mol Cell Biol 2009; 10: 458-67; PMID: 19491929; http://dx. doi. org/10. 1038/nrm2708.
2. Tian Y, Li Z, Hu W, Ren H, Tian E, Zhao Y, Lu Q, Huang X, Yang P, Li X, et al. C. elegans screen identifies autophagy genes specific to multicellular organisms. Cell 2010; 141: 1042-55; PMID: 20550938; http://dx. doi. org/10. 1016/j. cell. 2010. 04. 034.
3. Lu Q, Yang P, Huang X, Hu W, Guo B, Wu F, Lin L, Kovács AL, Yu L, Zhang H. The WD40 repeat PtdIns (3)P-binding protein EPG-6 regulates progression of omegasomes to autophagosomes. Dev Cell 2011; 21: 343-57; PMID: 21802374; http://dx. doi. org/10. 1016/j. devcel. 2011. 06. 024.
4. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42; PMID: 18191218; http://dx. doi. org/10. 1016/j. cell. 2007. 12. 018.
5. Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441: 885-9; PMID: 16625204; http://dx. doi. org/10. 1038/nature04724.
6. Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441: 880-4; PMID: 16625205; http://dx. doi. org/10. 1038/nature04723.
7. Zhao YG, Zhao H, Miao L, Wang L, Sun F, Zhang H. The p53-induced gene Ei24 is an essential component of the basal autophagy pathway. J Biol Chem 2012; 287: 42053-42063; PMID: 23074225; http://dx. doi. org/10. 1074/jbc. M112. 415968.
8. Haack TB, Hogarth P, Kruer MC, Gregory A, Wieland T, Schwarzmayr T, Graf E, Sanford L, Meyer E, Kara E, et al. Exome sequencing reveals de novo WDR45 mutations causing a phenotypically distinct, X-linked dominant form of NBIA. Am J Hum Genet 2012; 91: 1144-9; PMID: 23176820; http://dx. doi. org/10. 1016/j. ajhg. 2012. 10. 019.
9. Hayflick SJ, Kruer MC, Gregory A, Haack TB, Kurian MA, Houlden HH, Anderson J, Boddaert N, Sanford L, Harik SI, et al. b-Propeller protein-associated neurodegeneration: a new X-linked dominant disorder with brain iron accumulation. Brain 2013; 136: 1708-17; PMID: 23687123; http://dx. doi. org/10. 1093/brain/awt095.
10. Saitsu H, Nishimura T, Muramatsu K, Kodera H, Kumada S, Sugai K, Kasai-Yoshida E, Sawaura N, Nishida H, Hoshino A, et al. De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Nat Genet 2013; 45: 445-9; PMID: 23435086; http://dx. doi. org/10. 1038/ng. 2562.
11. Gregory A, Polster BJ, Hayflick SJ. Clinical and genetic delineation of neurodegeneration with brain iron accumulation. J Med Genet 2009; 46: 73-80; PMID: 18981035; http://dx. doi. org/10. 1136/jmg. 2008. 061929.
12. Schneider SA, Bhatia KP. Syndromes of neurodegeneration with brain iron accumulation. Semin Pediat Neurol 2012; 19: 57-66; http://dx. doi. org/10. 1016/j. spen. 2012. 03. 005.
13. D'Hooge R, De Deyn PP. Applications of the Morris water maze in the study of learning and memory. Brain Research Reviews. Brain Res Rev 2001; 36: 60-90; PMID: 11516773; http://dx. doi. org/10. 1016/S0165-0173(01)00067-4.
14. Packard MG, Cahill L. Affective modulation of multiple memory systems. Curr Opin Neurobiol 2001; 11: 752-6; PMID: 11741029; http://dx. doi. org/10. 1016/S0959-4388(01)00280-X.
15. Malenka RC. The long-term potential of LTP. Nat Rev Neurosci 2003; 4: 923-6; PMID: 14595403; http://dx. doi. org/10. 1038/nrn1258.
16. Zhao H, Zhao YG, Wang X, Xu L, Miao L, Feng D, Chen Q, Kovács AL, Fan D, Zhang H. Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration. J Cell Biol 2013; 200: 731-41; PMID: 23479740; http://dx. doi. org/10. 1083/jcb. 201211014.
17. Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140: 313-26; PMID: 20144757; http://dx. doi. org/10. 1016/j. cell. 2010. 01. 028.
18. Phillips RG, LeDoux JE. Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 1992; 106: 274-85; PMID: 1590953; http://dx. doi. org/10. 1037/0735-7044. 106. 2. 274.
19. Dooley HC, Razi M, Polson HE, Girardin SE, Wilson MI, Tooze SA. WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol Cell 2014; 55: 238-52; PMID: 24954904; http://dx. doi. org/10. 1016/j. molcel. 2014. 05. 021.
20. Lee S, Sato Y, Nixon RA. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer-like axonal dystrophy. J Neurosci 2011; 31: 7817-30; PMID: 21613495; http://dx. doi. org/10. 1523/JNEUROSCI. 6412-10. 2011.
21. Maday S, Wallace KE, Holzbaur EL. Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J Cell Biol 2012; 196: 407-17; PMID: 22331844; http://dx. doi. org/10. 1083/jcb. 201106120.
22. Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E, Chait BT, Tanaka K, Yue Z. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci USA 2007; 104: 14489-94; PMID: 17726112; http://dx. doi. org/10. 1073/pnas. 0701311104.
23. Subramani S, Malhotra V. Non-autophagic roles of autophagy-related proteins. EMBO Rep 2013; 14 (2): 143-51; PMID: 23337627; http://dx. doi. org/10. 1038/embor. 2012. 220.
24. Zhao Z, Fux B, Goodwin M, Dunay IR, Strong D, Miller BC, Cadwell K, Delgado MA, Ponpuak M, Green KG, et al. Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Microbe 2008; 4: 458-69; PMID: 18996346; http://dx. doi. org/10. 1016/j. chom. 2008. 10. 003.