Rate-Limiting Steps in the Development of Atherosclerosis: The Response-to-Influx Theory

Journal of Vascular Research

Volumn 41, Issue 1, 2004, Pages 1-17

  Weinberg, Peter D ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Age; Arterial branches; Arterial permeability; Atherosclerosis; Blood flow; Endothelium; Nitric oxide

Indexed keywords

CHOLESTEROL; NITRIC OXIDE; TRIACYLGLYCEROL;

AORTA FLOW; ARTERY ENDOTHELIUM; ARTERY PERMEABILITY; ARTERY WALL; ATHEROGENESIS; CHOLESTEROL DIET; CHOLESTEROL TRANSPORT; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY BLOOD FLOW; HUMAN; HYPERTRIGLYCERIDEMIA; PRIORITY JOURNAL; REVIEW; RISK FACTOR; STEADY STATE;

ANIMALS; ARTERIOSCLEROSIS; ENDOTHELIUM, VASCULAR; HUMANS;

EID: 1542289850     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000076124     Document Type: Review

References (127)

1. Mitchell JRA, Schwartz CJ: Arterial Disease. Oxford, Blackwell, 1965.
2. Anitschkow N: Experimental atherosclerosis in animals; in Cowdry EV (ed): Arteriosclerosis. New York, Macmillan, 1933, pp 271-322.
3. Petroff JR: Über die Vitalfärbung der Gefässwand. Beitr Pathol Anat Allg Pathol 1922;71:115-131.
4. 3H-cholesterol uptake in the pig aorta. Atherosclerosis 1971;13:293-304.
5. Friedman M, Byers SO: Endothelial permeability in atherosclerosis. Arch Pathol 1963;76:99-105.
6. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL: Beyond cholesterol: Modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med 1989;320:915-924.
7. Goldstein JL, Ho YK, Basu SK, Brown MS: Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein producing massive cholesterol deposition. Proc Natl Acad Sci USA 1979;76:333-337.
8. Caro CG, Fitz-Gerald JM, Schroter RM: Atheroma and arterial wall shear: Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis. Proc R Soc Lond B 1971;177:109-159.
9. Svindland A, Walloe L: Distribution pattern for sudanophilic plaques in the descending thoracic and proximal abdominal aorta. Atherosclerosis 1985;57:219-224.
10. Cornhill JF, Herderick EE, Stary HC: Topography of human aortic sudanophilic lesions; in Leipsch DW (ed): Blood Flow in Large Arteries: Application to Atherogenesis and Clinical Medicine. Basel, Karger, 1990, pp 13-19.
11. Cornhill JF, Roach MR: A quantitative study of the localization of atherosclerotic lesions in the rabbit aorta. Atherosclerosis 1976;23:489-501.
12. Roach MR, Cornhill JF, Fletcher J: A quantitative study of the development of sudanophilic lesions in the aorta of rabbits fed a low-cholesterol diet for up to six months. Atherosclerosis 1978;29:259-264.
13. Kratky RG, Ivey J, Rogers KA, Daley S, Roach MR: The distribution of fibro-fatty atherosclerotic lesions in the aortae of casein-and cholesterol-fed rabbits. Atherosclerosis 1993;99:121-131.
14. Forster BA, Javed Q, Leake DS, Weinberg PD: High-resolution mapping of the frequency of lipid deposits in thoracic aortae from cholesterol-fed and heritable hyperlipidaemic rabbits. Atherosclerosis 1996;120:249-253.
15. Ivey J, Roach MR, Kratky RG: A new probability mapping method to describe the development of atherosclerotic lesions in cholesterol-fed rabbits. Atherosclerosis 1995;115:73-84.
16. McGill HC, Geer JC, Holman RL: Sites of vascular vulnerability in dogs demonstrated by Evans blue. AMA Arch Pathol 1957;64:303-311.
17. Adams CWM: Permeability in atherosclerosis: An artefact with Evans' blue staining. Atherosclerosis 1981;39:131-132.
18. Lindner V, Heinle H: Binding properties of circulating Evans blue in rabbits as determined by disc electrophoresis. Atherosclerosis 1982;43:417-422.
19. Weinberg PD: Application of fluorescence densitometry to the study of albumin uptake by the rabbit aortic wall up- and downstream of branches. Atherosclerosis 1988;74:139-148.
20. Schwenke DC, Carew TE: Quantification in vivo of increased LDL content and rate of LDL degradation in normal rabbit aorta occurring at sites susceptible to early atherosclerotic lesions. Circ Res 1988;62:699-710.
21. Wiklund O, Carew TE, Steinberg D: Role of the low density lipoprotein receptor in penetration of low density lipoprotein into rabbit aortic wall. Arteriosclerosis 1985;5:135-141.
22. Smith EB, Ashall C: Low-density lipoprotein concentration in interstitial fluid from human atherosclerotic lesions. Relation to theories of endothelial damage and lipoprotein binding. Biochim Biophys Acta 1983;754:249-257.
23. Rippe B, Rosengren BI, Carlsson O, Venturoli D: Transendothelial transport: The vesicle controversy. J Vasc Res 2002;39:375-390.
24. Rutledge JC: Temperature and hydrostatic pressure-dependent pathways of low-density lipoprotein transport across the microvascular barrier. Am J Physiol 1992;262:H234-H245.
25. Sinzinger H, Silberbauer K, Auerswald W: Quantitative investigation of sudanophilic lesions around the aortic ostia of human fetuses, newborn and children. Blood Vessels 1980;17:44-52.
26. Sloop GD, Perret RS, Brahney JS, Oalmann M: A description of two morphologic patterns of aortic fatty streaks, and a hypothesis of their pathogenesis. Atherosclerosis 1998;141:153-160.
27. Weinberg PD: Disease patterns at arterial branches and their relation to flow. Biorheology 2002:39;533-537.
28. Sebkhi A, Weinberg PD: Age-related variations in transport properties of the rabbit arterial wall near branches. Atherosclerosis 1994;106:1-8.
29. Bragdon JH: Spontaneous atherosclerosis in the rabbit. Circulation 1952;5:641-646.
30. Barnes SE, Weinberg PD: Contrasting patterns of spontaneous aortic disease in young and old rabbits. Arterioscler Thromb Vasc Biol 1998;18:300-308.
31. Sebkhi A, Weinberg PD: Effect of age on the pattern of short-term albumin uptake by the rabbit aortic wall near intercostal branch ostia. Arterioscler Thromb Vasc Biol 1996;16:317-327.
32. Murphy CL, Lever MJ: Sulphorhodamine-B-labelled albumin uptake around the ostium of the renal artery in rabbits: Changes with age. J Vasc Res 2002;39:104-113.
33. Ewins BA, Majewicz J, Staughton TJ, Weinberg PD: 2-D maps of short-term albumin uptake by the immature and mature rabbit aortic wall around branch points. J Biomech Eng 2002;124:684-690.
34. Forster BA, Weinberg PD: Changes with age in the influence of endogenous nitric oxide on transport properties of the rabbit aortic wall near branches. Arterioscler Thromb Vasc Biol 1997;17:1361-1368.
35. Haraldsson B, Rippe B: Orosomucoid as one of the serum components contributing to normal capillary permselectivity in rat skeletal muscle. Acta Physiol Scand 1987;129:127-135.
36. Lever MJ, Jay MT: Convective and diffusive transport of plasma proteins across the walls of large blood vessels. Front Med Biol Eng 1993;5:45-50.
37. Baldwin AL, Wilson LM: Endothelium increases medial hydraulic conductance of aorta, possibly by release of EDRF. Am J Physiol 1993;264:H26-H32.
38. Tedgui A, Lever MJ: Filtration through damaged and undamaged rabbit thoracic aorta. Am J Physiol 1984;247:H784-H791.
39. Forster BA, Weinberg PD: Evans' blue dye abolishes endothelium-dependent relaxation of rabbit aortic rings. Atherosclerosis 1997;129:129-131.
40. Murphy CL: Arterial Mass Transport in Relation to Flow; PhD thesis Imperial College London, 1998.
41. Lin S-J, Jan K-M, Schuessler G, Weinbaum S, Chien S: Enhanced macromolecular permeability of aortic endothelial cells in association with mitosis. Atherosclerosis 1988;73:223-232.
42. Barakat AI, Uhthoff PAF, Colton CK: Topographical mapping of sites of enhanced HRP permeability in the normal rabbit aorta. J Biomech Eng 1992;114:283-292.
43. Stemerman MB, Morrel EM, Burke KR, Colton CK, Smith KA, Lees RS: Local variation in arterial wall permeability to low density lipoprotein in normal rabbit aorta. Arteriosclerosis 1986;6:64-69.
44. Chuang PT, Cheng HJ, Lin SJ, Jan KM, Lee MM, Chien S: Macromolecular transport across arterial and venous endothelium in rats. Studies with Evans blue-albumin and horse-radish peroxidase. Arteriosclerosis 1990;10:188-197.
45. 125I-low density lipoproteins in rabbit arteries by use of en face preparations. Circ Res 1992;71:883-897.
46. Herrmann RA, Malinauskas RA, Truskey GA: Characterization of sites with elevated LDL permeability at intercostal, celiac, and iliac branches of the normal rabbit aorta. Arterioscler Thromb 1994;14:313-323.
47. Kim DW, Langille BL, Wong MKK, Gotlieb AI: Patterns of endothelial microfilament distribution in the rabbit aorta in situ. Circ Res 1989;64:21-31.
48. Shimamoto T, Hidaka H, Moriya K, Kobayashi M, Takahashi T, Numano F: Hyperreactive arterial endothelial cells: A clue for the treatment of atherosclerosis. Ann NY Acad Sci 1976;275:266-285.
49. Fry DL: Certain chemorheologic considerations regarding the blood vascular wall interface with particular reference to coronary artery disease. Circulation 1969;40(suppl IV):38-59.
50. Flaherty JT, Pierce JE, Ferrans VJ, Patel DJ, Tucker WK, Fry DL: Endothelial nuclear patterns in the canine arterial tree with particular reference to haemodynamic events. Circ Res 1972;30:23-33.
51. Dewey CF Jr, Bussolari SR, Gimbrone MA Jr, Davies PF: The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng 1981;103:177-185.
52. Levesque MJ, Nerem RM: The elongation and orientation of cultured endothelial cells in response to shear stress. J Biomech Eng 1985;107:341-347.
53. Levesque M, Liepsch D, Moravec S, Nerem RM: Correlation of endothelial cell shape and wall shear stress in a stenosed dog aorta. Arteriosclerosis 1986;6:220-229.
54. Kim DW, Gotlieb AI, Langille BL: In vivo modulation of endothelial F-actin microfilaments by experimental alterations in shear stress. Arteriosclerosis 1989;9:439-445.
55. Walpola PL, Gotlieb AI, Langile BL: Monocyte adhesion and changes in endothelial cell number, morphology and F-actin distribution elicited by low shear stress in vivo. Am J Pathol 1993;142:1392-1400.
56. Davies PF, Dewey CF, Bussolari SR, Gordon EJ, Gimbrone MA Jr: Influence of hemodynamic forces on vascular endothelial function -in vitro studies of shear stress and pinocytosis in bovine aortic cell. J Clin Invest 1984;73:1121-1129.
57. Noria S, Cowan DB, Gotlieb AL, Langille BL: Transient and steady state effects of shear stress on endothelial cell adherens junctions. Circ Res 1999;85:504-514.
58. Seebach J, Dieterich P, Luo F, Schillers H, Vestweber D, Oberleithner H, Galla HJ, Schnittler HJ: Endothelial barrier function under laminar fluid shear stress. Lab Invest 2000;80:1819-1831.
59. Demaio L, Chang YS, Gardner TW, Tarbell JM, Antonetti DA: Shear stress regulates occludin content and phosphorylation. Am J Physiol 2001;281:H105-H113.
60. Davies PF, Remuzi A, Gordon EJ, Dewey CF Jr, Gimbrone MA Jr: Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro. Proc Natl Acad Sci USA 1986;83:2114-2117.
61. Lever MJ, Tarbell JM, Caro CG: The effect of luminal flow in rabbit carotid artery on transmural fluid transport. Exp Physiol 1992;77:553-563.
62. Fry DL: Certain histological and chemical responses of the vascular interface to acutely induced mechanical stress in the aorta of the dog. Circ Res 1969;24:93-108.
63. Markle RA, Hollis TM: Influence of locally altered in vivo shear stress on aortic histamine-forming capacity and aortic albumin uptake. Blood Vessels 1981;18:45-57.
64. Carew TE, Patel DJ: Effect of tensile and shear stress on intimal permeability of the left coronary artery in dogs. Atherosclerosis 1973;18:179-189.
65. 14C-cholesterol between serum and wall in the perfused dog common carotid artery. Circ Res 1973;32:187-205.
66. 131I-albumin. Biorheology 1976;13:71-77.
67. Friedman MH, Henderson JM, Aukerman JA, Clingnan PA: Effect of periodic alterations in shear on vascular macromolecular uptake. Biorheology 2000;37:265-277.
68. Bell FP, Somer JB, Craig IH, Schwartz CJ: Patterns of aortic Evans blue uptake in vivo and in vitro. Atherosclerosis 1972;16:369-375.
69. Baldwin AL, Winlove CP, Caro CG: Structural response of the rabbit thoracic aorta and inferior vena cava to in situ collapse. Artery 1982;10:420-439.
70. Staughton TJ, Lever MJ, Weinberg PD: Effect of altered flow on the pattern of permeability around rabbit aortic branches. Am J Physiol 2001;281:H53-H59.
71. Cheer AY, Dwyer HA, Barakat AI, Sy E, Bice M: Computational study of the effect of geometric and flow parameters on the steady flow field at the rabbit aorto-celiac bifurcation. Biorheology 1998;35:415-435.
72. Buchanan JR Jr, Kleinstreuer C, Truskey GA, Lei M: Relation between non-uniform hemodynamics and sites of altered permeability and lesion growth at the rabbit aorto-celiac junction. Atherosclerosis 1999;143:27-40.
73. Kratky RG, Roach MR: Endothelial cell morphometry near branch junctions of rabbit aortae. Can J Physiol Pharmacol 1987;65:1864-1871.
74. Okano M, Yoshida Y: Influence of shear stress on endothelial cell shapes and junction complexes at flow dividers of aortic bifurcations in cholesterol-fed rabbits. Front Med Biol Eng 1993;5:95-120.
75. Al-Musawi S, Bishton J, Dean J, Williams S, Cremers SG, Weinberg PD: Evidence for a reversal with age in the pattern of near-wall blood flow around aortic branches. Atherosclerosis 2004;172:79-84.
76. Ross R, Glomset JA: Atherosclerosis and the arterial smooth muscle cell: Proliferation of smooth muscle cells is a key event in the genesis of the lesions of atherosclerosis. Science 1973;180:1332-1339.
77. Minor RL Jr, Myers PR, Guerra R Jr, Bates JN, Harrison DG: Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest 1990;86:2109-2116.
78. Cooke JP, Andon NA, Girerd XJ, Hirsch AT, Creager MA: Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation 1991;83:1057-1062.
79. Sebkhi A, Weinberg PD: Effect of dietary cholesterol on the uptake of albumin by rabbit aortic wall in vivo. J Physiol 1994;479P:77P.
80. Barnes SE, Weinberg PD: Two patterns of lipid deposition in the cholesterol-fed rabbit. Arterioscler Thromb Vasc Biol 1999;19:2376-2386.
81. Barnes SE, Weinberg PD: Strain-dependent differences in the pattern of aortic lipid deposition in cholesterol-fed rabbits. Exp Mol Pathol 2001;71:161-170.
82. Staughton TJ, Weinberg PD: Effect of time of day and rabbit strain on patterns of aortic wall permeability. Exp Physiol, in press.
83. Weinberg PD, Cremers S: Changes with age in the atheroprotective effect of dietary L-arginine. Atherosclerosis 2003;S4:303.
84. Berger M, Jean-Faucher C, de Turckheim M, Veyssiere G, Blanc MR, Jean C: Testosterone, lutenizing hormone (LH) and follicle stimulating hormone (FSH) in plasma of rabbit from birth to adulthood - Correlation with sexual and behavioural development. Acta Endocrinol 1982;99:459-465.
85. Spagnoli LG, Orlandi A, Mauriello A, Santeusanio G, de Angelis C, Lucreziotti R, Ramacci MT: Aging and atherosclerosis in the rabbit. 1. Distribution, prevalence and morphology of atherosclerotic lesions. Atherosclerosis 1991;89:11-24.
86. Orlandi A, Marcellini M, Spagnoli LG: Aging influences development and progression of early atherosclerotic lesions in cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol 2000;20:1123-1136.
87. Cornhill JF, Levesque MJ, Nerem RM: Quantitative study of the localization of sudanophilic lesions in the White Carneau pigeon. Atherosclerosis 1980;35:103-110.
88. Richards JP, Weinberg PD: Distribution of disease around the aorto-coeliac branch of White Carneau pigeons at different ages. Exp Mol Pathol 2000;66:95-103.
89. McGillicuddy CJ, Carrier MJ, Weinberg PD: Distribution of lipid deposits around aortic branches of mice lacking low density lipoprotein receptors and apolipoprotein E. Arterioscler Thromb Vasc Biol 2001;21:1220-1225.
90. Cornhill JF, Barrett WA, Herderick EE, Mahley RW, Fry DL: Topographic study of sudanophilic lesions in cholesterol-fed minipigs by image analysis. Arteriosclerosis 1985;5:415-426.
91. Berceli SA, Warty VS, Sheppeck RA, Mandarino WA, Tanksale SK, Borovetz HS: Hemodynamics and low density lipoprotein metabolism: Rates of low density lipoprotein incorporation and degradation along medial and lateral walls of the rabbit aorto-iliac bifurcation. Arteriosclerosis 1990;10:688-694.
92. Friedman MH, Hutchins GM, Bargeron CB, Deters OJ, Mark FF: Correlation between intimal thickness and fluid shear in human arteries. Atherosclerosis 1981;39:425-436.
93. Kjaernes M, Svindland A, Walløe L, Wille SØ: Localization of early atherosclerotic lesions in an arterial bifurcation in humans. Acta Pathol Microbiol Scand Sect A 1981;89:35-40.
94. Grottum P, Svindland A, Walloe L: Localization of atherosclerotic lesions in the bifurcation of the main left coronary artery. Atherosclerosis 1983;47:55-62.
95. Nielsen LB, Nordestgaard BG, Stender S, Kjeldsen K: Aortic permeability to LDL as a predictor of aortic cholesterol accumulation in cholesterol-fed rabbits. Arterioscler Thromb 1992;12:1402-1409.
96. 125I-LDL and parenteral Evans blue dye complex along the aortas of normocholesterolemic minipigs as predictors of subsequent hypercholesterolemic atherogenesis. Arterioscler Thromb 1993;13:1193-1204.
97. Duncan LE, Buck K: Quantitative analysis of the development of experimental atherosclerosis in the dog. Circ Res 1960;8:1023-1027.
98. Kubes P: Nitric oxide affects microvascular permeability in the intact and inflamed vasculature. Microcirculation 1995;2:235-244.
99. i. Am J Physiol 1997;273:H747-H755.
100. Baldwin A, Lever MJ, Caro CG: Effect of noradrenaline, sodium nitrite and isosorbide dinitrate on albumin transport in the wall of the excised rabbit common carotid artery. Atherosclerosis 1983;46:1-11.
101. Shimamoto T: Experimental study on atherosclerosis - An attempt at its prevention and treatment. Acta Pathol Jpn 1969;19:15-43.
102. Walton KW, Dunkerley DJ, Johnson AG, Kahn MK, Morris C, Watts RB: Investigation by immunofluorescence of arterial lesions in rabbits on two different lipid supplements and treated with pyridinol carbamate. Atherosclerosis 1976;23:117-139.
103. Feig LA, Peppas NA, Colton CK, Smith KA, Lees RS: The effect of angiotensin II on in vivo albumin transport in normal rabbit aortic tissue. Atherosclerosis 1982;44:307-318.
104. Cardona-Sanclemente LE, Born GVR: Adrenaline increases the uptake of low-density lipoproteins in carotid arteries of rabbits. Atherosclerosis 1992;96:215-218.
105. Cardona-Sanclemente LE, Medina R, Born GVR: Effect of increasing doses of angiotensin II infused into normal and hypertensive rats on low density lipoproteins and fibrinogen uptake by aortic walls. Proc Natl Acad Sci USA 1994;91:3285-3288.
106. Shafi S, Cusack NJ, Born GV: Increased uptake of methylated low-density lipoprotein induced by noradrenaline in carotid arteries of anaesthetized rabbits. Proc R Soc Lond B 1989;235:289-298.
107. Nielsen LB, Stender S, Kjeldsen K, Nordestgaard BG: Effect of angiotensin II and enalapril on transfer of low-density lipoprotein into aortic intima in rabbits. Circ Res 1994;75:63-69.
108. Medina R, Cardona-Sanclemente LE, Born GVR: Effect of captopril and of losartan on blood pressure and accumulation of LDL and fibrinogen by aortic wall and other tissues in normotensive and hypertensive rats. J Cardiovasc Pharmacol 1997;29:125-129.
109. Medina R, Cardona-Sanclemente LE, Born GVR, Brown MJ: Effect of deoxycorticosterone acetate on blood pressure in relation to accumulation of low density lipoprotein and fibrinogen by aorta and other tissue of normotensive Wistar rats. J Hypertens 1997;15:531-536.
110. Cardona-Sanclemente LE, Born GVR: Effect of inhibition of nitric oxide synthesis on the uptake of LDL and fibrinogen by arterial walls and other organs of the rat. Br J Parmacol 1995;114:1490-1494.
111. Gammal EB, Monture MC: Uptake of Evans blue-bound albumin in the aorta of oestrogen-treated rats. Br J Exp Pathol 1979;60:58-64.
112. Walsh BA, Mullick AE, Banka CE, Rutledge JC: 17β-Estradiol acts separately on the LDL particle and artery wall to reduce LDL accumulation. J Lipid Res 2000;41:134-141.
113. Roberts KA, Woo MM, Rutledge JC: Nitric oxide mediates LDL uptake in the artery wall in response to high concentrations of 17 β estradiol. Arterioscler Thromb Vasc Biol 1997;17:2123-2131.
114. Schwenke DC: Gender differences in intimamedia permeability to low-density lipoprotein at atherosclerosis-prone aortic sites in rabbits. Lack of effect of 17β-estradiol. Arterioscler Thromb Vasc Biol 1997;17:2150-2157.
115. Haarbo J, Nielsen LB, Stender S, Christiansen C: Aortic permeability to LDL during estrogen therapy. A study in normocholesterolemic rabbits. Arterioscler Thromb 1994;14:243-247.
116. Nielsen LB: Transfer of low density lipoprotein into the arterial wall and risk of atherosclerosis. Atherosclerosis 1996;123:1-15.
117. Belmin J, Corman B, Merval R, Tedgui A: Age-related changes in endothelial permeability and distribution volume of albumin in rat aorta. Am J Physiol 1993;264:H679-H685.
118. Chang YS, Munn LL, Hillsley MV, Dull RO, Yuan J, Lakshminarayanan S, Gardner TW, Jain RK, Tarbell JM: Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties. Microvasc Res 2000;59:265-277.
119. Dejana E, Spagnuolo R, Bazzoni G: Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration. Thromb Haemost 2001;86:308-315.
120. Alexander JS, Elrod JW: Extracellular matrix, junctional integrity and matrix metalloproteinase interactions in endothelial permeability regulation. J Anat 2002;200:561-574.
121. van Hinsbergh VW, van Nieuw Amerongen GP: Intracellular signalling involved in modulating human endothelial barrier function. J Anat 2002;200:549-560.
122. Ogunrinade O, Kameya GT, Truskey GA: Effect of fluid shear stress on the permeability of the arterial endothelium. Ann Biomed Eng 2002;30:430-446.
123. Curmi PA, Juan L, Tedgui A: Effect of transmural pressure on low density lipoprotein and albumin transport and distribution across the intact arterial wall. Circ Res 1990;66:1692-1702.
124. Tedgui A, Merval R, Esposito B: Albumin transport characteristics of rat aorta in early phase of hypertension. Circ Res 1992;71:932-942.
125. 125I-labelled low density lipoprotein into the aortic intima in normal-fed rabbits. Atherosclerosis 1976;26:99-106.
126. Meyer G, Merval R, Tedgui A: Effects of pressure-induced stretch and convection on low-density lipoprotein and albumin uptake in the rabbit aortic wall. Circ Res 1996;79:532-540.
127. Williams KJ, Tabas I: The response-to-retention hypothesis of atherogenesis reinforced. Curr Opin Lipidol 1998;9:471-474.