A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

Autophagy

Volumn 11, Issue 8, 2015, Pages 1259-1279

  Zhou, Jing ^a   Li, Guobing ^a   Zheng, Yi ^a   Shen, Han Ming ^b   Hu, Xiaoye ^a   Ming, Qian Liang ^a   Huang, Cheng ^c   Li, Peng ^a   Gao, Ning ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Autophagic stress; Autophagy; Breast cancer; DNM1L; Liensinine; Lysosome; Mitochondrial fission; RAB7A

Indexed keywords

ANTINEOPLASTIC AGENT; DOXORUBICIN; DYNAMIN I; ISOQUINOLINE ALKALOID; LIENSININE; UNCLASSIFIED DRUG; DNM1L PROTEIN, HUMAN; GUANOSINE TRIPHOSPHATASE; ISOQUINOLINE DERIVATIVE; MICROTUBULE ASSOCIATED PROTEIN; MITOCHONDRIAL PROTEIN; PHENOL DERIVATIVE; RAB PROTEIN; RAB7 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BREAST CANCER; CANCER CELL; CANCER COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG POTENTIATION; FEMALE; LYSOSOME; MITOPHAGY; MOUSE; NONHUMAN; TUMOR GROWTH; ANIMAL; BREAST TUMOR; CANCER TRANSPLANTATION; CELL SURVIVAL; CHEMISTRY; GENE EXPRESSION REGULATION; HUMAN; MCF-7 CELL LINE; METABOLISM; MITOCHONDRIAL DYNAMICS; NUDE MOUSE; PATHOLOGY; PH; PHYSIOLOGY; RNA INTERFERENCE; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GTP PHOSPHOHYDROLASES; HUMANS; HYDROGEN-ION CONCENTRATION; ISOQUINOLINES; LYSOSOMES; MCF-7 CELLS; MICE; MICE, NUDE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL PROTEINS; NEOPLASM TRANSPLANTATION; PHENOLS; RAB GTP-BINDING PROTEINS; RNA INTERFERENCE;

EID: 84943745182     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.1080/15548627.2015.1056970     Document Type: Article

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