Both Relative Insulin Resistance and Defective Islet β-Cell Processing of Proinsulin Are Responsible for Transient Hyperglycemia in Extremely Preterm Infants

Pediatrics

Volumn 113, Issue 3 I, 2004, Pages 537-541

  Mitanchez Mokhtari, Delphine ^a   Lahlou, Najiba ^b   Kieffer, François ^c   Magny, Jean François ^c   Roger, Marc ^b   Voyer, Marcel ^c  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b HÔPITAL SAINT VINCENT DE PAUL   (France)

^c Institut de Puericulture   (France)

Author keywords

Extremely preterm infants; Hyperglycemia; Insulin resistance; Proinsulin processing

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; PROINSULIN;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN INFUSION; INSULIN RELEASE; INSULIN RESISTANCE; MALE; NEWBORN; PANCREAS ISLET BETA CELL; PREMATURITY; PRIORITY JOURNAL; PROSPECTIVE STUDY;

BLOOD GLUCOSE; C-PEPTIDE; FEMALE; HUMANS; HYPERGLYCEMIA; INFANT, NEWBORN; INFANT, PREMATURE; INFANT, PREMATURE, DISEASES; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS; MALE; PROINSULIN; PROSPECTIVE STUDIES;

EID: 1442323874     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.113.3.537     Document Type: Article

References (23)

1. Ogata ES. Carbohydrate metabolism in the foetus and neonate and altered neonatal glucoregulation. Pediatr Clin North Am. 1986;33:25-45
2. Hawdon JM, Aynsley-Green A, Alberti KG, Ward Platt MP. The role of pancreatic insulin secretion in neonatal glucoregulation. I. Healthy term and preterm infants. Arch Dis Child. 1993;68:274-279
3. Tyrala EE, Chen X, Boden G. Glucose metabolism in the infant weighing less than 1100 grams. J Pediatr. 1994;125:283-287
4. Pollak A, Cowett RM, Schwartz R, Oh W. Glucose disposal in low birth weight infants during steady state hyperglycemia: effects of exogenous insulin administration. Pediatrics. 1978;61:546-549
5. Hawdon JM, Hubbard M, Hales CN, Clark PM. Use of specific immunoradiometric assay to determine preterm neonatal insulin-glucose relations. Arch Dis Child. 1995;73:F166-F169
6. Mamelle N, Laumon B, Verney D, et al. Variations du poids de naissance en fonction de diverses caractéristiques foetales et maternelles. Arch Fr Pédiatr. 1986;43:311-316
7. Helbock HJ, Insoft RM, Conte FA. Glucocorticoid-responsive hypotension in extremely low birth weight newborns. Pediatrics. 1993;92:715-717
8. Wilkins BH. Renal function in sick very low birth weight infants: 4. Glucose excretion. Arch Dis Child. 1992;67:1162-1165
9. Revers RR, Henry R, Schmeiser L, et al. The effects of biosynthetic human proinsulin on carbohydrate metabolism. Diabetes. 1984;33:762-770
10. Ng PC, Lam CW, Fok TF, et al. Refractory hypotension in preterm infants with adrenocortical insufficiency. Arch Dis Child. 2001;84: F122-F124
11. Esteban NV, Loughlin T, Yergey AL, et al. Daily cortisol production rate in man determined by stable isotope dilution/mass spectrometry. J Clin Endocrinol Metab. 1991;72:39-45
12. Metzger DL, Wright NM, Veldhuis JD, Rogol AD, Kerrigan JR. Characterization of pulsatile secretion and clearance of plasma cortisol in premature and term neonates using deconvolution analysis. J Clin Endocrinol Metab. 1993;77:458-463
13. Binder ND, Raschko PK, Benda GI, Reynolds JW. Insulin infusion with parenteral nutrition in extremely low birth weight infants with hyperglycemia. J Pediatr. 1989;114:273-280
14. Collins JW, Hoppe M, Brown K, Edidin D, Padbury J, Ogata ES. A controlled trial of insulin infusion and parenteral nutrition in extremely low birth weight infants with glucose intolerance. J Pediatr. 1991;118:921-927
15. Kanarek KS, Santeiro ML, Malone JI. Continuous infusion of insulin in hyperglycemic low-birth weight infants receiving parenteral nutrition with and without lipid emulsion. J Parenteral Enteral Nutr. 1991;15:417-420
16. Pildes RS. Neonatal hyperglycemia. J Pediatr. 1986;109:905-907
17. Goldman SL, Hirata T. Attenuated response to insulin in very low birthweight infant. Pediatr Res. 1980;14:50-55
18. Farrag H, Cowett R. Glucose homeostasis in the micropremie., Clin Perinatol. 2000;27:1-22
19. Cowett RM, Oh W, Schwartz R. Persistent glucose production during glucose infusion in the neonate. J Clin Invest. 1983;71:467-475
20. Sunehag A, Gustafsson J, Ewald U. Very immature infants (less or = 30 wk) respond to glucose infusion with incomplete suppression of glucose production. Pediatr Res. 1994;36:550-555
21. Farrag HM, Nawrath LM, Healey JE, et al. Persistent glucose production and greater peripheral sensitivity to insulin in the neonate vs. the adult. Am J Physiol. 1997;272:E86-E93
22. Nordlie RC, Foster JD, Lange AJ. Regulation of glucose production by the liver. Annu Rev Nutr. 1999;19:379-406
23. Iynedjian PB, Jotterand D, Nouspikel T, Asfari M, Pilot PR. Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system. J Biol Chem. 1989;264:21824-1829