AP-1-targeted inhibition of macrophage function and lipopolysaccharide/d-galactosamine-induced hepatitis by phyllanthus acidus methanolic extract

American Journal of Chinese Medicine

Volumn 43, Issue 6, 2015, Pages 1137-1158

  Hossen, Muhammad Jahangir ^a,b   Kim, Mi Yeon ^c   Kim, Jong Hoon ^d   Cho, Jae Youl ^a  

^a Sungkyunkwan University   (South Korea)

^b PATUAKHALI SCIENCE AND TECHNOLOGY UNIVERSITY   (Bangladesh)

^c Soongsil University   (South Korea)

^d Chonbuk National University   (South Korea)

Author keywords

AP 1; Hepatitis; IL 1 ; IL 6; MAPK; Phyllanthus acidus (Phyllanthaceae); TNF

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BETA ACTIN; GALACTOSAMINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIVER PROTECTIVE AGENT; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PHYLLANTHUS ACIDUS EXTRACT; PLANT EXTRACT; PROTEIN C FOS; PROTEIN C JUN; QUERCETIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1;

ACUTE HEPATITIS; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DRUG EFFECT; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; LIVER PROTECTION; LUCIFERASE ASSAY; MACROPHAGE MIGRATION INHIBITION; MALE; MOLECULAR BIOLOGY; MOLECULARLY TARGETED THERAPY; MONOCYTE; NONHUMAN; PHYLLANTHUS; PHYLLANTHUS ACIDUS; PHYTOCHEMISTRY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; U937 CELL LINE; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE RAW 264.7; CHEMISTRY; DRUG EFFECTS; GENETICS; HEPATITIS; IMMUNOLOGY; LIVER; MACROPHAGE; MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; GALACTOSAMINE; HEPATITIS; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; PHYLLANTHUS; PLANT EXTRACTS; RAW 264.7 CELLS; TRANSCRIPTION FACTOR AP-1; U937 CELLS;

EID: 84943581715     PISSN: 0192415X     EISSN: 17936853     Source Type: Journal    
DOI: 10.1142/S0192415X15500652     Document Type: Article

References (59)

1. Ai , Q., Y. Jing, R. Jiang, L. Lin, J. Dai, Q. Che, D. Zhou, M. Jia, J. Wan and L. Zhang. Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepa titis in mice. Int. Immunopharmacol. 21: 200-207, 2014.
2. Anjaria, J. A Glossary of Selected Indigenous Medicinal Plants of India: Sristi Innovations, 1997.
3. Back, S.S., J. Kim, D. Choi, E.S . Lee, S.Y. Choi and K. Han. Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including liver-X-receptor. BMB Rep. 46: 322-327, 2013.
4. Banik, G., M. Bawari, M.D. Choudhury, S. Choudhury and G. Sharma. Some anti-diabetic plants of Southern Assam. Assam Univ. J. Sci. Technol. 5: 114-119, 2010.
5. Byeon, S.E., J. Lee, B.C. Yoo, G.H. Sung, T.W. Kim, H.J. Park and J.Y. Cho. p38-targeted inhibition of interleukin-12 expression by ethanol extract from Cordyceps bassiana in lipopolysaccharideactivated macrophages. Immunopharmacol. Immunotoxicol. 33: 90-96, 2011.
6. Byeon, S.E., T. Yu, Y. Yang, Y.G. Lee, J.H. Kim, J. Oh, H.Y. Jeong, S. Hong, B.C. Yoo, W.J. Cho, S. Hong and J.Y. Cho. Hydroquinone regulates hemeoxygenase-1 expression via modulati on of Src kinase activity through thiolation of cysteine residues. Free Radic. Biol. Med. 57: 105-118, 2013.
7. Chakraborty, R., D. Biplab, N. Devanna and S. Sen. Antiinflammatory, antinociceptive and antioxidant activities of Phyllanthus acidus L. extracts. Asian Pac. J. Trop. Biomed. 2: S953-S961, 2012.
8. Chan, E.D. and D.W.H. Riches. IFN-gamma + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38(MAPK) in a mouse macrophage cell line. Am. J. Physiol. Cell Physiol. 280: C441-C450, 2001.
9. Cho, J.Y., J.D. Yeon, J.Y. Kim, E.S. Yoo, Y.H. Yu and M.H. Park. Hepatoprotection by human epidermal growth factor (hE GF) against experimental hepatitis induced by D-galactosamine (D-GalN) or D-GalN/lipopolysaccharide. Biol. Pharm. Bull. 23: 1243-1246, 2000.
10. Chongsa, W., N. Radenahmad and C. Jansakul. Six weeks oral gavage of a Phyllanthus acidus leaf water extract decreased visceral fat, the serum lipid profile and liver lipid accumulation in middle-Aged male rats. J. Ethnopharmacol. 155: 396-404, 2014.
11. Chowdhary, Z., A. Alamgir, M. Alauddin, M. Islan, K. Chakma and M. Hogue. Traditional knowledge related to medicinal and aromatic plants in tribal societies and the quantitative study of alkaloids in medicinal plants of the hill tracts in Bangladesh. Pharma. Mag. 4: S137-S144, 2008.
12. Crispe, I.N. The liver as a lymphoid organ. Ann. Rev. Immunol. 27: 147-163, 2009.
13. Devi, S.S. and S.B. Paul. An overview on Cicca acida (Phyllanthus acidus). Assam Univ. J. Sci. Technol. 7: 156-160, 2011.
14. Feldmann, M. Many cytokines are very useful therapeutic targets in disease. J. Clin. Invest. 118: 3533-3536, 2008.
15. Fujihara, M., M. Muroi, K. Tanamoto, T. Suzuki, H. Azuma and H. Ikeda. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: Roles of the receptor complex. Pharmacol. Ther. 100: 171-194, 2003.
16. Ghosh, S. and M.S. Hayden. New regulators of NF-kappaB in inflammation. Nat. Rev. Immunol. 8: 837-848, 2008.
17. Guha, M. and N. Mackman. LPS induction of gene expression in human monocytes. Cell. Signal. 13: 85-94, 2001.
18. Hadi, S. and J.B. Bremner. Initial studies on alkaloids from Lombok medicinal plants. Molecules 6: 117-129, 2001.
19. Ham M.,A. Moon Inflammatory and microenvironmental factors involved in breast cancer progression. Arch. Pharm. Res. 36 1419-1431 2013.
20. Hossen, M.J., K.S. Baek, E. Kim, W.S. Yang, D. Jeong, J.H. Kim, D.H. Kweon, D.H. Yoon, T.W. Kim, J.H. Kim and J.Y. Cho. In vivo a nd in vitro anti-inflammatory activities of Persicaria chinensis methanolic extract targeting Src/Syk/NF-kappaB. J. Ethnopharmacol. 159: 9-16, 2015 a.
21. Hossen, M.J., S.H. Jeon, S.C. Kim, J.H. Kim, D. Jeong, N.Y. Sung, S. Yang, K.S. Baek, D.H. Yoon, W.O. Song, K.D. Yoon, S.H. Cho, S. Lee and J.Y. Cho. In vivo and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract. J. Ethnopharmacol. 2015b .
22. Hossen, M.J., S.C. Kim, Y.J. Son, K.S. Baek, E. Kim, W.S. Yang, D. Jeong, J.G. Park, H.G. Kim, W.J. Chung, K. Yoon, C. Ryou, S.Y. Lee, J.H. Kim and J.Y. Cho. AP-1-targeting anti-infla mmatory activity of the methanolic extract of Persicaria chinensis. Evid. Based Complement. Alternat. Med. 2015: 608126, 2015c.
23. Jagessar, R., A. Mars and G. Gomes. Selective antimicrobial properties of Phyllanthus acid us leaf extract against Candida albicans, Escherichia coli and Staphylococcus aureus using stokes disc diffusion, well diffusion, streak plate and a dilution method. Nat. Sci. 6: 24-38, 2008.
24. Jain, N.K., S. Lodhi, A. Jain, A. Nahata and A.K. Singhai. Effects of Phyllanthus acidus (L.) Skeels fruit on carbon tetrachloride-induced acute oxidative damage in livers of rats and mice. Zhong Xi Yi Jie He Xue Bao 9: 49-56, 2011.
25. Jeong, Y.H., J.W. Hyun, T. Kim Van Le, D.H. Kim and H.S. Kim. Kalopanaxsaponin A exerts anti-inflammatory effects in lipopolysaccharide-stimulated microglia via inhibition of JNK and NF-kappaB/AP-1 pathways. Biomol. Ther. 21: 332-337, 2013.
26. Jho, E.H., K. Kang, S. Oidovsambuu, E.H. Lee, S.H. Jung, I.S. Shin and C.W. Nho. Gymnaster koraiensis and its major components, 3,5-di-O-caffeoylquinic acid and gymnasterkoreayne B, reduce oxidative damage induced by tert-butyl hydroperoxide or acetaminophen in HepG2 cells. BMB Rep. 46: 513-518, 2013.
27. Jia, M.Y., Y.P. Jing, Q. Ai, R. Jiang, J.Y. Wan, L. Lin, D. Zhou, Q. Che, L.J. Li, L. Tang, Y. Shen and L. Zhang. Potential role of catalase in mice with lipopolysaccharide/D-galactosamineinduced fulminant liver injury. Hepatol. Res . 44: 1151-1158, 2014.
28. Kaminska, B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy-From molecular mechanisms to therapeutic benefits. Biochim. Biophys. Acta 1754: 253-262, 2005.
29. Kawai, T. and S. Akira. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34: 637-650, 2011.
30. Kim, H.S., A.R. Kim, H.J. P ark, D.K. Park, K. Kim do, N.Y. Ko, B. Kim, D.K. Choi, H.S. Won, W.S. Shin, Y.M. Kim and W.S. Choi. Morus bombycis Koidzumi extract suppresses collageninduced arthritis by inhibiting the activation of nuclear factor-kappaB and activator protein-1 in mice. J. Ethnopharmacol. 136: 392-398, 2011a .
31. Kim, J.K. and G.M. Park. Indirubin-3-monoxime exhibits anti-inflammatory properties by downregulating NF-kappaB and JNK signaling pathways in lipopolysaccharide-treat ed RAW264.7 cells. Inflamm. Res. 61: 319-325, 2012.
32. Kim, M.H., D.S. Yoo, S.Y. Lee, S.E. Byeon, Y.G. Lee, T. Min, H.S. Rho, M.H. Rhee, J. Lee and J.Y. Cho. The TRIF/TBK1/IRF-3 activati on pathway is the primary inhibitory target of resveratrol, contributing to its broad-spectrum anti-inflammatory effects. Pharmazie 66: 293-300, 2011 b.
33. Kim, M.Y. and J.Y. Cho. 20S-dihydroprotopanaxadiol, a gins enoside derivative, boosts innate immune responses of monocytes and macrophages. J. Ginseng Res. 37: 293-299, 2013.
34. Lee, C.W., F.L. Yen, H.W. Huang, T.H. Wu, H.H. Ko, W.S. Tzeng and C.C. Lin. Resveratrol nanoparticle system improves dissolution properties and enhances the hepatoprotective effect of resveratrol through antioxidant and anti-inflammatory pathways. J. Agric. Food Chem. 60: 4662-4671, 2012.
35. Lee, C.Y., W.H. Peng, H.Y. Cheng, F.N. Chen, M.T. Lai and T.H. Chiu. Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride. Am. J. Chin. Med. 34: 471-482, 2006.
36. Lee, M.S. Role of innate immunity in diabetes and metabolism: Recent progress in the study of inflammasomes. Immune Netw. 11: 95-99, 2011.
37. Leeya, Y., M.J. Mulvany, E.F. Queiroz, A. Marston, K. Hostettmann and C. Jansakul. Hypotensive activity of an n-butanol extract and their purified compounds from leaves of Phyllanthus acidus (L.) Skeels in rats. Eur. J. Pharmacol. 649: 301-313, 2010.
38. Lv, J.J., S. Yu, Y.F. Wang, D. Wang, H.T. Zhu, R.R. Cheng, C.R. Yang, M. Xu and Y.J. Zhang. Anti-hepatitis B virus norbisabolane sesquiterpenoids from Phyllanthus acidus and the establishment of their absolute config urations using theoretical calculations. J. Org. Chem. 79: 5432-5447, 2014.
39. Medzhitov, R. and T. Horng. Transcriptional control of the inflammatory response. Nat. Rev. Immunol. 9: 692-703, 2009.
40. Mehla, K., S. Balwani, A. Kulshreshtha, D. Nandi, P. Jaisankar and B. Ghosh. Ethyl gallate isolated from Pistacia integerrima Linn. inhibits cell adhesion molecu les by blocking AP-1 transcription factor. J. Ethnopharmacol. 137: 1345-1352, 2011.
41. Melendez, P.A. and V.A. Capriles. Antibacterial properties of tropical plants from Puerto Rico. Phytomedicine 13: 272-276, 2006.
42. O'Neill, L.A., K.A. Fitzgerald and A.G. Bowie. The toll-IL-1 receptor adaptor family grows to five members. Trends Immunol. 24: 286-290, 2003.
43. Panteva, M., H. Kor kaya and S. Jameel. Hepatitis viruses and the MAPK pathway: Is this a survival strategy? Virus Res. 92: 131-140, 2003.
44. Park, M.H. and K. Igarashi. Polyamines and their metabolites as diagnostic markers of human diseases. Biomol. Ther. 21: 1-9, 2013.
45. Pasparakis, M. Regulation of tissue homeostasis by NF-kappaB signalling: Implications for inflammatory diseases. Nat. Rev. Immunol. 9: 778-788, 2009.
46. Seo, S.J., J.Y. Cho, Y.H. Jeong and Y.S. Choi. Effect of Korean red ginseng extract on liver damage induced by short-term and long-term ethanol treatment in rats. J. Ginseng Res. 37: 194-200, 2013.
47. Sohn, S.H., S.K. Kim, Y.O. Kim, H.D. Kim, Y.S. Shin, S.O. Yang, S.Y. Kim and S.W. Lee. A comparison of antioxidant activity of Korean white and red ginsengs on H2O2-induced oxidative stress in HepG2 hepatoma cells. J. Ginseng Res. 37: 442-450, 2013.
48. Sousa, M., J. Ousingsawat, R. Seitz, S. Puntheeranurak, A. Regalado, A. Schmidt, T. Grego, C. Jansakul, M.D. Amaral, R. Schreiber and K. Kunzelmann. An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: A potential treatment for cystic fibrosis. Mol. Pharmacol. 71: 366-376, 2007.
49. Srirama, R., H.B. Dee pak, U. Senthilkumar, G. Ravikanth, B.R. Gurumurthy, M.B. Shivanna, C.V. Chandrasekaran, A. Agarwal and R.U. Shaanker. Hepatoprotective activity of Indian Phyllanthus. Pharm. Biol. 50: 948-953, 2012.
50. Steel, H.C., R. Cockeran, R. Anderson and C. Feldman. Overview of community-Acquired pneumonia and the role of inflammatory mechanisms in the immunopathogenesis of severe pneumococcal disease. Med. Inflamm. 2013: 490346, 2013. DOI: 10.1155/2013/490346.
51. Tacke, F., T. Luedde and C. Trautwein. Inflammatory pathways in liver homeostasis and liver injury. Clin. Rev. Allergy Immunol. 36: 4-12, 2009.
52. Tseng, C.K., C.K. Lin, H.W. Chang, Y.H. Wu, F.L. Yen, F.R. Chang, W.C. Chen, C.C. Yeh and J.C. Lee. Aqueous extract of Gracilaria tenuistipitata suppresses LPS-induced NF-kB and MAPK activation in RAW 264.7 and rat peritoneal macrophages and exerts hepatoprotective effects on carbon tetrachloride-treated rat. PLoS One 9: e86557, 2014.
53. Unander, D.W., G.L. Webster and B.S. Blumberg. Usage and bioassays in Phyllanthus (Euphorbiaceae). IV. Clustering of antiviral uses and other effects. J. Ethnopharmacol. 45: 1-18, 1995.
54. van Andel, T., J. Behari-Ramdas, R. Havinga and S. Groenendijk. The medicinal plant trade in Suriname. Ethnobotany Res. Appl. 5: 351-372, 2008.
55. Yang, Y., T. Yu, H.J. Jang, S.E. Byeon, S.Y. Song, B.H. Lee, M.H. Rhee, T.W. Kim, J. Lee, S. Hong and J.Y. Cho. In vivo and in vivo anti-inflammatory activities of Polygonum hydropiper methanol extract. J. Ethnopharmacol. 139: 616-625, 2012.
56. Yang, Y., T. Yu, Y.G. Lee, W.S. Yang, J. Oh, D. Jeong, S. Lee, T.W. Kim, Y.C. Park, G.H. Sung and J.Y. Cho. Methanol extract of Hopea odorata suppresses inflammatory responses via the direct inhibition of multiple kinases. J. Ethnopharmacol. 145: 598-607, 2013.
57. Yu, T., J. Lee, Y.G. Lee, S.E. By eon, M.H. Kim, E.H. Sohn, Y.J. Lee, S.G. Lee and J.Y. Cho. In vivo and in vivo anti-inflammatory effects of ethanol extract from Acer tegmentosum. J. Ethnopharmacol. 128: 139-147, 2010.
58. Yu, T., Y .J. Lee, H.M. Yang, S. Han, J.H. Kim, Y. Lee, C. Kim, M.H. Han, M.Y. Kim, J. Lee and J.Y. Cho. Inhibitory effect of Sanguisorba officinalis ethanol extract on NO and PGE(2) production is mediated by suppression of NF-kappaB and AP-1 activation signaling cascade. J. Ethnopharmacol. 134: 11-17, 2011a .
59. Yu, T., H.M. Ahn, T. Shen, K. Yoon, H.J. Jang, Y.J. Lee, H.M. Yang, J.H. Kim, C. Kim, M.H. Han, S.H. Cha, T.W. Kim, S.Y. Kim, J. Lee and J.Y. Cho. Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans. J. Ethnopharmacol. 137: 1197-1206, 2011 b.