20S-dihydroprotopanaxadiol, a ginsenoside derivative, boosts innate immune responses of monocytes and macrophages

Journal of Ginseng Research

Volumn 37, Issue 3, 2013, Pages 293-299

  Kim, Mi Yeon ^a   Cho, Jae Youl ^b  

^a Soongsil University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

20S dihydroprotopanaxadiol; Adhesion; Panax ginseng; Phagocytosis; Reactive oxygen species generation

Indexed keywords

EID: 84880063627     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2013.37.293     Document Type: Article

References (35)

1. Lee YG, Lee J, Byeon SE, Yoo DS, Kim MH, Lee SY, Cho JY. Functional role of Akt in macrophage-mediated innate immunity. Front Biosci 2011;16:517-530.
2. Yu T, Yi YS, Yang Y, Oh J, Jeong D, Cho JY. The pivotal role of TBK1 in inflammatory responses mediated by macrophages. Mediators Infamm 2012;2012:979105.
3. Byeon SE, Yi YS, Oh J, Yoo BC, Hong S, Cho JY. The role of Src kinase in macrophage-mediated infammatory responses. Mediators Infamm 2012;2012:512926.
4. Cho JY, Fox DA, Horejsi V, Sagawa K, Skubitz KM, Katz DR, Chain B. The functional interactions between CD98, beta1-integrins, and CD147 in the induction of U937 ho-motypic aggregation. Blood 2001;98:374-382.
5. Lee YG, Lee J, Cho J Y. Cell-permeable ceramides act as novel regulators of U937 cell-cell adhesion mediated by CD29, CD98, and CD147. Immunobiology 2010;215:294-303.
6. Jeannin P, Duluc D, Delneste Y. IL-6 and leukemia-inhibitory factor are involved in the generation of tumor-associated macrophage: regulation by IFN-γ. Immunotherapy 2011;3(4 Suppl):23-26.
7. Hasani-Ranjbar S, Nayebi N, Larijani B, Abdollahi M. A systematic review of the effcacy and safety of herbal medicines used in the treatment of obesity. World J Gas-troenterol 2009;15:3073-3085.
8. Kim DH. Chemical diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng. J Ginseng Res 2012;36:1-15.
9. Hasegawa H. Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsen-oside: deglycosylation by intestinal bacteria and esterification with fatty acid. J Pharmacol Sci 2004;95:153-157.
10. Byeon SE, Lee J, Kim JH, Yang WS, Kwak YS, Kim SY, Choung ES, Rhee MH, Cho JY. Molecular mechanism of macrophage activation by red ginseng acidic polysac-charide from Korean red ginseng. Mediators Inflamm 2012;2012:732860.
11. Yayeh T, Jung KH, Jeong HY, Park JH, Song YB, Kwak YS, Kang HS, Cho JY, Oh JW, Kim SK et al. Korean red ginseng saponin fraction downregulates proinflammatory mediators in LPS stimulated RAW264.7 cells and protects mice against endotoxic shock. J Ginseng Res 2012;36:263-269.
12. Wakabayashi C, Murakami K, Hasegawa H, Murata J, Saiki I. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun 1998;246:725-730.
13. Choo MK, Sakurai H, Kim DH, Saiki I. A ginseng saponin metabolite suppresses tumor necrosis factor-alpha-promoted metastasis by suppressing nuclear factor-kappaB signaling in murine colon cancer cells. Oncol Rep 2008;19:595-600.
14. Kim YS, Yoo MH, Lee GW, Choi JG, Kim KR, Oh DK. Ginsenoside F1 production from ginsenoside Rg1 by a purified β-glucosidase from Fusarium moniliforme var. subglutinans. Biotechnol Lett 2011;33:2457-2461.
15. Chen G, Yang X, Nong S, Yang M, Xu B, Zhang W. Two novel hydroperoxylated products of 20(S)-protopanaxa-diol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells. Biotechnol Lett 2013;35:439-443.
16. Zhu GY, Li YW, Tse AK, Hau DK, Leung CH, Yu ZL, Fong WF. 20(S)-protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells. Eur J Pharmacol 2011;668:88-98.
17. Lee SH, Seo GS, Ko G, Kim JB, Sohn DH. Anti-inflammatory activity of 20(S)-protopanaxadiol: enhanced heme oxygenase 1 expression in RAW 264.7 cells. Planta Med 2005;71:1167-1170.
18. Cho JY, Kim AR, Joo HG, Kim BH, Rhee MH, Yoo ES, Katz DR, Chain BM, Jung JH. Cynaropicrin, a sesquiterpene lactone, as a new strong regulator of CD29 and CD98 functions. Biochem Biophys Res Commun 2004;313:954-961.
19. Kim BH, Lee YG, Lee J, Lee JY, Cho JY. Regulatory effect of cinnamaldehyde on monocyte/macrophage-mediated inflammatory responses. Mediators Inflamm 2010;2010:529359.
20. Duperrier K, Eljaafari A, Dezutter-Dambuyant C, Bardin C, Jacquet C, Yoneda K, Schmitt D, Gebuhrer L, Rigal D. Distinct subsets of dendritic cells resembling dermal DCs can be generated in vitro from monocytes, in the presence of different serum supplements. J Immunol Methods 2000;238:119-131.
21. Park PH, Hur J, Lee DS, Kim CH, Jeong GS, Sohn DH. Inhibition of nitric oxide production by ethyl digallates isolated from Galla Rhois in RAW 264.7 macrophages. Biomol Ther 2011;19:419-424.
22. Cho JY, Skubitz KM, Katz DR, Chain BM. CD98-depen-dent homotypic aggregation is associated with transloca-tion of protein kinase Cdelta and activation of mitogen-activated protein kinases. Exp Cell Res 2003;286:1-11.
23. Larrucea S, Gonzalez-Rubio C, Cambronero R, Ballou B, Bonay P, Lopez-Granados E, Bouvet P, Fontan G, Fresno M, Lopez-Trascasa M. Cellular adhesion mediated by factor J, a complement inhibitor. Evidence for nucleolin involvement. J Biol Chem 1998;273:31718-31725.
24. Vo VA, Lee JW, Chang JE, Kim J Y, Kim NH, Lee HJ, Kim SS, Chun W, Kwon YS. Avicularin inhibits lipopoly-saccharide-induced inflammatory response by suppressing ERK phosphorylation in RAW 264.7 macrophages. Biomol Ther 2012;20:532-537.
25. Okai Y, Ishizaka S. A possible immunomodulating activity of arbekacin (ABK), a newly synthesized antibiotic against methicillin-resistant Staphylococcus aureus (MRSA). Int J Immunopharmacol 1994;16:321-327.
26. Lee YG, Byeon SE, Kim JY, Lee JY, Rhee MH, Hong S, Wu JC, Lee HS, Kim MJ, Cho DH et al. Immunomodulatory effect of Hibiscus cannabinus extract on macrophage functions. J Ethnopharmacol 2007;113:62-71.
27. Lee YG, Kim JY, Lee JY, Byeon SE, Hong EK, Lee J, Rhee MH, Park HJ, Cho JY. Regulatory effects of Co-donopsis lanceolata on macrophage-mediated immune responses. J Ethnopharmacol 2007;112:180-188.
28. Sprague AH, Khalil RA. Infammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol 2009;78:539-552.
29. Mork T, Hancock RE. Mechanisms of nonopsonic phagocytosis of Pseudomonas aeruginosa. Infect Immun 1993;61:3287-3293.
30. Yamaguchi H, Haranaga S, Widen R, Friedman H, Yama-moto Y. Chlamydia pneumoniae infection induces differentiation of monocytes into macrophages. Infect Immun 2002;70:2392-2398.
31. Syme RM, Spurrell JC, Ma LL, Green FH, Mody CH. Phagocytosis and protein processing are required for presentation of Cryptococcus neoformans mitogen to T lymphocytes. Infect Immun 2000;68:6147-6153.
32. Kim JY, Lee YG, Kim MY, Byeon SE, Rhee MH, Park J, Katz DR, Chain BM, Cho JY. Src-mediated regulation of infammatory responses by actin polymerization. Bio-chem Pharmacol 2010;79:431-443.
33. Kim BH, Cho J Y. Regulatory role of ginsenoside Rp1, a novel ginsenoside derivative, on CD29-mediated cell adhesion. Planta Med 2009;75:316-320.
34. Cho JY, Katz DR, Chain BM. Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation. Br J Pharmacol 2003;140:269-276.
35. Cho JY, Chain BM, Vives J, Horejsi V, Katz DR. Regulation of CD43-induced U937 homotypic aggregation. Exp Cell Res 2003;290:155-167.