Autophagy protects human brain microvascular endothelial cells against methylglyoxal-induced injuries, reproducible in a cerebral ischemic model in diabetic rats

Journal of Neurochemistry

Volumn 135, Issue 2, 2015, Pages 431-440

  Fang, Lili ^a   Li, Xue ^a   Zhong, Yinbo ^a   Yu, Jing ^a   Yu, Lina ^a   Dai, Haibin ^a   Yan, Min ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

autophagy; diabetes; FAK phosphorylation; human brain microvascular endothelial cells; methylglyoxal; stroke

Indexed keywords

3 METHYLADENINE; AMMONIUM CHLORIDE; BAFILOMYCIN A1; BECLIN 1; CASPASE 3; CHLOROQUINE; EVANS BLUE; FOCAL ADHESION KINASE INHIBITOR; LACTATE DEHYDROGENASE; METHYLGLYOXAL; PF 573228; SMALL INTERFERING RNA; STREPTOZOCIN; UNCLASSIFIED DRUG; FOCAL ADHESION KINASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; BRAIN ISCHEMIA; CELL PROTECTION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME RELEASE; FETUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PRIORITY JOURNAL; RAT; RNA INTERFERENCE; WESTERN BLOTTING; ANIMAL; CAPILLARY; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; CYTOLOGY; DIABETIC ANGIOPATHY; DRUG EFFECTS; ENDOTHELIUM CELL; EXPERIMENTAL DIABETES MELLITUS; METABOLISM; MIDDLE CEREBRAL ARTERY; PATHOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; AUTOPHAGY; BLOOD-BRAIN BARRIER; BRAIN ISCHEMIA; CAPILLARIES; CELL LINE; CELL SURVIVAL; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETIC ANGIOPATHIES; ENDOTHELIAL CELLS; FOCAL ADHESION KINASE 1; HUMANS; MALE; MIDDLE CEREBRAL ARTERY; PYRUVALDEHYDE; RATS; RATS, SPRAGUE-DAWLEY; RNA INTERFERENCE;

EID: 84943580588     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13277     Document Type: Article

References (43)

1. Beard R. S., Jr, Reynolds J. J., and, Bearden S. E., (2011) Hyperhomocysteinemia increases permeability of the blood-brain barrier by NMDA receptor-dependent regulation of adherens and tight junctions. Blood 118, 2007-2014.
2. Bijnsdorp I. V., and, Peters G. J., (2011) Deoxyribose protects against rapamycin-induced cytotoxicity in colorectal cancer cells in vitro. Nucleosides, Nucleotides Nucleic Acids 30, 1197-1202.
3. Booth L. A., Tavallai S., Hamed H. A., Cruickshanks N., and, Dent P., (2014) The role of cell signalling in the crosstalk between autophagy and apoptosis. Cell. Signal. 26, 549-555.
4. Cao Y., and, Klionsky D. J., (2007) Physiological functions of Atg6/Beclin 1: a unique autophagy-related protein. Cell Res. 17, 839-849.
5. Dai H., Yu Z., Fan X., Liu N., Yan M., Chen Z., Lo E. H., Hajjar K. A., and, Wang X., (2013) Dysfunction of annexin A2 contributes to hyperglycaemia-induced loss of human endothelial cell surface fibrinolytic activity. Thromb. Haemost. 109, 1070-1078.
6. English M., Nzinga J., Mbindyo P., Ayieko P., Irimu G., and, Mbaabu L., (2011) Explaining the effects of a multifaceted intervention to improve inpatient care in rural Kenyan hospitals-interpretation based on retrospective examination of data from participant observation, quantitative and qualitative studies. Implement. Sci. 6, 124.
7. Fan Y. J., and, Zong W. X., (2013) The cellular decision between apoptosis and autophagy. Chin. J. Cancer 32, 121-129.
8. Fan X., Qiu J., Yu Z., Dai H., Singhal A. B., Lo E. H., and, Wang X., (2012) A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes. Stroke 43, 567-570.
9. Goh S. Y., and, Cooper M. E., (2008) Clinical review: the role of advanced glycation end products in progression and complications of diabetes. J. Clin. Endocrinol. Metab. 93, 1143-1152.
10. Jin S., (2006) Autophagy, mitochondrial quality control, and oncogenesis. Autophagy 2, 80-84.
11. Jung H. S., Chung K. W., Won Kim J., et al,. (2008) Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab. 8, 318-324.
12. Kimura T., Takabatake Y., Takahashi A., and, Isaka Y., (2013) Chloroquine in cancer therapy: a double-edged sword of autophagy. Cancer Res. 73, 3-7.
13. Klionsky D. J., Elazar Z., Seglen P. O., and, Rubinsztein D. C., (2008) Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? Autophagy 4, 849-850.
14. Klionsky D. J., Abdalla F. C., Abeliovich H., et al,. (2012) Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8, 445-544.
15. Laakso M., (2001) Cardiovascular disease in type 2 diabetes: challenge for treatment and prevention. J. Intern. Med. 249, 225-235.
16. LaRocca T. J., Henson G. D., Thorburn A., Sindler A. L., Pierce G. L., and, Seals D. R., (2012) Translational evidence that impaired autophagy contributes to arterial ageing. J. Physiol. 590, 3305-3316.
17. Li W., Prakash R., Kelly-Cobbs A. I., Ogbi S., Kozak A., El-Remessy A. B., Schreihofer D. A., Fagan S. C., and, Ergul A., (2010) Adaptive cerebral neovascularization in a model of type 2 diabetes: relevance to focal cerebral ischemia. Diabetes 59, 228-235.
18. Li W., Qu Z., Prakash R., Chung C., Ma H., Hoda M. N., Fagan S. C., and, Ergul A., (2013a) Comparative analysis of the neurovascular injury and functional outcomes in experimental stroke models in diabetic Goto-Kakizaki rats. Brain Res. 1541, 106-114.
19. Li W., Xu H., Hu Y., He P., Ni Z., Xu H., Zhang Z., and, Dai H., (2013b) Edaravone protected human brain microvascular endothelial cells from methylglyoxal-induced injury by inhibiting AGEs/RAGE/oxidative stress. PLoS ONE 8, e76025.
20. Lok J., Sardi S. P., Guo S., Besancon E., Ha D. M., Rosell A., Kim W. J., Corfas G., and, Lo E. H., (2009) Neuregulin-1 signaling in brain endothelial cells. J. Cereb. Blood Flow Metab. 29, 39-43.
21. Ma X., Liu H., Foyil S. R., Godar R. J., Weinheimer C. J., Hill J. A., and, Diwan A., (2012) Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury. Circulation 125, 3170-3181.
22. Madden J. A., (2012) Role of the vascular endothelium and plaque in acute ischemic stroke. Neurology 79, S58-S62.
23. Mazure N. M., and, Pouyssegur J., (2010) Hypoxia-induced autophagy: cell death or cell survival? Curr. Opin. Cell Biol. 22, 177-180.
24. Mukohda M., Okada M., Hara Y., and, Yamawaki H., (2012) Exploring mechanisms of diabetes-related macrovascular complications: role of methylglyoxal, a metabolite of glucose on regulation of vascular contractility. J. Pharmacol. Sci. 118, 303-310.
25. Murata-Kamiya N., and, Kamiya H., (2001) Methylglyoxal, an endogenous aldehyde, crosslinks DNA polymerase and the substrate DNA. Nucleic Acids Res. 29, 3433-3438.
26. Najjar S., Pearlman D. M., Devinsky O., Najjar A., and, Zagzag D., (2013) Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence. J. Neuroinflammation 10, 142.
27. Ning R., Chopp M., Yan T., Zacharek A., Zhang C., Roberts C., Cui X., Lu M., and, Chen J., (2012) Tissue plasminogen activator treatment of stroke in type-1 diabetes rats. Neuroscience 222, 326-332.
28. Park S., Yamaguchi M., Zhou C., Calvert J. W., Tang J., and, Zhang J. H., (2004) Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke 35, 2412-2417.
29. Ramasamy R., Yan S. F., and, Schmidt A. M., (2012) Advanced glycation endproducts: from precursors to RAGE: round and round we go. Amino Acids 42, 1151-1161.
30. Sandilands E., Serrels B., McEwan D. G., et al,. (2012) Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat. Cell Biol. 14, 51-60.
31. Scherz-Shouval R., and, Elazar Z., (2011) Regulation of autophagy by ROS: physiology and pathology. Trends Biochem. Sci. 36, 30-38.
32. Shenouda S. M., Widlansky M. E., Chen K., et al,. (2011) Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 124, 444-453.
33. Shimamura N., Matchett G., Yatsushige H., Calvert J. W., Ohkuma H., and, Zhang J., (2006) Inhibition of integrin alphavbeta3 ameliorates focal cerebral ischemic damage in the rat middle cerebral artery occlusion model. Stroke 37, 1902-1909.
34. Shintani T., and, Klionsky D. J., (2004) Autophagy in health and disease: a double-edged sword. Science 306, 990-995.
35. Stitt A. W., Li Y. M., Gardiner T. A., Bucala R., Archer D. B., and, Vlassara H., (1997) Advanced glycation end products (AGEs) co-localize with AGE receptors in the retinal vasculature of diabetic and of AGE-infused rats. Am. J. Pathol. 150, 523-531.
36. Sun Y., Jin K., Xie L., Childs J., Mao X. O., Logvinova A., and, Greenberg D. A., (2003) VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Investig. 111, 1843-1851.
37. Tesch G. H., and, Allen T. J., (2007) Rodent models of streptozotocin-induced diabetic nephropathy. Nephrology 12, 261-266.
38. Wang Q., Liang B., Shirwany N. A., and, Zou M. H., (2011) 2-Deoxy-D-glucose treatment of endothelial cells induces autophagy by reactive oxygen species-mediated activation of the AMP-activated protein kinase. PLoS ONE 6, e17234.
39. Wu Y. T., Tan H. L., Shui G., Bauvy C., Huang Q., Wenk M. R., Ong C. N., Codogno P., and, Shen H. M., (2010) Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J. Biol. Chem. 285, 10850-10861.
40. Xie Y., You S. J., Zhang Y. L., Han Q., Cao Y. J., Xu X. S., Yang Y. P., Li J., and, Liu C. F., (2011) Protective role of autophagy in AGE-induced early injury of human vascular endothelial cells. Mol. Med. Rep. 4, 459-464.
41. Xing B., Chen H., Zhang M., Zhao D., Jiang R., Liu X., and, Zhang S., (2008) Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke 39, 2362-2369.
42. Yin D., Zhou C., Kusaka I., Calvert J. W., Parent A. D., Nanda A., and, Zhang J. H., (2003) Inhibition of apoptosis by hyperbaric oxygen in a rat focal cerebral ischemic model. J. Cereb. Blood Flow Metab. 23, 855-864.
43. Zhang Y., Hu G., Yuan Z., and, Chen L., (2012) Glycosylated hemoglobin in relationship to cardiovascular outcomes and death in patients with type 2 diabetes: a systematic review and meta-analysis. PLoS ONE 7, e42551.