Role of the vascular endothelium and plaque in acute ischemic stroke

Neurology

Volumn 79, Issue 13 SUPPL. 1, 2012, Pages

  Madden, Jane A ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; C REACTIVE PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ENDOTHELIN 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PHOSPHOTRANSFERASE; REACTIVE OXYGEN METABOLITE; 27 O [3 [2 (3 CARBOXYACRYLOYLAMINO) 5 HYDROXYPHENYL]ACRYLOYLOXY]MYRICERONE; DOXYCYCLINE; IVABRADINE; NITRIC OXIDE;

ARTICLE; ATHEROSCLEROSIS; BONE MARROW; BRAIN ISCHEMIA; DIABETES MELLITUS; ENDOTHELIAL PROGENITOR CELL; ENZYME INHIBITION; HUMAN; INFLAMMATION; LEUKOCYTE; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STROMA CELL; VASCULAR ENDOTHELIUM; BONE MARROW CELL; BRAIN ATHEROSCLEROSIS; CLINICAL TRIAL (TOPIC); DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG SAFETY; INTERVENTION STUDY;

EID: 84867559843     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182695836     Document Type: Article

References (26)

1. Malek AM, Alper SL, Izumo S. Hemodynamic shear stress and its role in atherosclerosis. JAMA 1999;282:2035-2042.
2. Lindsberg PJ, Grau AJ. Inflammation and infections as risk factors for ischemic stroke. Stroke 2003;34:2518-2532.
3. Badimon L, Vilahur G, Padro T. Lipoproteins, platelets and atherothrombosis. Rev Esp Cardiol 2009;62:1161-1178.
4. Beckman JA, Creager MA, Libby P. Diabetes and atherosclerosis: epidemiology, pathophysiology, and management. JAMA 2002;287:2570-2581.
5. Rikitake Y, Kim H-H, Huang Z, et al. Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 2005;36:2251-2257.
6. Cooper SA, Whaley-Connell A, Habibi J, et al. Reninangiotensinaldosterone system and oxidative stress in cardiovascular insulin resistance. Am J Physiol Heart Circ Physiol 2007;293:H2009-H2023.
7. Pires PW, Rogers CT, McClain JL, Garver HS, Fink GD, Dorrance AM. Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 2011;301:H87-H97.
8. Montaner J, Alvarez-Sabin J, Molina CA, et al. Matrix metalloproteinase expression is related to hemorrhagic transformation after cardioembolic stroke. Stroke 2001;32:2762-2767.
9. Fagan SC, Hess DC, Hohnadel EJ, Pollock DM, Ergul A. Targets for vascular protection after acute ischemic stroke. Stroke 2004;35:2220-2225.
10. Massberg S, Schurzinger K, Lorenz M, et al. Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb. Circulation 2005;112:1180-1188.
11. Mineo C, Gormley AK, Yuhanna IS, et al. FcγRIIB mediates C-reactive protein inhibition of endothelial NO synthase. Circ Res 2005;97:1124-1131.
12. Wang Q, Zhu X, Xu Q, Ding X, Chen YE, Song Q. Effect of C-reactive protein on gene expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol 2005;288:H1539-H1545.
13. Schwartz R, Osborne-Lawrence S, Hahner L, et al. C-reactive protein downregulates endothelial NO synthase and attenuates reendothelialization in vivo in mice. Circ Res 2007;100:1452-1459.
14. Reininger AJ, Bernlochner I, Penz SM, et al. A 2-step mechanism of arterial thrombus formation induced by human atherosclerotic plaques. J Am Coll Cardiol 2010;55:1147-1158.
15. Choi J, Kermode JC. New therapeutic approaches to combat arterial thrombosis: better drugs for old targets, novel targets, and future prospects. Mol Interv 2011;11:111-123.
16. Kelly-Cobbs AI, Harris AK, Elgebaly MM, et al. Endothelial endothelin B receptor-mediated prevention of cerebrovascular remodeling is attenuated in diabetes because of up-regulation of smooth muscle endothelin receptors. J Pharmacol Exp Ther 2011;337:9-15.
17. Moldes O, Sobrino T, Millan M, et al. High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA. Stroke 2008;39:2006-2010.
18. Chen J, Chen S, Chen Y, et al. Circulating endothelial progenitor cells and cellular membrane microparticles in db/db diabetic mouse: possible implications in cerebral ischemic damage. Am J Physiol Endocrinol Metab 2011;301:E62-E71.
19. Parmar JP, Rogers WJ, Mugler JP 3rd, et al. Magnetic resonance imaging of carotid atherosclerotic plaque in clinically suspected acute transient ischemic attack and acute ischemic stroke. Circulation 2010;122:2031-2038.
20. Endres M, Laufs U. Discontinuation of statin treatment in stroke patients. Stroke 2006;37:2640-2643.
21. Zhang RL, Zhang C, Zhang L, et al. Synergistic effect of an endothelin type A receptor antagonist, S-0139, with rtPA on the neuroprotection after embolic stroke. Stroke 2008;39:2830-2836.
22. Custodis F, Gertz K, Balkaya M, et al. Heart rate contributes to the vascular effects of chronic mental stress: effects on endothelial function and ischemic brain injury in mice. Stroke 2011;42:1742-1749.
23. Qin Z, Karabiyikoglu M, Hua Y, et al. Hyperbaric oxygeninduced attenuation of hemorrhagic transformation after experimental focal transient cerebral ischemia. Stroke 2007;38:1362-1367.
24. Rouhl RPW, van Oostenbrugge RJ, Damoiseaux J, Cohen Tervaert J-W, Lodder J. Endothelial progenitor cell research in stroke: a potential shift in pathophysiological and therapeutical concepts. Stroke 2008;39:2158-2165.
25. Chu K, Jung K-H, Lee S-T, et al. Circulating endothelial progenitor cells as a new marker of endothelial dysfunction or repair in acute stroke supplemental methods. Stroke 2008;39:1441-1447.
26. Yilmaz G, Vital S, Yilmaz CE, Stokes KY, Alexander JS, Granger DN. Selectin-mediated recruitment of bone marrow stromal cells in the postischemic cerebral microvasculature. Stroke 2011;42:806-811.