An enlarged profile of uremic solutes

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Tanaka, Hisae ^a   Sirich, Tammy L ^a   Plummer, Natalie S ^a   Weaver, Daniel S ^b   Meyer, Timothy W ^a  

^a STANFORD UNIVERSITY   (United States)

^b SRI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOPHENOL SULPHATE; 2 METHOXYPHENOL SULPHATE; 3 HYDROXYHIPPURIC ACID; 3 METHYLCATECHOL SULFATE; 3 [3 (SULFOOXY)PHENYL]PROPANOIC ACID; 4 HYDROXYHIPPURIC ACID; 4 HYDROXYPHENYLACETIC ACID; 4 VINYLPHENOL SULFATE; AMINO ACID; ANTHRANILIC ACID; BENZENE DERIVATIVE; CINNAMOYLGLYCINE; HIPPURIC ACID; HOMOVANILLIC ACID SULFATE; IMIDAZOLEPROPIONIC ACID; INDOLE DERIVATIVE; INDOLEACETIC ACID; INDOLEACETYL GLUTAMINE; INDOLELACTIC ACID; ISOVALERYLGLYCINE; KYNURENIC ACID; PHENOL SULPHATE; PHENYLACETIC ACID; PHENYLACETYLGLYCINE; PYROCATECHOL SULFATE; QUINOLINIC ACID; TIGLYLGLYCINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANILLIC ACID; VANILMANDELIC ACID; INDOLE; POLYPHENOL;

ARTICLE; BIOACCUMULATION; BLOOD LEVEL; CLINICAL ARTICLE; COLON RESECTION; CONTROLLED STUDY; GAS CHROMATOGRAPHY; HEMODIALYSIS PATIENT; HUMAN; KIDNEY FAILURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; PROTEIN ANALYSIS; PROTEIN FUNCTION; ULTRAFILTRATION; UREMIA; AGED; BLOOD; CASE CONTROL STUDY; FEMALE; HEMODIALYSIS; MALE; METABOLOME; MIDDLE AGED; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; FEMALE; HUMANS; INDOLES; MALE; METABOLOME; MIDDLE AGED; POLYPHENOLS; RENAL DIALYSIS; RENAL INSUFFICIENCY; UREMIA;

EID: 84943328573     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135657     Document Type: Article

References (50)

1. Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, et al. Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012;23(7):1258-70. doi: 10.1681/ASN. 2011121175 PMID: 22626821
2. Niwa T. Update of uremic toxin research by mass spectrometry. Mass Spectrom Rev. 2011;30(3):510-21. doi: 10.1002/mas.20323 PMID: 21328600
3. Kikuchi K, Itoh Y, Tateoka R, Ezawa A, Murakami K, Niwa T. Metabolomic analysis of uremic toxins by liquid chromatography/electrospray ionization-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2010;878(20):1662-8. doi: 10.1016/j.jchromb.2009.11.040 PMID: 20036201
4. Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, et al. Metabolite profiling identifies markers of uremia. J Am Soc Nephrol. 2010;21(6):1041-51. doi: ASN.2009111132 [pii] doi: 10.1681/ASN. 2009111132 PMID: 20378825
5. Toyohara T, Akiyama Y, Suzuki T, Takeuchi Y, Mishima E, Tanemoto M, et al. Metabolomic profiling of uremic solutes in CKD patients. Hypertens Res. 2010;33(9):944-52. doi: 10.1038/hr.2010.113 PMID: 20613759
6. Sato E, Kohno M, Yamamoto M, Fujisawa T, Fujiwara K, Tanaka N. Metabolomic analysis of human plasma from haemodialysis patients. Eur J Clin Invest. 2011;41(3):241-55. doi: 10.1111/j.1365-2362. 2010.02398.x PMID: 20955218
7. Aronov PA, Luo FJ, Plummer NS, Quan Z, Holmes S, Hostetter TH, et al. Colonic contribution to uremic solutes. J Am Soc Nephrol. 2011;22(9):1769-76. doi: 10.1681/ASN.2010121220 PMID: 21784895
8. Yu B, Zheng Y, Nettleton JA, Alexander D, Coresh J, Boerwinkle E. Serum metabolomic profiling and incident CKD among African Americans. Clin J Am Soc Nephrol. 2014;9(8):1410-7. doi: 10.2215/CJN. 11971113 PMID: 25011442
9. Boelaert J, D'kindt R, Schepers E, Jorge L, Glorieux G, Neirynck N, et al. State-of-the-are non-targeted metabolomics in the study of chronic kidney disease. Metabolomics. 2014;10:425-42. doi: 10.1007/s11306-013-0592-z
10. Vanholder R, Schepers E, Pletinck A, Nagler EV, Glorieux G. The uremic toxicity of indoxyl sulfate and p-cresyl sulfate: a systematic review. Journal of the American Society of Nephrology: JASN. 2014;25(9):1897-907. doi: 10.1681/ASN.2013101062 PMID: 24812165
11. Sirich TL, Funk BA, Plummer NS, Hostetter TH, Meyer TW. Prominent accumulation in hemodialysis patients of solutes normally cleared by tubular secretion. Journal of the American Society of Nephrology: JASN. 2014;25(3):615-22. doi: 10.1681/ASN.2013060597 PMID: 24231664
12. Evans AM, De Haven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem. 2009;81(16):6656-67. doi: 10.1021/ac901536h PMID: 19624122
13. Dehaven CD, Evans AM, Dai H, Lawton KA. Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J Cheminform. 2010;2(1):9. doi: 10.1186/1758-2946-2-9 PMID: 20955607
14. Caspi R, Altman T, Billington R, Dreher K, Foerster H, Fulcher CA, et al. The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases. Nucleic Acids Res. 2014;42(Database issue):D459-71. doi: 10.1093/nar/gkt1103 PMID: 24225315
15. Wishart DS, Jewison T, Guo AC, Wilson M, Knox C, Liu Y, et al. HMDB3.0-The Human Metabolome Database in 2013. Nucleic Acids Res. 2013;41(Database issue):D801-7. doi: 10.1093/nar/gks1065 PMID: 23161693
16. Consortium HM. Aframeworkfor human microbiome research. Nature. 2012;486(7402):215-21. doi: 10.1038/nature11209 PMID: 22699610
17. Vanholder R, De Smet R, Glorieux G, Argiles A, Baurmeister U, Brunet P, et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 2003;63(5):1934-43. doi: kid924 [pii] doi: 10.1046/j.1523-1755.2003.00924.x PMID: 12675874
18. Itoh Y, Ezawa A, Kikuchi K, Tsuruta Y, Niwa T. Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography/tandem mass spectrometry and their effects on endothelial ROS production. Anal Bioanal Chem. 2012;403(7):1841-50. doi: 10.1007/s00216-012-5929-3 PMID: 22447217
19. Sirich TL, Aronov PA, Plummer NS, Hostetter TH, Meyer TW. Numerous protein-bound solutes are cleared by the kidney with high efficiency. Kidney Int. 2013;84(3):585-90. doi: 10.1038/ki.2013.154 PMID: 23636170
20. Niwa T, Yamamoto N, Maeda K, Yamada K, Ohki T, Mori M. Gas chromatographic-mass spectrometric analysis of polyols in urine and serum of uremic patients. Identification of new deoxyalditols and inositol isomers. J Chromatogr. 1983;277:25-39. PMID: 6643610
21. Roboz J, Kappatos D, Holland JF. Polyol concentrations in serum during hemodialysis. ClinChem. 1990;36(12):2082-6. PMID: 2253350
22. Meyer TW, Hostetter TH. Uremic solutes from colon microbes. Kidney Int. 2012;81(10):949-54. doi: 10.1038/ki.2011.504 PMID: 22318422
23. Mogk A, Bukau B. Cell biology. When the beginning marks the end. Science. 2010;327(5968):966-7. doi: 10.1126/science.1187274 PMID: 20167776
24. Sass JO, Mohr V, Olbrich H, Engelke U, Horvath J, Fliegauf M, et al. Mutations in ACY1, the gene encoding aminoacylase 1, cause a novel inborn error of metabolism. Am J Hum Genet. 2006;78(3):401-9. doi: 10.1086/500563 PMID: 16465618
25. Lindner HA, Tafler-Naumann M, Rohm KH. N-acetylamino acid utilization by kidney aminoacylase-1. Biochimie. 2008;90(5):773-80. doi: 10.1016/j.biochi.2007.12.006 PMID: 18222180
26. Young VR, Alexis SD, Baliga BS, Munro HN, Muecke W. Metabolism of administered 3-methylhistidine. Lack of muscle transfer ribonucleic acid charging and quantitative excretion as 3-methylhistidine and its N-acetyl derivative. The Journal of biological chemistry. 1972;247(11):3592-600. PMID: 5030632
27. Boldyrev AA, Aldini G, Derave W. Physiology and pathophysiology of carnosine. Physiol Rev. 2013;93(4):1803-45. doi: 10.1152/physrev. 00039.2012 PMID: 24137022
28. Sjolin J, Hjort G, Friman G, Hambraeus L. Urinary excretion of 1-methylhistidine: a qualitative indicator of exogenous 3-methylhistidine and intake of meats from various sources. Metabolism. 1987;36(12):1175-84. PMID: 3683186
29. Raj DS, Ouwendyk M, Francoeur R, Pierratos A. Plasma amino acid profile on nocturnal hemodialysis. Blood Purif. 2000;18(2):97-102. doi: 14431. PMID: 10838467
30. Dou L, Sallee M, Cerini C, Poitevin S, Gondouin B, Jourde-Chiche N, et al. The Cardiovascular Effect of the Uremic Solute Indole-3 Acetic Acid. Journal of the American Society of Nephrology: JASN. 2014. doi: 10.1681/ASN.2013121283
31. Biesaga M, Ochnik U, Pyrzynska K. Analysis of phenolic acids in fruits by HPLCwith monolithic columns. J Sep. Sci. 2007;30(17):2929-34. doi: 10.1002/jssc.200700247 PMID: 17960844
32. Vine JH, Noiton D, Plummer JA, Baleriola-Lucas C, Mullins MG. Simultaneous quantitation of indole 3-acetic Acid and abscisic Acid in small samples of plant tissue by gas chromatography/mass spectrometry/selected ion monitoring. Plant Physiol. 1987;85(2):419-22. PMID: 16665713
33. Goldstein DS, Eisenhofer G, Kopin IJ. Sources and significance of plasma levels of catechols and their metabolites in humans. The Journal of pharmacology and experimental therapeutics. 2003;305(3):800-11. doi: 10.1124/jpet.103.049270 PMID: 12649306
34. Uribarri J. The obsession with high dietary protein intake in ESRD patients on dialysis: is it justified? Nephron. 2000;86(2):105-8. doi: nef86105[pii]. PMID: 11014977
35. Cathcart-Rake W, Porter R, Whittier F, Stein P, Carey M, Grantham J. Effect of diet on serum accumulation and renal excretion of aryl acids and secretory activity in normal and uremic man. Am J Clin Nutr. 1975;28(10):1110-5. PMID: 1180247
36. Crozier A, Jaganath IB, Clifford MN. Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep. 2009;26(8):1001-43. doi: 10.1039/b802662a PMID: 19636448
37. Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients. 2010;2(12):1231-46. doi: 10. 3390/nu2121231 PMID: 22254006
38. Williamson G, Clifford MN. Colonic metabolites of berry polyphenols: the missing link to biological activity? The British journal of nutrition. 2010;104 Suppl 3:S48-66. doi: 10.1017/S0007114510003946 PMID: 20955650
39. Cardona F, Andres-Lacueva C, Tulipani S, Tinahones FJ, Queipo-Ortuno MI. Benefits of polyphenols on gut microbiota and implications in human health. J NutrBiochem. 2013;24(8):1415-22. doi: 10. 1016/j.jnutbio.2013.05.001 PMID: 23849454
40. Schepers E, Glorieux G, Vanholder R. The gut: the forgotten organ in uremia? Blood Purif. 2010;29(2):130-6. doi: 000245639 [pii] doi: 10.1159/000245639 PMID: 20093818
41. Poesen R, Meijers B, Evenepoel P. The colon: an overlooked site for therapeutics in dialysis patients. Semin Dial. 2013;26(3):323-32. doi: 10.1111/sdi.12082 PMID: 23458264
42. Wood A, Baxter G, Thies F, Kyle J, Duthie G. A systematic review of salicylates in foods: estimated daily intake of a Scottish population. Mol Nutr Food Res. 2011;55 Suppl 1:S7-S14. doi: 10.1002/mnfr. 201000408 PMID: 21351247
43. Clase CM, Ki V, Holden RM. Water-soluble vitamins in people with low glomerular filtration rate or on dialysis: a review. Semin Dial. 2013;26(5):546-67. doi: 10.1111/sdi.12099 PMID: 23859229
44. Tucker BM, Safadi S, Friedman AN. Is Routine Multivitamin Supplementation Necessary in US Chronic Adult Hemodialysis Patients? A Systematic Review. Journal of renal nutrition: the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2014. doi: 10.1053/j.jrn. 2014.09.003
45. Lindner A, Bankson DD, Stehman-Breen C, Mahuren JD, Coburn SP. Vitamin B6 metabolism and homocysteine in end-stage renal disease and chronic renal insufficiency. American journal of kidney diseases: the official journal of the National Kidney Foundation. 2002;39(1):134-45. doi: 10.1053/ajkd. 2002.29904
46. Kalim S, Clish CB, Wenger J, Elmariah S, Yeh RW, Deferio JJ, et al. A plasma long-chain acylcarnitine predicts cardiovascular mortality in incident dialysis patients. J Am Heart Assoc. 2013;2(6):e000542. doi: 10.1161/JAHA. 113.000542 PMID: 24308938
47. Fagugli RM, De Smet R, Buoncristiani U, Lameire N, Vanholder R. Behavior of non-protein-bound and protein-bound uremic solutes during daily hemodialysis. Am J Kidney Dis. 2002;40(2):339-47. PMID: 12148107
48. Meyer TW, Leeper EC, Bartlett DW, Depner TA, Lit YZ, Robertson CR, et al. Increasing dialysate flow and dialyzer mass transfer area coefficient to increase the clearance of protein-bound solutes. Journal of the American Society of Nephrology: JASN. 2004;15(7):1927-35. PMID: 15213283
49. Yeung CK, Shen DD, Thummel KE, Himmelfarb J. Effects of chronic kidney disease and uremia on hepatic drug metabolism and transport. Kidney Int. 2014;85(3):522-8. doi: 10.1038/ki.2013.399 PMID: 24132209
50. Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, et al. The human serum metabolome. PLoSOne. 2011;6(2):e16957. doi: 10.1371/journal.pone.0016957 PMID: 21359215