Metabolomic analysis of human plasma from haemodialysis patients

European Journal of Clinical Investigation

Volumn 41, Issue 3, 2011, Pages 241-255

  Sato, Emiko ^a   Kohno, Masahiro ^a   Yamamoto, Masanori ^b   Fujisawa, Tatsuya ^c   Fujiwara, Kouichi ^c   Tanaka, Noriaki ^b,c  

^a TOHOKU UNIVERSITY   (Japan)

^b Hojyo Tanaka Hospital   (Japan)

^c Kiyokai Tanaka Kitanoda Hospital   (Japan)

Author keywords

Biomarkers; Haemodialysis; LC MS MS; Uraemic toxin

Indexed keywords

BIOLOGICAL MARKER; CREATININE; UREA;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HEMODIALYSIS; HUMAN; KIDNEY FAILURE; LIQUID CHROMATOGRAPHY; MALE; METABOLOMICS; MOLECULAR WEIGHT; PRIORITY JOURNAL; TIME OF FLIGHT MASS SPECTROMETRY;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; COHORT STUDIES; CREATININE; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; KIDNEY FUNCTION TESTS; MALE; METABOLOMICS; MIDDLE AGED; RENAL DIALYSIS; UREA;

EID: 79551665941     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2010.02398.x     Document Type: Article

References (16)

1. Lindon JC, Holmes E, Nicholson JK. Metabonomics techniques and applications to pharmaceutical research & development. Pharm Res 2006;23:1075-88.
2. Lemmel C, Stevanovic S. The use of HPLC-MS in T-cell epitope identification. Methods 2003;29:248-59.
3. Fenn JB. Electrospray wings for molecular elephants (Nobel Lecture). Angew Chem Int Ed 2003;42:3871.
4. Lysaght MJ. Maintenance dialysis population dynamics: current trends and long-term implications. J Am Soc Nephrol 2002;13(Suppl. 1):S37-40.
5. Vanholder R, De Smet R, Glorieux G, Argiles A, Baurmeister U, Brunet P et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003;63:1934-43.
6. Iseki K. Chronic kidney disease in Japan. Intern Med 2008;47:681-9.
7. Morton AR, Singer MA. The problem with Kt/V: dialysis dose should be normalized to metabolic rate not volume. Semin Dial 2007;20:12-5.
8. Vanholder R, De Smet R. Pathophysiologic effects of uremic retention solutes. J Am Soc Nephrol 1999;10:1815-23.
9. Vanholder R, DeSmet R, Lesaffer G. Dissociation between dialysis adequacy and Kt/V. Semin Dial 2002;15:3-7.
10. Lesaffer G, De Smet R, Lameire N, Dhondt A, Duym P, Vanholder R. Intradialytic removal of protein-bound uraemic toxins: role of solute characteristics and of dialyser membrane. Nephrol Dial Transplant 2000;15:50-7.
11. Li HY, Wang SM, Liu HM, Bu SS, Li J, Han D et al. Separation and identification of purine nucleosides in the urine of patients with malignant cancer by reverse phase liquid chromatography/electrospray tandem mass spectrometry. J Mass Spectrom 2009;44:641-51.
12. Bond A, Dudley E, Lemiere F, Tuytten R, El-Sharkawi S, Brenton AG et al. Analysis of urinary nucleosides. V. Identification of urinary pyrimidine nucleosides by liquid chromatography/electrospray mass spectrometry. Rapid Commun Mass Spectrom 2006;20:137-50.
13. Dudley E, Lemiere F, Van Dongen W, Tuytten R, El-Sharkawi S, Brenton AG et al. Analysis of urinary nucleosides. IV. Identification of urinary purine nucleosides by liquid chromatography/electrospray mass spectrometry. Rapid Commun Mass Spectrom 2004;18:2730-8.
14. Chan W, Cai Z. Aristolochic acid induced changes in the metabolic profile of rat urine. J Pharm Biomed Anal 2008;46:757-62.
15. Kim K, Aronov P, Zakharkin SO, Anderson D, Perroud B, Thompson IM et al. Urine metabolomics analysis for kidney cancer detection and biomarker discovery. Mol Cell Proteomics 2009;8:558-70.
16. Wang X, Lv H, Zhang G, Sun W, Zhou D, Jiao G et al. Development and validation of a ultra performance LC-ESI/MS method for analysis of metabolic phenotypes of healthy men in day and night urine samples. J Sep Sci 2008;31:2994-3001.