Aerobic and resistance training do not influence plasma carnosinase content or activity in type 2 diabetes

American Journal of Physiology - Endocrinology and Metabolism

Volumn 309, Issue 7, 2015, Pages E663-E669

  Stegen, Sanne ^a   Sigal, Ronald J ^b,c,d   Kenny, Glen P ^c,d   Khandwala, Farah ^e   Yard, Benito ^f   De Heer, Emile ^g   Baelde, Hans ^g   Peersman, Wim ^a   Derave, Wim ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF CALGARY   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^e ALBERTA HEALTH SERVICES   (Canada)

^f UNIVERSITY OF HEIDELBERG   (Germany)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Carnosinase activity and content; Carnosine; CNDP1; Histidine containing dipeptides

Indexed keywords

ANTIDIABETIC AGENT; CARNOSINASE; CARNOSINE; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; UNCLASSIFIED DRUG; CNDP1 PROTEIN, HUMAN; DIPEPTIDASE; GLUCOSE BLOOD LEVEL; LIPID;

ADULT; AEROBIC EXERCISE; ARTICLE; BLOOD PRESSURE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PARALLEL DESIGN; PRIORITY JOURNAL; PROTEIN CONTENT; RANDOMIZED CONTROLLED TRIAL; RESISTANCE TRAINING; SEX DIFFERENCE; AGE; BLOOD; EXERCISE; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; AGE FACTORS; BLOOD GLUCOSE; BLOOD PRESSURE; DIABETES MELLITUS, TYPE 2; DIPEPTIDASES; EXERCISE; FEMALE; HUMANS; LIPIDS; MALE; MIDDLE AGED; RESISTANCE TRAINING; SEX FACTORS;

EID: 84943278695     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00142.2015     Document Type: Article

References (39)

1. No authors listed. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20: 1183-1197, 1997.
2. Adelmann K, Frey D, Riedl E, Koeppel H, Pfister F, Peters V, Schmitt CP, Sternik P, Hofmann S, Zentgraf HW, Navis G, van den Born J, Bakker SJ, Kramer BK, Yard BA, Hauske SJ. Different conformational forms of serum carnosinase detected by a newly developed sandwich ELISA for the measurements of carnosinase concentrations. Amino Acids 43: 143-151, 2012.
3. Aldini G, Orioli M, Rossoni G, Savi F, Braidotti P, Vistoli G, Yeum KJ, Negrisoli G, Carini M. The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats. J Cell Mol Med 15: 1339-1354, 2011.
4. Baba SP, Hoetker JD, Merchant M, Klein JB, Cai J, Barski OA, Conklin DJ, Bhatnagar A. Role of aldose reductase in the metabolism and detoxification of carnosine-acrolein conjugates. J Biol Chem 288: 28163-28179, 2013.
5. Baguet A, Everaert I, De Naeyer H, Reyngoudt H, Stegen S, Beeckman S, Achten E, Vanhee L, Volkaert A, Petrovic M, Taes Y, Derave W. Effects of sprint training combined with vegetarian or mixed diet on muscle carnosine content and buffering capacity. Eur J Appl Physiol 111: 2571-2580, 2011.
6. Baguet A, Everaert I, Yard B, Peters V, Zschocke J, Zutinic A, De Heer E, Podgórski T, Domaszewska K, Derave W. Does low serum carnosinase activity favor high-intensity exercise capacity? J Appl Physiol (1985) 116: 553-559, 2014.
7. Bando K, Shimotsuji T, Toyoshima H, Hayashi C, Miyai K. Fluorometric assay of human serum carnosinase activity in normal children, adults and patients with myopathy. Ann Clin Biochem 21: 510-514, 1984.
8. Boldyrev AA, Aldini G, Derave W. Physiology and pathophysiology of carnosine. Physiol Rev 93: 1803-1845, 2013.
9. Cencioni C, Spallotta F, Greco S, Martelli F, Zeiher AM, Gaetano C. Epigenetic mechanisms of hyperglycemic memory. Int J Biochem Cell Biol 51: 155-158, 2014.
10. Decker EA, Livisay SA, Zhou S. A re-evaluation of the antioxidant activity of purified carnosine. Biochemistry (Mosc) 65: 766-770, 2000.
11. Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, Taes Y, de Heer E, Derave W. Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans. Amino Acids 40: 1221-1229, 2011.
12. Everaert I, Taes Y, De Heer E, Baelde H, Zutinic A, Yard B, Sauerhöfer S, Vanhee L, Delanghe J, Aldini G, Derave W. Low plasma carnosinase activity promotes carnosinemia after carnosine ingestion in humans. Am J Physiol Renal Physiol 302: F1537-F1544, 2012.
13. Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Xu J, McDonough C, Janssen B, Yard BA, van der Woude FJ, Bowden DW. A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans. Nephrol Dial Transplant 22: 1131-1135, 2007.
14. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502, 1972.
15. Hipkiss AR, Michaelis J, Syrris P. Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent. FEBS Lett 371: 81-85, 1995.
16. Ishikawa Y, Gohda T, Tanimoto M, Omote K, Furukawa M, Yamaguchi S, Murakoshi M, Hagiwara S, Horikoshi S, Funabiki K, Tomino Y. Effect of exercise on kidney function, oxidative stress, and inflammation in type 2 diabetic KK-A(y) mice. Exp Diabetes Res 2012: 702948, 2012.
17. Jackson MC, Kucera CM, Lenney JF. Purification and properties of human serum carnosinase. Clin Chim Acta 196: 193-205, 1991.
18. Janssen B, Hohenadel D, Brinkkoetter P, Peters V, Rind N, Fischer C, Rychlik I, Cerna M, Romzova M, de Heer E, Baelde H, Bakker SJ, Zirie M, Rondeau E, Mathieson P, Saleem MA, Meyer J, Koppel H, Sauerhoefer S, Bartram CR, Nawroth P, Hammes HP, Yard BA, Zschocke J, van der Woude FJ. Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. Diabetes 54: 2320-2327, 2005.
19. Kamenov ZA, Parapunova RA, Georgieva RT. Earlier development of diabetic neuropathy in men than in women with type 2 diabetes mellitus. Gend Med 7: 600-615, 2010.
20. Lee YT, Hsu CC, Lin MH, Liu KS, Yin MC. Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation. Eur J Pharmacol 513: 145-150, 2005.
21. Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS. Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium. Clin Chim Acta 123: 221-231, 1982.
22. Menini S, Iacobini C, Ricci C, Scipioni A, Blasetti FC, Giaccari A, Salomone E, Canevotti R, Lapolla A, Orioli M, Aldini G, Pugliese G. D-Carnosine octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation. Br J Pharmacol 166: 1344-1356, 2012.
23. Metz TO, Alderson NL, Thorpe SR, Baynes JW. Pyridoxamine, an inhibitor of advanced glycation and lipoxidation reactions: a novel therapy for treatment of diabetic complications. Arch Biochem Biophys 419: 41-49, 2003.
24. Mong MC, Chao CY, Yin MC. Histidine and carnosine alleviated hepatic steatosis in mice consumed high saturated fat diet. Eur J Pharmacol 653: 82-88, 2011.
25. Mooyaart AL, Zutinic A, Bakker SJ, Grootendorst DC, Kleefstra N, van Valkengoed IG, Bohringer S, Bilo HJ, Dekker FW, Bruijn JA, Navis G, Janssen B, Baelde HJ, de Heer E. Association between CNDP1 genotype and diabetic nephropathy is sex specific. Diabetes 59: 1555-1559, 2010.
26. Nagai K, Niijima A, Yamano T, Otani H, Okumra N, Tsuruoka N, Nakai M, Kiso Y. Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nerves. Exp Biol Med (Maywood) 228: 1138-1145, 2003.
27. Peters V, Jansen EE, Jakobs C, Riedl E, Janssen B, Yard BA, Wedel J, Hoffmann GF, Zschocke J, Gotthardt D, Fischer C, Koppel H. Anserine inhibits carnosine degradation but in human serum carnosinase (CN1) is not correlated with histidine dipeptide concentration. Clin Chim Acta 412: 263-267, 2011.
28. Peters V, Kebbewar M, Jansen EW, Jakobs C, Riedl E, Koeppel H, Frey D, Adelmann K, Klingbeil K, Mack M, Hoffmann GF, Janssen B, Zschocke J, Yard BA. Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity. Amino Acids 38: 1607-1615, 2010.
29. Peters V, Schmitt CP, Zschocke J, Gross ML, Brismar K, Forsberg E. Carnosine treatment largely prevents alterations of renal carnosine metabolism in diabetic mice. Amino Acids 42: 2411-2416, 2011.
30. Pfister F, Riedl E, Wang Q, vom Hagen F, Deinzer M, Harmsen MC, Molema G, Yard B, Feng Y, Hammes HP. Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy. Cell Physiol Biochem 28: 125-136, 2011.
31. Riedl E, Koeppel H, Pfister F, Peters V, Sauerhoefer S, Sternik P, Brinkkoetter P, Zentgraf H, Navis G, Henning RH, van den Born J, Bakker SJ, Janssen B, van der Woude FJ, Yard BA. N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia. Diabetes 59: 1984-1990, 2010.
32. Riedl E, Pfister F, Braunagel M, Brinkkotter P, Sternik P, Deinzer M, Bakker SJ, Henning RH, van den Born J, Kramer BK, Navis G, Hammes HP, Yard B, Koeppel H. Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats. Cell Physiol Biochem 28: 279-288, 2011.
33. Sauerhofer S, Yuan G, Braun GS, Deinzer M, Neumaier M, Gretz N, Floege J, Kriz W, van der Woude F, Moeller MJ. L-carnosine, a substrate of carnosinase-1, influences glucose metabolism. Diabetes 56: 2425-2432, 2007.
34. Sigal RJ, Kenny GP, Boule NG, Wells GA, Prud'homme D, Fortier M, Reid RD, Tulloch H, Coyle D, Phillips P, Jennings A, Jaffey J. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 147: 357-369, 2007.
35. Soliman K, Mohamed A, Metwally N. Attenuation of some metabolic deteriorations induced by diabetes mellitus using carnosine. J Appl Sci 7: 2252-2260, 2007.
36. Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, Ganzhorn AJ, Guenet C, Heintzelmann B, Laucher V, Sauvage C, Smirnova T. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. J Biol Chem 278: 6521-6531, 2003.
37. Tonna S, El-Osta A, Cooper ME, Tikellis C. Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms. Nat Rev Nephrol 6: 332-341, 2010.
38. Ward KM, Mahan JD, Sherman WM. Aerobic training and diabetic nephropathy in the obese Zucker rat. Ann Clin Lab Sci 24: 266-277, 1994.
39. Zhu JM, Wang B, Li J, Chen GM, Fan YG, Feng CC, Pan HF, Ye DQ. D18S880 microsatellite polymorphism of carnosinase gene and diabetic nephropathy: a meta-analysis. Genet Test Mol Biomarkers 17: 289-294, 2013.