Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity

Amino Acids

Volumn 38, Issue 5, 2010, Pages 1607-1615

  Peters, Verena ^a   Kebbewar, Moustafa ^a   Jansen, Erwin W ^b   Jakobs, Cornelis ^b   Riedl, Eva ^c   Koeppel, Hannes ^c   Frey, Dirk ^c   Adelmann, Katja ^c   Klingbeil, Kristina ^a   MacK, Matthias ^d   Hoffmann, Georg F ^a   Janssen, Bart ^a   Zschocke, Johannes ^a,e   Yard, Benito A ^c  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d MANNHEIM UNIVERSITY OF APPLIED SCIENCES   (Germany)

^e INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Carnosinase; Carnosine; CN1; Diabetic nephropathy; Homocarnosine

Indexed keywords

AMINOACYLHISTIDINE DIPEPTIDASE; BIOLOGICAL MARKER; CARNOSINE; DIPEPTIDASE; DITHIOTHREITOL; HISTIDINE; HOMOCARNOSINASE; HOMOCARNOSINE; PEPTIDE HYDROLASE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; AMINOACYL-HISTIDINE DIPEPTIDASE; DRUG DERIVATIVE;

ADULT; AGE; ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BLOOD ANALYSIS; CEREBROSPINAL FLUID LEVEL; CHILD; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE PREDISPOSITION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME CONFORMATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME MECHANISM; ENZYME REGULATION; ENZYME SPECIFICITY; FEMALE; HUMAN; INFANT; MALE; MOUSE; NEWBORN; NONHUMAN; NORMAL HUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; SCHOOL CHILD; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; METABOLISM; MIDDLE AGED; REFERENCE VALUE;

ADULT; ALLOSTERIC REGULATION; ANIMALS; BLOTTING, WESTERN; CARNOSINE; CHILD; DIPEPTIDASES; FEMALE; HUMANS; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; REFERENCE VALUES;

EID: 77955408218     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-009-0367-z     Document Type: Article

References (35)

1. Aydogan S, Yapislar H, Artis S et al (2008) Impaired erythrocytes deformability in H82)O(2)-induced oxidative stress: protective effect of L-carnosine. Clin Hemorheaol Microcirc 39:93-98 (Pubitemid 352039987)
2. Baguet A, Reyngoudt H, Pottier A et al (2009) Carnosine loading and washout in human skeletal muscles. J Appl Physiol 106:837-842
3. Balion CM, Benson C, Raina PS et al (2007) Brain type carnosinase in dementia: a pilot study. BMC Neurol 7:38
4. Bando K, Shimotsuji T, Toyoshima H (1984) Fluorometric assay of human serum carnosinase activity in normal children, adults and patients with myopathy. Ann Clin Biochem 21:510-514 (Pubitemid 15223532)
5. Baran EJ (2000) Metal complexes of carnosine. Biochemistry (Mosc) 65:757-765
6. Baslow MH (2009) A novel key-lock mechanism for inactivating amino acid neurotransmitters during transit across extracellular space. Amino Acids (epub ahead of print)
7. Bauer K (2005) Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brain. Neurochem Res 30:1339-1345 (Pubitemid 41772281)
8. Boldyrev AA (1993) Does carnosine possess direct antioxidant activity? Int J Biochem 25:1101-1107 (Pubitemid 23236246)
9. Boldyrev AA, Severin SE (1990) The histidine-containing dipeptides, carnosine and anserine: distribution, properties and biological significance. Adv Enzyme Regul 30:175-194
10. Boldyrev AA, Koldobski A, Kurella E et al (1993) Natural histidinecontaining dipeptide carnosine as a potent hydrophilic antioxidant with membrane stabilizing function. A biomedical aspect. Mol Chem Neuropathol 19:185-192 (Pubitemid 23183448)
11. Crush KG (1970) Carnosine and related substances in animal tissues. Comp Biochem Physiol 34:3-30
12. Duane P, Peters TJ (1988) Serum carnosinase activities in patients with alcoholic chronic skeletal muscle myopathy. Clin Sci (Lond) 75:185-190
13. Dunnett M, Harris RC, Dunnett CE et al (2002) Plasma carnosine concentration: diurnal variation and effects of age, exercise and muscle damage. Equine Vet J Suppl 34:283-287
14. Gjessing LR, Lunde HA, Morkid L et al (1990) Inborn errors of carnosine and homocarnosine metabolism. J Neural Transm Suppl 29:91-106
15. Hipkiss AR (1998) Carnosine, a protective, anti-ageing peptide? Int J Biochem Cell Biol 30:863-868 (Pubitemid 28383391)
16. Jansen EW, Gibson KM, Shigematsu Y et al (2006) A novel, quantitative assay for homocarnosine in cerebrospinal fluid using stable-isotope dilution liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 830:196-200 (Pubitemid 43078487)
17. Janssen B, Hohenadel D, Brinkkoetter P et al (2005) Carnosine as a protective factor in diabetic nephropathy. Association with a leucine repeat of the carnosinase gene CNDP1. Diabetes 54:2320-2327 (Pubitemid 41134258)
18. Kendrick IP, Harris RC, Kim HJ et al (2008) The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition. Amino Acids 34:547-554
19. Kim HJ (2009) Comparison of the carnosine and taurine contents of vastus lateralis of elderly Korean males, with impaired glucose tolerance, and young elite Korean swimmers. Amino Acids 36:359-363
20. Lenney JF, Georg RP, Weiss AM et al (1982) Human serum carnosinase: characterization, distinction from cellular carnosinase, and actvitation by cadmium. Clin Chim Acta 123:221-231 (Pubitemid 12098576)
21. Lenney JF, Peppers SC, Kucera-Orallo CM et al (1985) Characterization of human tissue carnosinsase. Biochem J 228:653-660
22. Margolis FL, Grillo M, Brown CE et al (1979) Enzymatic and immunological evidence for two forms of carnosinase in the mouse. Biochim Biophys Acta 570:311-323 (Pubitemid 10237248)
23. McFarland GA, Holliday R (1994) Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp Cell Res 212:167-175 (Pubitemid 24216690)
24. Min J, Senut MC, Rajanikant K (2008) Differential neuroprotective effects of carnosine, anserine and N-acetyl carnosine against permanent focal ischemia. J Neurosci Res 86:2984-2991
25. Pegova A, Abe H, Boldyrev A (2000) Hydrolysis of carnosine and related compounds by mammalian carnosinases. Comp Biochem Physiol B Biochem Mol Biol 127:443-446
26. Perry TL, Hansen S, Stedman D et al (1968) Homocarnosine in human cerebrospinal fluid: an age-dependent phenomenon. J Neurochem 15:1203-1206
27. Perry TL, Hansen S, Kennedy J (1974) CSF amino acids and plasma- CSF amino acid ratios in adults. J Neurochem 24:587-589
28. Quinn PJ, Boldyrev AA, Formazuyk VE (1992) Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med 13:379-444 (Pubitemid 23152963)
29. Schönherr J (2002) Analysis of products of animal origin in feeds by determination of carnosine and related dipeptides by highperformance liquid chromatography. J Agric Food Chem 27:1945-1950 (Pubitemid 34259993)
30. Tabakman R, Lazarovici P, Kohen R (2002) Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia. J Neurosci Res 68:463-469 (Pubitemid 34461577)
31. Teufel M, Saudek V, Ledig J-P et al (2003) Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. JBC 278:6521-6531 (Pubitemid 36800914)
32. Trombley PQ, Horning MS, Blakemore LJ (2000) Interactions between carnosine and zinc and copper: implications for neuromodulation and neuroprotection. Biochemistry (Mosc) 65:807-816
33. Vistoli G, Pedretti A, Cattaneo M et al (2006) Homology modelling of human serum carnosinase, a potential medicinal target, and MD simulation of its allosteric activation by citrate. J Med Chem 49(11):3269-3277 (Pubitemid 43830524)
34. Wassif WS, Sherwood RA, Amir A (1994) Serum carnosinase activities in central nervous system disorders. Clin Chim Acta 225:57-64 (Pubitemid 24118483)
35. Willi SM, Zhang Y, Hill JB et al (1997) A deletion in the long arm of chromosome 18 in a child with serum carnosinase deficiency. Pediatr Res 41:210-213 (Pubitemid 27066345)