Association between CNDP1 genotype and diabetic nephropathy is sex specific

Diabetes

Volumn 59, Issue 6, 2010, Pages 1555-1559

  Mooyaart, Antien L ^a   Zutinic, Ana ^a   Bakker, Stephan J L ^b   Grootendorst, Diana C ^a   Kleefstra, Nanne ^c,d   Van Valkengoed, Irene G M ^e   Böhringer, Stefan ^a   Bilo, Henk J G ^b,c   Dekker, Friedo W ^a   Bruijn, Jan Anthonie ^a   Navis, Gerjan ^b   Janssen, Bart ^f,g   Baelde, Hans J ^a   De Heer, Emile ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c ISALA HOSPITAL   (Netherlands)

^d LANGERHANS MEDICAL RESEARCH GROUP   (Netherlands)

^e ACADEMIC MEDICAL CENTER   (Netherlands)

^f Human Genetics   (Germany)

^g ServiceXS   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOACYLHISTIDINE DIPEPTIDASE; HYDROLASE; UNCLASSIFIED DRUG;

AGED; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; FEMALE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SEX DIFFERENCE;

AGE OF ONSET; AGED; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DIPEPTIDASES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOZYGOTE; HUMANS; LEUCINE; MALE; MIDDLE AGED; REFERENCE VALUES; REPETITIVE SEQUENCES, AMINO ACID; SEX CHARACTERISTICS;

EID: 77953178207     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-1377     Document Type: Article

References (18)

1. Krolewski AS, Warram JH, Rand LI, Kahn CR. Epidemiologic approach to the etiology of type I diabetes mellitus and its complications. N Engl J Med 1987;317:1390-1398
2. Pettitt DJ, Saad MF, Bennett PH, Nelson RG, Knowler WC. Familial predisposition to renal disease in two generations of Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1990;33: 438-443
3. Seaquist ER, Goetz FC, Rich S, Barbosa J. Familial clustering of diabetic kidney disease: evidence for genetic susceptibility to diabetic nephropathy. N Engl J Med 1989;320:1161-1165 (Pubitemid 19124296)
4. Mooyaart AL, van Valkengoed IG, Shaw PK, Peters V, Baelde HJ, Rabelink TJ, Bruijn JA, Stronks K, de Heer E. Lower frequency of the 5/5 homozygous CNDP1 genotype in South Asian Surinamese. Diabetes Res Clin Pract 2009;85:272-278
5. Maeda S. Genetics of diabetic nephropathy. Ther Adv Cardiovasc Dis 2008;2:363-371
6. Janssen B, Hohenadel D, Brinkkoetter P, Peters V, Rind N, Fischer C, Rychlik I, Cerna M, Romzova M, de Heer E, Baelde H, Bakker SJ, Zirie M, Rondeau E, Mathieson P, Saleem MA, Meyer J, Köppel H, Sauerhoefer S, Bartram CR, Nawroth P, Hammes HP, Yard BA, Zschocke J, van der Woude FJ. Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. Diabetes 2005;54: 2320-2327
7. Freedman BI, Hicks PJ, Sale MM, Pierson ED, Langefeld CD, Rich SS, Xu J, McDonough C, Janssen B, Yard BA, van der Woude FJ, Bowden DW. A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans. Nephrol Dial Transplant 2007;22:1131-1135
8. Wanic K, Placha G, Dunn J, Smiles A, Warram JH, Krolewski AS. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. Diabetes 2008;57:2547-2551
9. Trégouet DA, Groop PH, McGinn S, Forsblom C, Hadjadj S, Marre M, Parving HH, Tarnow L, Telgmann R, Godefroy T, Nicaud V, Rousseau R, Parkkonen M, Hoverfält A, Gut I, Heath S, Matsuda F, Cox R, Kazeem G, Farrall M, Gauguier D, Brand-Herrmann SM, Cambien F, Lathrop M, Vionnet N, EURAGEDIC Consortium. G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes. Diabetes 2008;57:2843-2850
10. McDonough CW, Hicks PJ, Lu L, Langefeld CD, Freedman BI, Bowden DW. The influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans. Hum Genet 2009;126:265-275
11. Riedl E, Koeppel H, Brinkkoetter P, Sternik P, Steinbeisser H, Sauerhoefer S, Janssen B, van der Woude FJ, Yard BA. A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells. Diabetes 2007;56:2410-2413
12. Hipkiss AR, Brownson C, Carrier MJ. Carnosine, the anti-ageing, antioxidant dipeptide, may react with protein carbonyl groups. Mech Ageing Dev 2001;122:1431-1445
13. Hobart LJ, Seibel I, Yeargans GS, Seidler NW. Anti-crosslinking properties of carnosine: significance of histidine. Life Sci 2004;75:1379-1389
14. Mlynarski WM, Placha GP, Wolkow PP, Bochenski JP, Warram JH, Krolewski AS. Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5): a sex-specific effect. Diabetes 2005;54:3331-3335
15. Ihalmo P, Wessman M, Kaunisto MA, Kilpikari R, Parkkonen M, Forsblom C, Holthöfer H, Groop PH, FinnDiane Study Group. Association analysis of podocyte slit diaphragm genes as candidates for diabetic nephropathy. Diabetologia 2008;51:86-90
16. Ubink-Veltmaat LJ, Bilo HJ, Groenier KH, Houweling ST, Rischen RO, Meyboom-de Jong B. Prevalence, incidence and mortality of type 2 diabetes mellitus revisited: a prospective population-based study in The Netherlands (ZODIAC-1). Eur J Epidemiol 2003;18:793-800
17. Levey AS, Gassman JJ, Hall PM, Walker WG. Assessing the progression of renal disease in clinical studies: effects of duration of follow-up and regression to the mean. Modification of Diet in Renal Disease (MDRD) Study Group. J Am Soc Nephrol 1991;1:1087-1094
18. Ninomiya T, Perkovic V, de Galan BE, Zoungas S, Pillai A, Jardine M, Patel A, Cass A, Neal B, Poulter N, Mogensen CE, Cooper M, Marre M, Williams B, Hamet P, Mancia G, Woodward M, Macmahon S, Chalmers J, ADVANCE Collaborative Group. Albuminuria and kidney function independently predict cardiovascular and renal outcomes in diabetes. J Am Soc Nephrol 2009;20:1813-1821