Does low serum carnosinase activity favor high-intensity exercise capacity

Journal of Applied Physiology

Volumn 116, Issue 5, 2014, Pages 553-559

  Baguet, Audrey ^a   Everaert, Inge ^a   Yard, Benito ^b   Peters, Verena ^b   Zschocke, Johannes ^c   Zutinic, Ana ^d   De Heer, Emile ^d   Podgórski, Tomasz ^e   Domaszewska, Katarzyna ^e   Derave, Wim ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e POZNAN UNIVERSITY OF PHYSICAL EDUCATION   (Poland)

Author keywords

Acute carnosine supplementation; Carnosinase activity content; Elite athletes; High intensity exercise

Indexed keywords

AMINOACYL-HISTIDINE DIPEPTIDASE; AMINOACYLHISTIDINE DIPEPTIDASE; BICARBONATE; CARNOSINE; CREATINE KINASE; DIPEPTIDASE; FERRIC ION; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ACID BASE BALANCE; ACUTE CARNOSINE SUPPLEMENTATION; ADOLESCENT; ADULT; ARTICLE; BLOOD; CARNOSINASE ACTIVITY/CONTENT; COLORIMETRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; ELITE ATHLETES; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; FEMALE; HIGH-INTENSITY EXERCISE; HUMAN; MALE; METABOLISM; MIDDLE AGED; OXIDATION REDUCTION REACTION; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; SPORT; YOUNG ADULT;

ACUTE CARNOSINE SUPPLEMENTATION; CARNOSINASE ACTIVITY/CONTENT; ELITE ATHLETES; HIGH-INTENSITY EXERCISE;

ACID-BASE EQUILIBRIUM; ADOLESCENT; ADULT; BICARBONATES; CARNOSINE; COLORIMETRY; CREATINE KINASE; CROSS-OVER STUDIES; CROSS-SECTIONAL STUDIES; DIETARY SUPPLEMENTS; DIPEPTIDASES; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXERCISE; FEMALE; FERRIC COMPOUNDS; HUMANS; MALE; MIDDLE AGED; OXIDATION-REDUCTION; SPORTS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; YOUNG ADULT;

EID: 84901251815     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01218.2013     Document Type: Article

References (30)

1. Adelmann K, Frey D, Riedl E, Koeppel H, Pfister F, Peters V, Schmitt CP, Sternik P, Hofmann S, Zentgraf HW, Navis G, Van Den Born J, Bakker SJ, Kramer BK, Yard BA, Hauske SJ. Different conformational forms of serum carnosinase detected by a newly developed sandwich ELISA for the measurements of carnosinase concentrations. Amino Acids 43: 143-151, 2012.
2. Aldini G, Orioli M, Rossoni G, Savi F, Braidotti P, Vistoli G, Yeum KJ, Negrisoli G, Carini M. The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats. J Cell Mol Med 15: 1339-1354, 2011.
3. Baguet A, Koppo K, Pottier A, Derave W. beta-Alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise. Eur J Appl Physiol 108: 495-503, 2010.
4. Benzie IF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of "antioxidant power": the FRAP assay. Anal Biochem 239: 70-76, 1996.
5. Bishop D, Edge J, Davis C, Goodman C. Induced metabolic alkalosis affects muscle metabolism and repeated-sprint ability. Med Sci Sports Exerc 36: 807-813, 2004.
6. Boldyrev AA. Carnosine and Oxidative Stress in Cells and Tissues. New York: Nova Science, 2007.
7. Boldyrev AA, Aldini G, Derave W. Physiology and pathophysiology of carnosine. Physiol Rev 93: 1803-1845, 2013.
8. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 52: 302-310, 1978.
9. Derave W, Everaert I, Beeckman S, Baguet A. Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training. Sports Med 40: 247-263, 2010.
10. Dutka TL, Lamboley CR, McKenna MJ, Murphy RM, Lamb GD. Effects of carnosine on contractile apparatus Ca(2) sensitivity and sarcoplasmic reticulum Ca(2) release in human skeletal muscle fibers. J Appl Physiol 112: 728-736, 2012.
11. Everaert I, Taes Y, de Heer E, Baelde HJ, Zutinic A, Yard B, Sauerhofer S, Vanhee L, Delanghe JR, Aldini G, Derave W. Low plasma carnosinase activity promotes carnosinemia following carnosine ingestion in humans. Am J Physiol Renal Physiol 302: F1537-F1544, 2012.
12. Gardner ML, Illingworth KM, Kelleher J, Wood D. Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. J Physiol 439: 411-422, 1991.
13. Grootveld M, Halliwell B. Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo Biochem J 243: 803-808, 1987.
14. Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA. The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 30: 279-289, 2006.
15. Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA. Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 32: 225-233, 2007.
16. Hipkiss AR. Glycation, ageing and carnosine: are carnivorous diets beneficial? Mech Ageing Dev 126: 1034-1039, 2005.
17. Hobson RM, Saunders B, Ball G, Harris RC, Sale C. Effects of beta-alanine supplementation on exercise performance: a meta-analysis. Amino Acids 43: 25-37, 2012.
18. Janaszewska A, Bartosz G. Assay of total antioxidant capacity: comparison of four methods as applied to human blood plasma. Scand J Clin Lab Invest 62: 231-236, 2002.
19. Janssen B, Hohenadel D, Brinkkoetter P, Peters V, Rind N, Fischer C, Rychlik I, Cerna M, Romzova M, de Heer E, Baelde H, Bakker SJ, Zirie M, Rondeau E, Mathieson P, Saleem MA, Meyer J, Koppel H, Sauerhoefer S, Bartram CR, Nawroth P, Hammes HP, Yard BA, Zschocke J, van der Woude FJ. Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1. Diabetes 54: 2320-2327, 2005.
20. Lenney JF, Peppers SC, Kucera-Orallo CM, George RP. Characterization of human tissue carnosinase. Biochem J 228: 653-660, 1985.
21. Medved I, Brown MJ, Bjorksten AR, Murphy KT, Petersen AC, Sostaric S, Gong X, McKenna MJ. N-Acetylcysteine enhances muscle cysteine and glutathione availability and attenuates fatigue during prolonged exercise in endurance-trained individuals. J Appl Physiol 97: 1477-1485, 2004.
22. Mooyaart AL, Zutinic A, Bakker SJ, Grootendorst DC, Kleefstra N, van Valkengoed IG, Bohringer S, Bilo HJ, Dekker FW, Bruijn JA, Navis G, Janssen B, Baelde HJ, de Heer E. Association between CNDP1 genotype and diabetic nephropathy is sex specific. Diabetes 59: 1555-1559, 2010.
23. Peters V, Jansen EE, Jakobs C, Riedl E, Janssen B, Yard BA, Wedel J, Hoffmann GF, Zschocke J, Gotthardt D, Fischer C, Koppel H. Anserine inhibits carnosine degradation but in human serum carnosinase (CN1) is not correlated with histidine dipeptide concentration. Clin Chim Acta 412: 263-267, 2011.
24. Peters V, Schmitt CP, Zschocke J, Gross ML, Brismar K, Forsberg E. Carnosine treatment largely prevents alterations of renal carnosine metabolism in diabetic mice. Amino Acids 42: 2411-2416, 2012.
25. Reid MB. Free radicals and muscle fatigue: Of ROS, canaries, and the IOC. Free Radic Biol Med 44: 169-179, 2008.
26. Riedl E, Koeppel H, Brinkkoetter P, Sternik P, Steinbeisser H, Sauerhoefer S, Janssen B, van der Woude FJ, Yard BA. A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells. Diabetes 56: 2410-2413, 2007.
27. Suzuki Y, Nakao T, Maemura H, Sato M, Kamahara K, Morimatsu F, Takamatsu K. Carnosine and anserine ingestion enhances contribution of nonbicarbonate buffering. Med Sci Sports Exerc 38: 334-338, 2006.
28. Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, Ganzhorn AJ, Guenet C, Heintzelmann B, Laucher V, Sauvage C, Smirnova T. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. J Biol Chem 278: 6521-6531, 2003.
29. Valle AM, Radic Z, Rana BK, Mahboubi V, Wessel J, Shih PA, Rao F, O'Connor DT, Taylor P. Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. J Pharmacol Exp Ther 338: 125-133, 2011.
30. Yeum KJ, Orioli M, Regazzoni L, Carini M, Rasmussen H, Russell RM, Aldini G. Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans. Amino Acids 38: 847-858, 2009.