메뉴 건너뛰기




Volumn 11, Issue 4, 2015, Pages 560-569

Robust generation of cardiomyocytes from human iPS cells requires precise modulation of BMP and WNT signaling

Author keywords

BMP signaling; Cardiac differentiation; Diseasemodeling; Human iPS cells; Lactate enrichment; WNT signaling

Indexed keywords

CALCIUM; PROCOLLAGEN C PROTEINASE; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN; BONE MORPHOGENETIC PROTEIN;

EID: 84943273870     PISSN: 15508943     EISSN: 15586804     Source Type: Journal    
DOI: 10.1007/s12015-014-9564-6     Document Type: Article
Times cited : (53)

References (43)
  • 1
    • 33646799069 scopus 로고    scopus 로고
    • Global and regional burden of disease and risk factors, 2001: Systematic analysis of population health data
    • Lopez, A. D., Mathers, C. D., Ezzati, M., Jamison, D. T., & Murray, C. J. (2006). Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet, 367, 1747–1757.
    • (2006) Lancet , vol.367 , pp. 1747-1757
    • Lopez, A.D.1    Mathers, C.D.2    Ezzati, M.3    Jamison, D.T.4    Murray, C.J.5
  • 4
    • 77952241680 scopus 로고    scopus 로고
    • Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse hearts
    • Zaruba, M. M., Soonpaa, M., Reuter, S., & Field, L. J. (2010). Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse hearts. Circulation, 121, 1992–2000.
    • (2010) Circulation , vol.121 , pp. 1992-2000
    • Zaruba, M.M.1    Soonpaa, M.2    Reuter, S.3    Field, L.J.4
  • 5
    • 13544272476 scopus 로고    scopus 로고
    • Postnatal ISL1+ cardioblasts enter fully differentiated cardiomyocyte lineages
    • Laugwitz, K. L., Moretti, A., Lam, J., et al. (2005). Postnatal ISL1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature, 433, 647–653.
    • (2005) Nature , vol.433 , pp. 647-653
    • Laugwitz, K.L.1    Moretti, A.2    Lam, J.3
  • 6
    • 84861637781 scopus 로고    scopus 로고
    • Perspectives on stem cell therapy for cardiac regeneration. Advances and challenges
    • Choi, S. H., Jung, S. Y., Kwon, S. M., & Baek, S. H. (2012). Perspectives on stem cell therapy for cardiac regeneration. Advances and challenges. Circulation Journal, 76, 1307–1312.
    • (2012) Circulation Journal , vol.76 , pp. 1307-1312
    • Choi, S.H.1    Jung, S.Y.2    Kwon, S.M.3    Baek, S.H.4
  • 7
    • 0346783332 scopus 로고    scopus 로고
    • ISL1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart
    • Cai, C. L., Liang, X., Shi, Y., et al. (2003). ISL1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Developmental Cell, 5, 877–889.
    • (2003) Developmental Cell , vol.5 , pp. 877-889
    • Cai, C.L.1    Liang, X.2    Shi, Y.3
  • 8
    • 84878993646 scopus 로고    scopus 로고
    • Cardiac stem cells and their roles in myocardial infarction
    • Hou, J., Wang, L., Jiang, J., et al. (2013). Cardiac stem cells and their roles in myocardial infarction. Stem Cell Reviews, 9, 326–338.
    • (2013) Stem Cell Reviews , vol.9 , pp. 326-338
    • Hou, J.1    Wang, L.2    Jiang, J.3
  • 9
    • 39349106325 scopus 로고    scopus 로고
    • Differentiation of embryonic stem cells to clinically relevant populations: Lessons from embryonic development
    • Murry, C. E., & Keller, G. (2008). Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. Cell, 132, 661–680.
    • (2008) Cell , vol.132 , pp. 661-680
    • Murry, C.E.1    Keller, G.2
  • 10
    • 79956334658 scopus 로고    scopus 로고
    • Heart regeneration
    • Laflamme, M. A., & Murry, C. E. (2011). Heart regeneration. Nature, 473, 326–335.
    • (2011) Nature , vol.473 , pp. 326-335
    • Laflamme, M.A.1    Murry, C.E.2
  • 11
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 126, 663–676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 12
    • 20344372655 scopus 로고    scopus 로고
    • Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures
    • Passier, R., Oostwaard, D. W., Snapper, J., et al. (2005). Increased cardiomyocyte differentiation from human embryonic stem cells in serum-free cultures. Stem Cells, 23, 772–780.
    • (2005) Stem Cells , vol.23 , pp. 772-780
    • Passier, R.1    Oostwaard, D.W.2    Snapper, J.3
  • 13
    • 0034904645 scopus 로고    scopus 로고
    • Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes
    • Kehat, I., Kenyagin-Karsenti, D., Snir, M., et al. (2001). Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. The Journal of Clinical Investigation, 108, 407–414.
    • (2001) The Journal of Clinical Investigation , vol.108 , pp. 407-414
    • Kehat, I.1    Kenyagin-Karsenti, D.2    Snir, M.3
  • 14
    • 66949175935 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development. American
    • Takei, S., Ichikawa, H., Johkura, K., et al. (2009). Bone morphogenetic protein-4 promotes induction of cardiomyocytes from human embryonic stem cells in serum-based embryoid body development. American Journal of Physiology. Heart and Circulatory Physiology, 296, H1793–H1803.
    • (2009) Journal of Physiology. Heart and Circulatory Physiology , vol.296
    • Takei, S.1    Ichikawa, H.2    Johkura, K.3
  • 15
    • 84864243791 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: A methods overview
    • Mummery, C. L., Zhang, J., Ng, E. S., Elliott, D. A., Elefanty, A. G., & Kamp, T. J. (2012). Differentiation of human embryonic stem cells and induced pluripotent stem cells to cardiomyocytes: a methods overview. Circulation Research, 111, 344–358.
    • (2012) Circulation Research , vol.111 , pp. 344-358
    • Mummery, C.L.1    Zhang, J.2    Ng, E.S.3    Elliott, D.A.4    Elefanty, A.G.5    Kamp, T.J.6
  • 16
    • 40449141341 scopus 로고    scopus 로고
    • Marked differences in differentiation propensity among human embryonic stem cell lines
    • Osafune, K., Caron, L., Borowiak, M., et al. (2008). Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology, 26, 313–315.
    • (2008) Nature Biotechnology , vol.26 , pp. 313-315
    • Osafune, K.1    Caron, L.2    Borowiak, M.3
  • 17
    • 77958096983 scopus 로고    scopus 로고
    • Cell linedependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice
    • Kaichi, S., Hasegawa, K., Takaya, T., et al. (2010). Cell linedependent differentiation of induced pluripotent stem cells into cardiomyocytes in mice. Cardiovascular Research, 88, 314–323.
    • (2010) Cardiovascular Research , vol.88 , pp. 314-323
    • Kaichi, S.1    Hasegawa, K.2    Takaya, T.3
  • 18
    • 84888869632 scopus 로고    scopus 로고
    • Distinct iPS Cells Show Different Cardiac Differentiation Efficiency
    • Ohno, Y., Yuasa, S., Egashira, T., et al. (2013). Distinct iPS Cells Show Different Cardiac Differentiation Efficiency. Stem Cells International, 2013, 659739.
    • (2013) Stem Cells International , vol.2013
    • Ohno, Y.1    Yuasa, S.2    Egashira, T.3
  • 19
    • 34948891467 scopus 로고    scopus 로고
    • Cardiomyocytes derived from human embryonic stem cells in prosurvival factors enhance function of infarcted rat hearts
    • Laflamme, M. A., Chen, K. Y., Naumova, A. V., et al. (2007). Cardiomyocytes derived from human embryonic stem cells in prosurvival factors enhance function of infarcted rat hearts. Nature Biotechnology, 25, 1015–1024.
    • (2007) Nature Biotechnology , vol.25 , pp. 1015-1024
    • Laflamme, M.A.1    Chen, K.Y.2    Naumova, A.V.3
  • 20
    • 79954418253 scopus 로고    scopus 로고
    • Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals
    • Zhang, Q., Jiang, J., Han, P., et al. (2011). Direct differentiation of atrial and ventricular myocytes from human embryonic stem cells by alternating retinoid signals. Cell Research, 21, 579–587.
    • (2011) Cell Research , vol.21 , pp. 579-587
    • Zhang, Q.1    Jiang, J.2    Han, P.3
  • 21
    • 80051847166 scopus 로고    scopus 로고
    • Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression
    • Uosaki, H., Fukushima, H., Takeuchi, A., et al. (2011). Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression. PLoS One, 6, e23657.
    • (2011) Plos One , vol.6
    • Uosaki, H.1    Fukushima, H.2    Takeuchi, A.3
  • 22
    • 79551597211 scopus 로고    scopus 로고
    • Stagespecific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines
    • Kattman, S. J., Witty, A. D., Gagliardi, M., et al. (2011). Stagespecific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. Cell Stem Cell, 8, 228–240.
    • (2011) Cell Stem Cell , vol.8 , pp. 228-240
    • Kattman, S.J.1    Witty, A.D.2    Gagliardi, M.3
  • 23
    • 84870364946 scopus 로고    scopus 로고
    • Stage-specific cardiomyocyte differentiation method for H7 and H9 human embryonic stem cells
    • Sa, S., & McCloskey, K. E. (2012). Stage-specific cardiomyocyte differentiation method for H7 and H9 human embryonic stem cells. Stem Cell Reviews, 8, 1120–1128.
    • (2012) Stem Cell Reviews , vol.8 , pp. 1120-1128
    • Sa, S.1    McCloskey, K.E.2
  • 24
    • 84862907693 scopus 로고    scopus 로고
    • Production of de novo cardiomyocytes: Human pluripotent stem cell differentiation and direct reprogramming
    • Burridge, P. W., Keller, G., Gold, J. D., & Wu, J. C. (2012). Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell, 10, 16–28.
    • (2012) Cell Stem Cell , vol.10 , pp. 16-28
    • Burridge, P.W.1    Keller, G.2    Gold, J.D.3    Wu, J.C.4
  • 27
    • 79960913156 scopus 로고    scopus 로고
    • Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells
    • Ren, Y., Lee, M. Y., Schliffke, S., et al. (2011). Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. Journal of Molecular and Cellular Cardiology, 51, 280–287.
    • (2011) Journal of Molecular and Cellular Cardiology , vol.51 , pp. 280-287
    • Ren, Y.1    Lee, M.Y.2    Schliffke, S.3
  • 28
  • 29
    • 84870421675 scopus 로고    scopus 로고
    • A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions
    • Minami, I., Yamada, K., Otsuji, T. G., et al. (2012). A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Reports, 2, 1448–1460.
    • (2012) Cell Reports , vol.2 , pp. 1448-1460
    • Minami, I.1    Yamada, K.2    Otsuji, T.G.3
  • 30
    • 84855487976 scopus 로고    scopus 로고
    • Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells
    • Cao, N., Liu, Z., Chen, Z., et al. (2011). Ascorbic acid enhances the cardiac differentiation of induced pluripotent stem cells through promoting the proliferation of cardiac progenitor cells. Cell Research, 22, 219–236.
    • (2011) Cell Research , vol.22 , pp. 219-236
    • Cao, N.1    Liu, Z.2    Chen, Z.3
  • 31
    • 84883465408 scopus 로고    scopus 로고
    • Highly efficient induction and long-term maintenance ofmultipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions
    • Cao, N., Liang, H., Huang, J., et al. (2013). Highly efficient induction and long-term maintenance ofmultipotent cardiovascular progenitors from human pluripotent stem cells under defined conditions. Cell Research, 23, 1119–1132.
    • (2013) Cell Research , vol.23 , pp. 1119-1132
    • Cao, N.1    Liang, H.2    Huang, J.3
  • 32
    • 84872048038 scopus 로고    scopus 로고
    • Distinct metabolic flow enables large-scale purification ofmouse and human pluripotent stem cell-derived cardiomyocytes
    • Tohyama, S., Hattori, F., Sano, M., et al. (2013). Distinct metabolic flow enables large-scale purification ofmouse and human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell, 12, 127–137.
    • (2013) Cell Stem Cell , vol.12 , pp. 127-137
    • Tohyama, S.1    Hattori, F.2    Sano, M.3
  • 33
    • 84900812586 scopus 로고    scopus 로고
    • Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells
    • Kadari, A., Lu, M., Li, M., et al. (2014). Excision of viral reprogramming cassettes by Cre protein transduction enables rapid, robust and efficient derivation of transgene-free human induced pluripotent stem cells. Stem Cell Research & Therapy, 5, 47.
    • (2014) Stem Cell Research &Amp; Therapy , vol.5 , pp. 47
    • Kadari, A.1    Lu, M.2    Li, M.3
  • 34
    • 84859383973 scopus 로고    scopus 로고
    • Rat embryonic fibroblasts improve reprogramming of human keratinocytes into induced pluripotent stem cells
    • Linta, L., Stockmann, M., Kleinhans, K. N., et al. (2012). Rat embryonic fibroblasts improve reprogramming of human keratinocytes into induced pluripotent stem cells. Stem Cells and Development, 21, 965–976.
    • (2012) Stem Cells and Development , vol.21 , pp. 965-976
    • Linta, L.1    Stockmann, M.2    Kleinhans, K.N.3
  • 35
    • 84355161952 scopus 로고    scopus 로고
    • Excitation-induced ataxin-3 aggregation in neurons from patients with Machado- Joseph disease
    • Koch, P., Breuer, P., Peitz, M., et al. (2011). Excitation-induced ataxin-3 aggregation in neurons from patients with Machado- Joseph disease. Nature, 480, 543–546.
    • (2011) Nature , vol.480 , pp. 543-546
    • Koch, P.1    Breuer, P.2    Peitz, M.3
  • 36
    • 77949587674 scopus 로고    scopus 로고
    • Lentiviral vectors to probe and manipulate the Wnt signaling pathway
    • Fuerer, C., & Nusse, R. (2010). Lentiviral vectors to probe and manipulate the Wnt signaling pathway. PloS One, 5, e9370.
    • (2010) Plos One , vol.5
    • Fuerer, C.1    Nusse, R.2
  • 37
    • 44349175948 scopus 로고    scopus 로고
    • Human cardiovascular progenitor cells develop from a KDR+embryonicstem- cell-derived population
    • Yang, L., Soonpaa, M. H., Adler, E. D., et al. (2008). Human cardiovascular progenitor cells develop from a KDR+embryonicstem- cell-derived population. Nature, 453, 524–528.
    • (2008) Nature , vol.453 , pp. 524-528
    • Yang, L.1    Soonpaa, M.H.2    Adler, E.D.3
  • 38
    • 80053574096 scopus 로고    scopus 로고
    • Cardiomyocytes obtained from induced pluripotent stem cells with long-QT syndrome 3 recapitulate typical disease-specific features in vitro
    • Malan, D., Friedrichs, S., Fleischmann, B. K., & Sasse, P. (2011). Cardiomyocytes obtained from induced pluripotent stem cells with long-QT syndrome 3 recapitulate typical disease-specific features in vitro. Circulation Research, 109, 841–847.
    • (2011) Circulation Research , vol.109 , pp. 841-847
    • Malan, D.1    Friedrichs, S.2    Fleischmann, B.K.3    Sasse, P.4
  • 39
    • 84874851964 scopus 로고    scopus 로고
    • Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition
    • Lian, X., Zhang, J., Zhu, K., Kamp, T. J., & Palecek, S. P. (2013). Insulin inhibits cardiac mesoderm, not mesendoderm, formation during cardiac differentiation of human pluripotent stem cells and modulation of canonical Wnt signaling can rescue this inhibition. Stem Cells, 31, 447–457.
    • (2013) Stem Cells , vol.31 , pp. 447-457
    • Lian, X.1    Zhang, J.2    Zhu, K.3    Kamp, T.J.4    Palecek, S.P.5
  • 40
    • 70849117791 scopus 로고    scopus 로고
    • Transgenic simulation of human heart failure-like L-type Ca2+-channels: Implications for fibrosis and heart rate in mice
    • Beetz, N., Hein, L., Meszaros, J., et al. (2009). Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice. Cardiovascular Research, 84, 396–406.
    • (2009) Cardiovascular Research , vol.84 , pp. 396-406
    • Beetz, N.1    Hein, L.2    Meszaros, J.3
  • 42
    • 84859418689 scopus 로고    scopus 로고
    • Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat
    • Carpenter, L., Carr, C., Yang, C. T., Stuckey, D. J., Clarke, K., & Watt, S. M. (2011). Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat. Stem Cells and Development, 21, 977–986.
    • (2011) Stem Cells and Development , vol.21 , pp. 977-986
    • Carpenter, L.1    Carr, C.2    Yang, C.T.3    Stuckey, D.J.4    Clarke, K.5    Watt, S.M.6
  • 43
    • 84907688545 scopus 로고    scopus 로고
    • Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones
    • Dambrot, C., Buermans, HP., Varga, E., et al. (2014). Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones. Exp Cell Res.
    • (2014) Exp Cell Res
    • Dambrot, C.1    Buermans, H.P.2    Varga, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.