AZT-induced mitochondrial toxicity: An epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stress

Physiological Genomics

Volumn 47, Issue 10, 2015, Pages 447-454

  Koczor, Christopher A ^a   Jiao, Zhe ^a   Fields, Earl ^a   Russ, Rodney ^a   Ludaway, Tomika ^a   Lewis, William ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AZT; Epigenetics; Mitochondria; Oxidative stress; S adenosylmethionine

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CATALASE; DNA; DNA METHYLTRANSFERASE; MESSENGER RNA; PROTEIN KINASE C ALPHA; REACTIVE OXYGEN METABOLITE; S ADENOSYLMETHIONINE; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA METHYLATION; EPIGENETICS; GENE EXPRESSION; IMMUNOPRECIPITATION; MITOCHONDRIAL TOXICITY; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; STEADY STATE; ANIMAL; C57BL MOUSE; CLUSTER ANALYSIS; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENETIC EPIGENESIS; GENETICS; HEART VENTRICLE; METABOLISM;

ANIMALS; CATALASE; CLUSTER ANALYSIS; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; HEART VENTRICLES; MICE, INBRED C57BL; MITOCHONDRIA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; S-ADENOSYLMETHIONINE; ZIDOVUDINE;

EID: 84943258103     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00045.2015     Document Type: Article

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