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Volumn 533, Issue 1, 2014, Pages 168-172

Methylenetetrahydrofolate reductase C677T and methionine synthase A2756G polymorphisms influence on leukocyte genomic DNA methylation level

Author keywords

Methionine synthase; Methylation; Methylenetetrahydrofolate reductase; Polymorphism

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); A2756G; C677T; GENOMIC DNA; HOMOCYSTEINE; METHIONINE SYNTHASE; UNCLASSIFIED DRUG;

EID: 84887422252     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2013.09.098     Document Type: Article
Times cited : (46)

References (33)
  • 1
    • 34547678487 scopus 로고    scopus 로고
    • Non-Latin European descent could be a requirement for association of NTDs and MTHFR variant 677C>T: a meta-analysis
    • Amorim M.R., Lima M.A., Castilla E.E., Orioli I.M. Non-Latin European descent could be a requirement for association of NTDs and MTHFR variant 677C>T: a meta-analysis. Am. J. Med. Genet. A 2007, 143A:1726-1732.
    • (2007) Am. J. Med. Genet. A , vol.143 A , pp. 1726-1732
    • Amorim, M.R.1    Lima, M.A.2    Castilla, E.E.3    Orioli, I.M.4
  • 2
    • 79955846242 scopus 로고    scopus 로고
    • Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects
    • Blom H.J., Smulders Y. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. J. Inherit. Metab. Dis. 2011, 34:75-81.
    • (2011) J. Inherit. Metab. Dis. , vol.34 , pp. 75-81
    • Blom, H.J.1    Smulders, Y.2
  • 3
    • 0037384215 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase 677C->T and 1298A->C mutations are genetic determinants of elevated homocysteine
    • Castro R., et al. 5,10-Methylenetetrahydrofolate reductase 677C->T and 1298A->C mutations are genetic determinants of elevated homocysteine. QJM 2003, 96:297-303.
    • (2003) QJM , vol.96 , pp. 297-303
    • Castro, R.1
  • 4
    • 0041866794 scopus 로고    scopus 로고
    • Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease
    • Castro R., et al. Increased homocysteine and S-adenosylhomocysteine concentrations and DNA hypomethylation in vascular disease. Clin. Chem. 2003, 49:1292-1296.
    • (2003) Clin. Chem. , vol.49 , pp. 1292-1296
    • Castro, R.1
  • 5
    • 2942700001 scopus 로고    scopus 로고
    • 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C->T and 1298A->C mutations are associated with DNA hypomethylation
    • Castro R., et al. 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C->T and 1298A->C mutations are associated with DNA hypomethylation. J. Med. Genet. 2004, 41:454-458.
    • (2004) J. Med. Genet. , vol.41 , pp. 454-458
    • Castro, R.1
  • 6
    • 26044468390 scopus 로고    scopus 로고
    • Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC
    • Castro R., et al. Intracellular S-adenosylhomocysteine increased levels are associated with DNA hypomethylation in HUVEC. J. Mol. Med. 2005, 83:831-836.
    • (2005) J. Mol. Med. , vol.83 , pp. 831-836
    • Castro, R.1
  • 8
    • 0035864635 scopus 로고    scopus 로고
    • Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction
    • Chen J., et al. Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Atherosclerosis 2001, 154:667-672.
    • (2001) Atherosclerosis , vol.154 , pp. 667-672
    • Chen, J.1
  • 9
    • 7244221348 scopus 로고    scopus 로고
    • DNA Methylation, Cancer Susceptibility, and Nutrient Interactions
    • Davis C.D., Uthus E.O. DNA Methylation, Cancer Susceptibility, and Nutrient Interactions. Exp. Biol. Med. 2004, 229:988-995.
    • (2004) Exp. Biol. Med. , vol.229 , pp. 988-995
    • Davis, C.D.1    Uthus, E.O.2
  • 10
    • 34848881628 scopus 로고    scopus 로고
    • Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism
    • Fredriksen A., Meyer K., Ueland P.M., Vollset S.E., Grotmol T., Schneede J. Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum. Mutat. 2007, 28:856-865.
    • (2007) Hum. Mutat. , vol.28 , pp. 856-865
    • Fredriksen, A.1    Meyer, K.2    Ueland, P.M.3    Vollset, S.E.4    Grotmol, T.5    Schneede, J.6
  • 11
    • 0037117501 scopus 로고    scopus 로고
    • A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
    • Friso S., et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:5606-5611.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 5606-5611
    • Friso, S.1
  • 12
    • 0032713815 scopus 로고    scopus 로고
    • Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations
    • Harmon D.L., et al. Methionine synthase D919G polymorphism is a significant but modest determinant of circulating homocysteine concentrations. Genet. Epidemiol. 1999, 17:298-309.
    • (1999) Genet. Epidemiol. , vol.17 , pp. 298-309
    • Harmon, D.L.1
  • 13
    • 59849118511 scopus 로고    scopus 로고
    • Plasma homocysteine and gene polymorphisms associated with the risk of hyperlipidemia in northern Chinese subjects
    • Huang L., Song X.M., Zhu W., Li Y. Plasma homocysteine and gene polymorphisms associated with the risk of hyperlipidemia in northern Chinese subjects. Biomed. Environ. Sci. 2008, 21:514-520.
    • (2008) Biomed. Environ. Sci. , vol.21 , pp. 514-520
    • Huang, L.1    Song, X.M.2    Zhu, W.3    Li, Y.4
  • 14
    • 0037212592 scopus 로고    scopus 로고
    • Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study
    • Jacques P.F., et al. Effects of polymorphisms of methionine synthase and methionine synthase reductase on total plasma homocysteine in the NHLBI Family Heart Study. Atherosclerosis 2003, 166:49-55.
    • (2003) Atherosclerosis , vol.166 , pp. 49-55
    • Jacques, P.F.1
  • 15
    • 0036326660 scopus 로고    scopus 로고
    • Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology
    • James S.J., Melnyk S., Pogribna M., Pogribny I.P., Caudill M.A. Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J. Nutr. 2002, 132:2361-2366.
    • (2002) J. Nutr. , vol.132 , pp. 2361-2366
    • James, S.J.1    Melnyk, S.2    Pogribna, M.3    Pogribny, I.P.4    Caudill, M.A.5
  • 16
    • 0142196591 scopus 로고    scopus 로고
    • The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study
    • Klerk M., et al. The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study. Thromb. Res. 2003, 110:87-91.
    • (2003) Thromb. Res. , vol.110 , pp. 87-91
    • Klerk, M.1
  • 17
    • 77957341225 scopus 로고    scopus 로고
    • Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer
    • Liu J.J., Ward R.L. Folate and one-carbon metabolism and its impact on aberrant DNA methylation in cancer. Adv. Genet. 2010, 71:79-121.
    • (2010) Adv. Genet. , vol.71 , pp. 79-121
    • Liu, J.J.1    Ward, R.L.2
  • 18
    • 0032878590 scopus 로고    scopus 로고
    • A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk
    • Ma J., et al. A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. Cancer Epidemiol. Biomarkers Prev. 1999, 8:825-829.
    • (1999) Cancer Epidemiol. Biomarkers Prev. , vol.8 , pp. 825-829
    • Ma, J.1
  • 19
    • 78751569721 scopus 로고    scopus 로고
    • Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts
    • Montjean D., et al. Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts. Fertil. Steril. 2011, 95:635-640.
    • (2011) Fertil. Steril. , vol.95 , pp. 635-640
    • Montjean, D.1
  • 20
    • 80054748434 scopus 로고    scopus 로고
    • Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics
    • Nordgren K.K., et al. Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics. Pharmacology 2011, 39:2135-2147.
    • (2011) Pharmacology , vol.39 , pp. 2135-2147
    • Nordgren, K.K.1
  • 21
    • 0036682379 scopus 로고    scopus 로고
    • Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors
    • Paz M.F., et al. Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors. Cancer Res. 2002, 62:4519-4524.
    • (2002) Cancer Res. , vol.62 , pp. 4519-4524
    • Paz, M.F.1
  • 22
    • 22844457491 scopus 로고    scopus 로고
    • DNA methylation and human disease
    • Robertson K.D. DNA methylation and human disease. Nat. Rev. Genet. 2005, 6:597-610.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 597-610
    • Robertson, K.D.1
  • 23
    • 0030811925 scopus 로고    scopus 로고
    • Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR)
    • Rozen R. Genetic predisposition to hyperhomocysteinemia: deficiency of methylenetetrahydrofolate reductase (MTHFR). Thromb. Haemost. 1997, 78:523-526.
    • (1997) Thromb. Haemost. , vol.78 , pp. 523-526
    • Rozen, R.1
  • 24
    • 0033846460 scopus 로고    scopus 로고
    • Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene
    • Stern L.L., Mason J.B., Selhub J., Choi S.W. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiol. Biomarkers Prev. 2000, 9:849-853.
    • (2000) Cancer Epidemiol. Biomarkers Prev. , vol.9 , pp. 849-853
    • Stern, L.L.1    Mason, J.B.2    Selhub, J.3    Choi, S.W.4
  • 25
    • 64149102559 scopus 로고    scopus 로고
    • Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations
    • Tanaka T., et al. Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am. J. Hum. Genet. 2009, 84:477-482.
    • (2009) Am. J. Hum. Genet. , vol.84 , pp. 477-482
    • Tanaka, T.1
  • 26
    • 0033999287 scopus 로고    scopus 로고
    • Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels
    • Tsai M.Y., Bignell M., Yang F., Welge B.G., Graham K.J., Hanson N.Q. Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels. Atherosclerosis 2000, 149:131-137.
    • (2000) Atherosclerosis , vol.149 , pp. 131-137
    • Tsai, M.Y.1    Bignell, M.2    Yang, F.3    Welge, B.G.4    Graham, K.J.5    Hanson, N.Q.6
  • 27
    • 0016658549 scopus 로고
    • S-adenosylhomocysteine metabolism in various species
    • Walker R.D., Duerre J.A. S-adenosylhomocysteine metabolism in various species. Can. J. Biochem. 1975, 53:312-319.
    • (1975) Can. J. Biochem. , vol.53 , pp. 312-319
    • Walker, R.D.1    Duerre, J.A.2
  • 28
    • 77951949256 scopus 로고    scopus 로고
    • Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects
    • Wang L., et al. Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects. Am. J. Clin. Nutr. 2010, 91:1359-1367.
    • (2010) Am. J. Clin. Nutr. , vol.91 , pp. 1359-1367
    • Wang, L.1
  • 29
    • 79952362893 scopus 로고    scopus 로고
    • Polymorphisms in folate-metabolizing genes and risk of non-Hodgkin's lymphoma
    • Weiner A.S., et al. Polymorphisms in folate-metabolizing genes and risk of non-Hodgkin's lymphoma. Leuk. Res. 2011, 35:508-515.
    • (2011) Leuk. Res. , vol.35 , pp. 508-515
    • Weiner, A.S.1
  • 30
    • 0033569641 scopus 로고    scopus 로고
    • Epigenetics: regulation through repression
    • Wolffe A.P., Matzke M.A. Epigenetics: regulation through repression. Science 1999, 286:481-486.
    • (1999) Science , vol.286 , pp. 481-486
    • Wolffe, A.P.1    Matzke, M.A.2
  • 31
    • 0036073377 scopus 로고    scopus 로고
    • Methionine synthase polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism
    • Yates Z., Lucock M. Methionine synthase polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism. Haematologica 2002, 87:751-756.
    • (2002) Haematologica , vol.87 , pp. 751-756
    • Yates, Z.1    Lucock, M.2
  • 32
    • 0034703084 scopus 로고    scopus 로고
    • Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation
    • Yi P., Melnyk S., Pogribna M., Pogribny I.P., Hine R.J., James S.J. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J. Biol. Chem. 2000, 275:29318-29323.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29318-29323
    • Yi, P.1    Melnyk, S.2    Pogribna, M.3    Pogribny, I.P.4    Hine, R.J.5    James, S.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.