Function of integrin-linked kinase in modulating the stemness of il-6-abundant breast cancer cells by regulating γ-secretase-mediated notch1 activation in caveolae

Neoplasia (United States)

Volumn 17, Issue 6, 2015, Pages 497-508

  Hsu, En Chi ^a   Kulp, Samuel K ^a   Huang, Han Li ^a,d   Tu, Huang Ju ^a,e   Salunke, Santosh B ^a   Sullivan, Nicholas J ^a   Sun, Duxin ^b   Wicha, Max S ^b   Shapiro, Charles L ^a,e   Chen, Ching Shih ^a,c  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^c INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE; INTEGRIN LINKED KINASE; INTERLEUKIN 6; NICASTRIN; NOTCH1 RECEPTOR; PRESENILIN; PRESENILIN 1; SHORT HAIRPIN RNA; IL6 PROTEIN, HUMAN; INTEGRIN-LINKED KINASE; MESSENGER RNA; NOTCH RECEPTOR; PROTEIN SERINE THREONINE KINASE; SECRETASE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; BREAST CANCER CELL LINE; CANCER STEM CELL; CARCINOGENICITY; CAVEOLA; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENHANCER REGION; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRIPLE NEGATIVE BREAST CANCER; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BREAST NEOPLASMS; CELL MEMBRANE; DRUG EFFECTS; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NONOBESE DIABETIC MOUSE; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCID MOUSE; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BLOTTING, WESTERN; BREAST NEOPLASMS; CAVEOLAE; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; INTERLEUKIN-6; MEMBRANE MICRODOMAINS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; PROTEIN-SERINE-THREONINE KINASES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84943155630     PISSN: 15228002     EISSN: 14765586     Source Type: Journal    
DOI: 10.1016/j.neo.2015.06.001     Document Type: Article

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