FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation

Free Radical Biology and Medicine

Volumn 89, Issue , 2015, Pages 274-286

  Chuang, Jih Ing ^a   Huang, Jui Yen ^a,b   Tsai, Shaw Jenq ^a   Sun, H Sunny ^a   Yang, Shang Hsun ^a   Chuang, Pei Chin ^c   Huang, Bu Miin ^a   Ching, Cheng Hsin ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b INDIANA UNIVERSITY   (United States)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

AKT; CREB; ERK1 2; Fibroblast growth factor 9; Freeradicals; Heme oxygenase 1; MPP+; Nrf2; Glutamylcysteine synthetase

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 9; FIBROBLAST GROWTH FACTOR RECEPTOR; GLUTAMATE CYSTEINE LIGASE; HEME OXYGENASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOLIPASE C GAMMA; PROTEIN KINASE B; TRANSCRIPTION FACTOR NRF2; FGF9 PROTEIN, RAT; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME INHIBITION; MALE; NEUROPROTECTION; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SUBSTANTIA NIGRA; UPREGULATION; ANIMAL; BRAIN CORTEX; CELL CULTURE; CYTOLOGY; ENZYME IMMUNOASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; OXIDATIVE STRESS; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 9; GENE EXPRESSION REGULATION; HEME OXYGENASE-1; IMMUNOENZYME TECHNIQUES; MALE; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, FIBROBLAST GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84943149251     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.08.011     Document Type: Article

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