Protection of HepG2 cells against acrolein toxicity by 2-cyano-3,12-dioxooleana-1,9-dien-28-imidazolide via glutathione-mediated mechanism

Experimental Biology and Medicine

Volumn 240, Issue 10, 2015, Pages 1340-1351

  Shah, Halley ^a   Speen, Adam M ^a   Saunders, Christina ^a   Brooke, Elizabeth AS ^a   Nallasamy, Palanisamy ^a   Zhu, Hong ^b   Li, Y Robert ^a,c   Jia, Zhenquan ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b Sampson Regional Medical Center Dermatology Residency Director   (United States)

^c VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

Author keywords

12 dioxooleana 1; 2 cyano 3; 9 dien 28 imidazolide; Acrolein; Aldose reductase; Cytoprotection; Glutathione S transferases; HepG2 cells

Indexed keywords

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 IMIDAZOLIDE; ACROLEIN; ALDEHYDE REDUCTASE; BUTHIONINE SULFOXIMINE; CARBONYL DERIVATIVE; GLUTATHIONE TRANSFERASE; IMIDAZOLE DERIVATIVE; LACTATE DEHYDROGENASE; MESSENGER RNA; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; 1-(2-CYANO-3,12-DIOXOOLEANA-1,9-DIEN-28-OYL) IMIDAZOLE; GLUTATHIONE; OLEANOLIC ACID; PROTECTIVE AGENT;

APOPTOSIS; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL VIABILITY; ENZYME ASSAY; FLOW CYTOMETRY; GLUTATHIONE METABOLISM; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIPID PEROXIDATION; LIVER TOXICITY; MTT ASSAY; PHOTOMETRY; PROTEIN DEPLETION; PROTEIN DETERMINATION; REAL TIME POLYMERASE CHAIN REACTION; SPECTROPHOTOMETRY; TISSUE CULTURE; ANALOGS AND DERIVATIVES; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; PROTEIN CARBONYLATION;

ACROLEIN; APOPTOSIS; GLUTATHIONE; HEP G2 CELLS; HUMANS; IMIDAZOLES; LIPID PEROXIDATION; OLEANOLIC ACID; PROTECTIVE AGENTS; PROTEIN CARBONYLATION; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 84942910848     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1177/1535370214563900     Document Type: Article

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