Chronic oral exposure to the aldehyde pollutant acrolein induces dilated cardiomyopathy

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 5, 2011, Pages

  Ismahil, Mohamed Ameen ^a   Hamid, Tariq ^a   Haberzettl, Petra ^a   Gu, Yan ^a,c   Chandrasekar, Bysani ^b   Srivastava, Sanjay ^a   Bhatnagar, Aruni ^a   Prabhu, Sumanth D ^a,c  

^a University of Louisville School of Medicine   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acrolein; Cardiomyopathy; Environmental pollution; Oxidative stress

Indexed keywords

3 NITROTYROSINE; ACROLEIN; ALDEHYDE; CYTOKINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DILATATION; DNA BINDING; EMERGENCY TREATMENT; FEEDING; GENE EXPRESSION; HEART DILATATION; HEART FAILURE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LONG TERM CARE; LONG TERM EXPOSURE; MOUSE; MULTIPLE SCLEROSIS; MUSCLE CELL; NITRATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PLASMA; POLLUTANT; PRIORITY JOURNAL; TUMOR NECROSIS; UPREGULATION;

ACROLEIN; ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; CARDIOMYOPATHY, DILATED; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION; HYPERTROPHY, LEFT VENTRICULAR; IMMUNOHISTOCHEMISTRY; INFLAMMATION MEDIATORS; MALE; MICE; MICE, INBRED C57BL; MYOCARDIAL CONTRACTION; MYOCARDITIS; MYOCARDIUM; OXIDATIVE STRESS; REAL-TIME POLYMERASE CHAIN REACTION; TIME FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 80355128961     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00120.2011     Document Type: Article

References (44)

1. Andre L, Boissiere J, Reboul C, Perrier R, Zalvidea S, Meyer G, Thireau J, Tanguy S, Bideaux P, Hayot M, Boucher F, Obert P, Cazorla O, Richard S. Carbon monoxide pollution promotes cardiac remodeling and ventricular arrhythmia in healthy rats. Am J Respir Crit Care Med 181: 587-595, 2010.
2. Assembly of Life Sciences (U.S.) Committee on Aldehydes. Formaldehyde and Other Aldehydes. Washington, DC: Natl Acad, 1981, p. ix, 340 p.
3. Bhatnagar A. Environmental cardiology: studying mechanistic links between pollution and heart disease. Circ Res 99: 692-705, 2006.
4. Boo YC, Kim HJ, Song H, Fulton D, Sessa W, Jo H. Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization. Free Radic Biol Med 41: 144-153, 2006.
5. Brook RD, Rajagopalan S, Pope CA, 3rd Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC Jr, Whitsel L, Kaufman JD. Partic-ulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation 121: 2331-2378, 2010.
6. Deswal A, Petersen NJ, Feldman AM, Young JB, White BG, Mann DL. Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST). Circulation 103: 2055-2059, 2001.
7. DeWoskin RS and United States Environmental Protection Agency. Toxicological Review of Acrolein (CAS No. 107-02-8) in Support of Summary Information on the Integrated Risk Information System (IRIS). Washington, DC: U.S. Environmental Protection Agency, 2003.
8. Eaton P, Li JM, Hearse DJ, Shattock MJ. Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart. Am J Physiol Heart Circ Physiol 276: H935-H943, 1999.
9. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11: 81-128, 1991.
10. Feron VJ, Til HP, de Vrijer F, Woutersen RA, Cassee FR, van Bladeren PJ. Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment. Mutat Res 259: 363-385, 1991.
11. Ghilarducci DP, Tjeerdema RS. Fate and effects of acrolein. Rev Environ Contam Toxicol 144: 95-146, 1995.
12. Giordano FJ. Oxygen, oxidative stress, hypoxia, and heart failure. J Clin Invest 115: 500-508, 2005.
13. Go YM, Halvey PJ, Hansen JM, Reed M, Pohl J, Jones DP. Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion. Am J Pathol 171: 1670-1681, 2007.
14. Hamid T, Gu Y, Ortines RV, Bhattacharya C, Wang G, Xuan YT, Prabhu SD. Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activation. Circulation 119: 1386-1397, 2009.
15. He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C, Whelton PK. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch Intern Med 161: 996-1002, 2001.
16. Jessup M, Brozena S. Heart failure. N Engl J Med 348: 2007-2018, 2003.
17. Kinugawa S, Tsutsui H, Hayashidani S, Ide T, Suematsu N, Satoh S, Utsumi H, Takeshita A. Treatment with dimethylthiourea prevents left ventricular remodeling and failure after experimental myocardial infarction in mice: role of oxidative stress. Circ Res 87: 392-398, 2000.
18. Logue JM, Small MJ, Stern D, Maranche J, Robinson AL. Spatial variation in ambient air toxics concentrations and health risks between industrial-influenced, urban, and rural sites. J Air Waste Manag Assoc 60: 271-286, 2010.
19. Luo J, Hill BG, Gu Y, Cai J, Srivastava S, Bhatnagar A, Prabhu SD. Mechanisms of acrolein-induced myocardial dysfunction: implications for environmental and endogenous aldehyde exposure. Am J Physiol Heart Circ Physiol 293: H3673-H3684, 2007.
20. Luo J, Xuan YT, Gu Y, Prabhu SD. Prolonged oxidative stress inverts the cardiac force-frequency relation: role of altered calcium handling and myofilament calcium responsiveness. J Mol Cell Cardiol 40: 64-75, 2006.
21. Mak S, Lehotay DC, Yazdanpanah M, Azevedo ER, Liu PP, Newton GE. Unsaturated aldehydes including 4-OH-nonenal are elevated in patients with congestive heart failure. J Card Fail 6: 108-114, 2000.
22. Mann DL. Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ Res 91: 988-998, 2002.
23. Marques C, Pereira P, Taylor A, Liang JN, Reddy VN, Szweda LI, Shang F. Ubiquitin-dependent lysosomal degradation of the HNE-modi-fied proteins in lens epithelial cells. FASEB J 18: 1424-1426, 2004.
24. Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, Paolocci N, Champion HC, Kass DA. Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation 117: 2626-2636, 2008.
25. Nath RG, Chung FL. Detection of exocyclic 1,N2-propanodeoxyguanos-ine adducts as common DNA lesions in rodents and humans. Proc Natl Acad Sci USA 91: 7491-7495, 1994.
26. Okada K, Wangpoengtrakul C, Osawa T, Toyokuni S, Tanaka K, Uchida K. 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules. J Biol Chem 274: 23787-23793, 1999.
27. Parola M, Bellomo G, Robino G, Barrera G, Dianzani MU. 4-Hy-droxynonenal as a biological signal: molecular basis and pathophysiolog-ical implications. Antioxid Redox Signal 1: 255-284, 1999.
28. rd, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, Godleski JJ. Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophys-iological pathways of disease. Circulation 109: 71-77, 2004.
29. Pratt GC, Palmer K, Wu CY, Oliaei F, Hollerbach C, Fenske MJ. An assessment of air toxics in Minnesota. Environ Health Perspect 108: 815-825, 2000.
30. Rahman I, Marwick J, Kirkham P. Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochem Pharmacol 68: 1255- 1267, 2004.
31. Ramana KV, Chandra D, Srivastava S, Bhatnagar A, Aggarwal BB, Srivastava SK. Aldose reductase mediates mitogenic signaling in vascular smooth muscle cells. J Biol Chem 277: 32063-32070, 2002.
32. Sawyer DB, Siwik DA, Xiao L, Pimentel DR, Singh K, Colucci WS. Role of oxidative stress in myocardial hypertrophy and failure. J Mol Cell Cardiol 34: 379-388, 2002.
33. Srivastava S, Chandrasekar B, Bhatnagar A, Prabhu SD. Lipid per-oxidation-derived aldehydes and oxidative stress in the failing heart: role of aldose reductase. Am J Physiol Heart Circ Physiol 283: H2612-H2619, 2002.
34. Srivastava S, Chandrasekar B, Gu Y, Luo J, Hamid T, Hill BG, Prabhu SD. Downregulation of CuZn-superoxide dismutase contributes to beta-adrenergic receptor-mediated oxidative stress in the heart. Cardio-vasc Res 74: 445-455, 2007.
35. Syed F, Diwan A, Hahn HS. Murine echocardiography: a practical approach for phenotyping genetically manipulated and surgically modeled mice. J Am Soc Echocardiogr 18: 982-990, 2005.
36. Takimoto E, Champion HC, Li M, Ren S, Rodriguez ER, Tavazzi B, Lazzarino G, Paolocci N, Gabrielson KL, Wang Y, Kass DA. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. J Clin Invest 115: 1221- 1231, 2005.
37. Uchida K, Kanematsu M, Sakai K, Matsuda T, Hattori N, Mizuno Y, Suzuki D, Miyata T, Noguchi N, Niki E, Osawa T. Protein-bound acrolein: potential markers for oxidative stress. Proc Natl Acad Sci USA 95: 4882-4887, 1998.
38. Uchida K, Shiraishi M, Naito Y, Torii Y, Nakamura Y, Osawa T. Activation of stress signaling pathways by the end product of lipid peroxidation 4-hydroxy-2-nonenal is a potential inducer of intracellular peroxide production. J Biol Chem 274: 2234-2242, 1999.
39. Umar S, van der Laarse A. Nitric oxide and nitric oxide synthase isoforms in the normal, hypertrophic, and failing heart. Mol Cell Biochem 333: 191-201, 2010.
40. Vasilyev N, Williams T, Brennan ML, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL, Penn MS. Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation 112: 2812-2820, 2005.
41. Wang G, Hamid T, Keith RJ, Zhou G, Partridge CR, Xiang X, Kingery JR, Lewis RK, Li Q, Rokosh DG, Ford R, Spinale FG, Riggs DW, Srivastava S, Bhatnagar A, Bolli R, Prabhu SD. Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. Circulation 121: 1912-1925, 2010.
42. Wang GW, Guo Y, Vondriska TM, Zhang J, Zhang S, Tsai LL, Zong NC, Bolli R, Bhatnagar A, Prabhu SD. Acrolein consumption exacerbates myocardial ischemic injury and blocks nitric oxide-induced PKCepsilon signaling and cardioprotection. J Mol Cell Cardiol 44: 1016-1022, 2008.
43. Yang YM, Huang A, Kaley G, Sun D. eNOS uncoupling and endothelial dysfunction in aged vessels. Am J Physiol Heart Circ Physiol 297: H1829-H1836, 2009.
44. Zanobetti A, Schwartz J. Particulate air pollution, progression, and survival after myocardial infarction. Environ Health Perspect 115: 769- 775, 2007.