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Volumn 96, Issue 5, 2005, Pages 897-905

Enzymatic remodeling of heparan sulfate proteoglycans within the tumor microenvironment: Growth regulation and the prospect of new cancer therapies

Author keywords

Cancer; Heparan sulfate proteoglycan (HSPG); Heparanase; Sulfatase; Tumor microenvironment

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; HEPARANASE; INTERLEUKIN 8; PROTEOHEPARAN SULFATE; SULFATASE; VASCULOTROPIN;

EID: 28044442504     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20602     Document Type: Article
Times cited : (137)

References (58)
  • 1
    • 0041671071 scopus 로고    scopus 로고
    • QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling
    • Ai X, Do AT, Lozynska O, Kusche-Gullberg M, Lindahl U, Emerson CP, Jr. 2003. QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signaling. J Cell Biol 162:341-351.
    • (2003) J Cell Biol , vol.162 , pp. 341-351
    • Ai, X.1    Do, A.T.2    Lozynska, O.3    Kusche-Gullberg, M.4    Lindahl, U.5    Emerson Jr., C.P.6
  • 3
    • 0024792629 scopus 로고
    • Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta
    • Andres JL, Stanley K, Cheifetz S, Massague J. 1989. Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta. J Cell Biol 109:3137-3145.
    • (1989) J Cell Biol , vol.109 , pp. 3137-3145
    • Andres, J.L.1    Stanley, K.2    Cheifetz, S.3    Massague, J.4
  • 5
    • 0034780729 scopus 로고    scopus 로고
    • Syndecan-1 (CD138) immunoreactivity in bone marrow biopsies of multiple myeloma: Shed syndecan-1 accumulates in fibrotic regions
    • Bayer-Garner IB, Sanderson RD, Dhodapkar MV, Owens RB, Wilson CS. 2001. Syndecan-1 (CD138) immunoreactivity in bone marrow biopsies of multiple myeloma: Shed syndecan-1 accumulates in fibrotic regions. Mod Pathol 14:1052-1058.
    • (2001) Mod Pathol , vol.14 , pp. 1052-1058
    • Bayer-Garner, I.B.1    Sanderson, R.D.2    Dhodapkar, M.V.3    Owens, R.B.4    Wilson, C.S.5
  • 6
    • 5444242206 scopus 로고    scopus 로고
    • The syndecan-1 ectodomain regulates {alpha}v{beta}3 integrin activity in human mammary carcinoma cells
    • Beauvais DM, Burbach BJ, Rapraeger AC. 2004. The syndecan-1 ectodomain regulates {alpha}v{beta}3 integrin activity in human mammary carcinoma cells. J Cell Biol 167:171-181.
    • (2004) J Cell Biol , vol.167 , pp. 171-181
    • Beauvais, D.M.1    Burbach, B.J.2    Rapraeger, A.C.3
  • 10
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM. 2002. Matrix metalloproteinase inhibitors and cancer: Trials and tribulations. Science 295:2387-2392.
    • (2002) Science , vol.295 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 12
    • 0030722012 scopus 로고    scopus 로고
    • Elevated levels of shed syndecan-1 correlate with tumour mass and decreased matrix metalloproteinase-9 activity in the serum of patients with multiple myeloma
    • Dhodapkar MV, Kelly T, Theus A, Athota AB, Barlogie B, Sanderson RD. 1997. Elevated levels of shed syndecan-1 correlate with tumour mass and decreased matrix metalloproteinase-9 activity in the serum of patients with multiple myeloma. Br J Haematol 99:368-371.
    • (1997) Br J Haematol , vol.99 , pp. 368-371
    • Dhodapkar, M.V.1    Kelly, T.2    Theus, A.3    Athota, A.B.4    Barlogie, B.5    Sanderson, R.D.6
  • 15
    • 0142103466 scopus 로고    scopus 로고
    • Cleavage of syndecan-1 by membrane-type matrix metalloproteinase-1 stimulates cell migration
    • Endo K, Takino T, Miyamori H, Kinsen H, Yoshizaki T, Furukawa M, Sato H. 2003. Cleavage of syndecan-1 by membrane-type matrix metalloproteinase-1 stimulates cell migration. J Biol Chem 278:40764-40770.
    • (2003) J Biol Chem , vol.278 , pp. 40764-40770
    • Endo, K.1    Takino, T.2    Miyamori, H.3    Kinsen, H.4    Yoshizaki, T.5    Furukawa, M.6    Sato, H.7
  • 16
    • 0035997376 scopus 로고    scopus 로고
    • Order out of chaos: Assembly of ligand binding sites in heparan sulfate
    • Esko JD, Selleck SB. 2002. Order out of chaos: Assembly of ligand binding sites in heparan sulfate. Annu Rev Biochem 71:435-471.
    • (2002) Annu Rev Biochem , vol.71 , pp. 435-471
    • Esko, J.D.1    Selleck, S.B.2
  • 17
    • 0027428744 scopus 로고
    • Activating and inhibitory heparin sequences for FGF-2 (Basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4
    • Guimond S, Maccarana M, Olwin BB, Lindahl U, Rapraeger AC. 1993. Activating and inhibitory heparin sequences for FGF-2 (Basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4. J Biol Chem 268:23906-23914.
    • (1993) J Biol Chem , vol.268 , pp. 23906-23914
    • Guimond, S.1    Maccarana, M.2    Olwin, B.B.3    Lindahl, U.4    Rapraeger, A.C.5
  • 18
  • 19
    • 0034904186 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycans: Heavy hitters in the angiogenesis arena
    • Iozzo RV, San Antonio JD. 2001. Heparan sulfate proteoglycans: Heavy hitters in the angiogenesis arena. J Clin Invest 108:349-355.
    • (2001) J Clin Invest , vol.108 , pp. 349-355
    • Iozzo, R.V.1    San Antonio, J.D.2
  • 20
    • 85014210101 scopus 로고    scopus 로고
    • Inhibitors of angiogenesis selectively reduce the malignant cell load in rodent models of human myeloid leukemias
    • Iversen PO, Sorensen DR, Benestad HB. 2002. Inhibitors of angiogenesis selectively reduce the malignant cell load in rodent models of human myeloid leukemias. Leukemia 16:376-381.
    • (2002) Leukemia , vol.16 , pp. 376-381
    • Iversen, P.O.1    Sorensen, D.R.2    Benestad, H.B.3
  • 21
    • 0037105784 scopus 로고    scopus 로고
    • Soluble syndecan-1 and serum basic fibroblast growth factor are new prognostic factors in lung cancer
    • Joensuu H, Anttonen A, Eriksson M, Makitaro R, Alfthan H, Kinnula V, Leppa S. 2002. Soluble syndecan-1 and serum basic fibroblast growth factor are new prognostic factors in lung cancer. Cancer Res 62:5210-5217.
    • (2002) Cancer Res , vol.62 , pp. 5210-5217
    • Joensuu, H.1    Anttonen, A.2    Eriksson, M.3    Makitaro, R.4    Alfthan, H.5    Kinnula, V.6    Leppa, S.7
  • 22
    • 0031749471 scopus 로고    scopus 로고
    • Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2
    • Kato M, Wang H, Kainulainen V, Fitzgerald ML, Ledbetter S, Ornitz DM, Bernfield M. 1998. Physiological degradation converts the soluble syndecan-1 ectodomain from an inhibitor to a potent activator of FGF-2. Nat Med 4:691-697.
    • (1998) Nat Med , vol.4 , pp. 691-697
    • Kato, M.1    Wang, H.2    Kainulainen, V.3    Fitzgerald, M.L.4    Ledbetter, S.5    Ornitz, D.M.6    Bernfield, M.7
  • 23
    • 21344452789 scopus 로고    scopus 로고
    • Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases
    • Kelly T, Suva LJ, Huang Y, Macleod V, Mino HQ, Walker RC, Sanderson RD. 2005. Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases. Cancer Res 65:5778-5784.
    • (2005) Cancer Res , vol.65 , pp. 5778-5784
    • Kelly, T.1    Suva, L.J.2    Huang, Y.3    Macleod, V.4    Mino, H.Q.5    Walker, R.C.6    Sanderson, R.D.7
  • 25
    • 0028016404 scopus 로고
    • Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns
    • Kim CW, Goldberger OA, Gallo RL, Bernfield M. 1994. Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns. Mol Biol Cell 5:797-805.
    • (1994) Mol Biol Cell , vol.5 , pp. 797-805
    • Kim, C.W.1    Goldberger, O.A.2    Gallo, R.L.3    Bernfield, M.4
  • 26
    • 0032876483 scopus 로고    scopus 로고
    • Stable transfection of a glypican-1 antisense construct decreases tumorigenicity in PANC-1 pancreatic carcinoma cells
    • Kleeff J, Wildi S, Kumbasar A, Friess H, Lander AD, Korc M. 1999. Stable transfection of a glypican-1 antisense construct decreases tumorigenicity in PANC-1 pancreatic carcinoma cells. Pancreas 19:281-288.
    • (1999) Pancreas , vol.19 , pp. 281-288
    • Kleeff, J.1    Wildi, S.2    Kumbasar, A.3    Friess, H.4    Lander, A.D.5    Korc, M.6
  • 30
    • 13544267411 scopus 로고    scopus 로고
    • Identification of an invasion regulatory domain within the core protein of syndecan-1
    • Langford JK, Yang Y, Kieber-Emmons T, Sanderson RD. 2005. Identification of an invasion regulatory domain within the core protein of syndecan-1. J Biol Chem 280:3467-3473.
    • (2005) J Biol Chem , vol.280 , pp. 3467-3473
    • Langford, J.K.1    Yang, Y.2    Kieber-Emmons, T.3    Sanderson, R.D.4
  • 32
    • 18744383614 scopus 로고    scopus 로고
    • Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury
    • Li Q, Park PW, Wilson CL, Parks WC. 2002. Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury. Cell 111:635-646.
    • (2002) Cell , vol.111 , pp. 635-646
    • Li, Q.1    Park, P.W.2    Wilson, C.L.3    Parks, W.C.4
  • 34
    • 0037154175 scopus 로고    scopus 로고
    • Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis
    • Liu D, Shriver Z, Venkataraman G, El Shabrawi Y, Sasisekharan R. 2002. Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis. Proc Natl Acad Sci USA 99:568-573.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 568-573
    • Liu, D.1    Shriver, Z.2    Venkataraman, G.3    El Shabrawi, Y.4    Sasisekharan, R.5
  • 35
    • 0037457306 scopus 로고    scopus 로고
    • Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues
    • Marchetti D, Reiland J, Erwin B, Roy M. 2003. Inhibition of heparanase activity and heparanase-induced angiogenesis by suramin analogues. Int J Cancer 104:167-174.
    • (2003) Int J Cancer , vol.104 , pp. 167-174
    • Marchetti, D.1    Reiland, J.2    Erwin, B.3    Roy, M.4
  • 36
    • 0033603298 scopus 로고    scopus 로고
    • Highly sensitive sequencing of the sulfated domains of heparan sulfate
    • Merry CL, Lyon M, Deakin JA, Hopwood JJ, Gallagher JT. 1999. Highly sensitive sequencing of the sulfated domains of heparan sulfate. J Biol Chem 274:18455-18462.
    • (1999) J Biol Chem , vol.274 , pp. 18455-18462
    • Merry, C.L.1    Lyon, M.2    Deakin, J.A.3    Hopwood, J.J.4    Gallagher, J.T.5
  • 37
    • 0032879625 scopus 로고    scopus 로고
    • Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides
    • Miao HQ, Elkin M, Aingorn E, Ishai-Michaeli R, Stein CA, Vlodavsky I. 1999. Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides. Int J Cancer 83:424-431.
    • (1999) Int J Cancer , vol.83 , pp. 424-431
    • Miao, H.Q.1    Elkin, M.2    Aingorn, E.3    Ishai-Michaeli, R.4    Stein, C.A.5    Vlodavsky, I.6
  • 38
    • 0037147259 scopus 로고    scopus 로고
    • Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans
    • Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD. 2002. Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans. J Biol Chem 277:49175-49185.
    • (2002) J Biol Chem , vol.277 , pp. 49175-49185
    • Morimoto-Tomita, M.1    Uchimura, K.2    Werb, Z.3    Hemmerich, S.4    Rosen, S.D.5
  • 39
    • 0035207952 scopus 로고    scopus 로고
    • Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis
    • Munshi NC, Wilson C. 2001. Increased bone marrow microvessel density in newly diagnosed multiple myeloma carries a poor prognosis. Semin Oncol 28:565-569.
    • (2001) Semin Oncol , vol.28 , pp. 565-569
    • Munshi, N.C.1    Wilson, C.2
  • 41
    • 0036198049 scopus 로고    scopus 로고
    • Identification of a novel nonlysosomal sulphatase expressed in the floor plate, choroid plexus and cartilage
    • Ohto T, Uchida H, Yamazaki H, Keino-Masu K, Matsui A, Masu M. 2002. Identification of a novel nonlysosomal sulphatase expressed in the floor plate, choroid plexus and cartilage. Genes Cells 7:173-185.
    • (2002) Genes Cells , vol.7 , pp. 173-185
    • Ohto, T.1    Uchida, H.2    Yamazaki, H.3    Keino-Masu, K.4    Matsui, A.5    Masu, M.6
  • 42
    • 0033565247 scopus 로고    scopus 로고
    • Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity
    • Parish CR, Freeman C, Brown KJ, Francis DJ, Cowden WB, 1999. Identification of sulfated oligosaccharide-based inhibitors of tumor growth and metastasis using novel in vitro assays for angiogenesis and heparanase activity. Cancer Res 59:3433-3441.
    • (1999) Cancer Res , vol.59 , pp. 3433-3441
    • Parish, C.R.1    Freeman, C.2    Brown, K.J.3    Francis, D.J.4    Cowden, W.B.5
  • 45
    • 0028321612 scopus 로고
    • Mapping the heparin-binding sites on type I collagen monomers and fibrils
    • San Antonio JD, Lander AD, Karnovsky MJ, Slayter HS. 1994. Mapping the heparin-binding sites on type I collagen monomers and fibrils. J Cell Biol 125:1179-1188.
    • (1994) J Cell Biol , vol.125 , pp. 1179-1188
    • San Antonio, J.D.1    Lander, A.D.2    Karnovsky, M.J.3    Slayter, H.S.4
  • 46
    • 7944230119 scopus 로고    scopus 로고
    • Heparan sulfate proteoglycans and heparanase-Partners in osteolytic tumor growth and metastasis
    • Sanderson RD, Yang Y, Suva LJ, Kelly T. 2004. Heparan sulfate proteoglycans and heparanase-Partners in osteolytic tumor growth and metastasis. Matrix Biol 23:341-352.
    • (2004) Matrix Biol , vol.23 , pp. 341-352
    • Sanderson, R.D.1    Yang, Y.2    Suva, L.J.3    Kelly, T.4
  • 51
    • 1242272044 scopus 로고    scopus 로고
    • Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin
    • Viviano BL, Paine-Saunders S, Gasiunas N, Gallagher J, Saunders S. 2004. Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist Noggin. J Biol Chem 279:5604-5611.
    • (2004) J Biol Chem , vol.279 , pp. 5604-5611
    • Viviano, B.L.1    Paine-Saunders, S.2    Gasiunas, N.3    Gallagher, J.4    Saunders, S.5
  • 52
    • 0034904048 scopus 로고    scopus 로고
    • Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis
    • Vlodavsky I, Friedmann Y. 2001. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J Clin Invest 108:341-347.
    • (2001) J Clin Invest , vol.108 , pp. 341-347
    • Vlodavsky, I.1    Friedmann, Y.2
  • 54
    • 0035880995 scopus 로고    scopus 로고
    • Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides
    • Wall D, Douglas S, Ferro V, Cowden W, Parish C. 2001. Characterisation of the anticoagulant properties of a range of structurally diverse sulfated oligosaccharides. Thromb Res 103:325-335.
    • (2001) Thromb Res , vol.103 , pp. 325-335
    • Wall, D.1    Douglas, S.2    Ferro, V.3    Cowden, W.4    Parish, C.5
  • 55
    • 1842737772 scopus 로고    scopus 로고
    • QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis
    • Wang S, Ai X, Freeman SD, Pownall ME, Lu Q, Kessler DS, Emerson CP, Jr. 2004. QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesis. Proc Natl Acad Sci USA 101:4833-4838.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4833-4838
    • Wang, S.1    Ai, X.2    Freeman, S.D.3    Pownall, M.E.4    Lu, Q.5    Kessler, D.S.6    Emerson Jr., C.P.7
  • 56
    • 0029876376 scopus 로고    scopus 로고
    • The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases
    • Whitelock JM, Murdoch AD, Iozzo RV, Underwood PA. 1996. The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases. J Biol Chem 271:10079-10086.
    • (1996) J Biol Chem , vol.271 , pp. 10079-10086
    • Whitelock, J.M.1    Murdoch, A.D.2    Iozzo, R.V.3    Underwood, P.A.4


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