Impact of genomics platform and statistical filtering on transcriptional benchmark doses (bmd) and multiple approaches for selection of chemical point of departure (PoD)

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Webster, A Francina ^a,b   Chepelev, Nikolai ^a   Gagné, Rémi ^a   Kuo, Byron ^a   Recio, Leslie ^c   Williams, Andrew ^a   Yauk, Carole L ^a  

^a HEALTH CANADA   (Canada)

^b CARLETON UNIVERSITY   (Canada)

^c INTEGRATED LABORATORY SYSTEMS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FURAN; CARCINOGEN; FURAN DERIVATIVE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BENCHMARK DOSE; BIOASSAY; COMPARATIVE STUDY; COMPUTER ANALYSIS; FEMALE; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENOMICS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; POINT OF DEPARTURE; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; RISK ASSESSMENT; RNA EXTRACTION; RNA SEQUENCE; TOXICOGENOMICS; TOXICOLOGY; ANIMAL; BENCHMARKING; DNA MICROARRAY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INBRED MOUSE STRAIN; LIVER; PHYSIOLOGY; PROCEDURES; SEQUENCE ANALYSIS; STATISTICS AND NUMERICAL DATA; THEORETICAL MODEL; TOXICOGENETICS;

ANIMALS; BENCHMARKING; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FURANS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENOMICS; LIVER; MICE, INBRED STRAINS; MODELS, THEORETICAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SEQUENCE ANALYSIS, RNA; TOXICOGENETICS;

EID: 84942904397     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136764     Document Type: Article

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