Biological Networks for Predicting Chemical Hepatocarcinogenicity Using Gene Expression Data from Treated Mice and Relevance across Human and Rat Species

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Thomas, Reuben ^a   Thomas, Russell S ^b   Auerbach, Scott S ^c   Portier, Christopher J ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 2,4 DIBROMOANTHRAQUINONE; 1,2 DIBROMOETHANE; 1,4 DICHLOROBENZENE; 1,5 NAPHTHALENEDIAMINE; 2 CHLOROMETHYLPYRIDINE HYDROCHLORIDE; 4 NITROANTHRANILIC ACID; ACRYLAMIDE DERIVATIVE; ANTHRANILIC ACID DERIVATIVE; ANTHRAQUINONE DERIVATIVE; BENZENE; BENZOFURAN DERIVATIVE; COUMARIN; DIBROMONEOPENTYL GLYCOL; DICHLOROMETHANE; DIMPYLATE; ETHYLENE OXIDE; ETHYLENEDIAMINE DERIVATIVE; IODOFORM; MALATHION; MESSENGER RNA; N (1 NAPHTHYL)ETHYLENEDIAMINE; N (HYDROXYMETHYL)ACRYLAMIDE; NAPHTHALENE DERIVATIVE; PHOSPHORIC ACID TRIS(2,3 DIBROMOPROPYL) ESTER; PROPANEDIOL DERIVATIVE; PYRIDINE DERIVATIVE; QUINTOZENE; TETRAFLUOROETHYLENE; UNCLASSIFIED DRUG; VANADIUM PENTOXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CANCER RISK; CARCINOGEN TESTING; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE EXPRESSION; GENOME; LIVER CARCINOGENESIS; LIVER TUMOR; MOLECULAR MODEL; MOUSE; NONHUMAN; PREDICTIVE VALIDITY; RAT; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SPECIES DIFFERENCE; VALIDATION PROCESS;

ALGORITHMS; ANIMALS; BIOLOGICAL ASSAY; CARCINOGENESIS; COMPUTATIONAL BIOLOGY; DATABASES, GENETIC; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; LIVER; LIVER NEOPLASMS; MICE; MODELS, STATISTICAL; RATS; ROC CURVE; SPECIES SPECIFICITY; TRANSCRIPTOME;

MUS; RATTUS; RODENTIA;

EID: 84878522427     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063308     Document Type: Article

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