Pharmacological ascorbate radiosensitizes pancreatic cancer

Cancer Research

Volumn 75, Issue 16, 2015, Pages 3314-3326

  Du, Juan ^a   Cieslak, John A ^a   Welsh, Jessemae L ^a   Sibenaller, Zita A ^a   Allen, Bryan G ^a,b   Wagner, Brett A ^a   Kalen, Amanda L ^a   Doskey, Claire M ^a   Strother, Robert K ^a   Button, Anna M ^b   Mott, Sarah L ^b   Smith, Brian ^b   Tsai, Susan ^c   Mezhir, James ^a,b   Goswami, Prabhat C ^a,b   Spitz, Douglas R ^a,b   Buettner, Garry R ^a,b   Cullen, Joseph J ^a,b,d  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; CATALASE; GEMCITABINE; HYDROGEN PEROXIDE; ANTIOXIDANT; GLUTATHIONE; GLUTATHIONE DISULFIDE; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL DESTRUCTION; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL VIABILITY; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DRUG MECHANISM; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VIVO STUDY; IONIZING RADIATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS CANCER; PANCREATIC CANCER CELL LINE; PRIORITY JOURNAL; RADIOSENSITIZATION; TUMOR XENOGRAFT; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMORADIOTHERAPY; DRUG EFFECTS; DRUG SCREENING; GENETICS; KAPLAN MEIER METHOD; METABOLISM; NUDE MOUSE; PANCREATIC NEOPLASMS; RADIATION RESPONSE; STATISTICAL MODEL; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CHEMORADIOTHERAPY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GLUTATHIONE; GLUTATHIONE DISULFIDE; HUMANS; HYDROGEN PEROXIDE; KAPLAN-MEIER ESTIMATE; LINEAR MODELS; MICE, NUDE; OXIDATIVE STRESS; PANCREATIC NEOPLASMS; RADIATION, IONIZING; RADIATION-SENSITIZING AGENTS; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84942893061     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-1707     Document Type: Article

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