The rate of cellular hydrogen peroxide removal shows dependency on GSH: Mathematical insight into in vivo H2O2 and GPx concentrations

Free Radical Research

Volumn 41, Issue 11, 2007, Pages 1201-1211

  Ng, Chin F ^a   Schafer, Freya Q ^b   Buettner, Garry R ^b   Rodgers, V G J ^a  

^a University of California Riverside   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Glutathione; Glutathione peroxidase; Hydrogen peroxide; Kinetics; Mathematical modelling

Indexed keywords

GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; HYDROGEN PEROXIDE;

ARTICLE; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MATHEMATICAL MODEL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR CELL; TUMOR GROWTH;

ANIMALS; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; MODELS, BIOLOGICAL; MODELS, THEORETICAL; SORPTION DETOXIFICATION;

EID: 36048938363     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.1080/10715760701625075     Document Type: Article

References (55)

1. 2 in cells and thereby their biological state. Free Radic Biol Med, 41, pp. 1338-1350.
2. Liu, R., Buettner, GR and Oberley, LW. (2000) Oxygen free radicals mediate the induction of manganese superoxide dismutase gene expression by TNF-α in human oral carcinoma SCC-25 cells. Free Radic Biol Med, 28, pp. 1197-1205.
3. Oberley, LW, Oberley, TD and Buettner, GR. (1981) Cell division in normal and transformed cells: The possible role of superoxide dismutase and hydrogen peroxide. Med Hypotheses, 7, pp. 21-42.
4. Jones, DP. (2006) Extracellular redox state: Refining the definition of oxidative stress in aging. Rejuvenation Res, 9, pp. 169-181.
5. Jones, DP. (2006) Disruption of mitochondrial redox circuitry in oxidative stress. Chem-Biol Interact, 163, pp. 38-53.
6. Chance, B., Sies, H. and Boveris, A. (1979) Hydroperoxide metabolism in mammalian organs. Physiol Rev, 59, pp. 527-605.
7. Rhee, SG, Chang, TS, Bae, YS, Lee, SR and Kang, SW. (2003) Cellular regulation by hydrogen peroxide. J Am Soc Nephrol, 14:8, pp. S211-S215.
8. Rhee, SG, Chae, HZ and Kim, K. (2005) Peroxiredoxins: A historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med, 38, pp. 1543-1552.
9. Mills, GC. (1957) Hemoglobin catabolism. I. Glutathione peroxidase, an erythrocyte enzyme which protects hemoglobin from oxidative breakdown. J Biol Chem, 229, pp. 189-197.
10. Ursini, F., Maiorino, M., Brigelius-Flohé, R., Aumann, KD, Roveri, A., Schomburg, D. and Flohé, L. (1995) Diversity of glutathione peroxidases. Methods Enzymol, 252, pp. 38-53.
11. Brigelius-Flohé, R. (1999) Tissue-specific functions of individual glutathione peroxidases. Free Radic Biol Med, 27, pp. 951-965.
12. Brigelius-Flohé, R., Wingler, R. and Muller, C. (2002) Estimation of individual types of glutathione peroxidases. Methods Enzymol, 347, pp. 101-112.
13. 2-oxydoreduktase (Glutathion-Peroxidase). Hoppe-Seylers Zeitschrift Fur Physiologische Chemie, 348, pp. 540-552.
14. Flohé, L., Schaich, E., Voelter, W. and Wendel, A. (1971) Glutathion peroxidase. 3. Spectral characteristics and experiments on reaction mechanism. Hoppe-Seylers Zeitschrift Fur Physiologische Chemie, 352, pp. 170-180.
15. Flohé, L. (1971) Glutathione peroxidase-enzymology and biological aspects. Klinische Wochenschrift, 49, pp. 669-683.
16. Flohé, L., Loschen, G., Gunzle, WA and Eichele, E. (1972) Glutathione peroxidase, V. The kinetic mechanism. Hoppe-Seylers Zeitschrift fur Physiologische Chemie, 353, pp. 987-999.
17. Maiorino, M., Roveri, A., Gregolin, C. and Ursini, F. (1986) Different effects of Triton X-100, deoxycholate, and fatty acids on the kinetics of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase. Arch Biochem Biophys, 251, pp. 600-605.
18. Flohé, L. (1978) Glutathione peroxidase: Fact and fiction. Ciba Foundation Symp, 65, pp. 95-122.
19. Gunzler, WA, Vergin, H., Muller, I. and Flohé, L. (1972) Glutathione peroxidase VI: The reaction of glutahione peroxidase with various hydroperoxides. Hoppe-Seylers Zeitschrift fur Physiologische Chemie, 353, pp. 1001-1004.
20. Ursini, F., Maiorino, M. and Gregolin, C. (1985) The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. Biochim Biophys Acta, 839, pp. 62-70.
21. Esworthy, RS, Chu, FF, Geiger, P., Girotti, AW and Doroshow, JH. (1993) Reactivity of plasma glutathione peroxidase with hydroperoxide substrates and glutathione. Arch Biochem Biophys, 307, pp. 29-34.
22. Aumann, KD, Bedorf, N., Brigelius-Flohé, R., Schomburg, D. and Flohé, L. (1997) Glutathione peroxidase revisited-simulation of the catalytic cycle by computer-assisted molecular modeling. Biomed Environ Sci, 10, pp. 136-155.
23. Salvador, A., Antunes, F. and Pinto, RE. (1995) Kinetic modeling of in vitro lipid peroxidation experiments - 'low level' validation of a model of in vivo lipid peroxidation. Free Radic Res, 23, pp. 151-172.
24. Yan, T., Yang, JQ, Oberley, TD and Oberley, LW. (2000) The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase. Cancer Res, 60, pp. 3927-3939.
25. Schafer, FQ and Buettner, GR. (2001) Redox state of the cell as viewed though the glutathione disulfide/glutathione couple. Free Radic Biol Med, 30, pp. 1191-1212.
26. Mawson, CA. (1955) Meaning of 'turnover' in biochemistry. Nature, 176, p. 317.
27. Antunes, F., Salvador, A., Marinho, S., Alves, R. and Pinto, RE. (1996) Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model. Free Radic Biol Med, 21, pp. 917-943.
28. Dalziel, K. (1957) Initial steady state velocities in the evaluation of enzyme-coenzyme-substrate reaction mechanisms. Acta Chem Scand, 11, pp. 1706-1723.
29. Forstrom, JW, Stults, FH and Tappel, AL. (1979) Rat liver cytosolic glutathione peroxidase: Reactivity with linoleic acid hydroperoxide and cumeme hydroperoxide. Arch Biochem Biophys, 193, pp. 51-55.
30. 2/GPx: Comparative importance on the reduction of hydroperoxides in rat liver mitochondria. Free Radic Biol Med, 19, pp. 669-677.
31. Stults, FH, Forstrom, JW, Chiu, DTY and Tappel, AL. (1977) Rat liver glutathione peroxidase: Purification and study of multiple forms. Arch Biochem Biophys, 183, pp. 490-497.
32. Marinho, HS, Antunes, F. and Pinto, RE. (1997) Role of glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase in the reduction of lysophospholipid hydroperoxides. Free Radic Biol Med, 22, pp. 871-883.
33. Liu, SY and Stadtman, TC. (1997) Heparin-binding properties of selenium-containing thioredoxin reductase from HeLa cells and human lung adenocarcinoma cells. Proc Natl Acad Sci USA, 94, pp. 6138-6141.
34. Giulivi, C., Hockstein, P. and Davies, KJA. (1994) Hydrogen peroxide production by red blood cells. Free Radic Biol Med, 16, pp. 123-129.
35. Roy, S., Khana, S., Nallu, K., Hunt, TK and Sen, SK. (2006) Dermal wound healing is subject to redox control. Molecular Therapy, 13, pp. 211-220.
36. 2 generation in perfused rat liver and the reaction of catalase compound I and hydrogen donors. Arch Biochem Biophys, 154, pp. 117-131.
37. Stone, JR. (2004) An assessment of proposed mechanisms for sensing hydrogen peroxide in mammalian systems. Arch Biochem Biophys, 422, pp. 119-124.
38. 2 induce apoptosis through Fenton chemistry independent of the cellular thiol state. Free Radic Biol Med, 30, pp. 1008-1018.
39. 2 gradients across biomembranes. FEBS Lett, 475, pp. 121-126.
40. Gear, CW. (1971) Numerical initial-value problems in ordinary differential equations, Prentice-Hall, Englewood Cliffs, NJ
41. Hindmarsh, AC (1974) GEAR: Ordinary differential equation system solver.
42. (1991) The IMSL Libraries, pp. 755-771. IMSL Inc, Houston, Texas
43. Lawrence, RA and Burk, RF. (1976) Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun, 71, pp. 952-958.
44. Oberley, LW and Buettner, GR. (1979) The role of superoxide dismutase in cancer: A review. Cancer Res, 39, pp. 1141-1149.
45. Sun, Y., Oberley, LW, Elwell, JH and Sierra-Rivera, E. (1989) Antioxidant enzyme activities in normal and transformed mouse liver cells. Int J Cancer, 44, pp. 1028-1033.
46. Hardman, WE, Munoz Jr, J. and Cameron, IL. (2002) Role of lipid peroxidation and antioxidant enzymes in omega 3 fatty acids induced suppression of breast cancer xenograft growth in mice. Cancer Cell Int, 2, p. 10.
47. Yang, J., Lam, EWN, Hammad, HM, Oberley, TD and Oberley, LW. (2002) Antioxidant enzyme levels in oral squamous cell carcinoma and normal human oral epithelium. J Oral Pathol Med, 31, pp. 71-77.
48. Hu, YJ, Dolan, ME, Bae, R., Yee, H., Roy, M., Glickman, R., Kiremidjian-Schumacher, L. and Diamond, AM. (2004) Allelic loss at the GPx-1 locus in cancer of the head and neck. Biol Trace Elem Res, 101, pp. 97-106.
49. Venkataraman, S., Jiang, X., Weydert, CJ, Zhang, Y., Zhang, HJ, Goswami, PC, Ritchie, JM, Oberley, LW and Buettner, GR. (2005) Manganese superoxide dismutase overexpression inhibits the growth of androgen-independent prostate cancer cells. Oncogene, 24, pp. 77-89.
50. Weydert, CJ, Waugh, TA, Ritchie, JM, Iyer, KS, Smith, JL, Spitz, DR and Oberley, LW. (2006) Overexpression of manganese or copper zinc superoxide dismutase inhibits breast cancer growth. Free Radic Biol Med, 41, pp. 226-237.
51. 2 permeation through cytoplasmic and peroxisomal membranes: Comparison with experimental data. Biochim Biophys Acta, 1673, pp. 149-159.
52. Reth, M. (2002) Hydrogen peroxide as second messenger in lymphocyte activation. Immunology, 3, pp. 1129-1134.
53. Schnell, S. and Turner, TE. (2004) Reaction kinetics in intracellular environments with macromolecular crowding: Simulations and rate laws. Prog Biophys Molec Biol, 85, pp. 235-260.
54. Hanggi, P., Talkner, P. and Borkovec, M. (1990) Reaction-rate theory-50 years after Kramers. Rev Mod Phys, 62, pp. 251-341.
55. Li, SJ (1999) The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by managanese superoxide dismutase [dissertation]. University of Iowa, University of Iowa, Iowa City, IA