Systems Biology with High-Throughput Sequencing Reveals Genetic Mechanisms Underlying the Metabolic Syndrome in the Lyon Hypertensive Rat

Circulation: Cardiovascular Genetics

Volumn 8, Issue 2, 2015, Pages 316-326

  Wang, Jinkai ^a,c   Ma, Man Chun John ^a   Mennie, Amanda K ^a   Pettus, Janette M ^a   Xu, Yang ^a   Lin, Lan ^a,c   Traxler, Matthew G ^a   Jakoubek, Jessica ^a   Atanur, Santosh S ^d   Aitman, Timothy J ^d   Xing, Yi ^a,c   Kwitek, Anne E ^a,b  

^a Department of Internal Medicine ^*  (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

genetics; systems biology; transcriptome

Indexed keywords

AQUAPORIN; AQUAPORIN 11; CHOLESTEROL; GLUCOSE; LEPTIN; MESSENGER RNA; ORGANIC CATION TRANSPORTER 1; PRELID1 PROTEIN; PROLINE CARBOXYPEPTIDASE; PROTEIN; SIDEROFLEXIN 1; TRANSCRIPTION FACTOR GATA 1; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

AFFECT; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; BODY GROWTH; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 1; CHROMOSOME 10; CHROMOSOME 14; CHROMOSOME 15; CHROMOSOME 17; CHROMOSOME 2; CHROMOSOME 7; CHROMOSOME 8; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOWN REGULATION; EPIDEMIOLOGY; FATTY ACID METABOLISM; FEMALE; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE LOCATION; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; GENOME; GENOTYPE; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HEART RATE; HIGH THROUGHPUT SEQUENCING; HORMONE BLOOD LEVEL; HYPERTENSION; IMMUNE RESPONSE; IMMUNOREGULATION; INFLAMMATION; LIPID BLOOD LEVEL; MALE; METABOLIC SYNDROME X; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PATHOGENESIS; PHENOTYPE; PHENOTYPIC VARIATION; PLEIOTROPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE TRAIT LOCUS; RAT; RNA SEQUENCE; RNA TRANSLATION; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMS BIOLOGY; TRIACYLGLYCEROL BLOOD LEVEL; UPREGULATION; WHITE ADIPOSE TISSUE; ANIMAL; CHROMOSOME; GENETICS;

ANIMALS; CHROMOSOMES, MAMMALIAN; HYPERTENSION; METABOLIC SYNDROME X; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RATS; SYSTEMS BIOLOGY;

EID: 84942872443     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.114.000520     Document Type: Article

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