Effects of chromosome 17 on features of the metabolic syndrome in the Lyon hypertensive rat

Physiological Genomics

Volumn 33, Issue 2, 2008, Pages 212-217

  Gilibert, S ^a   Kwitek, A E ^b,d   Hubner, N ^c   Tschannen, M ^b   Jacob, H J ^b   Sassard, J ^a   Bataillard, A ^a  

^a UNIVERSITÉ LYON 1   (France)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

Consomic; Hypertension

Indexed keywords

CHOLESTEROL; GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; BROWN NORWAY RAT; CHROMOSOME 17; CHROMOSOME ANALYSIS; CHROMOSOME SUBSTITUTION; CHROMOSOME SUBSTITUTION STRAIN; CONTROLLED STUDY; MALE; METABOLIC PARAMETERS; METABOLIC SYNDROME X; MORPHOLOGICAL TRAIT; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; WEIGHT REDUCTION;

ANIMALS; BLOOD PRESSURE; BODY WEIGHT; CHOLESTEROL; CHROMOSOMES, MAMMALIAN; HYPERTENSION; METABOLIC SYNDROME X; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RATS; RATS, INBRED STRAINS; TIME FACTORS; TRIGLYCERIDES;

RATTUS; RATTUS NORVEGICUS;

EID: 43049105402     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00262.2007     Document Type: Article

References (30)

1. Bilusic M, Bataillard A, Tschannen MR, Gao L, Barreto NE, Vincent M, Wang T, Jacob HJ, Sassard J, Kwitek AE. Mapping the genetic determinants of hypertension, metabolic diseases, and related phenotypes in the Lyon hypertensive rat. Hypertension 44: 695-701, 2004.
2. Bjorntorp P. Metabolic implications of body fat distribution. Diabetes Care 14: 1132-1143, 1991.
3. Blizard DA, Peterson WN, Iskandar SS, Shihabi ZK, Adams N. The effect of a high salt diet and gender on blood pressure, urinary protein excretion and renal pathology in SHR rats. Clin Exp Hypertens A 13: 687-697, 1991.
4. Boulanger M, Duhault J, Broux O, Bataillard A, Sassard J. Lack of insulin resistance in the Lyon hypertensive rat. Fundam Clin Pharmacol 11: 546-549, 1997.
5. Cowley AW Jr, Roman RJ, Jacob HJ. Application of chromosomal substitution techniques in gene-function discovery. J Physiol 554: 46-55, 2004.
6. Festing MFW. Inbred Strains in Biomedical Research. New York: Oxford Univ. Press, 1979, p. xii.
7. Florin M, Lo M, Liu KL, Sassard J. Salt sensitivity in genetically hypertensive rats of the Lyon strain. Kidney Int 59: 1865-1872, 2001.
8. Friedman J, Halaas J. Leptin and the regulation of body weight in mammals. Nature 396: 763-770, 1998.
9. Greenhouse DD, Festing MFW, Hasan S, Cohen AL. Inbred strains of rats. In: Genetic Monitoring of Inbred Strains of Rats, edited by Hedrich HJ. Stuttgart: Gustav Fischer, 1990.
10. Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109: 433-438, 2004.
11. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP. Prospective analysis of the insulin-resistance syndrome (syndrome X). Diabetes 41: 715-722, 1992.
12. Hardenbol P, Baner J, Jain M, Nilsson M, Namsaraev EA, Karlin-Neumann GA, Fakhrai-Rad H, Ronaghi M, Willis TD, Landegren U, Davis RW. Multiplexed genotyping with sequence-tagged molecular inversion probes. Nat Biotechnol 21: 673-678, 2003.
13. Hardenbol P, Yu F, Belmont J, Mackenzie J, Bruckner C, Brundage T, Boudreau A, Chow S, Eberle J, Erbilgin A, Falkowski M, Fitzgerald R, Ghose S, Iartchouk O, Jain M, Karlin-Neumann G, Lu X, Miao X, Moore B, Moorhead M, Namsaraev E, Pasternak S, Prakash E, Tran K, Wang Z, Jones HB, Davis RW, Willis TD, Gibbs RA. Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay. Genome Res 15: 269-275, 2005.
14. Hong Y, Pedersen NL, Brismar K, de Faire U. Genetic and environmental architecture of the features of the insulin-resistance syndrome. Am J Hum Genet 60: 143-152, 1997.
15. Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, Taskinen MR, Groop L. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24: 683-689, 2001.
16. Jacob HJ, Brown DM, Bunker RK, Daly MJ, Dzau VJ, Goodman A, Koike G, Kren V, Kurtz T, Lernmark Å , Levan G, Mao Y, Pettersson A, Pravenec M, Simon JS, Szpirer C, Szpirer J, Trolliet MR, Winer ES, Lander ES. A genetic linkage map of the laboratory rat, Rattus norvegicus. Nat Genet 9: 63-69, 1995.
17. Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA Jr, Roman RJ, Tonellato PJ, Cowley AW Jr. BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. Physiol Genomics 25: 303-313, 2006.
18. Lande R, Thompson R. Efficiency of marker-assisted selection in the improvement of quantitative traits. Genetics 124: 743-756, 1990.
19. Lazar J, Moreno C, Jacob HJ, Kwitek AE. Impact of genomics on research in the rat. Genome Res 15: 1717-1728, 2005.
20. Liese AD, Mayer-Davis EJ, Tyroler HA, Davis CE, Keil U, Schmidt MI, Brancati FL, Heiss G. Familial components of the multiple metabolic syndrome: the ARIC study. Diabetologia 40: 963-970, 1997.
21. Mitchell BD, Kammerer CM, Mahaney MC, Blangero J, Comuzzie AG, Atwood LD, Haffner SM, Stern MP, MacCluer JW. Genetic analysis of the IRS. Pleiotropic effects of genes influencing insulin levels on lipoprotein and obesity measures. Arterioscler Thromb Vasc Biol 16: 281-288, 1996.
22. Nadeau J, Singer J, Matin A, Lander E. Analysing complex genetic traits with chromosome substitution strains. Nat Genet 24: 221-225, 2000.
23. Rat Genome Sequencing Project Consortium. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428: 493-521, 2004.
24. Reaven GM. Insulin and hypertension. Clin Exp Hypertens A 12: 803-816, 1990.
25. Sarkis A, Liu KL, Lo M, Benzoni D. Renal medullary blood flow and salt load in Lyon hypertensive rats. Am J Hypertens 15: 212-216, 2002.
26. Uzu T, Kimura G, Yamauchi A, Kanasaki M, Isshiki K, Araki S, Sugiomoto T, Nishio Y, Maegawa H, Koya D, Haneda M, Kashiwagi A. Enhanced sodium sensitivity and disturbed circadian rhythm of blood pressure in essential hypertension. J Hypertens 24: 1627-1632, 2006.
27. Vincent M, Boussairi EH, Cartier R, Lo M, Sassolas A, Cerutti C, Barres C, Gustin MP, Cuisinaud G, Samani NJ. High blood pressure and metabolic disorders are associated in the Lyon hypertensive rat. J Hypertens 11: 1179-1185, 1993.
28. Vincent M, Cartier R, Privat P, Benzoni D, Samani NJ, Sassard J. Major cardiovascular risk factors in Lyon hypertensive rats. A correlation analysis in a segregating population. J Hypertens 14: 469-474, 1996.
29. Visscher PM. Speed congenics: accelerated genome recovery using genetic markers. Genet Res 74: 81-85, 1999.
30. Yagil C, Sapojnikov M, Kreutz R, Zurcher H, Ganten D, Yagil Y. Role of chromosome X in the Sabra rat model of salt-sensitive hypertension. Hypertension 33: 261-265, 1999.