Intraduodenal infusion of a combination of tastants decreases food intake in humans

American Journal of Clinical Nutrition

Volumn 102, Issue 4, 2015, Pages 729-735

  Van Avesaat, Mark ^a,b   Troost, Freddy J ^a,b   Ripken, Dina ^a,c,d   Peters, Jelmer ^b   Hendriks, Henk F J ^a   Masclee, Ad A M ^a,b  

^a TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c TNO   (Netherlands)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

Food intake; Gastrointestinal peptides; Intraduodenal infusion; Tastants

Indexed keywords

CHOLECYSTOKININ; GASTROINTESTINAL POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUTAMATE SODIUM; PEPTIDE YY; PLACEBO; QUININE; REBAUDIOSIDE A; SWEETENING AGENT; UNCLASSIFIED DRUG; FLAVORING AGENT; GLUCOSE BLOOD LEVEL; KAURANE DERIVATIVE;

ADULT; ARTICLE; BITTER TASTE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; FOOD INTAKE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN EXPERIMENT; HUNGER; MALE; MEAL; NORMAL HUMAN; PROTEIN SECRETION; RANDOMIZED CONTROLLED TRIAL; SATIETY; SWEETNESS; UMAMI; VISUAL ANALOG SCALE; YOUNG ADULT; BLOOD; BODY MASS; CALORIC INTAKE; DRUG EFFECTS; DUODENUM; GLUCOSE BLOOD LEVEL; METABOLISM; TASTE;

ADULT; BLOOD GLUCOSE; BODY MASS INDEX; BREAKFAST; CHOLECYSTOKININ; CROSS-OVER STUDIES; DITERPENES, KAURANE; DOUBLE-BLIND METHOD; DUODENUM; ENERGY INTAKE; FEMALE; FLAVORING AGENTS; GLUCAGON-LIKE PEPTIDE 1; HUMANS; HUNGER; MALE; PEPTIDE YY; QUININE; SATIATION; SODIUM GLUTAMATE; TASTE; TASTE PERCEPTION; YOUNG ADULT;

EID: 84942864485     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.115.113266     Document Type: Article

References (31)

1. Depoortere I. Taste receptors of the gut: emerging roles in health and disease. Gut 2014;63:179-90.
2. Dotson CD, Geraedts MC, Munger SD. Peptide regulators of peripheral taste function. Semin Cell Dev Biol 2013;24:232-9.
3. Geraedts MC, Munger SD. Gustatory stimuli representing different perceptual qualities elicit distinct patterns of neuropeptide secretion from taste buds. J Neurosci 2013;33:7559-64.
4. Chen MC, Wu SV, Reeve JR Jr., Rozengurt E. Bitter stimuli induce Ca2+ signaling and CCK release in enteroendocrine STC-1 cells: role of L-type voltage-sensitive Ca2+ channels. Am J Physiol Cell Physiol 2006;291:C726-39.
5. Geraedts MC, Troost FJ, Saris WH. Different tastants and low-caloric sweeteners induce differential effects on the release of satiety hormones. Food Chem 2011;129:731-8.
6. Bezençon C, le Coutre J, Damak S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses 2007;32:41-9.
7. van der Wielen N, van Avesaat M, de Wit NJ, Vogels JT, Troost F, Masclee A, Koopmans SJ, van der Meulen J, Boekschoten MV, Muller M, et al. Cross-species comparison of genes related to nutrient sensing mechanisms expressed along the intestine. PLoS One 2014;9:e107531.
8. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, Zhou J, Kim HH, Xu X, Chan SL, Juhaszova M, et al. Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci USA 2007;104:15069-74.
9. Young RL, Sutherland K, Pezos N, Brierley SM, Horowitz M, Rayner CK, Blackshaw LA. Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut 2009;58:337-46.
10. Andrews CNVS, Janssen P. The bitter taste receptor agonist denatonium benzoate alters intragastric pressure profiles during nutrient drink test in healthy volunteers. Gastroenterology 2013;144(Suppl 1):S-549.
11. Hosaka H, Kusano M, Zai H, Kawada A, Kuribayashi S, Shimoyama Y, Nagoshi A, Maeda M, Kawamura O, Mori M. Monosodium glutamate stimulates secretion of glucagon-like peptide-1 and reduces postprandial glucose after a lipid-containing meal. Aliment Pharmacol Ther 2012;36:895-903.
12. Van Strien T, Rookus MA, Bergers GP, Frijters JE, Defares PB. Life events, emotional eating and change in body mass index. Int J Obes 1986;10:29-35.
13. Maljaars PW, Symersky T, Kee BC, Haddeman E, Peters HP, Masclee AA. Effect of ileal fat perfusion on satiety and hormone release in healthy volunteers. Int J Obes (Lond) 2008;32:1633-9.
14. Blom WA, Lluch A, Stafleu A, Vinoy S, Holst JJ, Schaafsma G, Hendriks HF. Effect of a high-protein breakfast on the postprandial ghrelin response. Am J Clin Nutr 2006;83:211-20.
15. Parker BA, Sturm K, MacIntosh CG, Feinle C, Horowitz M, Chapman IM. Relation between food intake and visual analogue scale ratings of appetite and other sensations in healthy older and young subjects. Eur J Clin Nutr 2004;58:212-8.
16. Symonds EL, Peiris M, Page AJ, Chia B, Dogra H, Masding A, Galanakis V, Atiba M, Bulmer D, Young RL, et al. Mechanisms of activation of mouse and human enteroendocrine cells by nutrients. Gut 2015;64:618-26.
17. Ripken D, van der Wielen N, Wortelboer HM, Meijerink J, Witkamp RF, Hendriks HF. Steviol glycoside rebaudioside A induces glucagonlike peptide-1 and peptide YY release in a porcine ex vivo intestinal model. J Agric Food Chem 2014;62:8365-70.
18. Sternini C, Anselmi L, Rozengurt E. Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing. Curr Opin Endocrinol Diabetes Obes 2008;15:73-8.
19. Carter BE, Monsivais P, Perrigue MM, Drewnowski A. Supplementing chicken broth with monosodium glutamate reduces hunger and desire to snack but does not affect energy intake in women. Br J Nutr 2011; 106:1441-8.
20. Rogers PJ, Blundell JE. Umami and appetite: effects of monosodium glutamate on hunger and food intake in human subjects. Physiol Behav 1990;48:801-4.
21. Steinert RE, Frey F, Topfer A, Drewe J, Beglinger C. Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides. Br J Nutr 2011;105:1320-8.
22. Wu T, Zhao BR, Bound MJ, Checklin HL, Bellon M, Little TJ, Young RL, Jones KL, Horowitz M, Rayner CK. Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. Am J Clin Nutr 2012;95: 78-83.
23. Ma J, Chang J, Checklin HL, Young RL, Jones KL, Horowitz M, Rayner CK. Effect of the artificial sweetener, sucralose, on small intestinal glucose absorption in healthy human subjects. Br J Nutr 2010; 104:803-6.
24. Geraedts MC, Troost FJ, Munsters MJ, Stegen JH, de Ridder RJ, Conchillo JM, Kruimel JW, Masclee AA, Saris WH. Intraduodenal administration of intact pea protein effectively reduces food intake in both lean and obese male subjects. PLoS One 2011;6:e24878.
25. Ryan AT, Luscombe-Marsh ND, Saies AA, Little TJ, Standfield S, Horowitz M, Feinle-Bisset C. Effects of intraduodenal lipid and protein on gut motility and hormone release, glycemia, appetite, and energy intake in lean men. Am J Clin Nutr 2013;98:300-11.
26. van Avesaat M, Troost FJ, Ripken D, Hendriks HF, Masclee AA. Ileal brake activation: macronutrient-specific effects on eating behavior Int J Obes (Lond) 2015;39:235-43.
27. Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 2007;117:13-23.
28. Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS. The receptors and cells for mammalian taste. Nature 2006;444:288-94.
29. Caicedo A, Roper SD. Taste receptor cells that discriminate between bitter stimuli. Science 2001;291:1557-60.
30. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 2010;35:157-70.
31. Hellfritsch C, Brockhoff A, Stahler F, Meyerhof W, Hofmann T. Human psychometric and taste receptor responses to steviol glycosides. J Agric Food Chem 2012;60:6782-93.