Monosodium glutamate stimulates secretion of glucagon-like peptide-1 and reduces postprandial glucose after a lipid-containing meal

Alimentary Pharmacology and Therapeutics

Volumn 36, Issue 9, 2012, Pages 895-903

  Hosaka, H ^a   Kusano, M ^b   Zai, H ^a   Kawada, A ^a   Kuribayashi, S ^a   Shimoyama, Y ^a   Nagoshi, A ^a   Maeda, M ^a   Kawamura, O ^a   Mori, M ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b GUNMA UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; GLUTAMATE SODIUM; INCRETIN; INSULIN; SODIUM CHLORIDE;

ADULT; ARTICLE; BREATH ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG MECHANISM; FOOD COMPOSITION; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLYCEMIC CONTROL; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; LIPID DIET; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SINGLE BLIND PROCEDURE; STOMACH EMPTYING; VISUAL ANALOG SCALE; VOLUNTEER;

ADULT; AREA UNDER CURVE; BLOOD GLUCOSE; DIETARY FATS; FOOD ADDITIVES; GASTRIC EMPTYING; GLUCAGON-LIKE PEPTIDE 1; GLUTAMIC ACID; HUMANS; MALE; POSTPRANDIAL PERIOD; SINGLE-BLIND METHOD; SODIUM GLUTAMATE;

EID: 84878525407     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.12050     Document Type: Article

References (42)

1. Weaver CD, Yao TL, Powers AC, Verdoorn TA. Differential expression of glutamate receptor subtypes in rat pancreatic islets. J Biol Chem 1996; 271: 12977-84. (Pubitemid 26175874)
2. Bertrand G, Gross R, Puech R, Loubatières-Mariani MM, Bockaert J. Evidence for a glutamate receptor of the AMPA subtype which mediates insulin release from rat perfused pancreas. Br J Pharmacol 1992; 106: 354-9.
3. Bertrand G, Puech R, Loubatieres-Mariani MM, Bockaert J. Glutamate stimulates insulin secretion and improves glucose tolerance in rats. Am J Physiol 1995; 269: E551-6.
4. Graham TE, Sgro V, Friars D, Gibala MJ. Glutamate ingestion: the plasma and muscle free amino acid pools of resting humans. Am J Physiol Endocrinol Metab 2000; 278: E83-9. (Pubitemid 30101923)
5. Chevassus H, Renard E, Bertrand G, et al. Effects of oral monosodium (L)-glutamate on insulin secretion and glucose tolerance in healthy volunteers. Br J Clin Pharmacol 2002; 53: 641-3. (Pubitemid 34621790)
6. Höfer D, Asan E, Drenckhahn D. Chemosensory perception in the gut. News Physiol Sci 1999; 14: 18-23.
7. Uneyama H, Niijima A, San GA, Torii K. Luminal amino acid sensing in the rat gastric mucosa. Am J Physiol Gastrointest Liver Physiol 2006; 291: G1163-70. (Pubitemid 44904171)
8. Dyer J, Salmon KS, Zibrik L, Shirazi-Beechey SP. Expression of sweet taste receptors of the T1R family in the intestinal tract and enteroendocrine cells. Biochem Soc Trans 2005; 33(Pt 1): 302-5. (Pubitemid 40313828)
9. San GA, Maekawa T, Uneyama H, Torii K. Metabotropic glutamate receptor type 1 in taste tissue. Am J Clin Nutr 2009; 90: 743S-6S.
10. Zai H, Kusano M, Hosaka H, et al. Monosodium L-glutamate added to a high-energy, high-protein liquid diet promotes gastric emptying. Am J Clin Nutr 2009; 89: 431-5.
11. Toyomasu Y, Mochiki E, Yanai M, et al. Intragastric monosodium L-glutamate stimulates motility of upper gut via vagus nerve in conscious dogs. Am J Physiol Regul Integr Comp Physiol 2010; 298: R1125-35.
12. Horowitz M, Edelbroek MA, Wishart JM, Straathof JW. Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects. Diabetologia 1993; 36: 857-62. (Pubitemid 23248159)
13. Jones KL, Horowitz M, Carney BI, Wishart JM, Guha S, Green L. Gastric emptying in early noninsulin-dependent diabetes mellitus. J Nucl Med 1996; 37: 1643-8. (Pubitemid 26337168)
14. Nauck MA, Niedereichholz U, Ettler R, et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997; 273: E981-8.
15. Schirra J, Nicolaus M, Woerle HJ, Struckmeier C, Katschinski M, Göke B. GLP-1 regulates gastroduodenal motility involving cholinergic pathways. Neurogastroenterol Motil 2009; 21: e21-2.
16. Deane AM, Chapman MJ, Fraser RJ, et al. Effects of exogenous glucagon-like peptide-1 on gastric emptying and glucose absorption in the critically ill: relationship to glycemia. Crit Care Med 2010; 38: 1261-9.
17. Miki T, Minami K, Shinozaki H, et al. Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. Diabetes 2005; 54: 1056-63. (Pubitemid 40446319)
18. Ueda SY, Yoshikawa T, Katsura Y, Usui T, Nakao H, Fujimoto S. Changes in gut hormone levels and negative energy balance during aerobic exercise in obese young males. J Endocrinol 2009; 201: 151-9.
19. Ghoos YF, Maes BD, Geypens BJ, et al. Measurement of gastric-emptying rate of solids by means of a carbon-labeled octanoic-acid breath test. Gastroenterology 1993; 104: 1640-7. (Pubitemid 23235453)
20. 13C]acetate breath test accurately reflects gastric emptying of liquids in both liquid and semisolid test meals. Gastroenterology 1995; 108: 1048-55.
21. 13C]acetate breath test. Dig Dis Sci 1994; 39(Suppl.): 107S-9S.
22. 13C-acetate breath test: a validation study. Dig Liver Dis 2004; 36: 260-4. (Pubitemid 41115475)
23. Reimann F, Williams L, da Silva Xavier G, Rutter GA, Gribble FM. Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells. Diabetologia 2004; 47: 1592-601. (Pubitemid 39371642)
24. Greenfield JR, Farooqi IS, Keogh JM, et al. Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects. Am J Clin Nutr 2009; 89: 106-13.
25. Samocha-Bonet D, Wong O, Synnott EL, et al. Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients. J Nutr 2011; 141: 1233-8.
26. Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007; 132: 2131-57. (Pubitemid 46711096)
27. Herrmann C, Göke R, Richter G, Fehmann HC, Arnold R, Göke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion 1995; 56: 117-26.
28. Rocca AS, Brubaker PL. Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion. Endocrinology 1999; 140: 1687-94. (Pubitemid 29149238)
29. Bezençon C, le Coutre J, Damak S. Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells. Chem Senses 2007; 32: 41-9. (Pubitemid 46017873)
30. San GA, Maekawa T, Uneyama H, Yoshie S, Torii K. mGluR in the fundic glands of rat stomach. FEBS Lett 2007; 581: 1119-23. (Pubitemid 46385934)
31. Tsurugizawa T, Uematsu A, Nakamura E, et al. Mechanisms of neural response to gastrointestinal nutritive stimuli: the gut-brain axis. Gastroenterology 2009; 137: 262-73.
32. D'alessio DA, Kahn SE, Leusner CR, Ensinck JW. Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal. J Clin Invest 1994; 93: 2263-6. (Pubitemid 24143111)
33. Meneilly GS, McIntosh CH, Pederson RA, et al. Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes. Diabetes Care 2001; 24: 1951-6 (Pubitemid 33716507)
34. Egan JM, Meneilly GS, Habener JF, Elahi D. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. J Clin Endocrinol Metab 2002; 87: 3768-73. (Pubitemid 34879525)
35. Prigeon RL, Quddusi S, Paty B, D'Alessio DA. Suppression of endogenous glucose production by glucagon-like peptide 1 independent of islet hormones: an extrapancreatic effec of an incretin hormone. Am J Physiol 2003; 285: E701-7. (Pubitemid 37176420)
36. Thomassen A, Nielsen TT, Bagger JP, Henningsen P. Effects of intravenous glutamate on substrate availability and utilization across the human heart and leg. Metabolism 1991; 40: 378-84.
37. Ma J, Stevens JE, Cukier K, et al. Effects of a protein preload on gastric emptying, glycemia, and gut hormones after a carbohydrate meal in diet-controlled type 2 diabetes. Diabetes Care 2009; 32: 1600-2.
38. Wang JH, Inoue T, Higashiyama M, et al. Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats. J Pharmacol Exp Ther 2011; 339: 464-73.
39. Zhang F, Klebansky B, Fine RM, et al. Molecular mechanism for the umami taste synergism. Proc Natl Acad Sci USA 2008; 105: 20930-4.
40. Cunningham KM, Read NW. The effect of incorporating fat into different components of a meal on gastric emptying and postprandial blood glucose and insulin responses. Br J Nutr 1989; 61: 285-90. (Pubitemid 19088491)
41. Houghton LA, Mangnall YF, Read NW. Effect of incorporating fat into a liquid test meal on the relation between intragastric distribution and gastric emptying in human volunteers. Gut 1990; 31: 1226-9.
42. Khropycheva R, Andreeva J, Uneyama H, Torii K, Zolotarev V. Dietary glutamate signal evokes gastric juice excretion in dogs. Digestion 2011; 83(Suppl. 1): 7-12.