Apoptosis induced by lipid-associated membrane proteins from Mycoplasma hyopneumoniae in a porcine lung epithelial cell line with the involvement of caspase 3 and the MAPK pathway

Genetics and Molecular Research

Volumn 14, Issue 3, 2015, Pages 11429-11443

  Ni, B ^a   Bai, F F ^a   Wei, Y ^a   Liu, M J ^a   Feng, Z X ^a   Xiong, Q Y ^a   Hua, L Z ^a   Shao, G Q ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

Apoptosis; Caspase 3; Lipid associated membrane proteins; Mycoplasma hyopneumoniae

Indexed keywords

CASPASE 3; CASPASE 8; CYTOCHROME C; DNA NUCLEOTIDYLEXOTRANSFERASE; LIPID ASSOCIATED MEMBRANE PROTEIN; LIPOCORTIN 5; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PROPIDIUM IODIDE; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38;

ANIMAL CELL; APOPTOSIS; ARTICLE; CHROMOSOME; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME RELEASE; LUNG ALVEOLUS EPITHELIUM; MYCOPLASMA HYOPNEUMONIAE; NONHUMAN; PIG; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUNEL ASSAY; ANIMAL; BIOLOGICAL MODEL; CELL DEATH; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; EPITHELIUM CELL; LUNG; METABOLISM;

ANIMALS; APOPTOSIS; BACTERIAL PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 8; CELL DEATH; CELL LINE; CELL NUCLEUS; CELL SURVIVAL; CYTOCHROMES C; ENZYME ACTIVATION; EPITHELIAL CELLS; IN SITU NICK-END LABELING; LUNG; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; MYCOPLASMA HYOPNEUMONIAE; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; SUPEROXIDES; SUS SCROFA;

EID: 84942861589     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/2015.September.25.10     Document Type: Article

References (39)

1. Bai F, Ni B, Liu M, Feng Z, et al. (2013). Mycoplasma hyopneumoniae -derived lipid-associated membrane proteins induce apoptosis in porcine alveolar macrophage via increasing nitric oxide production, oxidative stress, and caspase-3 activation. Vet. Immunol. Immunopathol. 155: 155-161.
2. Beaudouin J, Liesche C, Aschenbrenner S, Hörner M, et al. (2013). Caspase-8 cleaves its substrates from the plasma membrane upon CD95-induced apoptosis. Cell Death Differ. 20: 599-610.
3. Behar SM, Martin CJ, Booty MG, Nishimura T, et al. (2011). Apoptosis is an innate defense function of macrophages against Mycobacterium tuberculosis. Mucosal Immunol. 4: 279-287.
4. Bogema DR, Deutscher AT, Woolley LK, Seymour LM, et al. (2012). Characterization of cleavage events in the multifunctional cilium adhesin Mhp684 (P146) reveals a mechanism by which Mycoplasma hyopneumoniae regulates surface topography. MBio. 3: e00282-11.
5. Damte D, Lee SJ, Hwang MH, Gebru E, et al. (2011). Inflammatory responses to Mycoplasma hyopneumoniae in murine alveolar macrophage cell lines. N Z Vet. J. 59: 185-190.
6. Deutscher AT, Tacchi JL, Minion FC, Padula MP, et al. (2012). Mycoplasma hyopneumoniae Surface proteins Mhp385 and Mhp384 bind host cilia and glycosaminoglycans and are endoproteolytically processed by proteases that recognize different cleavage motifs. J. Proteome Res. 11: 1924-1936.
7. Favaloro B, Allocati N, Graziano V, Di Ilio C, et al. (2012). Role of apoptosis in disease. Aging (Albany NY). 4: 330-349.
8. Ghatan S, Larner S, Kinoshita Y, Hetman M, et al. (2000). p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. J. Cell Biol. 150: 335-347.
9. Grassmé H, Jendrossek V and Gulbins E (2001). Molecular mechanisms of bacteria induced apoptosis. Apoptosis. 6: 441-445.
10. Hall RE, Agarwal S and Kestler DP (2000). Induction of leukemia cell differentiation and apoptosis by recombinant P48, a modulin derived from Mycoplasma fermentans. Biochem. Biophys. Res. Commun. 269: 284-289.
11. He J, You X, Zeng Y, Yu M, et al. (2009). Mycoplasma genitalium -derived lipid-associated membrane proteins activate NF-kappaB through toll-like receptors 1, 2, and 6 and CD14 in a MyD88-dependent pathway. Clin. Vaccine Immunol. 16: 1750-1757.
12. Hwang MH, Damte D, Lee JS, Gebru E, et al. (2011). Mycoplasma hyopneumoniae induces pro-inflammatory cytokine and nitric oxide production through NFκB and MAPK pathways in RAW264.7 cells. Vet. Res. Commun. 35: 21-34.
13. Into T and Shibata K (2005). Apoptosis signal-regulating kinase 1-mediated sustained p38 mitogen-activated protein kinase activation regulates mycoplasmal lipoprotein-and staphylococcal peptidoglycan-triggered Toll-like receptor 2 signalling pathways. Cell Microbiol. 7: 1305-1317.
14. Into T, Nodasaka Y, Hasebe A, Okuzawa T, et al. (2002). Mycoplasmal lipoproteins induce toll-like receptor 2-and caspases-mediated cell death in lymphocytes and monocytes. Microbiol. Immunol. 46: 265-276.
15. Into T, Kiura K, Yasuda M, Kataoka H, et al. (2004). Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappa B activation. Cell Microbiol. 6: 187-199.
16. Janssens S and Tinel A (2012). The PIDDosome, DNA-damage-induced apoptosis and beyond. Cell Death Differ. 19: 13-20.
17. MacKenzie SH and Clark AC (2012). Death by caspase dimerization. Adv. Exp. Med. Biol. 747: 55-73.
18. Mosmann T (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63.
19. Muneta Y, Minagawa Y, Shimoji Y, Ogawa Y, et al. (2008). Immune response of gnotobiotic piglets against Mycoplasma hyopneumoniae. J. Vet. Med. Sci. 70: 1065-1070.
20. Orrenius S, Gogvadze V and Zhivotovsky B (2007). Mitochondrial oxidative stress: implications for cell death. Annu. Rev. Pharmacol. Toxicol. 47: 143-183.
21. 2-treated HeLa cells. Mol. Med. Rep. 8: 557-564.
22. Qiu H, Wu YM, You XX, Yu MJ, et al. (2007). Mycoplasma genitalium lipid-associated membrane proteins induce human monocytic cell express proinflammatory cytokines and apoptosis by activating nuclear factor kappaB. Wei Sheng Wu Xue Bao. 47: 899-904.
23. Rawadi G and Roman-Roman S (1996). Mycoplasma membrane lipoproteins induced proinflammatory cytokines by a mechanism distinct from that of lipopolysaccharide. Infect. Immun. 64: 637-643.
24. Rawadi G, Roman-Roman S, Castedo M, Dutilleul V, et al. (1996). Effects of Mycoplasma fermentans on the myelomonocytic lineage. Different molecular entities with cytokine-inducing and cytocidal potential. J. Immunol. 156: 670-678.
25. Seo SH, Goloubeva O, Webby R and Webster RG (2001). Characterization of a porcine lung epithelial cell line suitable for influenza virus studies. J. Virol. 75: 9517-9525.
26. Seymour LM, Deutscher AT, Jenkins C, Kuit TA, et al. (2010). A processed multidomain Mycoplasma hyopneumoniae adhesin binds fibronectin, plasminogen, and swine respiratory cilia. J. Biol. Chem. 285: 33971-33978.
27. Shimizu T, Kida Y and Kuwano K (2008). A triacylated lipoprotein from Mycoplasma genitalium activates NF-kappaB through Toll-like receptor 1 (TLR1) and TLR2. Infect. Immun. 76: 3672-3678.
28. Su X, Wang P, Wang X, Guo L, et al. (2013). Involvement of MAPK activation and ROS generation in human leukemia U937 cells undergoing apoptosis in response to sonodynamic therapy. Int. J. Radiat. Biol. 89: 915-927.
29. Szczepanek SM, Frasca S Jr, Schumacher VL, Liao X, et al. (2010). Identification of lipoprotein MslA as a neoteric virulence factor of Mycoplasma gallisepticum. Infect. Immun. 78: 3475-3483.
30. Thacker EL and Minion FC (2012). Mycoplasmosis. Diseases of Swine 10th. edn. 2012. John Wiley and Sons Inc., USA. 57: 779-797.
31. Vieira H and Kroemer G (2003). Mitochondria as targets of apoptosis regulation by nitric oxide. IUBMB Life. 55: 613-616.
32. Washburn LR, Bird DW and Dybvig K (2003). Restoration of cytoadherence to an adherence-deficient mutant of Mycoplasma arthritidis by genetic complementation. Infect. Immun. 71: 671-675.
33. Watson RW, Redmond HP, Wang JH and Bouchier-Hayes D (1996). Mechanisms involved in sodium arsenite-induced apoptosis of human neutrophils. J. Leukoc Biol. 60: 625-632.
34. Wu Y, Qiu H, Zeng Y, You X, et al. (2008). Mycoplasma genitalium lipoproteins induce human monocytic cell expression of proinflammatory cytokines and apoptosis by activating nuclear factor kappaB. Mediators Inflamm. 2008: 195427.
35. Yang S, Zhao Q, Xiang H, Liu M, et al. (2013). Antiproliferative activity and apoptosis-inducing mechanism of constituents from Toona sinensis on human cancer cells. Cancer Cell Int. 13: 12.
36. You XX, Zeng YH and Wu YM (2006). Interactions between mycoplasma lipid-associated membrane proteins and the host cells. J. Zhejiang Univ. Sci. B. 7: 342-350.
37. Zeng Y, Wu Y, Deng Z, You X, et al. (2008). Apoptosis induced by lipid-associated membrane proteins from Mycoplasma penetrans is mediated by nuclear factor kappaB activation in mouse macrophage. Can. J. Microbiol. 54: 150-158.
38. Zhang M, Zhu LJ, Xiao Y and Zhang X (2013). Effects of p38 mitogen-activated protein kinases on the apoptosis of human bronchial epithelial cells induced by refractory ceramic fibers in vitro. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 31: 347-350.
39. Zhang Q, Young TF and Ross RF (1995). Identification and characterization of a Mycoplasma hyopneumoniae adhesin. Infect. Immun. 63: 1013-1019.