Transport of Cytokines and Neurotrophins across the Blood-Brain Barrier and Their Regulation after Spinal Cord Injury

Blood-Spinal Cord and Brain Barriers in Health and Disease

Volumn , Issue , 2004, Pages 395-407

  Pan, Weihong ^a   Kastin, Abba J ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autoimmune; Blood brain barrier; Chemokines; Cytokine; Interferons; Interleukins; LIF; Neurotrophin; Peptides; Protein; Regeneration; Spinal cord injury; TNF ; Transport system; Trauma

Indexed keywords

EID: 84942852165     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012639011-7/50024-3     Document Type: Chapter

References (86)

1. Arimura A. Pituitary adenylate cyclase activating polypeptide (PACAP): Discovery and current status of research. Regul. Peptides 1992, 37:287-303.
2. Banks W.A., Fasold M.B., Kastin A.J. Measurement of efflux rates from brain to blood. Methods in Molecular Biology, Neuropeptide Protocols 1997, 353-360. Humana Press, Totowa, NJ. G.B. Irvine, C.H. Williams (Eds.).
3. Banks W.A., Kastin A.J. Editorial review: Peptide transport systems for opiates across the blood-brain barrier. Am. J. Physiol. 1990, 259:E1-E10.
4. Banks W.A., Kastin A.J. Exchange of peptides between the circulation and the nervous system: Role of the blood-brain barrier. Circulating Regulatory Factors and Neuroendocrine Function 1990, 59-69. Plenum Press, New York. J.C. Porter, D. Jezova (Eds.).
5. Banks W.A., Kastin A.J. Measurement of transport of cytokines across the blood-brain barrier. Methods Neurosci. 1993, 16:67-77.
6. Banks W.A., Kastin A.J. Reversible association of the cytokines MIP-1α and MIP-1β with the endothelia of the blood-brain barrier. Neurosci. Lett. 1996, 205:202-206.
7. Banks W.A., Kastin A.J., Durham D.A. Bidirectional transport of interleukin-1 alpha across the blood-brain barrier. Brain Res. Bull. 1989, 23:433-437.
8. Banks W.A., Kastin A.J., Ehrensing C.A. Blood-borne interleukin-1α is transported across the endothelial blood-spinal cord barrier of mice. J. Physiol. 1994, 479:257-264.
9. Banks W.A., Kastin A.J., Gutierrez E.G. Interleukin-1α in blood has direct access to cortical brain cells. Neurosci. Lett. 1993, 163:41-44.
10. Banks W.A., Kastin A.J., Gutierrez E.G. Penetration of interleukin-6 across the murine blood-brain barrier. Neurosci. Lett. 1994, 179:53-56.
11. 1-38 across the blood-brain barrier. J. Pharmacol. Exp. Ther. 1993, 267:690-696.
12. Banks W.A., Moinuddin A., Morley J.E. Regional transport of TNF-α across the blood-brain barrier in young ICR and young and aged SAMP8 mice. Neurobiol. Aging 2001, 22:671-676.
13. Banks W.A., Ortiz L., Plotkin S.R., Kastin A.J. Human interleukin (IL)1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J. Pharmacol. Exp. Ther. 1991, 259:988-996.
14. Banks W.A., Plotkin S.R., Kastin A.J. Permeability of the blood-brain barrier to soluble cytokine receptors. Neuroimmunodulation 1995, 2:161-165.
15. Begley D.J. Peptides and the blood-brain barrier: The status of our understanding. Ann. N.Y. Acad. Sci. 1994, 739:89-100.
16. Blight A.R. Morphometric analysis of a model of spinal cord injury in guinea pigs, with behavioral evidence of delayed secondary pathology. J. Neurol. Sci. 1991, 103:156-171.
17. Bluthe R.M., Parnet P., Dantzer R., Kelley K.W. Interleukin-1 receptor antagonist blocks effects of IL-1α and IL-1β on social behavior and body weight in mice. Neurosci. Res. Commun. 1991, 15:151-158.
18. Bodnar R.J., Pasternak G.W., Mann P.E., Paul D., Warren R., Donner D.B. Mediation of anorexia by human recombinant tumor necrosis factor through a peripheral action in the rat. Cancer Res. 1989, 15:6280-6284.
19. Buttini M., Appel K., Sauter A., Gebicke-Haerter P.J., Boddeke H.W. Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat. Neuroscience 1996, 71:1-16.
20. Carpenter G. Receptors for epidermal growth factor and other polypeptide mitogens. Annu. Rev. Biochem. 1987, 56:881-914.
21. Cuevas P., Carceller F., Munoz-Willery I., Gimenez-Gallego G. Intravenous fibroblast growth factor penetrates the blood-brain barrier and protects hippocampal neurons against ischemia-reperfusion injury. Surg. Neurol. 1998, 49:77-83.
22. 125I-labeled basic fibroblast growth factor. Pharm. Res. 2000, 17:63-69.
23. Dvorak H.F., Brown L.F., Detmar M., Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am. J. Pathol. 1995, 146:1029-1039.
24. Fan L., Young P.R., Barone F.C., Feuerstein G.Z., Smith D.H., McIntosh T.K. Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS. Brain Res. Mol. Brain Res. 1996, 36:287-291.
25. Gutierrez E.G., Banks W.A., Kastin A.J. Murine tumor necrosis factor alpha is transported from blood to brain in the mouse. J. Neuroimmunol. 1993, 47:169-176.
26. Gutierrez E.G., Banks W.A., Kastin A.J. Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier. J. Neuroimmunol. 1994, 55:153-160.
27. Hesselgesser J., Horuk R. Chemokine and chemokine receptor expression in the central nervous system. J. Neurovirol. 1999, 5:13-26.
28. Hirschberg D.L., Yoles E., Belkin M., Schwartz M. Inflammation after axonal injury has conflicting consequences for recovery of function: Rescue of spared axons is impaired but regeneration is supported. J. Neuroimmunol. 1994, 50:9-16.
29. Jaeger C.B., Blight A.R. Spinal cord compression injury in guinea pigs: Structural changes of endothelium and its perivascular cell associations after blood-brain barrier breakdown and repair. Exp. Neurol. 1997, 144:381-399.
30. Johanson C.E. Ventricles and cerebrospinal fluid. Neuroscience in Medicine 1995, 171-196. Lippincott, Philadelphia. P.M. Conn (Ed.).
31. Kallen K.-J., Grötzinger J., Lelièvres E., Vollmer P., Aasland D., Renné C., Müllberg J., Meyer Zum Büschenfelde K.-H., Gascan H., Rose-John S. Receptor recognition sites of cytokines are organized as exchangeable modules: Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6. J. Biol. Chem. 1999, 274:11859-11867.
32. Kastin A.J., Akerstrom V., Pan W. Glial cell line-derived neurotrophic factor does not enter normal mouse brain. Neurosci. Lett. 2003, 340:239-241.
33. Kastin A.J., Nissen C., Coy D.H. Permeability of blood-brain barrier to DSIP peptides. Pharmacol. Biochem. Behav. 1981, 15:955-959.
34. Kastin A.J., Olson R.D., Schally A.V., Coy D.H. CNS effects of peripherally administered brain peptides. Life Sci. 1979, 25:401-414.
35. Kim K.S., Wass C.A., Cross A.S., Opal S.M. Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat. Lymphokine Cytokine Res. 1992, 11:293-298.
36. Klusman I., Schwab M.E. Effects of pro-inflammatory cytokines in experimental spinal cord injury. Brain Res. 1997, 762:173-184.
37. Kurek J.B., Radford A.J., Crump D.E., Bower J.J., Feeney S.J., Austin L., Byrne E. LIF(AM424), a promising growth factor for the treatment of ALS. J. Neurol. Sci. 1998, 160:S106-S113.
38. Lewis M., Tartaglia L.A., Lee A., Bennett G.L., Rice G.C., Wong G.H., Chen E.Y., Goeddel D.V. Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc. Natl. Acad. Sci. USA 1991, 88:2830-2834.
39. Liu T., Clark R.K., McDonnell P.C., Young P.R., White R.F., Barone F.C., Feuerstein G.Z. Tumor necrosis factor-alpha expression in ischemic neurons. Stroke 1994, 25:1481-1488.
40. Liu T., Young P.R., McDonnell P.C., White R.F., Barone F.C., Feuerstein G.Z. Cytokine-induced neutrophil chemoatractant mRNA expressed in cerebral ischemia. Neurosci. Lett. 1993, 164:125-128.
41. Maness L.M., Banks W.A., Zadina J.E., Kastin A.J. Selective transport of blood-borne interleukin-1α into the posterior division of the septum of the mouse brain. Brain Res. 1995, 700:83-88.
42. Mayhan W.G. Regulation of blood-brain barrier permeability. Microcirculation 2001, 8:89-104.
43. McKenzie A.L., Hall J.J., Aihara N., Fukuda K., Noble L.J. Immunolocalization of endothelin in the traumatized spinal cord: Relationship to blood-spinal cord barrier breakdown. J. Neurotrauma 1995, 12:257-268.
44. McLay R.N., Kimura M., Banks W.A., Kastin A.J. Granulocyte-macrophage colony-stimulating factor crosses the blood-brain and blood-spinal cord barriers. Brain 1997, 120:2083-2091.
45. Noble L.J., Maxwell D.S. Blood-spinal cord barrier response to transection. Exp. Neurol. 1983, 79:188-199.
46. Opp M.R., Krueger J.M. Interleukin 1-receptor antagonist blocks interleukin 1-induced sleep and fever. Am. J. Physiol. 1991, 260:R453-R457.
47. Pan W., Banks W.A., Fasold M.B., Bluth J., Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharm. 1998, 37:1553-1561.
48. Pan W., Banks W.A., Kastin A.J. BBB permeability to ebiratide and TNF in acute spinal cord injury. Exp. Neurol. 1997, 146:367-373.
49. Pan W., Banks W.A., Kastin A.J. Permeability of the blood-brain and blood-spinal cord barriers to interferons. J. Neuroimmunol. 1997, 76:105-111.
50. Pan W., Banks W.A., Kastin A.J. Permeability of the blood-brain/spinal cord barrier to neurotrophins. Brain Res. 1998, 788:87-94.
51. Pan W., Banks W.A., Kennedy M.K., Gutierrez E.G., Kastin A.J. Differential permeability of the BBB in acute EAE: Enhanced transport of TNF-α. Am. J. Physiol. 1996, 271:E636-E642.
52. Pan W., Kastin A.J. Entry of EGF into brain is rapid and saturable. Peptides 1999, 20:1091-1098.
53. Pan W., Kastin A.J. Interactions of IGF-1 with the blood-brain barrier in vivo and in situ. Neuroendocrinology 2000, 72:171-178.
54. Pan W., Kastin A.J. Changing the chemokine gradient: CINC1 crosses the blood-brain barrier. J. Neuroimmunol. 2001, 115:64-70.
55. Pan W., Kastin A.J. Increase in TNFα transport after SCI is specific for time, region, and type of lesion. Exp. Neurol. 2001, 170:357-363.
56. Pan W., Kastin A.J. TNFα transport across the blood-brain barrier is abolished in receptor knockout mice. Exp. Neurol. 2001, 174:193-200.
57. Pan W., Kastin A.J., Bell R.L., Olson R.D. Upregulation of tumor necrosis factor α transport across the blood-brain barrier after acute compressive spinal cord injury. J. Neurosci. 1999, 19:3649-3655.
58. Pan W., Kastin A.J., Brennan J.M. Saturable entry of leukemia inhibitory factor from blood to the central nervous system. J. Neuroimmunol. 2000, 106:172-180.
59. Pan W., Kastin A.J., Gera L., Stewart J.M. Bradykinin antagonist decreases early disruption of the blood-spinal cord barrier after spinal cord injury in mice. Neurosci. Lett. 2001, 307:25-28.
60. Pan W., Kastin A.J., Maness L.M., Brennan J.M. Saturable entry of ciliary neurotrophic factor into brain. Neurosci. Lett. 1999, 263:69-71.
61. Pan W., Vallance K., Kastin A.J. TGFα and the blood-brain barrier: Accumulation in cerebral vasculature. Exp. Neurol. 1999, 160:454-459.
62. Pan W., Zadina J.E., Harlan R.E., Weber J.T., Banks W.A., Kastin A.J. Tumor necrosis factor α: A neuromodulator in the CNS. Neurosci. Biobehav. Rev. 1997, 21:603-613.
63. Pertizzo B., Pastor F.E., Blázquez J.L., Schöbitz K., Peláez B., Amat P., Rodríguez E.M. A second look at the barriers of the medial basal hypothalamus. Exp. Brain Res. 2000, 132:10-26.
64. Plata-Salaman C.R., French-Mullen J.M.H. Intracerebroventricular administration of a specific IL-1 receptor antagonist blocks food and water intake suppression induced by interleukin-1β. Physiol. Behav. 1992, 51:1277-1279.
65. Plotkin S.R., Banks W.A., Kastin A.J. Comparison of saturable transport and extracellular pathways in the passage of interleukin-1α across the blood-brain barrier. J. Neuroimmunol. 1996, 67:41-47.
66. Popovich P.G., Horner P.J., Mullin B.B., Stokes B.T. A quantitative spatial analysis of the blood-spinal cord barrier: I. Permeability changes after experimental spinal cord confusion injury. Exp. Neurol. 1996, 142:258-275.
67. Reglodi D., Somogyvari-Vigh A., Vigh S., Kozicz T., Arimura A. Delayed systemic administration of PACAP38 is neuroprotective in middle cerebral artery occlusion in the rat. Stroke 2000, 31:1411-1417.
68. Rothwell N., Allan S., Toulmond S. The role of interleukin 1 in acute neurodegeneration and stroke: Pathophysiological and therapeutic implications. J. Clin. Invest. 1997, 100:2648-2652.
69. Schwartz M., Sivron T., Eitan S., Hirschberg D.L., Lotan M., Elman-Faber A. Cytokines and cytokine-related substances regulating glial cell response to injury of the central nervous system. Prog. Brain Res. 1994, 103:331-341.
70. Schwartz M., Solomon A., Lavie V., Ben-Bassat S., Belkin M., Cohen A. Tumor necrosis factor facilitates regeneration of injured central nervous system axons. Brain Res. 1991, 545:334-338.
71. Sharma H.S., Nyberg F., Westman J., Alm P., Gordh T., Lindholm D. Brain derived neurotrophic factor and insulin like growth factor-1 attenuate upregulation of nitric oxide synthase and cell injury following trauma to the spinal cord: An immunohistochemical study in the rat. Amino Acids 1998, 14:121-129.
72. Shimura T., Tabata S., Ohnishi T., Terasaki T., Tsuji A. Transport mechanism of a new behaviorally highly potent adrenocorticotropic hormone (ACTH) analog, ebiratide, through the blood-brain barrier. J. Pharmacol. Exp. Ther. 1991, 258:459-465.
73. Shimura T., Tabata S., Terasaki T., Deguchi Y., Tsuji A. In-vivo blood-brain barrier transport of a novel adrenocorticotropic hormone analogue, ebiratide, demonstrated by brain microdialysis and capillary depletion methods. J. Pharm. Pharmacol. 1992, 44:583-588.
74. Somogyvari-Vigh A., Pan W., Reglodi D., Kastin A.J., Arimura A. Effect of middle cerebral artery occlusion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat. Regul. Peptides 2000, 91:89-95.
75. Strand F.L. Neuropeptides: Regulators of Physiological Processes 1999, 89. MIT Press, Cambridge, MA.
76. Tache Y., Saperas E. Potent inhibition of gastric acid secretion and ulcer formation by centrally and peripherally administered interleukin-1. Ann. N.Y. Acad. Sci. 1992, 664:353-368.
77. Tanno H., Nockels R.P., Pitts L.H., Noble L.J. Breakdown of the blood-brain barrier after fluid percussive brain injury in the rat. I Distribution and time course of protein extravasation. J. Neurotrauma 1992, 9:21-32.
78. Terasaki T., Takakuwa S., Saheki A., Moritani S., Shimura T., Tabata S., Tsuji A. Absorptive-mediated endocytosis of an adrenocorticotropic hormone (ACTH) analogue, ebiratide, into the blood-brain barrier: Studies with monolayers of primary cultured bovine brain capillary endothelial cells. Pharm. Res. 1992, 9:529-534.
79. Triguero D., Buciak J., Pardridge W.M. Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J. Neurochem. 1990, 54:1882-1888.
80. Uchida D., Arimura A., Somogyvari-Vigh A., Shioda S., Banks W.A. Prevention of ischemia-induced death of hippocampal neurons by pituitary adenylate cyclase activating polypeptide. Brain Res. 1996, 736:280-286.
81. Waguespack P.J., Banks W.A., Kastin A.J. Interleukin-2 does not cross the blood-brain barrier by a saturable transport system. Brain Res. Bull. 1994, 34:103-109.
82. Wang C.X., Nuttin B., Heremans H., Dom R., Gybels J. Production of tumor necrosis factor in spinal cord following traumatic injury in rats. J. Neuroimmunol. 1996, 69:151-156.
83. Weiss T., Grell M., Hessabi B., Bourteele S., Müller G., Scheurich P., Wajant H. Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80. J. Immunol. 1997, 158:2398-2404.
84. Yamasaki Y., Matsuo Y., Matsuura N., Onodera H., Itoyama Y., Kogure K. Transient increase of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, in ischemic brain areas after focal ischemia in rats. Stroke 1995, 26:318-322.
85. Yamasaki Y., Matsuo Y., Zagorski J., Matsuura N., Onodera H., Itoyama Y., Kogure K. New therapeutic possibility of blocking cytokine-induced neutrophil chemoattractant on transient ischemic brain damage in rats. Brain Res. 1997, 759:103-111.
86. 3H]inulin after osmotic opening in the rat. Exp. Neurol. 1983, 79:845-857.