Entry of EGF into brain is rapid and saturable

Peptides

Volumn 20, Issue 9, 1999, Pages 1091-1098

  Pan, Weihong ^a   Kastin, Abba J ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood brain barrier; EGF receptor; Growth factor; Neurotrophic; Peptide; Transport

Indexed keywords

EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; MALE; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; EPIDERMAL GROWTH FACTOR; HALF-LIFE; IODINE RADIOISOTOPES; LIPID METABOLISM; MALE; MICE; MICE, INBRED ICR; SOLUBILITY;

EID: 0032871755     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(99)00094-7     Document Type: Article

References (27)

1. Banks W.A., Jaspan J.B., Kastin A.J. Effect of diabetes mellitus on the permeability of the blood-brain barrier to insulin. Peptides. 18:1997;1577-1584.
2. Banks W.A., Kastin A.J. Peptides and the blood-brain barrier lipophilicity as a predictor of permeability . Brain Res Bull. 15:1985;287-292.
3. Banks W.A., Kastin A.J. Passage of peptides across the blood-brain barrier pathophysiological perspectives . Life Sci. 59:1996;1923-1943.
4. Banks W.A., Kastin A.J., Jaspan J.B. Regional variation in transport of pancreatic polypeptide across the blood-brain barrier of mice. Pharmacol Biochem Behav. 51:1995;139-147.
5. 1-38 across the blood-brain barrier. J Pharmacol Exp Ther. 267:1993;690-696.
6. Banks W.A., Ortiz L., Plotkin S.R., Kastin A.J. Human interleukin (IL)1α, murine IL-1α and murine IL-1β are transported from blood to brain in the mouse by a shared saturable mechanism. J Pharmacol Exp Ther. 259:1991;988-996.
7. Barrie A., Chieregatti E., Miloso M., Benfenati F., Valtorta F. Epidermal growth factor-mediated inhibition of neurotransmitter glutamate release from rat forebrain synaptosomes. Mol Pharmacol. 49:1996;399-403.
8. Blasberg R.G., Fenstermacher J.D., Patlak C.S. Transport of α-aminoisobutyric acid across brain capillary and cellular membranes. J Cereb Blood Flow Metab. 3:1983;8-32.
9. Carpenter G. Receptors for epidermal growth factor and other polypeptide mitogens. Ann Rev Biochem. 56:1987;881-914.
10. Cohen S. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. J Biol Chem. 237:1962;1555-1562.
11. Fowler K.J., Walker F., Alexander W., Hibbs M.L., Nice E.C., Bohmer R.M., Mann G.B., Thumwood C., Maglitto R., Darks J.A., Chetty R., Burgess A.W., Dunn A.R. A mutation in the epidermal growth factor receptor in waved-2 mice has a profound effect on receptor biochemistry that results in impaired lactation. Proc Natl Acad Sci USA. 92:1995;1465-1469.
12. Gutierrez E.G., Banks W.A., Kastin A.J. Murine tumor necrosis factor (TNF) alpha is transported from blood to brain in the mouse. J Neuroimmunol. 47:1993;169-176.
13. Haller M.F., Saltzman W.M. Localized delivery of proteins in the brain can transport be customized? Pharm Res. 15:1998;377-385.
14. Kinoshita A., Yamada K., Hayakawa T., Kataoka K., Mushiroi T., Kohmura E., Mogami H. Modification of anoxic neuronal injury by human recombinant epidermal growth factor and its possible mechanism. J Neurosci Res. 25:1990;324-330.
15. Leutteke N.C., Phillips H.K., Qiu T.H., Copeland N.G., Earp H.S., Jenkins N.A., Lee D.C. The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev. 8:1994;399-413.
16. Luger A., Calogero A.E., Klogeras K., Gallucci W.T., Gold P.W., Loriaux D.L., Chrousos G.P. Interaction of epidermal growth factor with the hypothalamic-pituitary-adrenal axis potential physiological relevance . J Clin Endocrinol Metab. 66:1988;334-337.
17. Nave K.A., Probstmeier R., Schachner M. Epidermal growth factor does not cross the blood-brain barrier. Cell Tissue Res. 241:1985;453-457.
18. Pan W., Banks W.A., Kastin A.J. Permeability of the blood-brain/spinal cord barrier to neurotrophins. Brain Res. 788:1998;87-94.
19. Pan W., Kastin A.J. Penetration of neurotrophins and cytokines across the blood-brain/blood-spinal cord barrier. Adv Drug Delivery Rev. 36:1999;291-298.
20. Panaretto B.A., Moore G.P.M., Robertson D.M. Plasma concentrations and urinary excretion of mouse epidermal growth factor associated with the inhibition of food consumption and of wool growth in Merino wethers. J Endocrinol. 94:1982;191-202.
21. Patlak C.S., Blasberg R.G., Fenstermacher J.D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab. 3:1983;1-7.
22. Peng H., Wen T.C., Tanaka J., Maeda N., Matsuda S., Desaki J., Sudo S., Zhang B., Sakanaka M. Epidermal growth factor protects neuronal cells in vivo and in vitro against transient forebrain ischemia- and free radical-induced injuries. J Cereb Blood Flow Metab. 18:1998;349-360.
23. Plata-Salaman C.R. Food intake suppression by growth factors and platelet peptides by direct action in the central nervous system. Neurosci Lett. 94:1988;161-166.
24. Plata-Salaman C.R. Epidermal growth factor and the nervous system. Peptides. 12:1991;653-663.
25. Polk D.H., Ervin M.G., Padbury J.F., Lam R.W., Reviczky A.L., Fisher D.A. Epidermal growth factor acts as a corticortropin-releasing factor in chronically catheterized fetal lambs. J Clin Invest. 79:1987;984-988.
26. Schreiber A.B., Libermann T.A., Lax I., Yarden Y., Schlessinger J. Biological role of epidermal growth factor-receptor clustering. Investigation with monoclonal anti-receptor antibodies. J Biol Chem. 258:1983;846-853.
27. Yamada M., Enokido Y., Ikeuchi T., Hatanaka H. Epidermal growth factor prevents oxygen-triggered apoptosis and induces sustained signaling in cultured rat cerebral cortical neurons. Eur J Neurosci. 7:1995;2130-2138.