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Volumn 82, Issue 2, 2015, Pages 245-255

Bone biology, signaling pathways, and therapeutic targets for osteoporosis

Author keywords

Anti Dickkopf antibody; Anti sclerostin antibody; Cathepsin K inhibitors; Osteoporosis; PTH; PTHrP

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ACTIVIN A; BISPHOSPHONIC ACID DERIVATIVE; BLOSOZUMAB; BONE MORPHOGENETIC PROTEIN; CATHEPSIN K; CATHEPSIN K INHIBITOR; DENOSUMAB; GELATINASE; GELATINASE B; GLYCERYL TRINITRATE; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE[1-34]; RALOXIFENE; ROMOSOZUMAB; STRONTIUM RANELATE; BONE DENSITY CONSERVATION AGENT;

EID: 84942824156     PISSN: 03785122     EISSN: 18734111     Source Type: Journal    
DOI: 10.1016/j.maturitas.2015.07.003     Document Type: Review
Times cited : (60)

References (88)
  • 2
    • 26944498325 scopus 로고    scopus 로고
    • Significance of minimodeling in dialysis patients with adynamic bone disease
    • Y. Ubara, T. Tagami, S. Nakanishi, N. Sawa, J. Hoshino, T. Suwabe, and et al. Significance of minimodeling in dialysis patients with adynamic bone disease Kidney Int. 68 2005 833 839
    • (2005) Kidney Int. , vol.68 , pp. 833-839
    • Ubara, Y.1    Tagami, T.2    Nakanishi, S.3    Sawa, N.4    Hoshino, J.5    Suwabe, T.6
  • 3
    • 0037407251 scopus 로고    scopus 로고
    • Histomorphometric features of bone in patients with primary and secondary hyperparathyroidism
    • Y. Ubara, T. Fushimi, T. Tagami, N. Sawa, J. Hoshino, M. Yokota, and et al. Histomorphometric features of bone in patients with primary and secondary hyperparathyroidism Kidney Int. 63 2003 1809 1816
    • (2003) Kidney Int. , vol.63 , pp. 1809-1816
    • Ubara, Y.1    Fushimi, T.2    Tagami, T.3    Sawa, N.4    Hoshino, J.5    Yokota, M.6
  • 4
    • 33144457259 scopus 로고    scopus 로고
    • A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest biopsy: Early actions of teriparatide
    • R. Lindsay, F. Cosman, H. Zhou, M. Bostrom, V. Shen, J. Cruz, and et al. A novel tetracycline labeling schedule for longitudinal evaluation of the short-term effects of anabolic therapy with a single iliac crest biopsy: early actions of teriparatide J. Bone Miner. Res. 21 2006 366 373
    • (2006) J. Bone Miner. Res. , vol.21 , pp. 366-373
    • Lindsay, R.1    Cosman, F.2    Zhou, H.3    Bostrom, M.4    Shen, V.5    Cruz, J.6
  • 5
    • 0036138940 scopus 로고    scopus 로고
    • Targeted and nontargeted remodeling
    • D.B. Burr Targeted and nontargeted remodeling Bone 30 2002 2 4
    • (2002) Bone , vol.30 , pp. 2-4
    • Burr, D.B.1
  • 6
    • 0036140080 scopus 로고    scopus 로고
    • Targeted and nontargeted bone remodeling: Relationship to basic multicellular unit origination and progression
    • A.M. Parfitt Targeted and nontargeted bone remodeling: relationship to basic multicellular unit origination and progression Bone 30 2002 5 7
    • (2002) Bone , vol.30 , pp. 5-7
    • Parfitt, A.M.1
  • 7
    • 0032765892 scopus 로고    scopus 로고
    • Cell biology of the osteoclast
    • G.D. Roodman Cell biology of the osteoclast Exp. Hematol. 27 1999 1229 1241
    • (1999) Exp. Hematol. , vol.27 , pp. 1229-1241
    • Roodman, G.D.1
  • 8
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • W.S. Simonet, and D.L. Lacey Osteoclast differentiation and activation Nature 423 2003 337 342
    • (2003) Nature , vol.423 , pp. 337-342
    • Simonet, W.S.1    Lacey, D.L.2
  • 9
    • 1642433325 scopus 로고    scopus 로고
    • Recent advances in osteoclast biology and pathological bone resorption
    • H.C. Blair, and N.A. Athanasou Recent advances in osteoclast biology and pathological bone resorption Histol. Histopathol. 19 2004 189 199
    • (2004) Histol. Histopathol. , vol.19 , pp. 189-199
    • Blair, H.C.1    Athanasou, N.A.2
  • 10
    • 0023882543 scopus 로고
    • Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts
    • I.A. Silver, R.J. Murrills, and D.J. Etherington Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts Exp. Cell Res. 175 1988 266 276
    • (1988) Exp. Cell Res. , vol.175 , pp. 266-276
    • Silver, I.A.1    Murrills, R.J.2    Etherington, D.J.3
  • 12
    • 0022815786 scopus 로고
    • Normal and pathological remodeling of human trabecular bone: Three-dimensional reconstruction of the remodeling sequence in normals and metabolic bone disease
    • E.F. Eriksen Normal and pathological remodeling of human trabecular bone: three-dimensional reconstruction of the remodeling sequence in normals and metabolic bone disease Endocr. Rev. 7 1986 379 408
    • (1986) Endocr. Rev. , vol.7 , pp. 379-408
    • Eriksen, E.F.1
  • 13
    • 13544261700 scopus 로고    scopus 로고
    • Regulatory mechanisms operative in osteoclasts
    • S.V. Reddy Regulatory mechanisms operative in osteoclasts Crit. Rev. Eukaryot. Gene Expr. 14 2004 255 270
    • (2004) Crit. Rev. Eukaryot. Gene Expr. , vol.14 , pp. 255-270
    • Reddy, S.V.1
  • 14
    • 85118903551 scopus 로고
    • Role of transforming growth factor beta in bone remodeling
    • L. Bonewald, and G.R. Mundy Role of transforming growth factor beta in bone remodeling Clin. Orthop. Relat. Res. 2S 1990 35 40
    • (1990) Clin. Orthop. Relat. Res. , vol.2 S , pp. 35-40
    • Bonewald, L.1    Mundy, G.R.2
  • 15
    • 0023832454 scopus 로고    scopus 로고
    • Insulin-like growth factor i (IGF-I) has independent effects on bone matrix formation and cell replication
    • J.M. Hock, M. Centrella, and E. Canalis Insulin-like growth factor I (IGF-I) has independent effects on bone matrix formation and cell replication Endocrinology 122 2004 254 260
    • (2004) Endocrinology , vol.122 , pp. 254-260
    • Hock, J.M.1    Centrella, M.2    Canalis, E.3
  • 16
    • 0033084169 scopus 로고    scopus 로고
    • Effects of TGFbeta and bFGF on the differentiation of human bone marrow stromal fibroblasts
    • R.M. Locklin, R.O. Oreffo, and J.T. Triffitt Effects of TGFbeta and bFGF on the differentiation of human bone marrow stromal fibroblasts Cell Biol. Int. 23 1999 185 194
    • (1999) Cell Biol. Int. , vol.23 , pp. 185-194
    • Locklin, R.M.1    Oreffo, R.O.2    Triffitt, J.T.3
  • 17
    • 13244267455 scopus 로고    scopus 로고
    • Osteoclast-derived activity in the coupling of bone formation to resorption
    • T.J. Martin, and N.A. Sims Osteoclast-derived activity in the coupling of bone formation to resorption Trends Mol. Med. 11 2005 76 81
    • (2005) Trends Mol. Med. , vol.11 , pp. 76-81
    • Martin, T.J.1    Sims, N.A.2
  • 18
    • 0033963131 scopus 로고    scopus 로고
    • Is BMU-coupling a strain-regulated phenomenon? A finite element analysis
    • T.H. Smit, E.H. Burger, and J.M. Huyghe Is BMU-coupling a strain-regulated phenomenon? A finite element analysis J. Bone Miner. Res. 15 2000 301 307
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 301-307
    • Smit, T.H.1    Burger, E.H.2    Huyghe, J.M.3
  • 19
    • 0036829261 scopus 로고    scopus 로고
    • A case for strain-induced fluid flow as a regulator of BMU-coupling and osteonal alignment
    • T.H. Smit, E.H. Burger, and J.M. Huyghe A case for strain-induced fluid flow as a regulator of BMU-coupling and osteonal alignment J. Bone Miner. Res. 17 2002 2021 2029
    • (2002) J. Bone Miner. Res. , vol.17 , pp. 2021-2029
    • Smit, T.H.1    Burger, E.H.2    Huyghe, J.M.3
  • 20
    • 0141560730 scopus 로고    scopus 로고
    • Matrix vesicles and calcification
    • H.C. Anderson Matrix vesicles and calcification Curr. Rheumatol. Rep. 5 2003 222 226
    • (2003) Curr. Rheumatol. Rep. , vol.5 , pp. 222-226
    • Anderson, H.C.1
  • 21
    • 0141565397 scopus 로고    scopus 로고
    • Strain-derived canalicular fluid flow regulates osteoclast activity in a remodeling osteon - A proposal
    • E.H. Burger, J. Klein-Nuland, and T.H. Smit Strain-derived canalicular fluid flow regulates osteoclast activity in a remodeling osteon - a proposal J. Biomech. 36 2003 1452 1459
    • (2003) J. Biomech. , vol.36 , pp. 1452-1459
    • Burger, E.H.1    Klein-Nuland, J.2    Smit, T.H.3
  • 22
    • 0029116964 scopus 로고
    • Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells
    • H. Dobnig, and R.T. Turner Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells Endocrinology 136 1995 3632 3638
    • (1995) Endocrinology , vol.136 , pp. 3632-3638
    • Dobnig, H.1    Turner, R.T.2
  • 23
    • 0034874481 scopus 로고    scopus 로고
    • Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers
    • E.M. Hauge, D. Qvesel, E.F. Eriksen, L. Mosekilde, and F. Melsen Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers J. Bone Miner. Res. 16 2001 1575 1582
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 1575-1582
    • Hauge, E.M.1    Qvesel, D.2    Eriksen, E.F.3    Mosekilde, L.4    Melsen, F.5
  • 24
    • 0028362416 scopus 로고
    • Osteonal and hemiosteonal remodeling: The spatial and temporal framework for signal traffic in adult bone
    • A.M. Parfitt Osteonal and hemiosteonal remodeling: the spatial and temporal framework for signal traffic in adult bone J. Cell Biochem. 55 1994 273 276
    • (1994) J. Cell Biochem. , vol.55 , pp. 273-276
    • Parfitt, A.M.1
  • 25
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • W.J. Boyle, W.S. Simonet, and D.L. Lacey Osteoclast differentiation and activation Nature 423 2003 337 342
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 26
    • 0043267732 scopus 로고    scopus 로고
    • Genetic regulation of osteoclast development and function
    • S.L. Teitelbaum, and F.P. Ross Genetic regulation of osteoclast development and function Nat. Rev. Genet. 4 2003 638 649
    • (2003) Nat. Rev. Genet. , vol.4 , pp. 638-649
    • Teitelbaum, S.L.1    Ross, F.P.2
  • 27
    • 33644872519 scopus 로고    scopus 로고
    • The new bone biology: Pathologic, molecular, and clinical correlates
    • M.M. Cohen Jr. The new bone biology: pathologic, molecular, and clinical correlates Am. J. Med. Genet. A 140 2006 2646 2706
    • (2006) Am. J. Med. Genet. A , vol.140 , pp. 2646-2706
    • Cohen, M.M.1
  • 28
    • 28544443670 scopus 로고    scopus 로고
    • αvβ3 and macrophage colony-stimulating factor: Partners in osteoclast biology
    • F.P. Ross, and S.L. Teitelbaum αvβ3 and macrophage colony-stimulating factor: partners in osteoclast biology Immunol. Rev. 208 2005 88 105
    • (2005) Immunol. Rev. , vol.208 , pp. 88-105
    • Ross, F.P.1    Teitelbaum, S.L.2
  • 33
    • 8444251784 scopus 로고    scopus 로고
    • The Wnt signaling pathway in development and disease
    • C.Y. Logan, and R. Nusse The Wnt signaling pathway in development and disease Annu. Rev. Cell Dev. Biol. 20 2004 781 810
    • (2004) Annu. Rev. Cell Dev. Biol. , vol.20 , pp. 781-810
    • Logan, C.Y.1    Nusse, R.2
  • 35
    • 0037136577 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL receptor-related protein 5
    • R.D. Little, R.R. Recker, and M.L. Johnson High bone density due to a mutation in LDL receptor-related protein 5 N. Engl. J. Med. 347 2002 943 944
    • (2002) N. Engl. J. Med. , vol.347 , pp. 943-944
    • Little, R.D.1    Recker, R.R.2    Johnson, M.L.3
  • 36
    • 0033861575 scopus 로고    scopus 로고
    • Relative abundance of different cadherins defines differentiation of mesenchymal precursors into osteogenic, myogenic, or adipogenic pathways
    • C.S. Shin, F. Lecanda, S. Sheikh, L. Weitzmann, S.L. Cheng, and R. Civitelli Relative abundance of different cadherins defines differentiation of mesenchymal precursors into osteogenic, myogenic, or adipogenic pathways J. Cell Biochem. 78 2000 566 577
    • (2000) J. Cell Biochem. , vol.78 , pp. 566-577
    • Shin, C.S.1    Lecanda, F.2    Sheikh, S.3    Weitzmann, L.4    Cheng, S.L.5    Civitelli, R.6
  • 37
    • 0037129560 scopus 로고    scopus 로고
    • Epidemiology and outcomes of osteoporotic fractures
    • S.R. Cummings, and L.J. Melton Epidemiology and outcomes of osteoporotic fractures Lancet 359 9319 2002 1761 1767
    • (2002) Lancet , vol.359 , Issue.9319 , pp. 1761-1767
    • Cummings, S.R.1    Melton, L.J.2
  • 38
    • 0036261414 scopus 로고    scopus 로고
    • Quality of life assessment in osteoporosis: Health-status and preference-based measures
    • A.N. Tosteson, and C.S. Hammond Quality of life assessment in osteoporosis: health-status and preference-based measures Pharmacogenomics 20 2002 289 303
    • (2002) Pharmacogenomics , vol.20 , pp. 289-303
    • Tosteson, A.N.1    Hammond, C.S.2
  • 40
    • 79958695940 scopus 로고    scopus 로고
    • Bisphosphonates: The first 40 years
    • R.G. Russell Bisphosphonates: the first 40 years Bone 49 2011 2 19
    • (2011) Bone , vol.49 , pp. 2-19
    • Russell, R.G.1
  • 42
    • 38849159247 scopus 로고    scopus 로고
    • Biochemical properties and regulation of cathepsin K activity
    • F. Lecaille, D. Bromme, and G. Lalmanach Biochemical properties and regulation of cathepsin K activity Biochimie 90 2008 208 226
    • (2008) Biochimie , vol.90 , pp. 208-226
    • Lecaille, F.1    Bromme, D.2    Lalmanach, G.3
  • 43
    • 78649412131 scopus 로고    scopus 로고
    • Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1-34)] in postmenopausal osteoporosis
    • F. Cosman, E.F. Eriksen, C. Recknor, P.D. Miller, N. Guañabens, C. Kasperk, and et al. Effects of intravenous zoledronic acid plus subcutaneous teriparatide [rhPTH(1-34)] in postmenopausal osteoporosis J. Bone Miner. Res. 26 2011 503 511
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 503-511
    • Cosman, F.1    Eriksen, E.F.2    Recknor, C.3    Miller, P.D.4    Guañabens, N.5    Kasperk, C.6
  • 44
    • 84886852995 scopus 로고    scopus 로고
    • A comparison of parathyroid hormone-related protein (1-36) and parathyroid hormone (1-34) on markers of bone turnover and bone density in postmenopausal women: The PrOP Study
    • M.J. Horwitz, M. Augustine, L. Kahn, E. Martin, C.C. Oakley, R.M. Carneiro, and et al. A comparison of parathyroid hormone-related protein (1-36) and parathyroid hormone (1-34) on markers of bone turnover and bone density in postmenopausal women: the PrOP Study J. Bone Miner. Res. 28 2013 2266 2276
    • (2013) J. Bone Miner. Res. , vol.28 , pp. 2266-2276
    • Horwitz, M.J.1    Augustine, M.2    Kahn, L.3    Martin, E.4    Oakley, C.C.5    Carneiro, R.M.6
  • 45
    • 84873558051 scopus 로고    scopus 로고
    • WNT signaling in bone homeostasis and disease: From human mutations to treatments
    • R. Baron, and M. Kneissel WNT signaling in bone homeostasis and disease: from human mutations to treatments Nat. Med. 19 2013 179 192
    • (2013) Nat. Med. , vol.19 , pp. 179-192
    • Baron, R.1    Kneissel, M.2
  • 47
  • 48
    • 12144286871 scopus 로고    scopus 로고
    • Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist
    • R.L. van Bezooijen, B.A. Roelen, A. Visser, L. van der Wee-Pals, E. de Wilt, M. Karperien, and et al. Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist J. Exp. Med. 199 2004 805 814
    • (2004) J. Exp. Med. , vol.199 , pp. 805-814
    • Van Bezooijen, R.L.1    Roelen, B.A.2    Visser, A.3    Van Der Wee-Pals, L.4    De Wilt, E.5    Karperien, M.6
  • 49
    • 80053518269 scopus 로고    scopus 로고
    • Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway
    • A.R. Wijenayaka, M. Kogawa, H.P. Lim, L.F. Bonewald, D.M. Findlay, and G.J. Atkins Sclerostin stimulates osteocyte support of osteoclast activity by a RANKL-dependent pathway PLoS One 6 2011 e25900
    • (2011) PLoS One , vol.6 , pp. e25900
    • Wijenayaka, A.R.1    Kogawa, M.2    Lim, H.P.3    Bonewald, L.F.4    Findlay, D.M.5    Atkins, G.J.6
  • 51
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • X. Li, Y. Zhang, H. Kang, W. Liu, P. Liu, J. Zhang, and et al. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling J. Biol. Chem. 280 2005 19883 19887
    • (2005) J. Biol. Chem. , vol.280 , pp. 19883-19887
    • Li, X.1    Zhang, Y.2    Kang, H.3    Liu, W.4    Liu, P.5    Zhang, J.6
  • 52
    • 22844445934 scopus 로고    scopus 로고
    • SOST is a ligand for LRP5/6 and a Wnt signaling inhibitor
    • M. Semenov, K. Tamai, and X. He SOST is a ligand for LRP5/6 and a Wnt signaling inhibitor J. Biol. Chem. 280 2005 26770 26775
    • (2005) J. Biol. Chem. , vol.280 , pp. 26770-26775
    • Semenov, M.1    Tamai, K.2    He, X.3
  • 53
    • 41949089764 scopus 로고    scopus 로고
    • Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    • A.G. Robling, P.J. Niziolek, L.A. Baldridge, K.W. Condon, M.R. Allen, I. Alam, and et al. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin J. Biol. Chem. 283 2008 5866 5875
    • (2008) J. Biol. Chem. , vol.283 , pp. 5866-5875
    • Robling, A.G.1    Niziolek, P.J.2    Baldridge, L.A.3    Condon, K.W.4    Allen, M.R.5    Alam, I.6
  • 54
    • 84868290353 scopus 로고    scopus 로고
    • Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases
    • H.Z. Ke, W.G. Richards, X. Li, and M.S. Ominsky Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases Endocr. Rev. 33 2012 747 783
    • (2012) Endocr. Rev. , vol.33 , pp. 747-783
    • Ke, H.Z.1    Richards, W.G.2    Li, X.3    Ominsky, M.S.4
  • 56
    • 84861722759 scopus 로고    scopus 로고
    • Activin receptor signaling: A potential therapeutic target for osteoporosis
    • S. Lotinun, R.S. Pearsall, W.C. Horne, and R. Baron Activin receptor signaling: a potential therapeutic target for osteoporosis Curr. Mol. Pharmacol. 5 2012 195 204
    • (2012) Curr. Mol. Pharmacol. , vol.5 , pp. 195-204
    • Lotinun, S.1    Pearsall, R.S.2    Horne, W.C.3    Baron, R.4
  • 57
    • 79951991649 scopus 로고    scopus 로고
    • Effect of nitroglycerin ointment on bone density and strength in postmenopausal women: A randomized trial
    • S.A. Jamal, C.J. Hamilton, R. Eastell, and S.R. Cummings Effect of nitroglycerin ointment on bone density and strength in postmenopausal women: a randomized trial JAMA 305 2011 800 807
    • (2011) JAMA , vol.305 , pp. 800-807
    • Jamal, S.A.1    Hamilton, C.J.2    Eastell, R.3    Cummings, S.R.4
  • 60
    • 78049522060 scopus 로고    scopus 로고
    • Odanacatib in the treatment of postmenopausal women with low bone mineral density: Three-year continued therapy and resolution of effect
    • J.A. Eisman, H.G. Bone, D.J. Hosking, M.R. McClung, I.R. Reid, R. Rizzoli, and et al. Odanacatib in the treatment of postmenopausal women with low bone mineral density: three-year continued therapy and resolution of effect J. Bone Miner. Res. 26 2011 242 251
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 242-251
    • Eisman, J.A.1    Bone, H.G.2    Hosking, D.J.3    McClung, M.R.4    Reid, I.R.5    Rizzoli, R.6
  • 61
    • 77953510486 scopus 로고    scopus 로고
    • Odanacatib, a cathepsin-K inhibitor for osteoporosis: A two-year study in postmenopausal women with low bone density
    • H.G. Bone, M.R. McClung, C. Roux, R.R. Recker, J.A. Eisman, N. Verbruggen, and et al. Odanacatib, a cathepsin-K inhibitor for osteoporosis: a two-year study in postmenopausal women with low bone density J. Bone Miner. Res. 25 2010 937 947
    • (2010) J. Bone Miner. Res. , vol.25 , pp. 937-947
    • Bone, H.G.1    McClung, M.R.2    Roux, C.3    Recker, R.R.4    Eisman, J.A.5    Verbruggen, N.6
  • 62
    • 67651180563 scopus 로고    scopus 로고
    • Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: Two double-blind, randomized, placebo-controlled phase i studies
    • S.A. Stoch, S. Zajic, J. Stone, D.L. Miller, K. Van Dyck, M.J. Gutierrez, and et al. Effect of the cathepsin K inhibitor odanacatib on bone resorption biomarkers in healthy postmenopausal women: two double-blind, randomized, placebo-controlled phase I studies Clin. Pharmacol. Ther. 86 2009 175 182
    • (2009) Clin. Pharmacol. Ther. , vol.86 , pp. 175-182
    • Stoch, S.A.1    Zajic, S.2    Stone, J.3    Miller, D.L.4    Van Dyck, K.5    Gutierrez, M.J.6
  • 63
    • 84863116822 scopus 로고    scopus 로고
    • Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey
    • T. Cusick, C.M. Chen, B.L. Pennypacker, M. Pickarski, D.B. Kimmel, B.B. Scott, and et al. Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey J. Bone Miner. Res. 27 2012 524 537
    • (2012) J. Bone Miner. Res. , vol.27 , pp. 524-537
    • Cusick, T.1    Chen, C.M.2    Pennypacker, B.L.3    Pickarski, M.4    Kimmel, D.B.5    Scott, B.B.6
  • 64
    • 84863116889 scopus 로고    scopus 로고
    • Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys
    • P.J. Masarachia, B.L. Pennypacker, M. Pickarski, K.R. Scott, G.A. Wesolowski, S.Y. Smith, and et al. Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys J. Bone Miner. Res. 27 2012 509 523
    • (2012) J. Bone Miner. Res. , vol.27 , pp. 509-523
    • Masarachia, P.J.1    Pennypacker, B.L.2    Pickarski, M.3    Scott, K.R.4    Wesolowski, G.A.5    Smith, S.Y.6
  • 65
    • 84860131057 scopus 로고    scopus 로고
    • Pharmacodynamic effects on biochemical markers of bone turnover and pharmacokinetics of the cathepsin K inhibitor, ONO-5334, in an ascending multiple-dose, phase 1 study
    • S. Nagase, M. Ohyama, Y. Hashimoto, M. Small, T. Kuwayama, and S. Deacon Pharmacodynamic effects on biochemical markers of bone turnover and pharmacokinetics of the cathepsin K inhibitor, ONO-5334, in an ascending multiple-dose, phase 1 study J. Clin. Pharmacol. 52 2012 306 318
    • (2012) J. Clin. Pharmacol. , vol.52 , pp. 306-318
    • Nagase, S.1    Ohyama, M.2    Hashimoto, Y.3    Small, M.4    Kuwayama, T.5    Deacon, S.6
  • 66
    • 79958803353 scopus 로고    scopus 로고
    • Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: The OCEAN study
    • R. Eastell, S. Nagase, M. Ohyama, M. Small, J. Sawyer, S. Boonen, and et al. Safety and efficacy of the cathepsin K inhibitor ONO-5334 in postmenopausal osteoporosis: the OCEAN study J. Bone Miner. Res. 26 2011 1303 1312
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 1303-1312
    • Eastell, R.1    Nagase, S.2    Ohyama, M.3    Small, M.4    Sawyer, J.5    Boonen, S.6
  • 68
    • 84856783815 scopus 로고    scopus 로고
    • Update on bone anabolics in osteoporosis treatment: Rationale, current status, and perspectives
    • R. Baron, and E. Hesse Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives J. Clin. Endocrinol. Metab. 29 2012 311 325
    • (2012) J. Clin. Endocrinol. Metab. , vol.29 , pp. 311-325
    • Baron, R.1    Hesse, E.2
  • 69
    • 0035837553 scopus 로고    scopus 로고
    • Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
    • R.M. Neer, C.D. Arnaud, J.R. Zanchetta, R. Prince, G.A. Gaich, J.Y. Reginster, and et al. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis N. Engl. J. Med. 344 2001 1434 1441
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1434-1441
    • Neer, R.M.1    Arnaud, C.D.2    Zanchetta, J.R.3    Prince, R.4    Gaich, G.A.5    Reginster, J.Y.6
  • 70
    • 0141684971 scopus 로고    scopus 로고
    • The effects of parathyroid hormone and alendronate alone or in combination for postmenopausal osteoporosis
    • D.M. Black, S.L. Greenspan, K.E. Ensrud, L. Palermo, J.A. McGowan, T.F. Lang, and et al. The effects of parathyroid hormone and alendronate alone or in combination for postmenopausal osteoporosis N. Engl. J. Med. 349 2003 1207 1215
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1207-1215
    • Black, D.M.1    Greenspan, S.L.2    Ensrud, K.E.3    Palermo, L.4    McGowan, J.A.5    Lang, T.F.6
  • 73
    • 84866148169 scopus 로고    scopus 로고
    • Randomized teriparatide [human parathyroid hormone (PTH) 1-34] once-weekly efficacy research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk
    • T. Nakamura, T. Sugimoto, T. Nakano, H. Kishimoto, M. Ito, M. Fukunaga, and et al. Randomized teriparatide [human parathyroid hormone (PTH) 1-34] once-weekly efficacy research (TOWER) trial for examining the reduction in new vertebral fractures in subjects with primary osteoporosis and high fracture risk J. Clin. Endocrinol. Metab. 97 2012 3097 3106
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , pp. 3097-3106
    • Nakamura, T.1    Sugimoto, T.2    Nakano, T.3    Kishimoto, H.4    Ito, M.5    Fukunaga, M.6
  • 74
    • 84866017861 scopus 로고    scopus 로고
    • A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice
    • T. Ponnapakkam, R. Katikaneni, H. Suda, S. Miyata, O. Matsushita, J. Sakon, and et al. A single injection of the anabolic bone agent, parathyroid hormone-collagen binding domain (PTH-CBD), results in sustained increases in bone mineral density for up to 12 months in normal female mice Calcif. Tissue Int. 91 2012 196 201
    • (2012) Calcif. Tissue Int. , vol.91 , pp. 196-201
    • Ponnapakkam, T.1    Katikaneni, R.2    Suda, H.3    Miyata, S.4    Matsushita, O.5    Sakon, J.6
  • 76
    • 84858054312 scopus 로고    scopus 로고
    • The single dose pharmacokinetic profile of a novel oral human parathyroid hormone formulation in healthy postmenopausal women
    • S.P. Hammerle, L. Mindeholm, A. Launonen, B. Kiese, R. Loeffler, E. Harfst, and et al. The single dose pharmacokinetic profile of a novel oral human parathyroid hormone formulation in healthy postmenopausal women Bone 50 2012 965 973
    • (2012) Bone , vol.50 , pp. 965-973
    • Hammerle, S.P.1    Mindeholm, L.2    Launonen, A.3    Kiese, B.4    Loeffler, R.5    Harfst, E.6
  • 77
    • 79961216005 scopus 로고    scopus 로고
    • The effects of ronacaleret, a calcium-sensing receptor antagonist, on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mineral density
    • L.A. Fitzpatrick, C.E. Dabrowski, G. Cicconetti, D.N. Gordon, S. Papapoulos, H.G. Bone 3rd, and et al. The effects of ronacaleret, a calcium-sensing receptor antagonist, on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mineral density J. Clin. Endocrinol. Metab. 96 2011 2441 2449
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 2441-2449
    • Fitzpatrick, L.A.1    Dabrowski, C.E.2    Cicconetti, G.3    Gordon, D.N.4    Papapoulos, S.5    Bone, H.G.6
  • 78
    • 80052058754 scopus 로고    scopus 로고
    • JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats
    • S. Kimura, T. Nakagawa, Y. Matsuo, Y. Ishida, Y. Okamoto, and M. Hayashi JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats Eur. J. Pharmacol. 668 2011 331 336
    • (2011) Eur. J. Pharmacol. , vol.668 , pp. 331-336
    • Kimura, S.1    Nakagawa, T.2    Matsuo, Y.3    Ishida, Y.4    Okamoto, Y.5    Hayashi, M.6
  • 79
    • 84922553490 scopus 로고    scopus 로고
    • Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis
    • B.Z. Leder, L.S. O'Dea, J.R. Zanchetta, P. Kumar, K. Banks, K. McKay, and et al. Effects of abaloparatide, a human parathyroid hormone-related peptide analog, on bone mineral density in postmenopausal women with osteoporosis J. Clin. Endocrinol. Metab. 100 2015 697 706
    • (2015) J. Clin. Endocrinol. Metab. , vol.100 , pp. 697-706
    • Leder, B.Z.1    O'Dea, L.S.2    Zanchetta, J.R.3    Kumar, P.4    Banks, K.5    McKay, K.6
  • 81
    • 65549152230 scopus 로고    scopus 로고
    • Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis
    • X. Li, M.S. Ominsky, K.S. Warmington, S. Morony, J. Gong, J. Cao, and et al. Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis J. Bone Miner. Res. 24 2009 578 588
    • (2009) J. Bone Miner. Res. , vol.24 , pp. 578-588
    • Li, X.1    Ominsky, M.S.2    Warmington, K.S.3    Morony, S.4    Gong, J.5    Cao, J.6
  • 82
    • 78650958526 scopus 로고    scopus 로고
    • Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody
    • D. Padhi, G. Jang, B. Stouch, L. Fang, and E. Posvar Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody J. Bone Miner. Res. 26 2011 19 26
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 19-26
    • Padhi, D.1    Jang, G.2    Stouch, B.3    Fang, L.4    Posvar, E.5
  • 84
    • 84921809759 scopus 로고    scopus 로고
    • A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density
    • R.R. Recker, C.T. Benson, T. Matsumoto, M.A. Bolognese, D.A. Robins, J. Alam, and et al. A randomized, double-blind phase 2 clinical trial of blosozumab, a sclerostin antibody, in postmenopausal women with low bone mineral density J. Bone Miner. Res. 30 2015 216 224
    • (2015) J. Bone Miner. Res. , vol.30 , pp. 216-224
    • Recker, R.R.1    Benson, C.T.2    Matsumoto, T.3    Bolognese, M.A.4    Robins, D.A.5    Alam, J.6
  • 85
    • 84930642961 scopus 로고    scopus 로고
    • The effect of discontinuing treatment with blosozumab: Follow-up results of a phase 2 randomized clinical trial in postmenopausal women with low bone mineral density
    • February 24 [Epub ahead of print]
    • C.P. Recknor, R.R. Recker, C.T. Benson, D.A. Robins, A.Y. Chiang, J. Alam, and et al. The effect of discontinuing treatment with blosozumab: follow-up results of a phase 2 randomized clinical trial in postmenopausal women with low bone mineral density J. Bone Miner. Res. 2015 February 24 [Epub ahead of print]
    • (2015) J. Bone Miner. Res.
    • Recknor, C.P.1    Recker, R.R.2    Benson, C.T.3    Robins, D.A.4    Chiang, A.Y.5    Alam, J.6
  • 86
    • 79960509237 scopus 로고    scopus 로고
    • A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody
    • H. Glantschnig, K. Scott, R. Hamptom, N. Wei, P. McCracken, P. Nantermet, and et al. A rate-limiting role for Dickkopf-1 in bone formation and the remediation of bone loss in mouse and primate models of postmenopausal osteoporosis by an experimental therapeutic antibody J. Pharmacol. Exp. Ther. 338 2011 568 578
    • (2011) J. Pharmacol. Exp. Ther. , vol.338 , pp. 568-578
    • Glantschnig, H.1    Scott, K.2    Hamptom, R.3    Wei, N.4    McCracken, P.5    Nantermet, P.6
  • 87
    • 84861830328 scopus 로고    scopus 로고
    • Recombinant human bone morphogenetic protein type 2 application for a possible treatment of bisphosphonates-related osteonecrosis of the jaw
    • M. Cicciu, A.S. Herford, G. Juodzbalys, and E. Stoffella Recombinant human bone morphogenetic protein type 2 application for a possible treatment of bisphosphonates-related osteonecrosis of the jaw J. Craniofac. Surg. 23 2012 784 788
    • (2012) J. Craniofac. Surg. , vol.23 , pp. 784-788
    • Cicciu, M.1    Herford, A.S.2    Juodzbalys, G.3    Stoffella, E.4


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