메뉴 건너뛰기




Volumn 5, Issue 2, 2012, Pages 195-204

Activin receptor signaling: A potential therapeutic target for osteoporosis

Author keywords

Activin; Follistatin; Inhibin; Osteoblast; Osteoclast; Osteoporosis

Indexed keywords

ACTIVIN; ACTIVIN A; ACTIVIN RECEPTOR; ACTIVIN RECEPTOR 1; ACTIVIN RECEPTOR 2; ACTIVIN RECEPTOR LIKE KINASE 1; ACTRIIA FC FUSION PROTEIN; ALK4 PROTEIN; ALK7 PROTEIN; BAMBI PROTEIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; CRIPTO PROTEIN; FOLLISTATIN; FOLLISTATIN 288; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; HORMONE RELEASE INHIBITING FACTOR; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; INHIBIN; INHIBIN A; INHIBIN B; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84861722759     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467211205020195     Document Type: Article
Times cited : (47)

References (75)
  • 1
    • 4444308702 scopus 로고    scopus 로고
    • Coming to grips with bone loss
    • Marx, J. Coming to grips with bone loss. Science, 2004, 305, 1420-1422.
    • (2004) Science , vol.305 , pp. 1420-1422
    • Marx, J.1
  • 2
    • 21444449880 scopus 로고    scopus 로고
    • Osteonecrosis of the jaws and bisphosphonates
    • Durie, B.G.; Katz, M.; Crowley, J. Osteonecrosis of the jaws and bisphosphonates. N. Engl. J. Med., 2005, 353, 99-102.
    • (2005) N. Engl. J. Med , vol.353 , pp. 99-102
    • Durie, B.G.1    Katz, M.2    Crowley, J.3
  • 3
    • 38849086631 scopus 로고    scopus 로고
    • Bisphosphonate use and the risk of adverse jaw outcomes: A medical claims study of 714,217 people
    • Cartsos, V.M.; Zhu, S.; Zavras, A.I. Bisphosphonate use and the risk of adverse jaw outcomes: a medical claims study of 714,217 people. J. Am. Dent. Assoc., 2008, 139, 23-30.
    • (2008) J. Am. Dent. Assoc , vol.139 , pp. 23-30
    • Cartsos, V.M.1    Zhu, S.2    Zavras, A.I.3
  • 4
    • 34848819692 scopus 로고    scopus 로고
    • A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: Prevalence, risk factors, and clinical characteristics
    • Pazianas, M.; Miller, P.; Blumentals, W.A.; Bernal, M.; Kothawala, P. A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics. Clin. Ther., 2007, 29, 1548-1558.
    • (2007) Clin. Ther , vol.29 , pp. 1548-1558
    • Pazianas, M.1    Miller, P.2    Blumentals, W.A.3    Bernal, M.4    Kothawala, P.5
  • 5
    • 67149126908 scopus 로고    scopus 로고
    • Future therapeutic targets in osteoporosis
    • Deal, C. Future therapeutic targets in osteoporosis. Curr. Opin. Rheumatol., 2009, 21, 380-385.
    • (2009) Curr. Opin. Rheumatol , vol.21 , pp. 380-385
    • Deal, C.1
  • 9
    • 69249230778 scopus 로고    scopus 로고
    • Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin
    • Nicks, K.M.; Perrien, D.S.; Akel, N.S.; Suva, L.J.; Gaddy, D. Regulation of osteoblastogenesis and osteoclastogenesis by the other reproductive hormones, Activin and Inhibin. Mol. Cell Endocrinol., 2009, 310, 11-20.
    • (2009) Mol. Cell Endocrinol , vol.310 , pp. 11-20
    • Nicks, K.M.1    Perrien, D.S.2    Akel, N.S.3    Suva, L.J.4    Gaddy, D.5
  • 15
    • 3142619579 scopus 로고    scopus 로고
    • Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders
    • Tsuchida, K. Activins, myostatin and related TGF-beta family members as novel therapeutic targets for endocrine, metabolic and immune disorders. Curr. Drug Targets Immune. Endocr. Metabol. Disord., 2004, 4, 157-66.
    • (2004) Curr. Drug Targets Immune. Endocr. Metabol. Disord , vol.4 , pp. 157-166
    • Tsuchida, K.1
  • 16
    • 0036459180 scopus 로고    scopus 로고
    • The role of activin a in regulation of hemopoiesis
    • Shav-Tal, Y.; Zipori, D. The role of activin a in regulation of hemopoiesis. Stem Cells, 2002, 20, 493-500.
    • (2002) Stem Cells , vol.20 , pp. 493-500
    • Shav-Tal, Y.1    Zipori, D.2
  • 18
    • 0036904895 scopus 로고    scopus 로고
    • Genetic analysis of the mammalian transforming growth factor-beta superfamily
    • Chang, H.; Brown, C.W.; Matzuk, M.M. Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr. Rev., 2002, 23, 787-823.
    • (2002) Endocr. Rev , vol.23 , pp. 787-823
    • Chang, H.1    Brown, C.W.2    Matzuk, M.M.3
  • 20
    • 0025222517 scopus 로고
    • The transforming growth factor-β family
    • Massague, J. The transforming growth factor-β family. Annu. Rev. Cell Biol, 1990, 6, 597-641.
    • (1990) Annu. Rev. Cell Biol , vol.6 , pp. 597-641
    • Massague, J.1
  • 22
    • 0029003329 scopus 로고
    • Molecular cloning and functional analysis of a new activin beta subunit: A dorsal mesoderm-inducing activity in Xenopus
    • Oda, S.; Nishimatsu, S.; Murakami, K.; Ueno, N. Molecular cloning and functional analysis of a new activin beta subunit: a dorsal mesoderm-inducing activity in Xenopus. Biochem. Biophys. Res. Commun., 1995, 210, 581-588.
    • (1995) Biochem. Biophys. Res. Commun , vol.210 , pp. 581-588
    • Oda, S.1    Nishimatsu, S.2    Murakami, K.3    Ueno, N.4
  • 23
    • 34547422406 scopus 로고    scopus 로고
    • Nodal signalling and apoptosis
    • Wang, H.; Tsang, B.K. Nodal signalling and apoptosis. Reproduction, 2007, 133, 847-853.
    • (2007) Reproduction , vol.133 , pp. 847-853
    • Wang, H.1    Tsang, B.K.2
  • 24
    • 1542673128 scopus 로고    scopus 로고
    • The TGF-beta superfamily and its roles in the human ovary and placenta
    • Peng, C. The TGF-beta superfamily and its roles in the human ovary and placenta. J. Obstet. Gynaecol. Can., 2003, 25, 834-844.
    • (2003) J. Obstet. Gynaecol. Can , vol.25 , pp. 834-844
    • Peng, C.1
  • 25
    • 0036910425 scopus 로고    scopus 로고
    • Two major Smad pathways in TGF-beta superfamily signalling
    • Miyazawa, K.; Shinozaki, M.; Hara, T.; Furuya, T.; Miyazon, K. Two major Smad pathways in TGF-beta superfamily signalling. Genes Cells, 2002, 7, 1191-1204.
    • (2002) Genes Cells , vol.7 , pp. 1191-1204
    • Miyazawa, K.1    Shinozaki, M.2    Hara, T.3    Furuya, T.4    Miyazon, K.5
  • 27
    • 0042237016 scopus 로고    scopus 로고
    • A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure
    • Zhang, L.; Wang, W.; Hayashi, Y.; Jester, J.V.; Birk, D.E.; Gao, M.; Liu, C.Y.; Kao, W.W.; Karin, M.; Xia, Y. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. EMBO J., 2003, 22, 4443-4454.
    • (2003) EMBO J , vol.22 , pp. 4443-4454
    • Zhang, L.1    Wang, W.2    Hayashi, Y.3    Jester, J.V.4    Birk, D.E.5    Gao, M.6    Liu, C.Y.7    Kao, W.W.8    Karin, M.9    Xia, Y.10
  • 28
    • 37249088295 scopus 로고    scopus 로고
    • Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I
    • Zhu, W.; Xu, P.; Cuascut, F.X.; Hall, A.K.; Oxford, G.S. Activin acutely sensitizes dorsal root ganglion neurons and induces hyperalgesia via PKC-mediated potentiation of transient receptor potential vanilloid I. J. Neurosci., 2007, 27, 13770-13780.
    • (2007) J. Neurosci , vol.27 , pp. 13770-13780
    • Zhu, W.1    Xu, P.2    Cuascut, F.X.3    Hall, A.K.4    Oxford, G.S.5
  • 29
    • 15844405843 scopus 로고    scopus 로고
    • Synergistic activity of activin A and basic fibroblast growth factor on tyrosine hydroxylase expression through Smad3 and ERK1/ERK2 MAPK signaling pathways
    • Bao, Y.L.; Tsuchida, K.; Liu, B.; Kurisaki, A.; Matsuzaki, T.; Sugino, H. Synergistic activity of activin A and basic fibroblast growth factor on tyrosine hydroxylase expression through Smad3 and ERK1/ERK2 MAPK signaling pathways. J. Endocrinol., 2005, 184, 493-504.
    • (2005) J. Endocrinol , vol.184 , pp. 493-504
    • Bao, Y.L.1    Tsuchida, K.2    Liu, B.3    Kurisaki, A.4    Matsuzaki, T.5    Sugino, H.6
  • 30
    • 33747597788 scopus 로고    scopus 로고
    • Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a Smad-independent manner
    • de Guise, C.; Lacerte, A.; Rafiei, S.; Reynaud, R.; Roy, M.; Brue, T.; Lebrun, J.J. Activin inhibits the human Pit-1 gene promoter through the p38 kinase pathway in a Smad-independent manner. Endocrinology, 2006, 147, 4351-4362.
    • (2006) Endocrinology , vol.147 , pp. 4351-4362
    • de Guise, C.1    Lacerte, A.2    Rafiei, S.3    Reynaud, R.4    Roy, M.5    Brue, T.6    Lebrun, J.J.7
  • 31
    • 47049131867 scopus 로고    scopus 로고
    • Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300
    • Hirota, M.; Watanabe, K.; Hamada, S.; Sun, Y.; Strizzi, L.; Mancino, M.; Nagaoka, T.; Gonzales, M.; Seno, M.; Bianco, C.; Salomon, D.S. Smad2 functions as a co-activator of canonical Wnt/beta-catenin signaling pathway independent of Smad4 through histone acetyltransferase activity of p300. Cell Signal., 2008, 20, 1632-1641.
    • (2008) Cell Signal , vol.20 , pp. 1632-1641
    • Hirota, M.1    Watanabe, K.2    Hamada, S.3    Sun, Y.4    Strizzi, L.5    Mancino, M.6    Nagaoka, T.7    Gonzales, M.8    Seno, M.9    Bianco, C.10    Salomon, D.S.11
  • 33
    • 0042822157 scopus 로고    scopus 로고
    • Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors
    • Sugatani, T.; Alvarez, U.M.; Hruska, K.A. Activin A stimulates IkappaB-alpha/NFkappaB and RANK expression for osteoclast differentiation, but not AKT survival pathway in osteoclast precursors. J. Cell Biochem., 2003, 90, 59-67.
    • (2003) J. Cell Biochem , vol.90 , pp. 59-67
    • Sugatani, T.1    Alvarez, U.M.2    Hruska, K.A.3
  • 34
    • 0032893161 scopus 로고    scopus 로고
    • Roles of pathwayspecific and inhibitory Smads in activin receptor signaling
    • Lebrun, J.J.; Takabe, K.; Chen, Y.; Vale, W. Roles of pathwayspecific and inhibitory Smads in activin receptor signaling. Mol. Endocrinol., 1999, 13, 15-23.
    • (1999) Mol. Endocrinol , vol.13 , pp. 15-23
    • Lebrun, J.J.1    Takabe, K.2    Chen, Y.3    Vale, W.4
  • 35
    • 0006000627 scopus 로고
    • Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid
    • Ling, N.; Ying, S.Y.; Ueno, N.; Esch, F.; Denoroy, L.; Guillemin, R. Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid. Proc. Natl. Acad. Sci. USA, 1985, 82, 7217-7221.
    • (1985) Proc. Natl. Acad. Sci. USA , vol.82 , pp. 7217-7221
    • Ling, N.1    Ying, S.Y.2    Ueno, N.3    Esch, F.4    Denoroy, L.5    Guillemin, R.6
  • 36
    • 0025905181 scopus 로고
    • Expression cloning of an activin receptor, a predicted transmembrane serine kinase
    • Mathews, L.S.; Vale, W.W. Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell, 1991, 65, 973-982.
    • (1991) Cell , vol.65 , pp. 973-982
    • Mathews, L.S.1    Vale, W.W.2
  • 37
    • 77949328305 scopus 로고    scopus 로고
    • Inhibins: From reproductive hormones to tumor suppressors
    • Stenvers, K.L.; Findlay, J.K. Inhibins: from reproductive hormones to tumor suppressors. Trends Endocrinol. Metab., 2010, 21, 174-180.
    • (2010) Trends Endocrinol. Metab , vol.21 , pp. 174-180
    • Stenvers, K.L.1    Findlay, J.K.2
  • 38
    • 33745124059 scopus 로고    scopus 로고
    • Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line
    • Farnworth, P.G.; Stanton, P.G.; Wang, Y.; Escalona, R.; Findlay, J.K.; Ooi, G.T. Inhibins differentially antagonize activin and bone morphogenetic protein action in a mouse adrenocortical cell line. Endocrinology, 2006, 147, 3462-3471.
    • (2006) Endocrinology , vol.147 , pp. 3462-3471
    • Farnworth, P.G.1    Stanton, P.G.2    Wang, Y.3    Escalona, R.4    Findlay, J.K.5    Ooi, G.T.6
  • 40
    • 41949137589 scopus 로고    scopus 로고
    • Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal
    • Kelber, J.A.; Shani, G.; Booker, E.C.; Vale, W.W.; Gray, P.C. Cripto is a noncompetitive activin antagonist that forms analogous signaling complexes with activin and nodal. J. Biol. Chem., 2008, 283, 4490-4500.
    • (2008) J. Biol. Chem , vol.283 , pp. 4490-4500
    • Kelber, J.A.1    Shani, G.2    Booker, E.C.3    Vale, W.W.4    Gray, P.C.5
  • 41
    • 0034237708 scopus 로고    scopus 로고
    • The EGF-CFC gene family in vertebrate development
    • Shen, M.M.; Schier, A.F. The EGF-CFC gene family in vertebrate development. Trends Genet., 2000, 16, 303-309.
    • (2000) Trends Genet , vol.16 , pp. 303-309
    • Shen, M.M.1    Schier, A.F.2
  • 42
    • 0032482928 scopus 로고    scopus 로고
    • Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo
    • Iemura, S.; Yamamoto, T.S.; Takagi, C.; Uchiyama, H.; Natsume, T.; Shimasaki, S.; Sugino, H.; Ueno, N. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo. Proc. Natl. Acad. Sci. USA, 1998, 95, 9337-9342.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9337-9342
    • Iemura, S.1    Yamamoto, T.S.2    Takagi, C.3    Uchiyama, H.4    Natsume, T.5    Shimasaki, S.6    Sugino, H.7    Ueno, N.8
  • 43
    • 0033120212 scopus 로고    scopus 로고
    • A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos
    • Gamer, L.W.; Wolfman, N.M.; Celeste, A.J.; Hattersley, G.; Hewick, R.; Rosen, V. A novel BMP expressed in developing mouse limb, spinal cord, and tail bud is a potent mesoderm inducer in Xenopus embryos. Dev. Biol., 1999, 208, 222-232.
    • (1999) Dev. Biol , vol.208 , pp. 222-232
    • Gamer, L.W.1    Wolfman, N.M.2    Celeste, A.J.3    Hattersley, G.4    Hewick, R.5    Rosen, V.6
  • 44
    • 0025935385 scopus 로고
    • Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells
    • Nakamura, T.; Sugino, K.; Titani, K.; Sugino, H. Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells. J. Biol. Chem., 1991, 266, 19432-19437.
    • (1991) J. Biol. Chem , vol.266 , pp. 19432-19437
    • Nakamura, T.1    Sugino, K.2    Titani, K.3    Sugino, H.4
  • 45
    • 0026014287 scopus 로고
    • Recombinant expression of human follistatin with 315 and 288 amino acids: Chemical and biological comparison with native porcine follistatin
    • Inouye, S.; Guo, Y.; DePaolo, L.; Shimonaka, M.; Ling, N.; Shimasaki, S. Recombinant expression of human follistatin with 315 and 288 amino acids: chemical and biological comparison with native porcine follistatin. Endocrinology, 1991, 129, 815-822.
    • (1991) Endocrinology , vol.129 , pp. 815-822
    • Inouye, S.1    Guo, Y.2    DePaolo, L.3    Shimonaka, M.4    Ling, N.5    Shimasaki, S.6
  • 46
    • 0027268691 scopus 로고
    • Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell
    • Sugino, K.; Kurosawa, N.; Nakamura, T.; Takio, K.; Shimasaki, S.; Ling, N.; Titani, K.; Sugino, H. Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell. J. Biol. Chem., 1993, 268, 15579-15587.
    • (1993) J. Biol. Chem , vol.268 , pp. 15579-15587
    • Sugino, K.1    Kurosawa, N.2    Nakamura, T.3    Takio, K.4    Shimasaki, S.5    Ling, N.6    Titani, K.7    Sugino, H.8
  • 47
    • 6344282425 scopus 로고    scopus 로고
    • Differential distribution of follistatin isoforms: Application of a new FS315-specific immunoassay
    • Schneyer, A.L.; Wang, Q.; Sidis, Y.; Sluss, P.M. Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay. J. Clin. Endocrinol. Metab., 2004, 89, 5067-5075.
    • (2004) J. Clin. Endocrinol. Metab , vol.89 , pp. 5067-5075
    • Schneyer, A.L.1    Wang, Q.2    Sidis, Y.3    Sluss, P.M.4
  • 49
    • 33745175570 scopus 로고    scopus 로고
    • Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins
    • Sidis, Y.; Mukherjee, A.; Keutmann, H.; Delbaere, A.; Sadatsuki, M.; Schneyer, A. Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenetic proteins. Endocrinology, 2006, 147, 3586-3597.
    • (2006) Endocrinology , vol.147 , pp. 3586-3597
    • Sidis, Y.1    Mukherjee, A.2    Keutmann, H.3    Delbaere, A.4    Sadatsuki, M.5    Schneyer, A.6
  • 50
    • 0034425726 scopus 로고    scopus 로고
    • Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions
    • Brown, C.W.; Houston-Hawkins, D.E.; Woodruff, T.K.; Matzuk, M.M. Insertion of Inhbb into the Inhba locus rescues the Inhba-null phenotype and reveals new activin functions. Nat. Genet., 2000, 25, 453-457.
    • (2000) Nat. Genet , vol.25 , pp. 453-457
    • Brown, C.W.1    Houston-Hawkins, D.E.2    Woodruff, T.K.3    Matzuk, M.M.4
  • 53
    • 0025977099 scopus 로고
    • Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone
    • Centrella, M.; McCarthy, T.L.; Canalis, E. Activin-A binding and biochemical effects in osteoblast-enriched cultures from fetal-rat parietal bone. Mol. Cell. Biol., 1991, 11, 250-258.
    • (1991) Mol. Cell. Biol , vol.11 , pp. 250-258
    • Centrella, M.1    McCarthy, T.L.2    Canalis, E.3
  • 54
    • 0034080583 scopus 로고    scopus 로고
    • Activin increases bone mass and mechanical strength of lumbar vertebrae in aged ovariectomized rats
    • Sakai, R.; Fujita, S.; Horie, T.; Ohyama, T.; Miwa, K.; Maki, T.; Okimoto, N.; Nakamura, T.; Eto, Y. Activin increases bone mass and mechanical strength of lumbar vertebrae in aged ovariectomized rats. Bone, 2000, 27, 91-96.
    • (2000) Bone , vol.27 , pp. 91-96
    • Sakai, R.1    Fujita, S.2    Horie, T.3    Ohyama, T.4    Miwa, K.5    Maki, T.6    Okimoto, N.7    Nakamura, T.8    Eto, Y.9
  • 55
    • 0033016747 scopus 로고    scopus 로고
    • Local administration of activin promotes fracture healing in the rat fibula fracture model
    • Sakai, R.; Miwa, K.; Eto, Y. Local administration of activin promotes fracture healing in the rat fibula fracture model. Bone, 1999, 25, 191-196.
    • (1999) Bone , vol.25 , pp. 191-196
    • Sakai, R.1    Miwa, K.2    Eto, Y.3
  • 56
    • 0027949278 scopus 로고
    • Effect of local injection of activin A on bone formation in newborn rats
    • Oue, Y.; Kanatani, H.; Kiyoki, M.; Eto, Y.; Ogata, E.; Matsumoto, T. Effect of local injection of activin A on bone formation in newborn rats. Bone, 1994, 15, 361-366.
    • (1994) Bone , vol.15 , pp. 361-366
    • Oue, Y.1    Kanatani, H.2    Kiyoki, M.3    Eto, Y.4    Ogata, E.5    Matsumoto, T.6
  • 58
    • 0033231930 scopus 로고    scopus 로고
    • Inhibitory effects of activin-A on osteoblast differentiation during cultures of fetal rat calvarial cells
    • Ikenoue, T.; Jingushi, S.; Urabe, K.; Okazaki, K.; Iwamoto, Y. Inhibitory effects of activin-A on osteoblast differentiation during cultures of fetal rat calvarial cells. J. Cell. Biochem., 1999, 75, 206-214.
    • (1999) J. Cell. Biochem , vol.75 , pp. 206-214
    • Ikenoue, T.1    Jingushi, S.2    Urabe, K.3    Okazaki, K.4    Iwamoto, Y.5
  • 60
    • 0036144102 scopus 로고    scopus 로고
    • Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures
    • Gaddy-Kurten, D.; Coker, J. K.; Abe, E.; Jilka, R. L.; Manolagas, S. C. Inhibin suppresses and activin stimulates osteoblastogenesis and osteoclastogenesis in murine bone marrow cultures. Endocrinology, 2002, 143, 74-83.
    • (2002) Endocrinology , vol.143 , pp. 74-83
    • Gaddy-Kurten, D.1    Coker, J.K.2    Abe, E.3    Jilka, R.L.4    Manolagas, S.C.5
  • 63
    • 0029766812 scopus 로고    scopus 로고
    • Follistatin and activin in bone: Expression and localization during endochondral bone development
    • Funaba, M.; Ogawa, K.; Murata, T.; Fujimura, H.; Murata, E.; Abe, M.; Takahashi, M.; Torii, K. Follistatin and activin in bone: Expression and localization during endochondral bone development. Endocrinology, 1996, 137, 4250-4259.
    • (1996) Endocrinology , vol.137 , pp. 4250-4259
    • Funaba, M.1    Ogawa, K.2    Murata, T.3    Fujimura, H.4    Murata, E.5    Abe, M.6    Takahashi, M.7    Torii, K.8
  • 64
    • 0028918915 scopus 로고
    • Multiple defects and perinatal death in mice deficient in follistatin
    • Matzuk, M.M.; Lu, N.; Vogel, H.; Sellheyer, K.; Roop, D.R.; Bradley, A. Multiple defects and perinatal death in mice deficient in follistatin. Nature, 1995, 374, 360-363.
    • (1995) Nature , vol.374 , pp. 360-363
    • Matzuk, M.M.1    Lu, N.2    Vogel, H.3    Sellheyer, K.4    Roop, D.R.5    Bradley, A.6
  • 65
    • 0031941395 scopus 로고    scopus 로고
    • Overexpression of mouse follistatin causes reproductive defects in transgenic mice
    • Guo, Q., Kumar, T. R., Woodruff, T., Hadsell, L. A., DeMayo, F. J., Matzuk, M. M. Overexpression of mouse follistatin causes reproductive defects in transgenic mice. Mol. Endocrinol., 1998, 12, 96-106.
    • (1998) Mol. Endocrinol , vol.12 , pp. 96-106
    • Guo, Q.1    Kumar, T.R.2    Woodruff, T.3    Hadsell, L.A.4    DeMayo, F.J.5    Matzuk, M.M.6
  • 66
    • 0023598057 scopus 로고
    • Importance of FSH-releasing protein and inhibin in erythrodifferentiation
    • Yu, J.; Shao, L.E.; Lemas, V.; Yu, A.L.; Vaughan, J.; Rivier, J.; Vale, W. Importance of FSH-releasing protein and inhibin in erythrodifferentiation. Nature, 1987, 330, 765-767.
    • (1987) Nature , vol.330 , pp. 765-767
    • Yu, J.1    Shao, L.E.2    Lemas, V.3    Yu, A.L.4    Vaughan, J.5    Rivier, J.6    Vale, W.7
  • 68
    • 0010259884 scopus 로고
    • 1988 Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin
    • Broxmeyer, H.E.; Lu, L.; Cooper, S.; Schwall, R.H.; Mason, A.J.; Nikolics, K. 1988 Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin. Proc. Natl. Acad. Sci. USA, 1988, 85, 9052-9056.
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 9052-9056
    • Broxmeyer, H.E.1    Lu, L.2    Cooper, S.3    Schwall, R.H.4    Mason, A.J.5    Nikolics, K.6
  • 73
    • 70349086989 scopus 로고    scopus 로고
    • Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer
    • Kang, H.Y.; Huang, H.Y.; Hsieh, C.Y.; Li, C.F.; Shyr, C.R.; Tsai, M.Y.; Chang, C.; Chuang, Y.C.; Huang, K.E. Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer. J. Bone Miner. Res., 2009, 24, 1180-1193.
    • (2009) J. Bone Miner. Res , vol.24 , pp. 1180-1193
    • Kang, H.Y.1    Huang, H.Y.2    Hsieh, C.Y.3    Li, C.F.4    Shyr, C.R.5    Tsai, M.Y.6    Chang, C.7    Chuang, Y.C.8    Huang, K.E.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.